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Biomolecules 2015, 5(4), 3204-3259;

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R-2J6, Canada
Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC G1V-0A6, Canada
DNA repair regulation team, UFIP, CNRS UMR 6286, Université de Nantes, 2 rue de la Houssinière, Nantes 44322, France
CHU de Québec Research Center, Oncology Axis, 2705 boul. Laurier, Quebec city, QC G1V-4G2, Canada
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Wolf-Dietrich Heyer, Thomas Helleday and Fumio Hanaoka
Received: 7 September 2015 / Accepted: 9 November 2015 / Published: 20 November 2015
(This article belongs to the Special Issue DNA Damage Response)
Full-Text   |   PDF [2322 KB, uploaded 20 November 2015]   |  


For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is both effective and selective to the malignancy. Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repair has offered the possibility of therapeutic improvements in oncology. In this review, we summarize the current knowledge of DNA damage signalling and repair inhibitors, their molecular and cellular effects, and future therapeutic use. View Full-Text
Keywords: DNA repair; inhibitors; ATM; ATR; CHK1; CHK2; MRE11; RAD51; PARP DNA repair; inhibitors; ATM; ATR; CHK1; CHK2; MRE11; RAD51; PARP

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Velic, D.; Couturier, A.M.; Ferreira, M.T.; Rodrigue, A.; Poirier, G.G.; Fleury, F.; Masson, J.-Y. DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer. Biomolecules 2015, 5, 3204-3259.

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