Rapid root abscission in the water fern Azolla pinnata is an ethylene-insensitive organ separation response to environmental stimuli and diverse chemical inducers. However, the physiological processes underlying this rapid response remain poorly unde...
Pancreatic ductal adenocarcinoma (PDAC) exhibits oxidative stress adaptation and ferroptosis-associated transcriptional remodeling. We assessed redox- and ferroptosis-related expression scores using public transcriptomic cohorts and evaluated explora...
Drought is one of the most critical limiting factors in crop production. Our study investigated how salicylic acid (SA) pretreatment modified the subsequent drought stress response of tomato (Kecskeméti 549). Four groups (control, drought-stre...
Background/Objectives: The Q-Collar™, a device that mildly compresses the jugular veins to increase cranial fluid volume, has been investigated for potential protection against brain changes associated with concussive and subconcussive impacts...
Background: An estimated 28,900 deaths around the world in 2021 were attributed to unintentional CO poisoning. Following inhalation, CO binds to hemoglobin with an affinity 220–240 times greater than that of oxygen to form carboxyhemoglobin (CO...
Oxidative stress contributes to acute myeloid leukemia (AML) biology and treatment resistance, but its prognostic relevance remains incompletely defined. We analyzed 553 patients from GSE37642, treating paired GPL96/GPL97 measurements from 417 patien...
Although dioxygen is indispensable for aerobic metabolism and cellular energy production, excessive exposure to oxygen can induce oxidative damage, thereby accelerating cellular dysfunction, promoting disease progression, and contributing to aging&md...
Dry eye disease (DED) is a complex, multifactorial condition in which oxidative stress is increasingly recognized as a recurrent feature of ocular-surface dysfunction and as a signaling hub linking environmental stress, organelle dysfunction, innate...
Futsal is a high-intensity, intermittent team sport that places substantial physiological demands on the cardiovascular and musculoskeletal systems. This study aimed to analyze acute changes in hemodynamic variables, anthropometric circumferences, an...
Tumor hypoxia is a hallmark of solid tumors that promotes aggressiveness and resistance to therapy. Within hypoxic tumors, hypoxia-inducible factor (HIF)-dependent transcriptional programs drive metabolic reprogramming, lactate accumulation, extracel...
Oxidative stress is a major pathological mechanism underlying ischemic stroke and contributes to neuronal injury, neuroinflammation, blood–brain barrier dysfunction, and chronic neurological sequelae. Although numerous experimental models of ce...
Triple-negative breast cancer (TNBC) is an aggressive and molecularly heterogeneous breast cancer subtype. We developed a six-gene oxidative stress-related signature (BAG5, ANXA2, LONP1, GBE1, CBR1, and DDIT4) in GSE58812 (107 patients; 29 deaths) an...
Gamma irradiation is widely used for microbial decontamination and preservation of plant-derived materials intended for the food, pharmaceutical, and cosmetic industries. The effects of gamma irradiation (1, 5, and 10 kGy) on free radical formation,...
Objective: To determine whether a high concentration of oxygen and hyaluronic acid applied vaginally in the two weeks preceding embryo transfer may increase implantation rates in human IVF. Design: Retrospective, observational, non-randomized proof-o...
We introduce triproximity, a conceptual framework that organizes tree–soil greenhouse gas (GHG) interactions across three spatial dimensions: (i) horizontal distance from tree stems, (ii) vertical soil profile depth, and (iii) structural positi...
α-Tocopherol (αT) is the major form of vitamin E. Although it is metabolized in the liver when high levels of αT are present, the function of its metabolites has not yet been fully elucidated. This study aimed to evaluate the antiox...
Carbohydrates are among the most highly oxygenated biomolecules in nature, possessing dense arrays of hydroxyl, ether, carbonyl, carboxylate, phosphate, and sulfate functionalities that govern hydration, hydrogen bonding, molecular recognition, and s...
Pressure ulcers are a major clinical problem in patients with severe immobility; however, their pathophysiology extends beyond mechanical pressure and localized ischemia. Repetitive ischemia–reperfusion promotes sustained reactive oxygen specie...
Neonates born at higher altitudes may be at increased risk for adverse outcomes due to lower ambient oxygen availability. Despite frequent use of home oxygen therapy following neonatal intensive care unit (NICU) discharge, evidence-based guidelines a...
Arguably, the most vital function of the cardiovascular system (CVS) is its ability to facilitate the oxygenation of blood in the lungs, and to deliver that oxygen to the rest of the body. This relies on the ability of oxygen to diffuse in and out of...
Singlet oxygen is produced by light-dependent excitation of molecular oxygen using photosensitizers. Using blue light and riboflavin (RF) or riboflavin phosphate (RFP) as photosensitizers, we studied the reaction of singlet oxygen with tertiary amine...
We studied the Stokes signals generated following the Raman photoexcitation of dissolved oxygen in water. When a water sample is pumped with intense nanosecond radiation, Stokes signals of different origins are generated. These signals form a charact...
Introduction: Survival at high altitudes requires efficient energy management. Although hypobaric hypoxia alters thermodynamic efficiency, the independent impact of altitude versus demographic factors on basal and exertional caloric costs remains unc...
Medical ozone has emerged as a potential redox-modulating intervention in inflammatory and degenerative conditions, particularly in dermatological contexts characterized by chronic oxidative imbalance and impaired tissue remodeling. Unlike convention...
