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185 Results Found

  • Article
  • Open Access
11 Citations
4,067 Views
17 Pages

28 February 2024

Gardenia jasminoides Ellis is abundant in crocin and has a longstanding historical usage both as a dietary and natural ethnic medicine. Enhanced studies have increasingly revealed the intricate interplay between glycolipid metabolism and gut microbio...

  • Article
  • Open Access
1,419 Views
17 Pages

28 February 2025

The primary active compound in vine tea is dihydromyricetin (DMY), which has a longstanding history as a dietary supplement and traditional ethnic medicine. However, the precise molecular mechanism by which vine tea dihydromyricetin extract (VDMY) re...

  • Article
  • Open Access
5 Citations
1,960 Views
12 Pages

Rabies Virus Regulates Inflammatory Response in BV-2 Cells through Activation of Myd88 and NF-κB Signaling Pathways via TLR7

  • Yuan Xie,
  • Yinglin Chi,
  • Xiaoyan Tao,
  • Pengcheng Yu,
  • Qian Liu,
  • Minghui Zhang,
  • Nuo Yang,
  • Shuqing Liu and
  • Wuyang Zhu

23 August 2024

Rabies is a fatal neurological infectious disease caused by rabies virus (RABV), which invades the central nervous system (CNS). RABV with varying virulence regulates chemokine expression, and the mechanisms of signaling pathway activation remains to...

  • Article
  • Open Access
3 Citations
2,893 Views
12 Pages

In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides

  • Li Li,
  • Shenghui Yang,
  • Dilu Chen,
  • Zhihuang Wu,
  • Meijun Zhang,
  • Fang Yang,
  • Li Qin and
  • Xiaojiang Zhou

29 November 2022

Due to a high content of sesquiterpenes, Carpesium abrotanoides has been investigated to fully explore its health-promoting properties. Therefore, this work aimed to assess, for the first time, the anti-influenza A virus H1N1 potential of sesquiterpe...

  • Article
  • Open Access
29 Citations
3,526 Views
14 Pages

Inosine Pretreatment Attenuates LPS-Induced Lung Injury through Regulating the TLR4/MyD88/NF-κB Signaling Pathway In Vivo

  • Bingyong Mao,
  • Weiling Guo,
  • Xin Tang,
  • Qiuxiang Zhang,
  • Bo Yang,
  • Jianxin Zhao,
  • Shumao Cui and
  • Hao Zhang

9 July 2022

Inosine is a type of purine nucleoside, which is considered to a physiological energy source, and exerts a widely range of anti-inflammatory efficacy. The TLR4/MyD88/NF-κB signaling pathway is essential for preventing host oxidative stresses an...

  • Article
  • Open Access
6 Citations
4,004 Views
13 Pages

Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway

  • Shih-Hung Wang,
  • Shu-Hung Huang,
  • Meng-Chien Hsieh,
  • I-Cheng Lu,
  • Ping-Ruey Chou,
  • Ming-Hong Tai and
  • Sheng-Hua Wu

Paclitaxel (PAC) results in long-term chemotherapy-induced peripheral neuropathy (CIPN). The coexpression of transient receptor potential vanilloid 1 (TRPV1) and Toll-like receptor 4 (TLR4) in the nervous system plays an essential role in mediating C...

  • Article
  • Open Access
543 Views
17 Pages

Adipose-Derived Mesenchymal Stem Cells Improve Acute Liver Injury: A Mechanistic Study Based on the TLR4/MyD88/NF-κB Pathway

  • Zhongfa Wang,
  • Minjuan Li,
  • Xingxing Yan,
  • Yanchen Liu,
  • Pengkun Yang,
  • Wenzhong Liu and
  • Weijun Guan

6 December 2025

Acute liver injury (ALI) involves complex pathogenesis and lacks effective clinical therapies. Although mesenchymal stem cells (MSCs) demonstrate therapeutic potential, the role and mechanisms of adipose-derived mesenchymal stem cells (ADSCs) from Lu...

