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63 Results Found

  • Article
  • Open Access
10 Citations
6,667 Views
10 Pages

Mini-Invasive, Ultrasound Guided Repair of the Achilles Tendon Rupture—A Pilot Study

  • Łukasz Paczesny,
  • Jan Zabrzyński,
  • Marcin Domżalski,
  • Maciej Gagat,
  • Miron Termanowski,
  • Dawid Szwedowski,
  • Łukasz Łapaj and
  • Jacek Kruczyński

28 May 2021

Percutaneous acute Achilles tendon rupture suturing has become a leading treatment option in recent years. A common complication after this mini-invasive procedure is sural nerve injury, which can reduce the patients’ satisfaction and final outcomes....

  • Article
  • Open Access
5 Citations
2,553 Views
10 Pages

Open vs. Percutaneous Achilles Tendon Repair: Experience of Single Orthopedic Institute with Long-Term Follow-Up

  • Gaetano Caruso,
  • Edoardo Gambuti,
  • Achille Saracco,
  • Elisa Spadoni,
  • Elena Corso,
  • Ilaria Pinotti,
  • Alessandro Pisano and
  • Leo Massari

23 August 2024

Background and Objectives: There are numerous techniques for the surgical treatment of Achilles tendon lesions described in the literature, and it is possible to distinguish repair techniques as either open surgery or percutaneous repair techniques....

  • Case Report
  • Open Access
2,153 Views
10 Pages

Augmented Repair of Achilles Tendon Rupture with Bioinductive Regeneten Implant: A Case Report on Enhanced Healing and Functional Recovery

  • Umile Giuseppe Longo,
  • Antonio Suma,
  • Gianmarco Marcello,
  • Alessandra Corradini,
  • Alice Ceccaroli,
  • Pieter D’Hooghe and
  • Alessandro de Sire

Background/Objectives: Complete rupture of the Achilles tendon is a common and challenging injury, specifically for individuals engaged in high-demand activities such as sports. Surgical repair is often required, but conventional methods, including d...

  • Article
  • Open Access
617 Views
11 Pages

Endoscopic Assistance in Minimally Invasive Repair of Acute Achilles Ruptures: A Prospective Observational Study Comparing Endoscopic-Assisted, Minimally Invasive, and Open Techniques

  • Paolo Ceccarini,
  • Marco Donantoni,
  • Lorenzo Lucchetta,
  • Andrea Marinozzi,
  • Pierluigi Antinolfi,
  • Giuseppe Rinonapoli and
  • Auro Caraffa

17 November 2025

Background: The optimal management of acute Achilles tendon (AT) ruptures remains debated. Historically, surgical treatment has been preferred over conservative management because of a lower risk of rerupture. In recent decades, minimally invasive (M...

  • Communication
  • Open Access
15 Citations
5,872 Views
16 Pages

Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies

  • Lara Gil-Melgosa,
  • Jorge Grasa,
  • Ainhoa Urbiola,
  • Rafael Llombart,
  • Miguel Susaeta Ruiz,
  • Verónica Montiel,
  • Cristina Ederra,
  • Begoña Calvo,
  • Mikel Ariz and
  • Ana Pérez Ruiz
  • + 4 authors

Achilles tendon rupture is a frequent injury with an increasing incidence. After clinical surgical repair, aimed at suturing the tendon stumps back into their original position, the repaired Achilles tendon is often plastically deformed and mechanica...

  • Article
  • Open Access
8 Citations
2,475 Views
11 Pages

14 September 2022

Background: Achilles tendon ruptures are one of the most common sports injuries. Recently, platelet-rich plasma (PRP) has been widely used in tendon-related disorders to enhance tendon healing. However, studies regarding PRP treatment in Achilles ten...

  • Review
  • Open Access
31 Citations
10,550 Views
17 Pages

Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery

  • Sabino Padilla,
  • Mikel Sánchez,
  • Victor Vaquerizo,
  • Gerard A. Malanga,
  • Nicolás Fiz,
  • Juan Azofra,
  • Christopher J. Rogers,
  • Gonzalo Samitier,
  • Steven Sampson and
  • Eduardo Anitua
  • + 6 authors

Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platele...

