2,332 Results Found

Human mesenchymal stem cells (hMSCs) are promising candidates for stem cell therapy and are known to secrete programmed death-1 (PD-1) ligand 1 (PD-L1) regulating T cell-mediated immunosuppression. Given the limitations of current stem cell therapy a...

Hydrogen peroxide (H₂O₂) is an important industrial chemical that is widely applied in many areas. The direct synthesis of H₂O₂ from H₂ and O₂ has proved to be a green and economic pathway. Pd-based bimetallic catalysts, due to their superior catalyt...

Immunotherapy, particularly targeting the PD-1/PD-L1 pathway, holds promise in cancer treatment by regulating the immune response and preventing cancer cells from evading immune destruction. Nonetheless, this approach poses a risk of unwanted immune...

Tailoring the shape of Pd nanocrystals is one of the main ways to enhance catalytic activity; however, the effect of shapes and electrolyte pH on carbon monoxide oxidation (CO_Oxid) is not highlighted enough. This article presents the controlled fabri...

In this study, we investigated the catalytic properties of mono- and bimetallic palladium (Pd) and platinum (Pt) nanoparticles deposited via supercritical fluid reactive deposition (SFRD) on titanium dioxide (TiO₂) powder. Transmission electron micro...

Hydrogen (H₂) gas, with its high calorimetric combustion energy and cleanness, is a green source of energy and an alternative to fossil fuels. However, it has a small kinetic diameter, with high diffusivity and a highly explosive nature. Hence, the r...

The treatment of non-small cell lung cancer (NSCLC) has changed dramatically with the advent of immune checkpoint inhibitors (ICIs). Despite encouraging results, their efficacy remains limited to a subgroup of patients. Circulating immune checkpoints...

Background: FAM83H has been implicated in cancer progression, and PD1 is an important target for anti-cancer immune checkpoint therapy. Recent studies suggest an association between FAM83H expression and immune infiltration. However, studies on the r...

In this contribution, an eco-friendly, sustainable, and efficient palladium nanoparticle-decorated chitosan (Pd@Chitosan) catalyst was synthesized by a simple impregnation method. The synthesized material was utilized as a heterogeneous catalyst for...

As a typical p-type semiconductor gas-sensing material, LaFeO₃ has good response stability to H₂S, but its responsiveness is low, and the detection limit is not low enough for large-scale use in the field of gas sensors. To obtain better performance,...

The study of the reactivity of three 2-phenyl-3H-indole ligands of general formulae C₈H₃N-2-(C₆H₄-4-R¹)-3-NOMe-5-R² (1) [with R¹ = H, R² = OMe (a); R¹ = R² = H (b) or R¹ = Cl, R² = H (c)] with [Pd(η³-1-R³C₃H₄)(μ-Cl)]₂ (R³ = H or Ph) has allowe...

Platinum- and/or palladium-containing silica-based supports were applied for the selective catalytic reduction of NO_x with hydrogen (H₂-SCR-DeNO_x). To obtain enhanced activity and N₂ selectivity below 150 °C, we varied the type and loading of nob...

Evidence of a Wheland intermediate in carboxylate-assisted C−H activation was found using DFT calculations when the Pd(IV) catalyst species was postulated as the active catalyst species (ACS). In order to delineate the reaction mechanism of Pd-...

In this review paper, we provide an overview of state-of-the-art Pd-based materials for optical H₂ sensors. The first part of the manuscript introduces the operating principles, providing background information on the thermodynamics and the primary m...

Carbon monoxide (CO) is a colourless, odourless, and toxic gas. Long-term exposure to high concentrations of CO causes poisoning and even death; therefore, CO removal is particularly important. Current research has focused on the efficient and rapid...

The C-3 modification of 1H-indazole has produced active pharmaceuticals for the treatment of cancer and HIV. But, so far, this transformation has seemed less available, due to the lack of efficient C-C bond formation at the less reactive C-3 position...