  • Article
  • Open Access
1 Citations
1,311 Views
23 Pages

19 September 2025

Background/Objectives: Ulcerative colitis (UC) pathogenesis involves gut barrier dysfunction, dysregulated immune responses, and gut microbiota imbalance. Alfalfa polysaccharide (APS), a bioactive compound with immunomodulatory potential, remains und...

  • Article
  • Open Access
6 Citations
4,002 Views
18 Pages

13 June 2024

This study aimed to explore the protective effects of raffinose (Raf) against inflammatory bowel disease in mice with colitis. Mice were administered 100, 200, or 400 mg/kg Raf for 21 d, followed by drinking-water containing 3% dextran sulfate sodium...

  • Article
  • Open Access
8 Citations
3,336 Views
15 Pages

14 November 2024

Chronic inflammation is a common factor in the pathological processes of multiple human diseases. EPS-LM, an exopolysaccharide (EPS) from the Cordyceps sinensis fungus Cs-HK1, has shown notable anti-inflammatory activities in previous studies. This s...

  • Article
  • Open Access
11 Citations
5,286 Views
19 Pages

Exercise Promotes Hippocampal Neurogenesis in T2DM Mice via Irisin/TLR4/MyD88/NF-κB-Mediated Neuroinflammation Pathway

  • Haocheng Xu,
  • Xin Tian,
  • Yuanxin Wang,
  • Junjie Lin,
  • Baishu Zhu,
  • Chen Zhao,
  • Bin Wang,
  • Xin Zhang,
  • Yu Sun and
  • Renqing Zhao
  • + 5 authors

10 October 2024

Neuroinflammation is a major feature of type 2 diabetic mellitus (T2DM), adversely affecting hippocampal neurogenesis. However, the precise mechanism is not fully understood, and therapeutic approaches are currently lacking. Therefore, we determined...

  • Article
  • Open Access
46 Citations
6,204 Views
17 Pages

Objective: To investigate the role of aerobic exercise in inhibiting chronic unpredictable mild stress (CUMS) depressed mice hippocampal inflammatory response and its potential mechanisms. Methods: Fifty-four male eight-week-old C57BL/6 mice were div...

  • Article
  • Open Access
4 Citations
2,040 Views
15 Pages

2 March 2025

Intestinal inflammation significantly compromises broiler health and adversely affects growth performance. Epigallocatechin gallate (EGCG) was found to maintain the gut health of animals. However, the role and mechanism of EGCG in preventing lipopoly...

  • Review
  • Open Access
558 Views
20 Pages

Sympathetic remodeling following myocardial infarction (MI) is a critical mechanism underlying the development of malignant arrhythmias and sudden cardiac death (SCD). The cardiac sympathetic nervous system functions as a multi-level regulatory netwo...

  • Article
  • Open Access
30 Citations
4,201 Views
19 Pages

Novel 1,8-naphthyridine-2-carboxamide derivatives with various substituents (HSR2101-HSR2113) were synthesized and evaluated for their effects on the production of pro-inflammatory mediators and cell migration in lipopolysaccharide (LPS)-treated BV2...

  • Article
  • Open Access
34 Citations
4,204 Views
17 Pages

Oleacein Attenuates Lipopolysaccharide-Induced Inflammation in THP-1-Derived Macrophages by the Inhibition of TLR4/MyD88/NF-κB Pathway

  • Santa Cirmi,
  • Alessandro Maugeri,
  • Caterina Russo,
  • Laura Musumeci,
  • Michele Navarra and
  • Giovanni Enrico Lombardo

21 January 2022

It is known that plant phenolic compounds exert anti-inflammatory activity through both anti-oxidant effects and modulation of pivotal pro-inflammatory factors. Recently, Olea europaea has been studied as a natural source of bioactive molecules; howe...

