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  • Review
  • Open Access
18 Citations
4,105 Views
12 Pages

ZIKV Infection and miRNA Network in Pathogenesis and Immune Response

  • Carolina Manganeli Polonio and
  • Jean Pierre Schatzmann Peron

4 October 2021

Over the years, viral infections have caused severe illness in humans. Zika Virus (ZIKV) is a flavivirus transmitted by mosquito vectors that leads to notable neurological impairment, whose most dramatic impact is the Congenital ZIKV Syndrome (CZS)....

  • Article
  • Open Access
11 Citations
3,431 Views
9 Pages

Zika Virus (ZIKV): A New Perspective on the Nanomechanical and Structural Properties

  • Maria Luiza de Araujo Dorneles,
  • Ruana Cardoso-Lima,
  • Pedro Filho Noronha Souza,
  • Daniela Santoro Rosa,
  • Tais Monteiro Magne,
  • Ralph Santos-Oliveira and
  • Luciana Magalhães Rebelo Alencar

5 August 2022

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) from Flavivirus. In 2015, Brazil and other Latin American countries experienced an outbreak of ZIKV infections associated with severe neurological disorders such as Guillain–Barre syndro...

  • Article
  • Open Access
12 Citations
5,711 Views
12 Pages

Host Immune Response to ZIKV in an Immunocompetent Embryonic Mouse Model of Intravaginal Infection

  • Svetlana F. Khaiboullina,
  • Priscila Lopes,
  • Toniana G. de Carvalho,
  • Ana Luiza C. V. Real,
  • Danielle G. Souza,
  • Vivian V. Costa,
  • Mauro M. Teixeira,
  • Enrrico Bloise,
  • Subhash C. Verma and
  • Fabiola M. Ribeiro

17 June 2019

Zika virus (ZIKV) only induces mild symptoms in adults; however, it can cause congenital Zika syndrome (CZS), including microcephaly. Most of the knowledge on ZIKV pathogenesis was gained using immunocompromised mouse models, which do not fully recap...

  • Review
  • Open Access
6 Citations
3,620 Views
14 Pages

13 September 2022

Zika virus (ZIKV) is an arthropod-borne virus that belongs to the Flavivirus genus and is principally transmitted by Aedes aegypti mosquitoes. ZIKV infection often causes no or only mild symptoms, but it can also trigger severe consequences, includin...

  • Review
  • Open Access
33 Citations
8,105 Views
21 Pages

The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response

  • Rosa C. Coldbeck-Shackley,
  • Nicholas S. Eyre and
  • Michael R. Beard

14 September 2020

Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses a...

  • Article
  • Open Access
35 Citations
6,737 Views
17 Pages

A Novel Microfluidic Device Integrated with Chitosan-Modified Capillaries for Rapid ZIKV Detection

  • Xinchao Zhu,
  • Jun Zhao,
  • Anzhong Hu,
  • Jingyu Pan,
  • Guoqing Deng,
  • Changyi Hua,
  • Cancan Zhu,
  • Yong Liu,
  • Ke Yang and
  • Ling Zhu

11 February 2020

The outbreak of Zika virus (ZIKV) has posed a great challenge to public health in recent years. To address the urgent need of ZIKV RNA assays, we integrate the microfluidic chip embedded with chitosan-modified silicon dioxide capillaries, smartphone-...

  • Article
  • Open Access
66 Views
11 Pages

Protein NS4A of ZIKV Inhibits Glycolytic Flux by Targeting Enolase-1

  • Rui Ma,
  • Kexin Zhang,
  • Zhengfei Qi,
  • Lina Wang and
  • Qingshan Bill Fu

NS4A plays a role in forming the flavivirus replication complex, which inhibits apoptosis in host cells by inducing autophagy, thereby promoting viral replication. The host protein ENO1 interacts with NS4A, but the precise mechanism underlying this i...