  • Article
  • Open Access
9 Citations
6,951 Views
11 Pages

Comparing Absorbable and Nonabsorbable Suture Materials for Repair of Achilles Tendon Rupture: A Magnetic Resonance Imaging-Based Study

  • Jaeho Cho,
  • Hyun-Joo Kim,
  • Jeong Seok Lee,
  • Jahyung Kim,
  • Sung Hun Won,
  • Young Yi and
  • Dong-Il Chun

13 December 2020

We aimed to compare magnetic resonance imaging (MRI) findings and corresponding clinical outcomes of repaired Achilles tendons using absorbable and nonabsorbable sutures. Patients who underwent Achilles tendon repair were divided into 2 groups, with...

  • Technical Note
  • Open Access
2,966 Views
11 Pages

23 November 2024

Background/Objectives: Acute ruptures of the Achilles Tendon (AT) are common injuries in the active population, in particular among men aged 30 to 50. Full functional recovery after this kind of injury is long and challenging and nowadays there is no...

  • Article
  • Open Access
1,962 Views
13 Pages

Haglund’s Deformity with Preoperative Achilles Tendon Rupture: A Retrospective Comparative Study

  • Kevin A. Wu,
  • Alexandra N. Krez,
  • Katherine M. Kutzer,
  • Albert T. Anastasio,
  • Zoe W. Hinton,
  • Kali J. Morrissette,
  • Andrew E. Hanselman,
  • Karl M. Schweitzer,
  • Samuel B. Adams and
  • Annunziato Amendola
  • + 2 authors

Introduction: Haglund’s deformity, characterized by bony enlargement at the back of the heel, often coincides with Achilles tendon pathology due to impingement on the retrocalcaneal bursa and tendon insertion. Surgical management of Haglund&rsq...

  • Systematic Review
  • Open Access
19 Citations
10,739 Views
11 Pages

The Acute Achilles Tendon Rupture: An Evidence-Based Approach from the Diagnosis to the Treatment

  • Francesco Amendola,
  • Léa Barbasse,
  • Riccardo Carbonaro,
  • Mario Alessandri-Bonetti,
  • Giuseppe Cottone,
  • Michele Riccio,
  • Francesco De Francesco,
  • Luca Vaienti and
  • Kevin Serror

1 September 2022

Background and Objective: Acute Achilles tendon rupture (AATR) is a common injury with a significant impact on daily living. Although various systematic reviews and meta-analyses have been written on the topic, no actual consensus exists on the best...

  • Article
  • Open Access
1,337 Views
14 Pages

Intraoperative Application of Hyaluronic Acid in Achilles Tendon Repair: A Retrospective Cohort Study on Short-Term Functional Outcomes

  • Goker Yurdakul,
  • Mehmet Okan Atahan,
  • Aydogan Askin,
  • Mehmet Fatih Uzun,
  • Abdullah Iyigun,
  • Fatih Golgelioglu and
  • Haci Ali Olcar

10 October 2025

Background and Objectives: This study aimed to investigate the effect of intraoperative hyaluronic acid (HA) application on short-term functional outcomes after open surgical repair of Achilles tendon rupture. Materials and Methods: This retrospectiv...

  • Review
  • Open Access
50 Citations
12,573 Views
14 Pages

Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer’s Achilles’ Heel

  • Daniele Caracciolo,
  • Caterina Riillo,
  • Maria Teresa Di Martino,
  • Pierosandro Tagliaferri and
  • Pierfrancesco Tassone

19 March 2021

Error-prone DNA repair pathways promote genomic instability which leads to the onset of cancer hallmarks by progressive genetic aberrations in tumor cells. The molecular mechanisms which foster this process remain mostly undefined, and breakthrough a...

  • Article
  • Open Access
8 Citations
5,634 Views
9 Pages

Clinical Features and Treatment of Intra-Tendinous Suture Reaction Following Achilles Tendon Repair Using Nonabsorbable Suture Material: A Retrospective Case Series Study

  • Jahyung Kim,
  • Hwa-Jun Kang,
  • Bom-Soo Kim,
  • Yu-Mi Kim,
  • Hyong-Nyun Kim,
  • Jae-Yong Park,
  • Young-Rak Choi,
  • Altanzul Bat-Ulzii and
  • Jaeho Cho

We aimed to investigate the clinical manifestations, radiological findings, and therapeutic outcome of treatment for patients with surgically confirmed foreign body reaction following an Achilles tendon repair using non-absorbable suture material. Ei...