  • Article
  • Open Access
808 Views
16 Pages

Alpinetin Alleviates Cardiac Inflammation and Remodeling via TLR4/MyD88/NF-κB Signaling Pathway in Rats with Acute Myocardial Infarction

  • Mei Feng,
  • Xinxiang Chen,
  • Fan Huang,
  • Lin Chen,
  • Can Liu,
  • Wei Li,
  • Yinyan Li,
  • Shaobin Chen,
  • Zhen Deng and
  • Aiping Qin
  • + 3 authors

16 October 2025

Alpinetin, a distinctive plant-derived dihydroflavonoid from cardamom seeds, represents an under-explored chemical scaffold compared to common flavonoids like quercetin or kaempferol. While many flavonoids have shown general cardioprotective potentia...

  • Article
  • Open Access
15 Citations
2,738 Views
23 Pages

Dietary Fiber-Derived Butyrate Alleviates Piglet Weaning Stress by Modulating the TLR4/MyD88/NF-κB Pathway

  • Weikang Huangfu,
  • Jixiang Ma,
  • Yan Zhang,
  • Mengqi Liu,
  • Boshuai Liu,
  • Jiangchao Zhao,
  • Zhichang Wang and
  • Yinghua Shi

30 May 2024

During weaning, piglets are susceptible to intestinal inflammation and impairment in barrier function. Dietary fiber (DF) plays an active role in alleviating weaning stress in piglets. However, the effects of different sources of dietary fiber on the...

  • Article
  • Open Access
5 Citations
2,121 Views
19 Pages

27 March 2025

Nowadays, the risk of oral intake of microplastics (MPs) and cadmium (Cd) by poultry is high. In some industrially polluted areas, the chicken feed samples contain 9.60 × 102 ± 1.09 × 102 MPs per kilogram (mean ± std) in wet...

  • Article
  • Open Access
5 Citations
3,211 Views
15 Pages

30 April 2023

Pullorum disease (PD), caused by Salmonella Pullorum (S. Pullorum), is a serious threat to the poultry industry worldwide. Antimicrobial peptides (AMPs) have drawn extensive attention as new-generation antibiotics because of their broad antimicrobial...

  • Article
  • Open Access
23 Citations
4,137 Views
16 Pages

Chlamydia psittaci PmpD-N Modulated Chicken Macrophage Function by Triggering Th2 Polarization and the TLR2/MyD88/NF-κB Signaling Pathway

  • Jun Chu,
  • Xiaohui Li,
  • Guanggang Qu,
  • Yihui Wang,
  • Qiang Li,
  • Yongxia Guo,
  • Lei Hou,
  • Jue Liu,
  • Francis O. Eko and
  • Cheng He

The polymorphic membrane protein D (PmpD) is a highly conserved outer membrane protein which plays an important role in pathogenesis during Chlamydia psittaci infection. In this study, we evaluated the ability of the N-terminus of PmpD (PmpD-N) to mo...

  • Article
  • Open Access
15 Citations
3,452 Views
14 Pages

Huangshui Polysaccharide Exerts Intestinal Barrier Protective Effects through the TLR4/MyD88/NF-κB and MAPK Signaling Pathways in Caco-2 Cells

  • Jiaying Huo,
  • Wenhao Pei,
  • Guoying Liu,
  • Weizheng Sun,
  • Jihong Wu,
  • Mingquan Huang,
  • Wei Lu,
  • Jinyuan Sun and
  • Baoguo Sun

18 January 2023

Several reports have demonstrated that natural polysaccharides exert protective effects on intestinal barrier function. In our previous study, we isolated a polysaccharide named HSP-W from Huangshui (HS). In the present study, the protective role of...

