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DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

1
Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R-2J6, Canada
2
Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC G1V-0A6, Canada
3
DNA repair regulation team, UFIP, CNRS UMR 6286, Université de Nantes, 2 rue de la Houssinière, Nantes 44322, France
4
CHU de Québec Research Center, Oncology Axis, 2705 boul. Laurier, Quebec city, QC G1V-4G2, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Wolf-Dietrich Heyer, Thomas Helleday and Fumio Hanaoka
Biomolecules 2015, 5(4), 3204-3259; https://doi.org/10.3390/biom5043204
Received: 7 September 2015 / Accepted: 9 November 2015 / Published: 20 November 2015
(This article belongs to the Special Issue DNA Damage Response)
For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is both effective and selective to the malignancy. Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repair has offered the possibility of therapeutic improvements in oncology. In this review, we summarize the current knowledge of DNA damage signalling and repair inhibitors, their molecular and cellular effects, and future therapeutic use. View Full-Text
Keywords: DNA repair; inhibitors; ATM; ATR; CHK1; CHK2; MRE11; RAD51; PARP DNA repair; inhibitors; ATM; ATR; CHK1; CHK2; MRE11; RAD51; PARP
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Velic, D.; Couturier, A.M.; Ferreira, M.T.; Rodrigue, A.; Poirier, G.G.; Fleury, F.; Masson, J.-Y. DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer. Biomolecules 2015, 5, 3204-3259.

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