  • Article
  • Open Access
160 Views
15 Pages

15 January 2026

Background/Objectives: The Achilles tendon is the largest tendon in the human body; it is frequently ruptured during sports and other dynamic physical activities. The purpose of this study was to compare recovery patterns over time between injuries t...

  • Article
  • Open Access
769 Views
13 Pages

Augmented Tendon Repair with Internal Bracing: Surgical Technique

  • Nina Handzewniak,
  • Richard Pearse,
  • Abbie Randall,
  • Abid Mahmood,
  • Tanvir Khan,
  • Shahnawaz Khan and
  • Henry Atkinson

10 November 2025

Objectives: The role of internal bracing in lower limb tendon repairs and reconstructions is not widely published. We report our techniques for internal brace-augmented tendon repair (IBA-TR) in the surgical treatment of acute ruptures of the patella...

  • Article
  • Open Access
6 Citations
3,669 Views
10 Pages

Outcomes of Open Repair Treatment for Acute Versus Chronic Achilles Tendon Ruptures: Long-Term Retrospective Follow-Up of a Minimum 10 Years—A Pilot Study

  • Marta Tarczyńska,
  • Mateusz Szubstarski,
  • Krzysztof Gawęda,
  • Piotr Przybylski and
  • Elżbieta Czekajska-Chehab

24 March 2023

The aim of the present study was to compare repaired Achilles tendon (AT) remodelling, whether its function was restored and what effects the surgery had on our patients’ gait cycle in a long-term follow-up study. The study population comprised...

  • Article
  • Open Access
3 Citations
3,768 Views
11 Pages

Fast Functional Rehabilitation Protocol versus Plaster Cast Immobilization Protocol after Achilles Tendon Tenorrhaphy: Is It Different? Clinical, Ultrasonographic, and Elastographic Comparison

  • Mario Mosconi,
  • Gianluigi Pasta,
  • Salvatore Annunziata,
  • Viviana Guerrieri,
  • Matteo Ghiara,
  • Simone Perelli,
  • Camilla Torriani,
  • Federico Alberto Grassi and
  • Eugenio Jannelli

Background: the incidence of Achilles tendon (AT) rupture is rising; however, there is no clear consensus regarding the optimal treatment. The aim of this retrospective study was to compare instrumental and patient-reported outcome scores after fast...

  • Case Report
  • Open Access
3 Citations
3,132 Views
10 Pages

Achilles Tendon Repair after Tenorraphy Imaging and the Doughnut Metaphor

  • Gian Nicola Bisciotti,
  • Andrea Bisciotti,
  • Alessio Auci,
  • Alessandro Bisciotti,
  • Cristiano Eirale,
  • Alessandro Corsini and
  • Piero Volpi

After Achilles tendon tenorraphy, tendon tissue undergoes a long period of biological healing. During this period, tissue turnover shows heterogeneity between its peripheral and central regions. This case report concerns the description of the tendon...

  • Review
  • Open Access
8 Citations
4,757 Views
22 Pages

The Use of Extracellular Vesicles in Achilles Tendon Repair: A Systematic Review

  • Varun Kasula,
  • Vikram Padala,
  • Nithin Gupta,
  • David Doyle,
  • Kian Bagheri,
  • Albert Anastasio and
  • Samuel Bruce Adams

Achilles tendon (AT) pathologies are common musculoskeletal conditions that can significantly impair function. Despite various traditional treatments, recovery is often slow and may not restore full functionality. The use of extracellular vesicles (E...

  • Review
  • Open Access
79 Citations
19,531 Views
56 Pages

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

  • Denis Velic,
  • Anthony M. Couturier,
  • Maria Tedim Ferreira,
  • Amélie Rodrigue,
  • Guy G. Poirier,
  • Fabrice Fleury and
  • Jean-Yves Masson

20 November 2015

For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is bo...

  • Article
  • Open Access
18 Citations
4,244 Views
20 Pages

A Pilot Study of Musculoskeletal Abnormalities in Patients in Recovery from a Unilateral Rupture-Repaired Achilles Tendon

  • Dong Sun,
  • Gusztáv Fekete,
  • Julien S. Baker,
  • Qichang Mei,
  • Bíró István,
  • Yan Zhang and
  • Yaodong Gu

The purpose of this study was to compare the inter-limb joint kinematics, joint moments, muscle forces, and joint reaction forces in patients after an Achilles tendon rupture (ATR) via subject-specific musculoskeletal modeling. Six patients recoverin...