  • Article
  • Open Access
33 Citations
3,759 Views
18 Pages

Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NF-κB Signaling Pathways

  • Mohamed A. Morsy,
  • Yasmine F. Ibrahim,
  • Sara Mohamed Naguib Abdel Hafez,
  • Nagwa M. Zenhom,
  • Anroop B. Nair,
  • Katharigatta N. Venugopala,
  • Pottathil Shinu and
  • Seham A. Abdel-Gaber

29 August 2022

Hepatic ischemia/reperfusion (HIR) is the most common type of liver injury following several clinical situations. Modulating oxidative stress and inflammation by Nrf2/HO-1 and TLR4/MYD88/NF-κB pathways, respectively, is involved in alleviating...

  • Article
  • Open Access
10 Citations
3,261 Views
14 Pages

15 November 2022

Background: Immunological liver injury (ILI) is a common liver disease and lacks potent drugs for treatment. Artemisia argyi Lévl. et Vant. (A. argyi), a medicinal and edible homologous plant usually used in diet therapy to cure various liver...

  • Article
  • Open Access
2 Citations
1,667 Views
16 Pages

Chlorella pyrenoidosa Polysaccharide CPP-3a Promotes M1 Polarization of Macrophages via TLR4/2-MyD88-NF-κB/p38 MAPK Signaling Pathways

  • Yihua Pi,
  • Qingxia Yuan,
  • Shaoting Qin,
  • Chundie Lan,
  • Qingdong Nong,
  • Chenxia Yun,
  • Haibo Tang,
  • Jing Leng,
  • Jian Xiao and
  • Lifeng Zhang
  • + 1 author

16 July 2025

The immunomodulatory polysaccharide CPP-3a, purified from Chlorella pyrenoidosa, was investigated for its effects on RAW264.7 macrophages and underlying mechanisms, revealing that CPP-3a significantly enhanced phagocytic capacity and nitric oxide pro...

  • Article
  • Open Access
18 Citations
5,117 Views
18 Pages

24 May 2019

Mycoplasma gallisepticum (MG), a pathogen that infects chickens and some other birds, triggers chronic respiratory disease (CRD) in chickens, which is characterized by inflammation. The investigation of microbial pathogenesis would contribute to the...

  • Article
  • Open Access
9 Citations
4,096 Views
16 Pages

24 September 2024

Irritable bowel syndrome (IBS) is a common chronic functional bowel disorder and is strongly associated with an increased risk of depression and anxiety. The brain–gut axis plays an important role in the pathophysiologic changes in IBS, yet eff...

  • Article
  • Open Access
19 Citations
3,802 Views
19 Pages

PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway

  • So Eun Youn,
  • Fen Jiang,
  • Hye Yun Won,
  • Da Eun Hong,
  • Tae Heung Kang,
  • Yun-Yong Park and
  • Sang Seok Koh

27 September 2022

PAUF, a tumor-promoting protein secreted by cancer cells, exerts paracrine effects on immune cells through TLR4 receptors expressed on immune cell surfaces. This study aimed to investigate if PAUF elicits autocrine effects on pancreatic cancer (PC) c...

  • Article
  • Open Access
11 Citations
2,890 Views
13 Pages

18 October 2023

Korean ginseng (Panax ginseng) contains various ginsenosides as active ingredients, and they show diverse biological activities. Black ginseng is manufactured by repeated steaming and drying of white ginseng, which alters the polarity of ginsenosides...

  • Article
  • Open Access
87 Citations
9,897 Views
14 Pages

Background: Psoriasis is a chronic, immune-mediated inflammatory skin disease, and the inflammatory response plays an important role in its development and progression. Datura metel L. is a traditional Chinese medicine that exhibited a significant th...

  • Article
  • Open Access
14 Citations
3,341 Views
18 Pages

Replacing antibiotics with probiotics has become an important way to safely and effectively prevent and treat some gastrointestinal diseases. This study was conducted to investigate whether Lactobacillus salivarius WZ1 (L.S) could reduce the inflamma...