  • Article
  • Open Access
6 Citations
2,508 Views
11 Pages

Evaluation of Anomalies and Neurodevelopment in Children Exposed to ZIKV during Pregnancy

  • Kathia Guardado,
  • Miguel Varela-Cardoso,
  • Verónica Ofelia Pérez-Roa,
  • Jaime Morales-Romero,
  • Roberto Zenteno-Cuevas,
  • Ángel Ramos-Ligonio,
  • Oscar Guzmán-Martínez,
  • Clara L. Sampieri,
  • Christian S. Ortiz-Chacha and
  • Hilda Montero
  • + 2 authors

12 August 2022

Zika virus (ZIKV) infection in pregnancy is associated with birth and developmental alterations in infants. In this study, clinical records of 47 infants whose mothers had Zika during pregnancy or clinical manifestations compatible with Zika were rev...

  • Article
  • Open Access
13 Citations
3,941 Views
13 Pages

Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity

  • Eleonora Cimini,
  • Alessandra Sacchi,
  • Sara De Minicis,
  • Veronica Bordoni,
  • Rita Casetti,
  • Germana Grassi,
  • Francesca Colavita,
  • Concetta Castilletti,
  • Maria Rosaria Capobianchi and
  • Chiara Agrati
  • + 3 authors

An expansion of effector/activated Vδ2 T-cells was recently described in acute Zika virus (ZIKV)-infected patients, but their role in the protective immune response was not clarified. The aim of this study was to define the antiviral activity o...

  • Article
  • Open Access
9 Citations
4,532 Views
27 Pages

The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor

  • Silvia Pérez-Yanes,
  • Iria Lorenzo-Sánchez,
  • Romina Cabrera-Rodríguez,
  • Jonay García-Luis,
  • Rodrigo Trujillo-González,
  • Judith Estévez-Herrera and
  • Agustín Valenzuela-Fernández

29 March 2024

Zika virus (ZIKV) infection and pathogenesis are linked to the disruption of neurogenesis, congenital Zika syndrome and microcephaly by affecting neural progenitor cells. Nonstructural protein 5 (NS5) is the largest product encoded by ZIKV-RNA and is...

  • Article
  • Open Access
1 Citations
2,514 Views
15 Pages

The Relationship between HERV, Interleukin, and Transcription Factor Expression in ZIKV Infected versus Uninfected Trophoblastic Cells

  • Anderson Luís da Costa,
  • Paula Prieto-Oliveira,
  • Márcia Duarte-Barbosa,
  • Robert Andreata-Santos,
  • Cristina M. Peter,
  • Thamires Prolo de Brito,
  • Fernando Antoneli,
  • Ricardo Durães-Carvalho,
  • Marcelo R. S. Briones and
  • Luiz M. R. Janini
  • + 3 authors

5 September 2024

Zika virus (ZIKV) is an arbovirus with maternal, sexual, and TORCH-related transmission capabilities. After 2015, Brazil had the highest number of ZIVK-infected pregnant women who lost their babies or delivered them with Congenital ZIKV Syndrome (CZS...

  • Article
  • Open Access
4 Citations
2,700 Views
13 Pages

A Marine Natural Product, Harzianopyridone, as an Anti-ZIKV Agent by Targeting RNA-Dependent RNA Polymerase

  • Kexin Zhang,
  • Jingyao Liang,
  • Bingzhi Zhang,
  • Lishan Huang,
  • Jianchen Yu,
  • Xuhan Xiao,
  • Zhenjian He,
  • Huaming Tao and
  • Jie Yuan

23 February 2024

The Zika virus (ZIKV) is a mosquito-borne virus that already poses a danger to worldwide human health. Patients infected with ZIKV generally have mild symptoms like a low-grade fever and joint pain. However, severe symptoms can also occur, such as Gu...