  • Systematic Review
  • Open Access
1,243 Views
15 Pages

Isolated Flexor Hallucis Longus Tendon Transfer for Chronic Achilles Tendon Rupture: Systematic Review and Meta-Analysis

  • Yasmine J. Khair,
  • Hugh Milchem,
  • Maamoun Adra,
  • Anthony Fong,
  • Thant Htoo Nyan,
  • Shayndhan Sivanathan,
  • Hayato Nakanishi,
  • Christian A. Than,
  • Nadim Tarazi and
  • Marcus Mumme
  • + 1 author

30 October 2025

Background: Chronic Achilles tendon ruptures (CATRs) pose a clinical challenge because guidelines on optimal treatment modalities are lacking. This meta-analysis aims to investigate the use of Flexor Hallucis Longus (FHL) tendon transfer as a treatme...

  • Article
  • Open Access
2 Citations
2,341 Views
9 Pages

Patients with Achilles Tendon Rupture Are Prone to Develop Ventricular Arrhythmia

  • Volkan Gür,
  • Furkan Yapici,
  • Uğur Küçük,
  • İzzet Özay Subaşi,
  • Mehmet Burak Gökgöz,
  • Reşit Karaköse and
  • Nizamettin Koçkara

21 May 2023

Background and Objectives: This study aimed to examine the ventricular repolarization (VR) disturbances of patients operated on for acute spontaneous Achilles tendon ruptures (ATRs), by comparing them with a healthy individual control group. Material...

  • Article
  • Open Access
1,583 Views
24 Pages

Neural Markers Predict Tendon Healing Outcomes in an Ovine Achilles Tendon Injury Model: Spontaneous Repair Versus Amniotic Epithelial Cell-Induced Regeneration

  • Valeria Giovanna Festinese,
  • Melisa Faydaver,
  • Delia Nardinocchi,
  • Oriana Di Giacinto,
  • Mohammad El Khatib,
  • Annunziata Mauro,
  • Maura Turriani,
  • Angelo Canciello,
  • Paolo Berardinelli and
  • Barbara Barboni
  • + 1 author

Tendon injuries pose a clinical challenge due to tendons’ limited recovery. Emerging evidence points to the nervous system’s critical role in tendon healing, with neural markers NGF, NF-200, NPY, CGRP, and GAL modulating inflammation, cel...

  • Article
  • Open Access
15 Citations
3,241 Views
16 Pages

29 June 2022

Achilles tendon rupture is a severe injury, and its optimal therapy remains controversial. Tissue engineering scaffolds play a significant role in tendon healing and tissue regeneration. In this study, we developed tri-layered doxycycline/collagen/bu...

  • Case Report
  • Open Access
3 Citations
8,511 Views
7 Pages

Chronic Rupture of Achilles Tendon Caused by Haglund’s Deformity: A Case Report

  • Muhammad Andry Usman,
  • Benny Murtaza,
  • Putu Acarya Nugraha Winangun and
  • Dave Kennedy

4 September 2022

A chronic Achilles tendon rupture is a tendon rupture occurring more than 4–6 weeks after a traumatic injury. Haglund’s deformity, caused by bony abnormalities in the ankle (mostly due to osteophyte or bone spur), can cause chronic inflam...

  • Article
  • Open Access
1 Citations
2,459 Views
17 Pages

Reconstruction of Chronic Quadriceps and Achilles Tendon Ruptures Using Achilles Allografts: Clinical Findings and Review of Literature

  • Cătălin-Adrian Miu,
  • Mihai Hurmuz,
  • Luminița-Oana Miu,
  • Daniel Ceachir and
  • Romulus-Fabian Tatu

Background/Objectives: Chronic ruptures of the quadriceps and Achilles tendons present significant reconstructive challenges due to factors such as tendon retraction, scar tissue formation, and compromised tissue quality. Traditional repair methods,...