  • Article
  • Open Access
20 Citations
2,873 Views
17 Pages

13 August 2022

Background: Renal ischemia/reperfusion injury is a clinically recurrent event during kidney transplantation. Geraniol is a natural monoterpene essential oil component. This study aimed to inspect geraniol’s reno-protective actions against renal...

  • Article
  • Open Access
91 Citations
8,868 Views
16 Pages

22 April 2014

Resveratrol is a natural polyphenolic compound that prevents inflammation in chondrocytes and animal models of osteoarthritis (OA) via yet to be defined mechanisms. The purpose of this study was to determine whether the protective effect of resveratr...

  • Article
  • Open Access
2 Citations
1,938 Views
17 Pages

MyD88 Contributes to TLR3-Mediated NF-κB Activation and Cytokine Production in Macrophages

  • Zhuodong Chai,
  • Yuqi Zhou,
  • Ling Yang,
  • Yan Zhang,
  • Sukria Hossain,
  • Sahelosadat Hajimirzaei,
  • Jiaqian Qi,
  • Guoying Zhang,
  • Yinan Wei and
  • Zhenyu Li

27 September 2025

Toll-like receptor 3 (TLR3) initiates antiviral and inflammatory responses exclusively through the adaptor protein TRIF (TIR-domain-containing adapter-inducing interferon-β). In contrast, MyD88 (myeloid differentiation primary response 88), a ce...

  • Article
  • Open Access
7 Citations
2,237 Views
19 Pages

Association of IL-9 Cytokines with Hepatic Injury in Echinococcus granulosus Infection

  • Tanfang Zhou,
  • Xinlu Xu,
  • Jiang Zhu,
  • Mayire Aizezi,
  • Aili Aierken,
  • Menggen Meng,
  • Rongdong He,
  • Kalibixiati Aimulajiang and
  • Hao Wen

14 August 2024

Cystic echinococcosis (CE) is a zoonotic disease caused by the parasite Echinococcus granulosus (E. granulosus), which can lead to the formation of liver lesions. Research indicates that E. granulosus releases both Toll-like receptor 2 (TLR2) and Int...

  • Article
  • Open Access
29 Citations
4,281 Views
15 Pages

The Protective Effect of Anethole against Renal Ischemia/Reperfusion: The Role of the TLR2,4/MYD88/NFκB Pathway

  • Maged Elsayed Mohamed,
  • Mahmoud Kandeel,
  • Hany M. Abd El-Lateef,
  • Hossam S. El-Beltagi and
  • Nancy S. Younis

Background: Anethole is the principle essential oil component of anise and fennel. Renal ischemia/reperfusion (RIR) is one of the utmost imperative reasons for acute kidney injury and often associated with high mortality rate. The aim of this study i...

  • Article
  • Open Access
513 Views
17 Pages

Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways

  • Jing Yan,
  • Jiazheng Cai,
  • Xiaojing Pan,
  • Si Li,
  • Christopher Graham Fenton,
  • Kristin Andreassen Fenton,
  • Alpdogan Kantarci,
  • Yaxin Xue,
  • Ying Xue and
  • Zhe Xing

10 December 2025

Objectives: Periodontitis is a multifactorial inflammatory disease initiated by pathogenic bacteria, such as Porphyromonas gingivalis. Resolvin D1 (RvD1) plays a pivotal role in inflammation resolution. This study aimed to identify the mechanism of t...

  • Article
  • Open Access
82 Citations
7,063 Views
16 Pages

Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia

  • Mariana Leticia Matias,
  • Virginia Juliani Gomes,
  • Mariana Romao-Veiga,
  • Vanessa Rocha Ribeiro,
  • Priscila Rezeck Nunes,
  • Graziela Gorete Romagnoli,
  • Jose Carlos Peracoli and
  • Maria Terezinha Serrao Peracoli

19 April 2019

Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether silibinin (SB) treatment of monocytes from preeclamptic women could modulate NLRP1 and NLRP3...

