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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitral and Tricuspid Valve Disease and Imaging Techniques—2nd Edition

edited by

Valeria Cammalleri

and Annalisa Pasquini

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1589 | Submission Open

Keywords: imaging in valvular heart disease; mitral valve disease; tricuspid valve disease; computed tomography; echocardiography; transesophageal echocardiography; cardiac magnetic resonance imaging; cardiac surgery; structural interventional cardiology; multi-modality imaging

(This special issue belongs to the Section Cardiovascular Medicine)

Targeted Diagnosis and Treatment of Coronary Artery Disease: 2nd Edition

edited by

Antonio Nenna

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1517 | Submission Open

Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis

(This special issue belongs to the Section Cardiology)

Clinical Medicine and Surgery in the Digital Age: Advances in Virtual, Augmented, Mixed, and Extended Reality

edited by Mohsen Annabestani and

Bobak Mosadegh

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1365 | Submission Open

Keywords: virtual reality (VR); augmented reality (AR); mixed reality (MR); extended reality (XR); clinical medicine; surgery; diagnostic accuracy; surgical outcome; patient care; medical training

(This special issue belongs to the Section General Surgery)

Artificial Intelligence, Computer Modeling and Technology: Clinical Changing Practice in Reconstructive Surgery

edited by

Warren Matthew Rozen

and

Ishith Seth

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1342 | Submission Open

Keywords: reconstructive surgery; plastic surgery; breast surgery; breast reconstruction; oncologic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Perspectives on Physical Activity and Health in Children and Adolescents

edited by

Nuria Marín-Jiménez

Lucia Torres-Lopez

and Rocío Izquierdo-Gómez

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1221 | Submission Open

Keywords: physical activity; sedentary behavior; health promotion; childhood obesity; well-being; fitness

(This special issue belongs to the Section Clinical Pediatrics)

Advancements in Otitis Media Diagnosis and Management

edited by Sharon Ovnat Tamir and Tal Marom

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1095 | Submission Open

Keywords: otitis media; mastoidectomy for cholesteatoma; vaccines; diagnosis; AI; mastoiditis; artificial intelligence; hearing loss

(This special issue belongs to the Section Otolaryngology)

New Clinical Advances in Minimally Invasive Cardiac Surgery

edited by

Christian Rustenbach

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1029 | Submission Open

Keywords: minimally invasive cardiac surgery; valve surgery; coronary artery bypass grafting; heart failure management; surgical techniques

(This special issue belongs to the Section Cardiology)

Innovations in the Treatment for Depression and Anxiety

edited by Lucie Bartova

submission deadline 30 Sep 2025 | 1 articles | Viewed by 974 | Submission Open

Keywords: depression; anxiety; antidepressant; anxiolytic; psychopharmacotherapy; psychotherapy; brain stimulation; treatment; response; resistance

(This special issue belongs to the Section Mental Health)

New Advances in Musculoskeletal Physiotherapy: Exercise, Manual Therapy and Invasive Physiotherapy

edited by

Marcos José Navarro-Santana

and Ignacio Cancela-Cilleruelo

submission deadline 30 Sep 2025 | 1 articles | Viewed by 919 | Submission Open

Keywords: musculoskeletal disorders; exercise therapy; manual therapy; invasive physical therapy; rehabilitation

(This special issue belongs to the Section Orthopedics)

Pediatric Sleep-Disordered Breathing

edited by Audrey Yoon

submission deadline 30 Sep 2025 | 1 articles | Viewed by 910 | Submission Open

Keywords: pediatric sleep-disordered breathing; growth modification; pediatric obstructive sleep apnea; interdisciplinary management; craniofacial development; obstructive sleep disorders; cognitive behavioral sleep medicine; pediatric dental sleep medicine; pediatric sleep surgery

(This special issue belongs to the Section Clinical Pediatrics)

Multiple Sclerosis: Advances in Therapeutic Approaches

edited by Renata Balnytė

submission deadline 30 Sep 2025 | 1 articles | Viewed by 753 | Submission Open

Keywords: multiple sclerosis; disease modifying treatment; immunomodulating teratment; new therapeutic approaches; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Clinical Neurology)

New Progress in Pediatric Orthopedics and Pediatric Spine Surgery

edited by

Barbara Jasiewicz

submission deadline 30 Sep 2025 | 2 articles | Viewed by 750 | Submission Open

Keywords: pediatric spine; scoliosis; clubfoot; flatfoot; developmental dysplasia of the hip; rare diseases

(This special issue belongs to the Section Clinical Pediatrics)

Management of Inflammatory Bowel Disease: A Multidisciplinary Perspective

edited by

Gary Edward Wild

and

Kimberly Carrière

submission deadline 30 Sep 2025 | 1 articles | Viewed by 702 | Submission Open

Keywords: inflammatory bowel disease management; Crohn's disease; ulcerative colitis; patient-centered care; multidisciplinary management; personalized treatment

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Modern Approaches to the Management of Orthopedic Injuries

edited by

Moshe Salai

submission deadline 30 Sep 2025 | 1 articles | Viewed by 640 | Submission Open

Keywords: orthopedic trauma; surgical integration; trauma management; modern approaches; rehabilitation advances

(This special issue belongs to the Section Orthopedics)

General Orthopedic Surgery: Trends and Prospects

edited by John T. Riehl

submission deadline 30 Sep 2025 | 1 articles | Viewed by 537 | Submission Open

Keywords: general orthopedic surgery; orthopedic trauma; hand; tumor; foot and ankle; spine; sports medicine; arthroplasty

(This special issue belongs to the Section Orthopedics)