  • Article
  • Open Access
32 Citations
4,657 Views
12 Pages

Achilles Tendon Rupture and Dysmetabolic Diseases: A Multicentric, Epidemiologic Study

  • Francesco Oliva,
  • Emanuela Marsilio,
  • Giovanni Asparago,
  • Alessio Giai Via,
  • Carlo Biz,
  • Johnny Padulo,
  • Marco Spoliti,
  • Calogero Foti,
  • Gabriella Oliva and
  • Nicola Maffulli
  • + 3 authors

27 June 2022

Introduction: Achilles tendon ruptures are common. Metabolic disorders, such as diabetes mellitus, hypercholesterolemia, thyroid disorders, and obesity, impair tendons health, leading to Achilles tendinopathy and likely predisposing patients to Achil...

  • Case Report
  • Open Access
4 Citations
6,331 Views
7 Pages

Bilateral Achilles Tendon Rupture: A Case Report and Review of the Literature

  • Christian A. Cruz,
  • Jeffrey L. Wake,
  • Ryan J. Bickley,
  • Logan Morin,
  • Brian J. Mannino,
  • Kevin P. Krul and
  • Paul Ryan

26 April 2022

While Achilles tendon injuries are common amongst the general population, there are very few cases in which simultaneous bilateral injuries occur. Medial malleolar fractures at the time of Achilles tendon rupture have been cited in the literature and...

  • Article
  • Open Access
9 Citations
2,946 Views
14 Pages

Electrospun, Resorbable, Drug-Eluting, Nanofibrous Membranes Promote Healing of Allograft Tendons

  • Chun-Jui Weng,
  • Yu-Chen Wu,
  • Ming-Yi Hsu,
  • Fu-Pang Chang and
  • Shih-Jung Liu

In spite of advances in medical technology, the repair of Achilles tendon ruptures remains challenging. Reconstruction with an autograft tendon provides the advantage of a higher healing rate; nevertheless, the development of donor-site morbidity can...

  • Article
  • Open Access
13 Citations
7,183 Views
10 Pages

Allograft and Autologous Reconstruction Techniques for Neglected Achilles Tendon Rupture: A Mid-Long-Term Follow-Up Analysis

  • Cristina Jiménez-Carrasco,
  • Fadi Ammari-Sánchez-Villanueva,
  • Estefanía Prada-Chamorro,
  • Antonio Jesús García-Guirao and
  • Sergio Tejero

1 February 2023

Achilles tendon ruptures that are not immediately recognized and treated are sometimes diagnosed as delayed injuries and may require different surgical repair options based on gap size. The potential complications associated with using an allograft f...

  • Review
  • Open Access
2 Citations
10,546 Views
13 Pages

4 July 2025

Background/Objectives: Achilles tendon pathologies, such as Achilles tendinitis, tendinosis, ruptures, and equinus contracture, cause pain and functional impairment. While surgical intervention is indicated in some cases, many patients are successful...

  • Review
  • Open Access
84 Citations
31,709 Views
15 Pages

Achilles Tendon Rupture: Mechanisms of Injury, Principles of Rehabilitation and Return to Play

  • Domiziano Tarantino,
  • Stefano Palermi,
  • Felice Sirico and
  • Bruno Corrado

The Achilles tendon is the thickest, strongest and largest tendon in the human body, but despite its size and tensile strength, it frequently gets injured. Achilles tendon ruptures (ATRs) mainly occur during sports activities, and their incidence has...

  • Article
  • Open Access
1,589 Views
16 Pages

Histological Alterations and Interferon-Gamma and AKT-mTOR Expression in an Experimental Model of Achilles Tendinopathy—A Comparison of Stem Cell and Amniotic Membrane Treatment

  • Guilherme Vieira Cavalcante,
  • Rosangela Fedato,
  • Lucia de Noronha,
  • Seigo Nagashima,
  • Ana Paula Camargo Martins,
  • Márcia Olandoski,
  • Ricardo Pinho,
  • Aline Takejima,
  • Rossana Simeoni and
  • Luiz César Guarita-Souza
  • + 1 author

Achilles tendon injuries are extremely common and have a significant impact on the physical and mental health of individuals. Both conservative and surgical treatments have unsatisfactory results. The search for new therapeutic tools, using cell ther...

  • Technical Note
  • Open Access
5 Citations
3,287 Views
8 Pages

Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note

  • Umile Giuseppe Longo,
  • Vincenzo Candela,
  • Alessandra Berton,
  • Calogero Di Naro,
  • Giovanna Stelitano,
  • Nicola Maffulli and
  • Vincenzo Denaro

19 December 2020

Purpose: Nowadays, surgical treatment of acute avulsions of the Achilles tendon represents a hard challenge. There is often the possibility that the calcaneus remains completely uncovered from the tendon, making the reinsertion of its distal stub com...