  • Article
  • Open Access
66 Citations
8,339 Views
16 Pages

7 February 2013

Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) are considered to mediate the inflammatory reaction of cerebral ischemia injury, and exercise can inhibit the activity of the Toll-like receptor signaling pathway in the peripheral blood of...

  • Article
  • Open Access
29 Citations
4,371 Views
20 Pages

Sp1 S-Sulfhydration Induced by Hydrogen Sulfide Inhibits Inflammation via HDAC6/MyD88/NF-κB Signaling Pathway in Adjuvant-Induced Arthritis

  • Meng Li,
  • Wei Hu,
  • Ran Wang,
  • Zhaoyi Li,
  • Yue Yu,
  • Yue Zhuo,
  • Yida Zhang,
  • Zhou Wang,
  • Yuanye Qiu and
  • Yizhun Zhu
  • + 4 authors

Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-κB) signaling pathway by deacetylating the non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter prote...

  • Article
  • Open Access
11 Citations
3,571 Views
16 Pages

RAGE–TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages

  • Longfei Yan,
  • Yanran Li,
  • Tianyu Tan,
  • Jiancheng Qi,
  • Jing Fang,
  • Hongrui Guo,
  • Zhihua Ren,
  • Liping Gou,
  • Yi Geng and
  • Zhicai Zuo
  • + 4 authors

The receptor of advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4) are important receptors for inflammatory responses induced by high glucose (HG) and lipopolysaccharide (LPS) and show crosstalk phenomena in inflammatory responses...

  • Article
  • Open Access
6 Citations
2,325 Views
20 Pages

Ophiopogon Polysaccharide Liposome Regulated the Immune Activity of Kupffer Cell through miR-4796

  • Jing Cui,
  • Xingxue Pan,
  • Xueqin Duan,
  • Liting Ke,
  • Xiaoping Song,
  • Weimin Zhang,
  • Wuren Ma,
  • Yingqiu Liu and
  • Yunpeng Fan

24 November 2022

The purpose of this article is to study the effects and mechanism of miR-4796 in the process of ophiopogon polysaccharide liposome (OPL) regulation of the immune activity of Kupffer cells (KCs). In this study, KCs were used as cell models, and were t...

  • Article
  • Open Access
10 Citations
4,877 Views
16 Pages

Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells

  • Junbin Chen,
  • Yuguo Liu,
  • Huiyu Luo,
  • Guoxun Chen,
  • Zhongdaixi Zheng,
  • Tiannan Wang,
  • Xinge Hu,
  • Yue Zhao,
  • Jiaqi Tang and
  • Longying Zha
  • + 1 author

Recently, multiple studies have shown that chronic inflammation disturbs cholesterol homeostasis and promotes its accumulation in the liver. The underlying molecular mechanism remains to be revealed. The relationship between the toll-like receptor 4...

  • Article
  • Open Access
52 Citations
8,353 Views
11 Pages

Forsythoside A Controls Influenza A Virus Infection and Improves the Prognosis by Inhibiting Virus Replication in Mice

  • Li Deng,
  • Peng Pang,
  • Ke Zheng,
  • Jiao Nie,
  • Huachong Xu,
  • Sizhi Wu,
  • Jia Chen and
  • Xiaoyin Chen

Objective: The objective of this study was to observe the effects of forsythoside A on controlling influenza A virus (IAV) infection and improving the prognosis of IAV infection. Methods: Forty-eight SPF C57BL/6j mice were randomly divided into the f...

  • Article
  • Open Access
105 Citations
6,313 Views
21 Pages

Mesoporous Silica Nanoparticles Trigger Liver and Kidney Injury and Fibrosis Via Altering TLR4/NF-κB, JAK2/STAT3 and Nrf2/HO-1 Signaling in Rats

  • Ayman M. Mahmoud,
  • Ekram M. Desouky,
  • Walaa G. Hozayen,
  • May Bin-Jumah,
  • El-Shaymaa El-Nahass,
  • Hanan A. Soliman and
  • Ahmed A. Farghali

25 September 2019

Mesoporous silica nanoparticles (MSNs) represent a promising inorganic platform for multiple biomedical applications. Previous studies have reported MSNs-induced hepatic and renal toxicity; however, the toxic mechanism remains unclear. This study aim...