  • Article
  • Open Access
15 Citations
5,694 Views
17 Pages

Pre-Existing Dengue Immunity Drives a DENV-Biased Plasmablast Response in ZIKV-Infected Patient

  • Siddhartha K. Bhaumik,
  • Lalita Priyamvada,
  • Robert C. Kauffman,
  • Lilin Lai,
  • Muktha S. Natrajan,
  • Alice Cho,
  • Nadine Rouphael,
  • Mehul S. Suthar,
  • Mark J. Mulligan and
  • Jens Wrammert

29 December 2018

The re-emergence of Zika virus (ZIKV) in the western hemisphere has most significantly affected dengue virus (DENV) endemic regions. Due to the geographical overlap between these two closely related flaviviruses, numerous individuals who suffered ZIK...

  • Article
  • Open Access
6 Citations
2,043 Views
18 Pages

Sustained Microglial Activation Promotes Synaptic Loss and Neuronal Dysfunction after Recovery from ZIKV Infection

  • Nahyun Kim,
  • Hanul Choi,
  • Uijin Kim,
  • Suyeon Kim,
  • Young Bong Kim and
  • Ha Youn Shin

30 August 2024

Zika virus (ZIKV), transmitted by Aedes mosquitoes, has been a global health concern since 2007. It primarily causes fetal microcephaly and neuronal defects through maternal transmission and induces neurological complications in adults. Recent studie...

  • Communication
  • Open Access
6 Citations
3,618 Views
7 Pages

RT-dPCR in Mosquito Samples for ZIKV Detection: Effects of RNA Extraction and Reverse Transcription in Target Concentration

  • Paula Rodrigues de Almeida,
  • Ana Karolina Antunes Eisen,
  • Meriane Demoliner and
  • Fernando Rosado Spilki

30 July 2020

Zika virus (ZIKV) is an important arbovirus, responsible for recent outbreaks of Guillain Barré Syndrome and Congenital Zika Syndrome (CZS). After thousands of CZS cases, ZIKV is under constant surveillance in Brazil. Reliable and robust detec...

  • Article
  • Open Access
4 Citations
3,613 Views
18 Pages

Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy

  • Débora Familiar-Macedo,
  • Iury Amancio Paiva,
  • Jessica Badolato-Corrêa da Silva,
  • Fabiana Rabe de Carvalho,
  • Helver Gonçalves Dias,
  • Alex Pauvolid-Corrêa,
  • Caroline Fernandes dos Santos,
  • Mariana Gandini,
  • Andréa Alice Silva and
  • Luzia Maria de-Oliveira-Pinto
  • + 8 authors

28 January 2021

There have been reports of neurological abnormalities associated with the Zika virus (ZIKV), such as congenital Zika syndrome (CZS) in children born to mothers infected during pregnancy. We investigated how the immune response to ZIKV during pregnanc...

  • Article
  • Open Access
2 Citations
2,159 Views
18 Pages

Non-Nucleoside Lycorine-Based Analogs as Potential DENV/ZIKV NS5 Dual Inhibitors: Structure-Based Virtual Screening and Chemoinformatic Analysis

  • Adrián Camilo Rodríguez-Ararat,
  • Yasser Hayek-Orduz,
  • Andrés-Felipe Vásquez,
  • Felipe Sierra-Hurtado,
  • María-Francisca Villegas-Torres,
  • Paola A. Caicedo-Burbano,
  • Luke E. K. Achenie and
  • Andrés Fernando González Barrios

26 September 2024

Dengue (DENV) and Zika (ZIKV) virus continue to pose significant challenges globally due to their widespread prevalence and severe health implications. Given the absence of effective vaccines and specific therapeutics, targeting the highly conserved...

  • Article
  • Open Access
6 Citations
8,120 Views
16 Pages

Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State

  • Anna Lappala,
  • Wataru Nishima,
  • Jacob Miner,
  • Paul Fenimore,
  • Will Fischer,
  • Peter Hraber,
  • Ming Zhang,
  • Benjamin McMahon and
  • Chang-Shung Tung

Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in v...