  • Article
  • Open Access
2 Citations
5,977 Views
8 Pages

Treatment of Calcific Insertional Achilles Tendinopathy: Knotless Internal Brace versus Knot-Tying Suture Bridge

  • Xiaodong Zhao,
  • Xiaolei Yang,
  • Yifan Hao,
  • Fujun Yang,
  • Zhenping Zhang,
  • Qirong Qian,
  • Peiliang Fu and
  • Qi Zhou

24 February 2023

Background: This study aimed to compare the knotless internal brace technique and the knot-tying suture bridge technique via the medial approach in the treatment of calcific Achilles tendinopathy. Methods: The clinical data of 25 cases of calcific Ac...

  • Article
  • Open Access
6 Citations
2,320 Views
16 Pages

Anti-Adhesive Resorbable Indomethacin/Bupivacaine-Eluting Nanofibers for Tendon Rupture Repair: In Vitro and In Vivo Studies

  • Yi-Hsun Yu,
  • Chen-Hung Lee,
  • Yung-Heng Hsu,
  • Ying-Chao Chou,
  • Ping-Chun Yu,
  • Chao-Tsai Huang and
  • Shih-Jung Liu

12 November 2023

The treatment and surgical repair of torn Achilles tendons seldom return the wounded tendon to its original elasticity and stiffness. This study explored the in vitro and in vivo simultaneous release of indomethacin and bupivacaine from electrospun p...

  • Review
  • Open Access
20 Citations
4,114 Views
20 Pages

Clinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas

  • Michela Camilla Milanesio,
  • Silvia Giordano and
  • Giorgio Valabrega

21 May 2020

Despite significant improvements in surgical and medical management, high grade serous ovarian cancer (HGSOC) still represents the deadliest gynecologic malignancy and the fifth most frequent cause of cancer-related mortality in women in the USA. Sin...

  • Review
  • Open Access
1 Citations
965 Views
21 Pages

Achilles tendon injuries are among the most frequent and debilitating musculoskeletal conditions, often resulting in incomplete healing and functional deficits. Conventional repair techniques primarily restore structural continuity but rarely achieve...

  • Article
  • Open Access
2 Citations
3,457 Views
13 Pages

Modified Ankle Joint Neuromechanics during One-Legged Heel Raise Test after an Achilles Rupture and Its Associations with Jumping

  • Kao-Shang Shih,
  • Pei-Yu Chen,
  • Wen-Ling Yeh,
  • Hsiao-Li Ma,
  • Chui-Jia Farn,
  • Chun-Han Hou,
  • Wei-Chen Peng and
  • Hsing-Kuo Wang

3 March 2021

This study had two purposes. The first purpose of the study was to compare the electromyographic(EMG) and dynamic characteristics in injured and non-injured legs during the one-legged heel-raise test after a unilateral Achilles repair. The second pur...

  • Article
  • Open Access
33 Citations
6,397 Views
22 Pages

Injured Achilles Tendons Treated with Adipose-Derived Stem Cells Transplantation and GDF-5

  • Andrea Aparecida De Aro,
  • Giane Daniela Carneiro,
  • Luis Felipe R. Teodoro,
  • Fernanda Cristina Da Veiga,
  • Danilo Lopes Ferrucci,
  • Gustavo Ferreira Simões,
  • Priscyla Waleska Simões,
  • Lúcia Elvira Alvares,
  • Alexandre Leite R. De Oliveira and
  • Edson Rosa Pimentel
  • + 5 authors

31 August 2018

Tendon injuries represent a clinical challenge in regenerative medicine because their natural repair process is complex and inefficient. The high incidence of tendon injuries is frequently associated with sports practice, aging, tendinopathies, hyper...

  • Article
  • Open Access
28 Citations
5,258 Views
18 Pages

Changes in Gene Expression Associated with Collagen Regeneration and Remodeling of Extracellular Matrix after Percutaneous Electrolysis on Collagenase-Induced Achilles Tendinopathy in an Experimental Animal Model: A Pilot Study

  • José Luis Sánchez-Sánchez,
  • Laura Calderón-Díez,
  • Javier Herrero-Turrión,
  • Roberto Méndez-Sánchez,
  • José L. Arias-Buría and
  • César Fernández-de-las-Peñas

15 October 2020

Percutaneous electrolysis is an emerging intervention proposed for the management of tendinopathies. Tendon pathology is characterized by a significant cell response to injury and gene expression. No study investigating changes in expression of those...