A 21.7 wt.% Pd—7.3 wt.% Zn/C electrocatalyst prepared via the wet impregnation (w.i.) method was deposited onto commercial carbon cloth (E-TEK) and tested towards its electrocatalytic performance as a cathode electrode material for oxygen reduc...

Pancreatic cancer is one of the deadliest cancers globally, with limited success from existing therapies, including chemotherapies and immunotherapies like checkpoint inhibitors for patients with advanced pancreatic ductal adenocarcinoma (PDAC). A pr...

Glypican-3 (GPC3), as an emerging biomarker, has been shown to be beneficial for the early diagnosis and treatment of hepatocellular carcinoma (HCC). In this study, an ultrasensitive electrochemical biosensor for GPC3 detection has been constructed b...

The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D₂O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biolog...

In the category of drugs approved by the U.S. FDA, pyrrolidine is the most frequently used core of five-membered nonaromatic heterocycles containing nitrogen. Herein, a Rh(II)/Pd(0) dual-catalyzed carbenoid N-H insertion/allylation cascade reaction h...

Oncolytic coxsackievirus B3 (oCVB3) strain PD-H has shown potent oncolytic efficacy and a remarkable safety profile in the treatment of colorectal cancer in vivo after intratumoral (i.t.) injection. In this study, we investigated the safety and effic...

Objective Glioblastoma (GBM), a type of malignant glioma, is the most aggressive type of brain tumor and is associated with high mortality. Hexose-6-phosphate dehydrogenase (H6PD) has been detected in multiple tumors and is involved in tumor initiati...

Hexadecyl palmitate (C₁₅H₃₁COOC₁₆H₃₃, used as a model compound for Euglena oil) was deoxygenated to hydrocarbons over various solid catalysts in autoclave reactors. In a H₂ atmosphere, 1 wt.% of Pd/Mg(Al)O catalyst, derived from a hydrotalcite precur...

Recently, we demonstrated that the oncolytic Coxsackievirus B3 (CVB3) strain PD-H can be efficiently adapted to resistant colorectal cancer cells through dose-dependent passaging in colorectal cancer cells. However, the method is time-consuming, whic...

Lung squamous cell carcinoma (LSCC) is refractory to various therapies for non-small cell cancer; therefore, new therapeutic approaches are required to improve the prognosis of LSCC. Although immunotherapies targeting B7 family molecules were explore...

Metastatic prostate cancer (mPCa) is a disease for which to date there is not curative therapy. Even the recent and attractive immunotherapeutic approaches targeting PD-L1, an immune checkpoint protein which helps cancer cells to escape from immunosu...

Although inhibitors targeting the PD1/PD-L1 immune checkpoint are showing comparably good outcomes, a significant percentage of head and neck squamous cell carcinoma (HNSCC) patients do not respond to treatment. Apart from using different treatment s...

Pt,Pd,Ni/MgO, Pt,Pd,Ni/Mg_0.97La³⁺_0.03O, Pt,Pd,Ni/Mg_0.93La³⁺_0.07O, and Pt,Pd,Ni/Mg_0.85La³⁺_0.15O (1% of each of the Ni, Pd, and Pt) catalysts were prepared by a surfactant-assisted co-precipitation method. Samples were characterized by the XRD, XPS, XR...

The bimetallic Crⁿ⁺/Pd⁰ nanoparticles have been synthesized for the first time by a two-step redox method. The method includes the deposition of Pd⁰ nanoparticles on the surface of SiO₂ and TiO₂ carriers followed by the deposition of Crⁿ⁺ on the surf...

The majority of NO_x is exhausted during the cold-start period for the low temperature of vehicle emissions, which can be solved by using Pd/zeolite catalysts to trap NO_x at low temperature and release NO_x at a high temperature that must be higher tha...

The development of novel drugs with different mechanisms of action has dramatically changed the treatment landscape of AML patients in recent years. Considering a significant dysregulation of the immune system, inhibitors of immune checkpoint (ICI) p...