  • Article
  • Open Access
21 Citations
5,377 Views
24 Pages

Identification of Inhibitors of ZIKV Replication

  • Desarey Morales Vasquez,
  • Jun-Gyu Park,
  • Ginés Ávila-Pérez,
  • Aitor Nogales,
  • Juan Carlos de la Torre,
  • Fernando Almazan and
  • Luis Martinez-Sobrido

18 September 2020

Zika virus (ZIKV) was identified in 1947 in the Zika forest of Uganda and it has emerged recently as a global health threat, with recurring outbreaks and its associations with congenital microcephaly through maternal fetal transmission and Guillain-B...

  • Review
  • Open Access
19 Citations
6,274 Views
15 Pages

The Potential Role of the ZIKV NS5 Nuclear Spherical-Shell Structures in Cell Type-Specific Host Immune Modulation during ZIKV Infection

  • Min Jie Alvin Tan,
  • Kitti Wing Ki Chan,
  • Ivan H. W. Ng,
  • Sean Yao Zu Kong,
  • Chin Piaw Gwee,
  • Satoru Watanabe and
  • Subhash G. Vasudevan

26 November 2019

The Zika virus (ZIKV) non-structural protein 5 (NS5) plays multiple viral and cellular roles during infection, with its primary role in virus RNA replication taking place in the cytoplasm. However, immunofluorescence assay studies have detected the p...

  • Article
  • Open Access
7 Citations
3,229 Views
10 Pages

Persistence of Anti-ZIKV-IgG over Time Is Not a Useful Congenital Infection Marker in Infants Born to ZIKV-Infected Mothers: The NATZIG Cohort

  • Conrado Milani Coutinho,
  • Juliana Dias Crivelenti Pereira Fernandes,
  • Aparecida Yulie Yamamoto,
  • Silvia Fabiana Biason de Moura Negrini,
  • Bento Vidal de Moura Negrini,
  • Sara Reis Teixeira,
  • Fabiana Rezende Amaral,
  • Márcia Soares Freitas da Motta,
  • Adriana Aparecida Tiraboschi Bárbaro and
  • for the NATZIG Cohort Study Team
  • + 5 authors

20 April 2021

Confirming ZIKV congenital infection is challenging because viral RNA is infrequently detected. We compared the presence of anti-ZIKV-IgM and the persistence of anti-ZIKV-IgG antibodies over 18 months in two cohorts of infants born to ZIKV-infected m...

  • Article
  • Open Access
9 Citations
5,388 Views
23 Pages

ZIKV Envelope Domain-Specific Antibodies: Production, Purification and Characterization

  • Sami Akhras,
  • Marie-Luise Herrlein,
  • Fabian Elgner,
  • Thomas Holzhauser and
  • Eberhard Hildt

13 August 2019

Infection with Zika virus (ZIKV) came first to public attention after it was found to be associated with congenital microcephaly during the outbreak in Brazil (2015–2016). Diagnosis of ZIKV suffers from extensive cross-reactivity with other Flaviviru...

  • Article
  • Open Access
41 Citations
7,247 Views
25 Pages

Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection

  • Catarina Sabino,
  • Michael Basic,
  • Daniela Bender,
  • Fabian Elgner,
  • Kiyoshi Himmelsbach and
  • Eberhard Hildt

6 June 2019

Zika virus (ZIKV) is a highly transmissive virus that belongs to the Flaviviridae family, which comprises several other pathogens that threaten human health. This re-emerging virus gained attention during the outbreak in Brazil in 2016, where a consi...

  • Article
  • Open Access
2 Citations
3,236 Views
22 Pages

Detection of Anti-ZIKV NS1 IgA, IgM, and Combined IgA/IgM and Identification of IL-4 and IL-10 as Potential Biomarkers for Early ZIKV and DENV Infections in Hyperendemic Regions, Thailand

  • Vajee Petphong,
  • Nathamon Kosoltanapiwat,
  • Kriengsak Limkittikul,
  • Pannamas Maneekan,
  • Supawat Chatchen,
  • Akanitt Jittmittraphap,
  • Pimolpachr Sriburin,
  • Siriporn Chattanadee and
  • Pornsawan Leaungwutiwong

The frequency of Zika virus (ZIKV)-specific IgA and IgM and the cytokine expression profile of ZIKV-infected patients in hyperendemic areas remain unclear. This study investigated the rates of ZIKV non-structural protein 1 (NS1)-specific IgA and IgM...