The authors requested to update Equation (5) in the original publication [...]
Introduction: A major health issue in individuals living at high-altitude regions is an increase in the number of red blood cells (RBCs). This condition generates a series of physiological alterations including the nervous system, where damage can oc...
Hydroperoxides (R–OOH, organic hydroperoxides) constitute a relatively small but structurally diverse class of natural metabolites occurring in higher plants, fungi, and marine organisms. Their formation is closely associated with oxidative pro...
Background: The aim of this study was to assess the effectiveness of supplemental low-flow oxygen on emergency clinicians in improving their quality and length of performance of external chest compressions (ECCs) on a resuscitation manikin. Methods:...
This study explores the potential of utilizing biogenic manganese oxides (BMOs) produced by Mn-oxidizing Pseudomonas putida MnB1 to facilitate metal cation uptake for rare earth element (REE) sequestration and the synthesis of novel materials. Previo...
Chlorine dioxide (ClO2) is a neutral oxidant molecule with a short lifespan once in contact with electron donors (organic matter). ClO2 solutions have antiviral, antibacterial, antifungal, anti-protozoan, anti-inflammatory, anticancer, and wound-heal...
Catechol (benzene-1,2-diol) is a highly versatile chemical motif that plays a central role in both terrestrial and marine systems, where its reactivity is governed by a combination of enzymatic oxidation and non-enzymatic interactions. This review ex...
The yak (Bos grunniens), a unique bovine species that is endemic to the Qinghai–Tibet Plateau and adjacent mountainous regions, exhibits remarkable adaptations to chronic high-altitude hypoxia. However, the molecular mechanisms underlying yaks&...
Uterine fibroids (leiomyomas) are common benign smooth muscle tumors that impose substantial symptom burden and healthcare costs worldwide. Although uterine fibroid (leiomyoma) pathogenesis is multifactorial, hypoxia has emerged as a key feature of t...
Pneumonia, an acute inflammatory condition of the lung tissue, imposes a significant burden on global health and is characterized by a high rate of illness and death. The pathogenesis of the disease extends beyond infection to breakdown of redox hemo...
Background: Severe lung compromise from COVID-19, ARDS, and recently AH3N2 can progress to life-threatening hypoxia. Past experience led to standardized protocols that assumed similarity to SARS-CoV. Methods: COVID-19 pathophysiology and histopatholo...
Systemic inflammation leading to neuroinflammation is a matter of concern in recent years because of its implication with neurological disorders. Selective peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists have shown promising...
The authors have requested to replace the Molecular Operating Environment (MOE) mentioned in the main text with AutoDock (SWISS Dock, (version 1 [...]
Hypoxic pulmonary vasoconstriction (HPV) is a rapid and reversible constrictor response of the pulmonary vasculature, and especially its small muscular precapillary arteries, which is initiated by episodes of local alveolar hypoxia. Acting as a prote...
Oxidative stress seems to be part of many deranged processes in the organism, affecting multiple degenerative conditions at a cellular and tissue level. Coumarins and flavonoids comprise two main categories of naturally derived compounds with multipl...
Salt stress is a major agricultural issue. A promising modern agriculture method is the foliar treatment of zinc oxide nanoparticles (ZnONPs). This approach has shown promise in boosting challenged tomato yields, fruit quality, and leaf extract antib...
Age-related macular degeneration (AMD) is an age-associated disease characterized by damage to the central retina and represents a leading cause of acquired blindness, with increasing prevalence in aging populations. However, effective therapeutic op...
Background: During an apnea, oxygen depletion occurs at all tissue levels, so apnea duration is influenced by the mammalian dive reflex, which includes a bradycardia resulting in reduced cardiac oxygen consumption. This study aimed to examine the rel...
The purpose of this analysis is to report on the clinical efficacy of Continuous Diffusion of Oxygen (CDO) therapy in real-world clinical practice and compare those results to data published in controlled clinical studies. For the real-world clinical...
Maximal aerobic power (V̇O2peak) in youth depends on hemoglobin (Hb)—mediated oxygen transport. While sex- and age-specific patterns are established in untrained cohorts, further research is needed in competitive adolescent athletes. We st...
Root pruning has been proposed as a practical method to regulate growth and metabolite accumulation in horticultural crops, yet its physiological and metabolic consequences in hydroponically grown lettuce remain poorly understood. In this study, we e...
This review indicates that microalgae may serve as a sustainable supply of bioactive compounds and lipids over the long run. It also discusses the significance of lactic acid bacteria (LAB) and Saccharomyces cerevisiae in biotransformation processes....
Photosensitized excitation of molecular oxygen generates singlet oxygen, a reactive oxygen species that has been studied in biological systems, synthetic methods and in aquatic ecosystems. The reaction of singlet oxygen with tertiary amines is import...
Swine effluents require effective treatment due to their high pollutant load, particularly nitrogen and phosphorus, which can cause eutrophication of water bodies. This study focused on monitoring nutrient removal in a sequential biological reactor t...
Chronic kidney disease is closely associated with an increased risk of cardiovascular disease. Although kidney transplantation represents the treatment of choice for patients with end-stage chronic kidney disease, it is also linked to significant car...
Background/Objectives: Trypanosoma evansi (T. evansi) is an etiological agent of surra, and it causes significant economic losses in livestock. Rising trypanocide resistance demands alternatives that control parasitemia while mitigating oxidative and...
