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Article

Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers

1
CEA, LETI, MINATEC Campus, F-38054 Grenoble, France
2
University Grenoble Alpes, CNRS, Grenoble INP, GIPSA-Lab, 38000 Grenoble, France
3
Politecnico di Milano, Dipartimento di Fisica, 20133 Milano, Italy
4
Visual Computing Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
5
Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, 20133 Milano, Italy
*
Authors to whom correspondence should be addressed.
Sensors 2020, 20(10), 2815; https://doi.org/10.3390/s20102815
Received: 6 April 2020 / Revised: 11 May 2020 / Accepted: 12 May 2020 / Published: 15 May 2020
(This article belongs to the Special Issue Scattering-Based Techniques for Sensing Applications)
Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength (670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution. View Full-Text
Keywords: diffuse optical tomography; time-correlated single-photon counting; silicon photomultipliers; functional imaging diffuse optical tomography; time-correlated single-photon counting; silicon photomultipliers; functional imaging
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MDPI and ACS Style

Orive-Miguel, D.; Di Sieno, L.; Behera, A.; Ferocino, E.; Contini, D.; Condat, L.; Hervé, L.; Mars, J.; Torricelli, A.; Pifferi, A.; Dalla Mora, A. Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers. Sensors 2020, 20, 2815. https://doi.org/10.3390/s20102815

AMA Style

Orive-Miguel D, Di Sieno L, Behera A, Ferocino E, Contini D, Condat L, Hervé L, Mars J, Torricelli A, Pifferi A, Dalla Mora A. Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers. Sensors. 2020; 20(10):2815. https://doi.org/10.3390/s20102815

Chicago/Turabian Style

Orive-Miguel, David, Laura Di Sieno, Anurag Behera, Edoardo Ferocino, Davide Contini, Laurent Condat, Lionel Hervé, Jérôme Mars, Alessandro Torricelli, Antonio Pifferi, and Alberto Dalla Mora. 2020. "Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers" Sensors 20, no. 10: 2815. https://doi.org/10.3390/s20102815

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