  • Article
  • Open Access
1,110 Views
16 Pages

Novel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors

  • Isabella Luiza Ralph de Oliveira,
  • José Arion da Silva Moura,
  • Patricia Recordon-Pinson,
  • Floriane Lagadec,
  • Michelle Melgarejo da Rosa,
  • Sayonara Maria Calado Gonçalves,
  • Douglas Carvalho Francisco Viana,
  • Paulo André Teixeira de Moraes Gomes,
  • Marina Galdino da Rocha Pitta and
  • Maira Galdino da Rocha Pitta
  • + 4 authors

Zika virus (ZIKV) remains a pressing global health concern due to its association with congenital Zika syndrome and the current lack of approved antiviral therapies. In this study, we evaluated the antiviral activity of three novel thiazolidinedione...

  • Article
  • Open Access
7 Citations
3,152 Views
15 Pages

Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells

  • Audrien Alves Andrade de Souza,
  • Lauana Ribas Torres,
  • Lyana Rodrigues Pinto Lima Capobianco,
  • Vanessa Salete de Paula,
  • Cynthia Machado Cascabulho,
  • Kelly Salomão,
  • Maria da Gloria Bonecini-Almeida,
  • Maria de Lourdes Garcia Ferreira,
  • Nubia Boechat and
  • Elen Mello de Souza
  • + 1 author

29 December 2020

Despite the severe morbidity caused by Zika fever, its specific treatment is still a challenge for public health. Several research groups have investigated the drug repurposing of chloroquine. However, the highly toxic side effect induced by chloroqu...

  • Review
  • Open Access
7 Citations
5,493 Views
44 Pages

13 April 2021

The emergence of the Zika virus (ZIKV) mirrors its evolutionary nature and, thus, its ability to grow in diversity or complexity (i.e., related to genome, host response, environment changes, tropism, and pathogenicity), leading to it recently joining...

  • Review
  • Open Access
16 Citations
7,238 Views
29 Pages

30 August 2019

Zika virus (ZIKV) is a mosquito-borne flavivirus that spread throughout the American continent in 2015 causing considerable worldwide social and health alarm due to its association with ocular lesions and microcephaly in newborns, and Guillain–...

  • Article
  • Open Access
13 Citations
6,573 Views
15 Pages

Detection of Specific ZIKV IgM in Travelers Using a Multiplexed Flavivirus Microsphere Immunoassay

  • Carmel T. Taylor,
  • Ian M. Mackay,
  • Jamie L. McMahon,
  • Sarah L. Wheatley,
  • Peter R. Moore,
  • Mitchell J. Finger,
  • Glen R. Hewitson and
  • Frederick A. Moore

12 May 2018

Zika virus (ZIKV) has spread widely in the Pacific and recently throughout the Americas. Unless detected by RT-PCR, confirming an acute ZIKV infection can be challenging. We developed and validated a multiplexed flavivirus immunoglobulin M (IgM) micr...

  • Article
  • Open Access
9 Citations
3,590 Views
13 Pages

17 July 2020

The zika virus (ZIKV) is a neurotropic virus that causes congenital abnormalities in babies when they are infected in utero. Some studies have reported these congenital abnormalities result from ZIKV attacking neural progenitor cells within the brain...

  • Communication
  • Open Access
1 Citations
2,688 Views
10 Pages

Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas

  • Laise de Moraes,
  • Moyra M. Portilho,
  • Bram Vrancken,
  • Frederik Van den Broeck,
  • Luciane Amorim Santos,
  • Marina Cucco,
  • Laura B. Tauro,
  • Mariana Kikuti,
  • Monaise M. O. Silva and
  • Ricardo Khouri
  • + 9 authors

25 May 2023

The Americas, particularly Brazil, were greatly impacted by the widespread Zika virus (ZIKV) outbreak in 2015 and 2016. Efforts were made to implement genomic surveillance of ZIKV as part of the public health responses. The accuracy of spatiotemporal...