In recent years, research efforts have focused on the development of safe and efficient H₂ generation/storage materials toward a fuel-cell-based H₂ economy as a long-term solution in the near future. Herein, we report the development of Pd nanopartic...

Sodium borohydride (SBH) hydrolysis in the presence of cheap and efficient catalysts has been proposed as a safe and efficient method for generating clean hydrogen energy for use in portable applications. In this work, we synthesized bimetallic NiPd...

Immune therapy improves cancer outcomes, yet many patients do not respond. This pre-clinical study investigated whether vascular disrupting agents (VDAs) could convert an immune unresponsive tumor into a responder. CDF1 mice, with 200 mm³ C3H mammary...

Hydrogen (H₂) is a renewable energy source that has the potential to reduce greenhouse gas emissions. However, H₂ is also highly flammable and explosive, requiring sensitive and safe sensors for its detection. This work presents the synthesis and cha...

Hydrangea macrophylla, renowned for its large inflorescences and a diverse range of colors, highlights a significant limitation in current gene function research, which is the lack of effective molecular genetic tools. This study utilized a tobacco r...

A PtPd/Al₂O₃ catalyst developed for the complete oxidation of methane from the ventilation air of underground coal mines is compared against a model PdO/Al₂O₃ catalyst. Although the PtPd/Al₂O₃ catalyst is substantially more active and stable than the...

Background: Isocitrate dehydrogenase (IDH) wild-type (wt) glioblastoma is an aggressive malignancy associated with poor clinical outcomes, marked by high heterogeneity and resistance to treatment. This study aims to investigate the prognostic signifi...

Immunotherapy has emerged as a transformative approach in gastrointestinal (GI) cancers, addressing historically poor survival rates in advanced-stage disease. Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis demonstrate remarkable e...

This review is focused on palladium-catalyzed reactions as efficient strategies aimed at the synthesis of different classes of benzodiazepines. Several reaction typologies are reported including hydroamination, amination, C–H arylation, N-aryla...

Small-molecule inhibitors of PD-L1 are postulated to control immune evasion in tumors similar to antibodies that target the PD-L1/PD-1 immune checkpoint axis. However, the identity of targetable PD-L1 inducers is required to develop small-molecule PD...

Microbial production of 1,3-propanediol (1,3-PD) has attracted the interest of scientists for decades. Its product offers an environmentally friendly and sustainable alternative to fossil-based raw materials for chemical synthesis. Citrobacter freund...

Catalytic combustion of volatile organic compounds (VOCs) usually requires external energy input to hold the desired reaction temperature via electric heating. This work presents an example of internal onsite heating of the catalytic active sites via...

Indole moiety is well-known as a superlative framework in many natural products and synthetic pharmaceuticals. Herein, we report an efficient procedure to synthesize a series of functionalized 2-methyl-1H-indole-3-carboxylate derivatives from commerc...

This study investigated the impact of molar ratio of CO₂ to reductants H₂O and H₂, as well as Pd loading weight on CO₂ reduction performance with Pd/TiO₂ as the photocatalyst. The Pd/TiO₂ film photocatalyst is prepared by the sol-gel and dip-coating...

Passion fruit is a very important tropical and subtropical fruit that not only has a good edible flavour, but also has high ornamental value. However, the functions of important trait genes in passion fruit have been difficult to elucidate due to the...

Triple-negative breast cancer (TNBC), as one of the most aggressive forms of breast cancer, is characterized by a poor prognosis and a very low rate of disease-free and overall survival. In recent years, immunotherapeutic approaches targeting T cell...

The devising and development of numerous enzyme mimics, particularly nanoparticles and nanomaterials (nanozymes), have been sparked by the inherent limitations imposed by natural enzymes. Peroxidase is one of the enzymes that is extensively utilized...

The sol–gel template technique makes it possible to synthesize a stable and efficient nickel catalyst based on magnesium-modified cerium oxide Ce_0.5Mg_0.5O_1.5 for the combined steam and CO₂ reforming of methane. To stabilize dispersed forms of t...