  • Review
  • Open Access
9 Citations
6,872 Views
18 Pages

Extensive Ossification of the Achilles Tendon with and without Acute Fracture: A Scoping Review

  • Daniel Sullivan,
  • Allison Pabich,
  • Ryan Enslow,
  • Avery Roe,
  • Donald Borchert,
  • Keenan Barr,
  • Bailey Cook and
  • Amanda Brooks

6 August 2021

Extensive Ossification of the Achilles Tendon (EOAT) is an uncommon condition characterized by the presence of heterotopic ossification within the substance of the Achilles Tendon and is distinct from other tendinopathies associated with tendon miner...

  • Article
  • Open Access
458 Views
16 Pages

Amniotic Membrane and Stem Cells Can Improve the Immunohistochemical Profile of Achilles Tendons in Injured Rats

  • Rosangela Alquieri Fedato,
  • Guilherme Vieira Cavalcante Da Silva,
  • Lúcia De Noronha,
  • Seigo Nagashima,
  • Ana Paula Camargo Martins,
  • Márcia Olandoski,
  • Ricardo Aurino De Pinho,
  • Aline Luri Takejima,
  • Rossana Baggio Simeoni and
  • Luiz César Guarita-Souza
  • + 1 author

Disorders of the Achilles tendon are common and have a major socio-economic impact. Current treatments (drugs, physiotherapy, and surgery) do not provide lasting relief, leading to chronicity and recurrence. In this context, experimental studies on r...

  • Article
  • Open Access
67 Citations
7,338 Views
20 Pages

11 August 2017

Silk fibroin (SF) and fiber alignment were introduced into polycaprolactone (PCL)-based electrospun nanofibers as chemical and physical cues for tendon tissue engineering applications. The physicochemical properties of random PCL (RP) nanofibers, ran...

  • Article
  • Open Access
1,280 Views
20 Pages

Avocado–Soybean Unsaponifiables Enhance Tendon Healing via Anti-Inflammatory and Antioxidant Mechanisms in a Rat Achilles Injury Model

  • Mustafa Dinç,
  • Ömer Cevdet Soydemir,
  • Hünkar Çağdaş Bayrak,
  • Recep Karasu,
  • Bilal Aykaç and
  • Mehmet Emre Topcu

14 November 2025

Background and Objectives: Tendon healing is a multifactorial process influenced by inflammation and oxidative stress. Avocado–soybean unsaponifiables (ASU), recognized for their anti-inflammatory and antioxidant properties in osteoarthritis, h...

  • Article
  • Open Access
48 Citations
5,014 Views
16 Pages

Extracellular Vesicles of Adipose-Derived Stem Cells Promote the Healing of Traumatized Achilles Tendons

  • Shih-Heng Chen,
  • Zhi-Yu Chen,
  • Ya-Hsuan Lin,
  • Shih-Hsien Chen,
  • Pang-Yun Chou,
  • Huang-Kai Kao and
  • Feng-Huei Lin

16 November 2021

Healing of ruptured tendons remains a clinical challenge because of its slow progress and relatively weak mechanical force at an early stage. Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have therapeutic potential for tissu...

  • Review
  • Open Access
19 Citations
6,309 Views
17 Pages

Physiological and Pathological Roles of RAD52 at DNA Replication Forks

  • Eva Malacaria,
  • Masayoshi Honda,
  • Annapaola Franchitto,
  • Maria Spies and
  • Pietro Pichierri

10 February 2020

Understanding basic molecular mechanisms underlying the biology of cancer cells is of outmost importance for identification of novel therapeutic targets and biomarkers for patient stratification and better therapy selection. One of these mechanisms,...

  • Article
  • Open Access
2 Citations
1,912 Views
8 Pages

29 September 2024

Background/Objectives: An early accelerated rehabilitation is generally recommended after surgery for acute Achilles tendon ruptures (ATRs). The modified side-locking loop suture (MSLLS) is a surgical technique that provides high tensile strength to...

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