  • Article
  • Open Access
1 Citations
1,993 Views
14 Pages

Temperature Interference on ZIKV and CHIKV Cycles in Mosquitoes and Mammalian Cells

  • Tiago Souza Salles,
  • Erica Santos Martins-Duarte,
  • Marcelo Damião Ferreira de Meneses,
  • Monica Ferreira Moreira,
  • Davis Fernandes Ferreira,
  • Renata Campos Azevedo,
  • Wanderley De Souza and
  • Lucio Ayres Caldas

21 September 2024

Temperature is a determining factor for the viral cycle. In this study, we investigate the effect of different temperatures on the cycles of two important arboviruses—Zika (ZIKV) and Chikungunya (CHIKV)—in Vero (mammalian) and C6/36 (mosq...

  • Article
  • Open Access
25 Citations
5,711 Views
15 Pages

Storage-Dependent Generation of Potent Anti-ZIKV Activity in Human Breast Milk

  • Carina Conzelmann,
  • Min Zou,
  • Rüdiger Groß,
  • Mirja Harms,
  • Annika Röcker,
  • Christian U. Riedel,
  • Jan Münch and
  • Janis A. Müller

28 June 2019

Zika virus (ZIKV) causes congenital neurologic birth defects, notably microcephaly, and has been associated with other serious complications in adults. The virus has been detected in human breast milk and possible transmissions via breastfeeding have...

  • Article
  • Open Access
14 Citations
3,368 Views
22 Pages

ZIKV Strains Elicit Different Inflammatory and Anti-Viral Responses in Microglia Cells

  • Fernanda Bellaniza Caminha de Oliveira,
  • Vanessa Paola Alves Sampaio de Sá Freire,
  • Sharton Vinicius Antunes Coelho,
  • Lana Monteiro Meuren,
  • Julys da Fonseca Palmeira,
  • Ana Luísa Cardoso,
  • Francisco de Assis Rocha Neves,
  • Bergmann Morais Ribeiro,
  • Gustavo Adolfo Argañaraz and
  • Enrique Roberto Argañaraz
  • + 1 author

26 May 2023

In recent years, the Zika Virus (ZIKV) has caused pandemic outbreaks associated with a high rate of congenital ZIKV syndrome (CZS). Although all strains associated with worldwide outbreaks derive from the Asian lineage, the reasons for their enhanced...

  • Article
  • Open Access
13 Citations
6,659 Views
20 Pages

ZIKV Demonstrates Minimal Pathologic Effects and Mosquito Infectivity in Viremic Cynomolgus Macaques

  • Sasha R. Azar,
  • Shannan L. Rossi,
  • Sherry H. Haller,
  • Ruimei Yun,
  • Jing H. Huang,
  • Jessica A. Plante,
  • Jiehua Zhou,
  • Juan P. Olano,
  • Christopher M. Roundy and
  • Nikos Vasilakis
  • + 2 authors

21 November 2018

To evaluate the effects of ZIKV infection on non-human primates (NHPs), as well as to investigate whether these NHPs develop sufficient viremia to infect the major urban vector mosquito, Aedes aegypti, four cynomolgus macaques (Macaca fascicularis) w...

  • Article
  • Open Access
7 Citations
2,399 Views
15 Pages

Favipiravir Suppresses Zika Virus (ZIKV) through Activity as a Mutagen

  • Evelyn J. Franco,
  • Eleonora Cella,
  • Xun Tao,
  • Kaley C. Hanrahan,
  • Taj Azarian and
  • Ashley N. Brown

In a companion paper, we demonstrated that the nucleoside analogue favipiravir (FAV) suppressed Zika virus (ZIKV) replication in three human-derived cell lines—HeLa, SK-N-MC, and HUH-7. Our results revealed that FAV’s effect was most pron...

