975,627 Results Found

Androgen receptor splice variants (AR-SVs) contribute to the aggressive growth of castration-resistant prostate cancer (CRPC). AR-SVs, including AR-V7, are expressed in ~30% of CRPC, but minimally in treatment-naïve primary prostate cancer (PCa)...

Androgen receptor (AR, a member of the steroid hormone receptor family) status has become increasingly important as both a prognostic marker and potential therapeutic target in breast cancer. AR is expressed in up to 90% of estrogen receptor (ER) pos...

Over the past decade, advances in prostate cancer research have led to discovery and development of novel biomarkers and effective treatments. As treatment options diversify, it is critical to further develop and use optimal biomarkers for the purpos...

Comprehensive collisional radiative (CR) models have been developed for the diagnostic of argon plasma using Ar and Ar⁺ emission lines. The present CR models consist of 42 and 114 fine-structure levels of Ar and Ar⁺, respectively. Various populating...

A number of Augmented Reality (AR) frameworks are now available and used to support the development of mobile AR applications. In this paper, we measure and compare the recognition performance of the commercial AR frameworks and identify potential is...

Chrome chlorites are usually found as secondary phases formed by hydrothermal alteration of chromite deposits and associated mafic/ultramafic rocks. Here, we report the ⁴⁰Ar/³⁹Ar age of chrome chlorites separated from the Luobusa massive chromitites...

Prostate cancer (PCa) relies in part on AR-signaling for disease development and progression. Earlier, we developed drug candidate galeterone, which advanced through phase 2-clinical trials in treating castration-resistant PCa (CRPC). Subsequently, w...

The recently discovered Daping tungsten deposit is located about 25 km north of Tongcheng County, Hubei Province, in the northern margin of the Sijiapu granite deposit of the Mufushan composite batholith. The ore body is produced in the northeast-ori...

The Maozaishan Sn deposit, located south of the Dayishan ore field in the Nanling Range, is a newly explored greisen-type Sn deposit. Two muscovite samples from tin-bearing ores yielded ⁴⁰Ar/³⁹Ar plateau ages of 154.7 ± 1.1 Ma (Mean standard w...

Background: Epigenetic modification influences androgen receptor (AR) activation, often resulting in prostate cancer (PCa) development and progression. Silencing histone-modifying enzymes (histone deacetylases-HDACs) either genetically or pharmacolog...

Controversy surrounds the genetic relationship between gold mineralization and magmatism, especially in deposits in granite. Jiaodong Peninsula is the leading gold province in China, and most deposits are in Mesozoic granites; moreover, debate on the...

Economic and subeconomic concentrations of Sn, In, rare earth elements (REE), Ta, and Nb are known in Central Brazil, in the Goias Tin Province. The Sn-P enriched albitites studied in this paper occur in sharp contact with peraluminous granites of th...

Data and services are available anywhere at any time thanks to the Internet and mobile devices. Nowadays, there are new ways of representing data through trendy technologies such as augmented reality (AR), which extends our perception of reality thro...

Friedel-Craft acylation at 100 °C of 2,5,9,9-tetramethyl-6,7,8,9-tetrahydro-5H-benzocycloheptene [ar-himachalene (1)], a sesquiterpenic hydrocarbon obtained by catalytic dehydrogenation of α-, β- and γ-himachalenes, produces a mixture of two compound...

The Lake George antimony mine was at one time North America’s largest producer of antimony. Despite being widely known for the antimony mineralization, the deposit also hosts a range of styles of mineralization such as multiple generations of W...

The Heilongjiang Complex provides a crucial geological record of the evolutionary history of the Mudanjiang Ocean, making it significant for understanding the accretion process between the Jiamusi Block and the Songliao Block. In this study, we analy...

Background: The outgrowth of castration-resistant prostate cancer (CRPC) dictates patient morbidity and mortality. Recurrence of prostate cancer (PC) following androgen-deprivation therapy (ADT) often occurs due to constitutively active androgen rece...

This study investigates the use of Augmented Reality (AR) to teach the concept of chirality—a fundamental topic in organic chemistry. Building on Cognitive Load Theory (CLT) and previous research on AR’s educational benefits, we designed...

The Great Xing’an Range (GXR) is a significant belt of polymetallic deposits located in the eastern segment of the Central Asian Orogenic Belt. The recently found Huoluotai porphyry Cu (Mo) deposit is situated in the northern GXR region in nort...

Slave Province in Canada is an Archean granite–supracrustal terrane at the northwestern corner of the Canadian Shield. It is bordered by the Thelon–Taltson orogen (2.0 to 1.9 Ga) to the southeast and the Wopmay orogen (1.9 to 1.8 Ga) to t...

Detection of androgen receptor (AR) variant 7 (AR-V7) is emerging as a clinically important biomarker in castrate resistant prostate cancer (CRPC). Detection is possible from tumor tissue, which is often inaccessible in the advanced disease setting....

The COVID-19 pandemic has exacerbated the global antimicrobial resistance (AMR) crisis. Consequently, it is more urgent than ever to prioritize AMR containment and support countries in improving the detection, characterization, and rapid response to...

Translational research is aimed at turning discoveries from basic science into results that advance patient treatment. The translation of technical solutions into clinical use is a complex, iterative process that involves different stages of design,...

Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant signaling in the androgen pathway is critical in the development and progression of prostate cancer. Despite ongoing reliance on androgen receptor (AR) signaling in...

The simultaneous localization and mapping (SLAM) market is growing rapidly with advances in Machine Learning, Drones, and Augmented Reality (AR) technologies. However, due to the absence of an open source-based SLAM library for developing AR content,...

Over the past decade, the use of AR has significantly increased over a wide range of applications. Although there are many good examples of AR technology being used in engineering, retail, and for entertainment, the technology has not been widely ado...

Building heritage contributes to the historical context and industrial history of a city. Brick warehouses, which comprise a systematic interface between components, demand an interactive manipulation of inspected parts to interpret their constructio...

Ancient paintings are an intangible window to the economy, politics, and customs of the past. Their characteristics have evolved or were made obsolete, with only limited contemporary connections remaining. This research aims to preserve and to intera...

A direct application of autoregressive (AR) models with independent and identically distributed (iid) errors is sometimes inadequate to fit the time series data well. A natural alternative is further to assume the model errors following an AR process...

Typically, ⁴⁰Ar/³⁹Ar dating of phlogopites from deep-seated xenoliths of kimberlite pipes produces estimates that suggest much older ages than those when these pipes were intruded. High-pressure (3 GPa) laboratory experiments enabled the authors to e...

Recently released, depth-sensing-capable, and moderately priced handheld devices support the implementation of augmented reality (AR) applications without the requirement of tracking visually distinct markers. This relaxed constraint allows for appli...

Graffiti relies on social instrumentation for its creation on spatial structures. It is questioned whether different mechanisms exist to transfer social and spatial hierarchies under a new model for better engagement, management, and governance. This...

Background: Circulating tumor cells (CTC), androgen receptor full-length (AR-FL), and androgen receptor splice variant 7 (AR-V7) are prognostic in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). AR-V7 seems to predict res...

With the increasing demand for near real-time atmospheric water vapor monitoring, this study evaluates the performance of the open-source PRIDE PPP-AR software (version 3.0.5) for retrieving Zenith Total Delay (ZTD) and Integrated Water Vapor (IWV) o...

Augmented reality (AR) applications are currently used in many fields for communication and educational purposes. Tourism is also a sector where augmented reality is used for destination marketing and cultural heritage promotion. This study will focu...

The growing number of mobile augmented reality applications has been favoring its awareness and usage among diversified areas. Focusing on cultural heritage applications, this study presents an evaluation of a mobile augmented reality application tes...

The recently explored Xitian tungsten-tin (W-Sn) polymetallic ore field, located in Hunan province, South China, is one of the largest ore fields in the Nanling Range (NLR). Two major metallogenic types appeared in this ore field, skarn- and quartz v...

Digitalization of production environment, also called Industry 4.0 (the term invented by Wahlster Wolfgang in Germany) is now one of the hottest topics in the computer science departments at universities and companies. One of the most significant top...

The expanded use of second-generation antiandrogens revolutionized the treatment landscape of progressed prostate cancer. However, resistances to these novel drugs are already the next obstacle to be solved. Various previous studies depicted an invol...

In the context of web augmented reality (AR), 3D rendering that maintains visual quality and frame rate requirements remains a challenge. The lack of a dedicated and efficient 3D format often results in the degraded visual quality of the original dat...

Augmented reality (AR) is a technology whose presence has increased in the field of education in recent years. However, its role in secondary education has not been thoroughly explored. Therefore, this research aims to analyse the influence of AR on...

A robust AR-DSNet (Augmented Reality method based on DSST and SiamFC networks) tracking registration method in complex scenarios is proposed to improve the ability of AR (Augmented Reality) tracking registration to distinguish target foreground and s...

Metastatic prostate cancer is the most common cancer in males and the fifth cause of cancer mortality worldwide. Despite the major progress in this field, leading to the approval of novel anti-androgens, the prognosis is still poor. A significant num...

Although there is a growing body of literature about the use of Augmented Reality (AR) in language learning, research regarding its effectiveness for vocabulary development among secondary students is scarce. This study aims to measure the perception...

We present in this paper the results of a theoretical study of electron impact broadening for several lines of the Ar VII ion. The results have been obtained using our quantum mechanical method and the semiclassical perturbation one. Results are pres...

Using the semi-classical perturbation approach in the impact approximation, full width at half maximum and shift have been determined for eight spectral lines of Ar VII, for broadening by electron-, proton-, and He III-impacts. The results are provid...

The use of augmented reality head-up displays (AR-HUD) in automobile safety driving has drawn more and more interest in recent years. An AR-HUD display system should be developed to fit the vehicle and the complicated traffic environment in order to...

Unlike other civil engineering works, water pipe works require digging out before construction because the construction site is buried. The AR application is a system that displays buried objects in the ground in three dimensions when users hold a de...

With the advancement of multi-frequency and multi-constellation GNSS signals and the introduction of observable-specific bias (OSB) products, the uncombined precise point positioning (PPP) model has grown more prevalent. However, this model faces cha...

Augmented reality (AR) technology enables paper maps to dynamically express three-dimensional geographic information, realizing the fusion of virtual and real information. However, in the current mainstream AR development software, the virtual inform...