32 Results Found

A series of novel N-benzylidenesulfonohydrazide compounds were designedand synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) andUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved inthe biosynth...

Staphylococcus aureus is an opportunistic pathogen that can cause fatal bacterial infections. MurD catalyzes the formation of peptide bond between UDP-N-acetylehyl-l-alanine and d-glutamic acid, which plays an important role in the synthesis of pepti...

Nitrogen-fixing Actinobacteria of the genus Frankia can be subdivided into four phylogenetically distinct clades; members of clusters one to three engage in nitrogen-fixing root nodule symbioses with actinorhizal plants. Mur enzymes are responsible f...

Staphylococcus aureus (S. aureus) is a major bacterial infection in humans, leading to severe disease and causing death. The stagnation of antibiotic development in recent decades has made it difficult to combat drug-resistant infections. In this stu...

Sphingopyxis sp. USTB-05, which we previously identified and examined, is a well-known bacterial strain for biodegrading cyanobacterial hepatotoxins of both nodularins (NODs) and microcystins (MCs). Although the pathways for biodegrading the differen...

To understand the mechanism of tolerance of lactic acid bacteria (LAB) during cold storage of fermented milk, 31 LAB strains were isolated from traditional fermented products, and Lactiplantibacillus plantarum NMGL2 was identified with good tolerance...

A series of 5-methyl-7-phenyl-3H-thiazolo[4,5-b]pyridin-2-ones has been designed, synthesized, and characterized by spectral data. Target compounds were screened for their antimicrobial activity against some pathogenic bacteria and fungi, and most of...

In recent years active façades have acquired greater importance given their capacity to improve the energy efficiency of buildings. One such type is the so-called Active Transparent Façade (ATF). A 3D numerical model based on computatio...

Il pleut. La salle d’attente des médecins est baignée d’une lumière grisâtre, à peine égayée par des images d’oiseaux et de nature affichées aux murs [...]

The biophysical composition index (BCI)-based linear spectral mixture model (LSMM) is used in this study to extract the impervious surface (IS), vegetation, and soil coverage of the main urban region (MUR) of Hefei City over the 2001–2021 perio...

De nombreux thèmes touchant à la formation postgraduée (FPG) ont d’ores et déjà été largement discutés, tandis que d’autres ne sont pas encore mûrs pour être soumis au débat public [...]

Si vous êtes très observateur, vous avez peutêtre déjà remarqué dans certains lieux publics (gares, aéroports,) ou dans des couloirs d’hôtels des petits boîtiers fixés aux murs, d’où dépassaient deux petites antennes en V comme des cornes d’escargot...

Arcangelo Scacchi (1810–1893) one of the greatest Italian geoscientists known worldwide, especially for his contributions in the fields of mineralogy and volcanology, dedicated his early years to malacological and zoological works. This paper a...

The growing emergence of multidrug-resistant bacterial pathogens drives the need for new antibacterial agents. Punicalagin exhibits efficacy against methicillin-resistant Staphylococcus aureus (MRSA), but its specific antibacterial mechanisms remain...

The SCIAMI International Workshop was held in Chieti, Italy, at University G. d’Annunzio, Chieti-Pescara, from 7 to 8 June 2024. It was organized by Simonetta D’Ercole and was funded by the European Union–Next Generation EU, “...

Unmanned aerial vehicles (UAVs) require reliable autonomous positioning independent of external satellite navigation signals, motivating the development of a vision-based, end-to-end finding point in map (FPI) framework. This study introduces MuRDE-F...

A multichannel microfluidic cell (MFC) obtained using 3D printing for studying the structure of complex solutions by small-angle X-ray scattering (SAXS) is described. MFC was tested at the BioMUR beamline of the Kurchatov synchrotron. A comparative a...

In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation expose...

Si je reprends les propos de mes confrères d’une tendance à l’oubli de soi [1], du besoin de trouver la bonne distance ou «le bon focus » [2] en tant que praticien médecin de premier recours, mais surtout au «long cours» (comme le dit pertinemment J....

The development of a whole-cell vaccine from bacteria auxotrophic for D-amino acids present in the bacterial cell wall is considered a promising strategy for providing protection against bacterial infections. Here, we constructed a prototype vaccine,...

Plastids in plants are assumed to have evolved from cyanobacteria as they have maintained several bacterial features. Recently, peptidoglycans, as bacterial cell wall components, have been shown to exist in the envelopes of moss chloroplasts. Phyloge...

The synthesis of tetra- and pentanorlabdane compounds with rearranged cycle B based on commercially available (+)-sclareolide is reported. Desired compounds were prepared from intermediate ketones via Baeyer–Villiger oxidation. The structures o...

This manuscript deals with the synthesis and computational and experimental evaluation of the antimicrobial activity of twenty-nine 4-(indol-3-yl)thiazole-2-amines and 4-ιndol-3-yl)thiazole acylamines. An evaluation of antibacterial activity against...

Pseudomonas lundensis is the main bacterium responsible for meat spoilage and its control is of great significance. 3-Carene, a natural monoterpene, has been proved to possess antimicrobial activities. This study aimed to investigate the antibacteria...

The intestinal epithelium, which is protected by mucosal surfaces composed of mucins and other glycoproteins, functions as a selective barrier that absorbs nutrients while preventing the translocation of harmful substances. To understand the mechanis...

Herein we report the design, synthesis, computational, and experimental evaluation of the antimicrobial activity of fourteen new 3-amino-5-(indol-3-yl) methylene-4-oxo-2-thioxothiazolidine derivatives. The structures were designed, and their antimicr...

Peptidoglycan (PGN) is a component of bacterial cell walls; its fragments are recognized by the cytoplasmic receptors Nod1 and Nod2, thereby promoting the production of inflammatory cytokines and antibodies. To further elucidate these biological defe...

Analyses of climate change, due to its impact not only on the weather and the environment but also on human health and life, are one of the most important study activities made in recent years. There is relatively high confidence that glacial melt an...

Infrared (IR) radiometers from geostationary (GEO) satellites have an advantage over low-earth orbiting (LEO) satellites as they provide continuous observations to monitor the diurnal variations in the sea surface temperature (SST), typically better...

Background: antibiotic resistance encourages the development of new therapies, or the discovery of novel antibacterial agents. Previous research revealed that Myrmecodia pendans (Sarang Semut) contain potential antibacterial agents. However, specific...

The emergence of multidrug-resistant (MDR) bacterial pathogens has heightened the urgency for novel antibacterial agents. The bacterial cell wall usually comprises peptidoglycan, which presents a prime target for antibacterial drug development due to...

This contribution is aimed at analyzing a series of life-prolonging and rejuvenating treatments (bcud len), recipes of ambrosia for immortality (bdud rtsi sman), and yogic and meditative techniques incorporated in the Man ngag bye ba ring bsrel (Ten...