  • Article
  • Open Access
8 Citations
4,676 Views
15 Pages

Acceptability of a Hypothetical Zika Vaccine among Women from Colombia and Spain Exposed to ZIKV: A Qualitative Study

  • Elena Marbán-Castro,
  • Ana Villén-Gonzalvo,
  • Cristina Enguita-Fernàndez,
  • Kelly Carolina Romero-Acosta,
  • Anna Marín-Cos,
  • Germán J. Arrieta,
  • Salim Mattar,
  • Clara Menéndez,
  • Maria Maixenchs and
  • Azucena Bardají

3 October 2020

Zika virus (ZIKV) can cause pregnancy loss and congenital Zika syndrome, among other poor health outcomes. The ZIKV epidemic in 2015–2017 disproportionately affected pregnant women in poor-resource settings. We aimed to understand perceptions a...

  • Article
  • Open Access
6 Citations
3,087 Views
14 Pages

High Glucose Induces in HK2 Kidney Cells an IFN–Dependent ZIKV Antiviral Status Fueled by Viperin

  • Alawiya Reslan,
  • Juliano G. Haddad,
  • Philippe Desprès,
  • Jean-Loup Bascands and
  • Gilles Gadea

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that rapidly became a major medical concern worldwide. We have recently reported that a high glucose level decreases the rate of Zika virus (ZIKV) replication with an impact on human kidney H...

  • Article
  • Open Access
4 Citations
1,522 Views
15 Pages

tRNA modifications are crucial for efficient protein synthesis, impacting codon recognition, tRNA stability, and translation rates. RNA viruses hijack the host’s translational machinery, including the pool of modified tRNA, to translate their o...

  • Article
  • Open Access
3 Citations
2,202 Views
13 Pages

Distinct Replication Kinetics, Cytopathogenicity, and Immune Gene Regulation in Human Microglia Cells Infected with Asian and African Lineages of Zika Virus

  • Ian M. Bird,
  • Victoria Cavener,
  • Meera Surendran Nair,
  • Ruth H. Nissly,
  • Shubhada K. Chothe,
  • Joshy Jacob and
  • Suresh V. Kuchipudi

Zika virus (ZIKV), a mosquito-borne flavivirus, is a significant global health concern due to its association with neurodevelopmental disorders such as congenital Zika syndrome (CZS). This study aimed to compare the replication kinetics, viral persis...

  • Article
  • Open Access
5 Citations
2,546 Views
15 Pages

This study aims to evaluate the antiviral potential of the nucleoside analogue favipiravir (FAV) against ZIKV, an arbovirus for which there are no approved antiviral therapies, in three human-derived cell lines. HeLa (cervical), SK-N-MC (neuronal), a...

  • Article
  • Open Access
25 Citations
3,836 Views
20 Pages

Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood–Brain Barrier System

  • Antonios Fikatas,
  • Jonas Dehairs,
  • Sam Noppen,
  • Jordi Doijen,
  • Frank Vanderhoydonc,
  • Eef Meyen,
  • Johannes V. Swinnen,
  • Christophe Pannecouque and
  • Dominique Schols

25 November 2021

To date, no vaccines or antivirals are available against Zika virus (ZIKV). In addition, the mechanisms underlying ZIKV-associated pathogenesis of the central nervous system (CNS) are largely unexplored. Getting more insight into the cellular pathway...

  • Article
  • Open Access
1,805 Views
13 Pages

Uncovering DENV, CHIKV, and ZIKV in Urban Wastewater in Brazil Through Genomic and Molecular Screening

  • Juliana Calabria de Araujo,
  • Ana Paula A. Carvalho,
  • Talita Adelino,
  • Felipe Campos M. Iani,
  • Natalia Rocha Guimaraes,
  • Sara Candida F. Santos,
  • Cintia D. Leal,
  • Manuelle Natividade,
  • Mauricio Lima and
  • Luiz Carlos Junior Alcantara
  • + 8 authors

This study evaluated and compared molecular methods (Whole Genome Sequencing-WGS, MinION, and RT-qPCR) for the detection of arboviruses Dengue (DENV), Chikungunya (CHIKV), and Zika (ZIKV) in 63 hospital and municipal wastewater samples collected from...