  • Article
  • Open Access
102 Citations
10,453 Views
17 Pages

Emodin Inhibition of Influenza A Virus Replication and Influenza Viral Pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB Pathways

  • Jian-Ping Dai,
  • Qian-Wen Wang,
  • Yun Su,
  • Li-Ming Gu,
  • Ying Zhao,
  • Xiao-Xua Chen,
  • Cheng Chen,
  • Wei-Zhong Li,
  • Ge-Fei Wang and
  • Kang-Sheng Li

18 October 2017

Lasting activations of toll-like receptors (TLRs), MAPK and NF-κB pathways can support influenza A virus (IAV) infection and promote pneumonia. In this study, we have investigated the effect and mechanism of action of emodin on IAV infection using qR...

  • Article
  • Open Access
69 Citations
8,197 Views
17 Pages

Oxymatrine Inhibits Influenza A Virus Replication and Inflammation via TLR4, p38 MAPK and NF-κB Pathways

  • Jian-Ping Dai,
  • Qian-Wen Wang,
  • Yun Su,
  • Li-Ming Gu,
  • Hui-Xiong Deng,
  • Xiao-Xuan Chen,
  • Wei-Zhong Li and
  • Kang-Sheng Li

Oxymatrine (OMT) is a strong immunosuppressive agent that has been used in the clinic for many years. In the present study, by using plaque inhibition, luciferase reporter plasmids, qRT-PCR, western blotting, and ELISA assays, we have investigated th...

  • Article
  • Open Access
1 Citations
1,517 Views
16 Pages

PS-MPs Induced Inflammation and Phosphorylation of Inflammatory Signalling Pathways in Liver

  • Mengchao Ying,
  • Naimin Shao,
  • Cheng Dong,
  • Yijie Sha,
  • Chen Li,
  • Xinyu Hong,
  • Yu Ding,
  • Jing Xu,
  • Kelei Qian and
  • Ping Xiao
  • + 1 author

22 December 2024

As new pollutants, microplastics (MPs) have attracted much attention worldwide because they cause serious environmental pollution and pose potential health risks to humans. However, the toxic effects of MPs are still unclear. In this study, we analys...

  • Article
  • Open Access
3 Citations
2,039 Views
15 Pages

Luteolin Alleviates Inflammation Induced by Staphylococcus aureus in Bovine Mammary Epithelial Cells by Attenuating NF-κB and MAPK Activation

  • Yingfang Guo,
  • Jinxin Zhang,
  • Ting Yuan,
  • Cheng Yang,
  • Qingqing Zhou,
  • Aftab Shaukat,
  • Ganzhen Deng and
  • Xiaoyan Wang

27 January 2025

The internalization of S. aureus in bMECs is a major pathogenic mechanism leading to mastitis, causing significant economic losses in the dairy industry. Numerous plants contain Lut, a natural flavonoid with anti-inflammatory and antioxidant pro...

  • Review
  • Open Access
26 Citations
24,275 Views
16 Pages

Thymosin α1 and Its Role in Viral Infectious Diseases: The Mechanism and Clinical Application

  • Nana Tao,
  • Xie Xu,
  • Yuyuan Ying,
  • Shiyu Hu,
  • Qingru Sun,
  • Guiyuan Lv and
  • Jianli Gao

17 April 2023

Thymosin α1 (Tα1) is an immunostimulatory peptide that is commonly used as an immune enhancer in viral infectious diseases such as hepatitis B, hepatitis C, and acquired immune deficiency syndrome (AIDS). Tα1 can influence the funct...

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