  • Article
  • Open Access
8 Citations
5,015 Views
12 Pages

Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts

  • Luana Damasceno,
  • Ana Carolina B. Terzian,
  • Trevon Fuller,
  • Cassia F. Estofolete,
  • Adriana Andrade,
  • Erna G. Kroon,
  • Andrea A. Zin,
  • Zilton Vasconcelos,
  • Jose P. Pereira and
  • Patricia Brasil
  • + 7 authors

23 April 2021

The Zika virus (ZIKV) epidemic in Brazil occurred in regions where dengue viruses (DENV) are historically endemic. We investigated the differences in adverse pregnancy/infant outcomes in two cohorts comprising 114 pregnant women with PCR-confirmed ZI...

  • Review
  • Open Access
77 Citations
11,485 Views
26 Pages

Probing Molecular Insights into Zika Virus–Host Interactions

  • Ina Lee,
  • Sandra Bos,
  • Ge Li,
  • Shusheng Wang,
  • Gilles Gadea,
  • Philippe Desprès and
  • Richard Y. Zhao

2 May 2018

The recent Zika virus (ZIKV) outbreak in the Americas surprised all of us because of its rapid spread and association with neurologic disorders including fetal microcephaly, brain and ocular anomalies, and Guillain–Barré syndrome. In response to this...

  • Article
  • Open Access
3 Citations
1,183 Views
21 Pages

The expanding distribution and geographic range of mosquitoes have potentially contributed to increased flaviviral dissemination and transmission. Despite the growing burden of flaviviral infections, there are no effective antiviral treatments or vac...

  • Review
  • Open Access
23 Citations
4,632 Views
13 Pages

Zika virus (ZIKV) acquired a special relevance due to the pandemic that occurred in the Americas in 2015, when an important number of fetal microcephaly cases occurred. Since then, numerous studies have tried to elucidate the pathogenic mechanisms an...

  • Article
  • Open Access
23 Citations
4,709 Views
13 Pages

Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage

  • Raimunda S. S. Azevedo,
  • Marialva T. Araujo,
  • Consuelo S. Oliveira,
  • Arnaldo Jorge Martins Filho,
  • Bruno T. D. Nunes,
  • Daniele F. Henriques,
  • Eliana V. P. Silva,
  • Valéria L. Carvalho,
  • Jannifer O. Chiang and
  • Pedro F. C. Vasconcelos
  • + 14 authors

28 November 2018

Introduction: The recent Zika virus(ZIKV) epidemic in Brazil was characterized by a range of different clinical presentations, particularly microcephaly, Guillain-Barré syndrome, and death. In this context, we determined the causal relationship betwe...

  • Article
  • Open Access
9 Citations
4,588 Views
17 Pages

Novel Approach for Insertion of Heterologous Sequences into Full-Length ZIKV Genome Results in Superior Level of Gene Expression and Insert Stability

  • Evgeniya Volkova,
  • Konstantin A. Tsetsarkin,
  • Emilia Sippert,
  • Felipe Assis,
  • Guangping Liu,
  • Maria Rios and
  • Alexander G. Pletnev

3 January 2020

Zika virus (ZIKV) emerged in the Americas in 2015, presenting unique challenges to public health. Unlike other arboviruses of the Flaviviridae family, it is transmissible by sexual contact, which facilitates the spread of the virus into new geographi...

  • Article
  • Open Access
15 Citations
9,621 Views
15 Pages

A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time

  • Michael J. McFadden,
  • Aaron Mitchell-Dick,
  • Christine Vazquez,
  • Allison E. Roder,
  • Kevin F. Labagnara,
  • John J. McMahon,
  • Debra L. Silver and
  • Stacy M. Horner

24 February 2018

Zika virus (ZIKV) is a re-emerging flavivirus that is transmitted to humans through the bite of an infected mosquito or through sexual contact with an infected partner. ZIKV infection during pregnancy has been associated with numerous fetal abnormali...

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