Psoriasis in Focus: Current Research, Treatments, and Future Directions

edited by

Tamara Gracia-Cazaña

and Josep Riera-Monroig

submission deadline 30 Sep 2025 | 1 articles | Viewed by 510 | Submission Open

Keywords: psoriasis; biologic therapies; immunopathogenesis; precision medicine; comorbidities in psoriasis; psoriatic arthritis; phototherapy; topical treatments; systemic therapies

(This special issue belongs to the Section Dermatology)

Hemodialysis: Clinical Updates and Advances

edited by

Gubensek Jakob

submission deadline 30 Sep 2025 | Viewed by 484 | Submission Open

Keywords: hemodiafiltration; medium cut-off membranes; expanded hemodialysis; vascular calcifications; renal anemia; vas-cular access; arterio-venous fistula; anticoagulation; outcomes

(This special issue belongs to the Section Nephrology & Urology)

Ventricular Tachycardia: Diagnosis, Treatment and Management

edited by Antonio Dello Russo and

Paolo Compagnucci

submission deadline 30 Sep 2025 | Viewed by 371 | Submission Open

Keywords: ventricular tachycardia; cardiomyopathy; electroanatomical mapping; intracardiac echocardiography (ICE); radiofrequency ablation; pulsed field ablation; catheter ablation

(This special issue belongs to the Section Cardiology)

Chronic Kidney Disease: Clinical Updates and Perspectives, Opportunities and Challenges, 2nd Edition

edited by Botond Csiky

submission deadline 30 Sep 2025 | 1 articles | Viewed by 359 | Submission Open

Keywords: chronic kidney disease progression; cardiovascular risk factors; diabetes mellitus; obesity; kidney transplantation; survival; pathophysiology of CKD; hemodialysis; peritoneal dialysis; metabolic and mineral bone disease

(This special issue belongs to the Section Nephrology & Urology)

Advances in Sarcopenia Research: Clinical Approaches to Muscle Health and Aging

edited by

Alejandro Álvarez-Bustos

and Helio José Coelho-Júnior

submission deadline 30 Sep 2025 | Viewed by 231 | Submission Open

Keywords: sarcopenia; functional decline; physical performance; muscle strength; muscle assessment; exercise interventions; nutri-tional strategies; adverse outcomes

(This special issue belongs to the Section Orthopedics)

COVID-19 and Endocrine Complications

edited by

Kamyar Asadipooya

submission deadline 30 Sep 2025 | Viewed by 204 | Submission Open

Keywords: adrenal; ACE2; diabetes; gonads; pituitary; SARS-CoV-2; thyroid

(This special issue belongs to the Section Endocrinology & Metabolism)

Latest Advances in Thoracic Surgery: 2nd Edition

edited by

Hideki Ujiie

submission deadline 30 Sep 2025 | Viewed by 200 | Submission Open

Keywords: lung cancer; surgical oncology; robotic surgery; thoracic surgery; lung diseases; minimally invasive surgery

(This special issue belongs to the Section Respiratory Medicine)

Sequelae of COVID-19: Clinical to Prognostic Follow-Up

edited by

Mariana Tudoran

and

Cristina Tudoran

submission deadline 30 Sep 2025 | Viewed by 191 | Submission Open

Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19

(This special issue belongs to the Section Vascular Medicine)

Multidisciplinary Approach to the Diagnosis and Treatment of Temporomandibular Disorders: Patient Care Challenges—2nd Edition

edited by

Monika Lukomska-Szymanska

and

Klara Saczuk

submission deadline 30 Sep 2025 | Viewed by 190 | Submission Open

Keywords: multidisciplinary approach; mental health; bruxism; masticatory muscles; temporomandibular joint; orofacial pain; temporomandibular disorders

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Structural Heart Diseases

edited by

Konstantinos Papadopoulos

Ignatios Ikonomidis

and Erwan Donal

submission deadline 30 Sep 2025 | 1 articles | Viewed by 186 | Submission Open

Keywords: valvular heart diseases; transcatheter interventions; TEER; LAA closure; ASD closure; interventional echocardiography; multimodality cardiac imaging; three-dimensional echocardiography

(This special issue belongs to the Section Cardiovascular Medicine)

Emerging Trends in Cervical Spine Surgery

edited by Daniel Hafez, Rory Murphy and Jacob Greenberg

submission deadline 30 Sep 2025 | 1 articles | Viewed by 186 | Submission Open

Keywords: cervical disk arthroplasty; laminoplasty; hybrid fusion; endoscopic cervical foraminotomy; endoscopic cervical laminectomy; cervical myelopathy; MIS cervical spine fusion; robotic/navigated cervical surgery

(This special issue belongs to the Section Orthopedics)

Hepatobiliary and Pancreatic (HPB) Surgery: Current Status and Future Perspectives

edited by Andrea Benedetti Cacciaguerra and Paolo Vincenzi

submission deadline 30 Sep 2025 | Viewed by 185 | Submission Open

Keywords: hepatobiliary and pancreatic surgery; laparoscopic surgery; robot-assisted surgery; artificial intelligence; augmented reality; indocyanine green; liver tumors; pancreatic tumors

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

State of the Art in Management of Aortic Aneurysm in Vascular Surgery

edited by Rana O. Afifi and Eanas Yassa

submission deadline 30 Sep 2025 | Viewed by 169 | Submission Open

Keywords: aortic dissection; complex aortic surgery; endovascular aortic repair; aortic imaging; aortic aneurysm

(This special issue belongs to the Section Vascular Medicine)

New Advances in Retinal Diseases

edited by

Seong Joon Ahn

submission deadline 30 Sep 2025 | Viewed by 161 | Submission Open

Keywords: retinal diseases; advanced imaging; biomarkers; diabetic retinopathy; macular degeneration; artificial intelligence; clinical outcomes

(This special issue belongs to the Section Ophthalmology)

Imaging and Surgery in Endometriosis—Recent Advances

edited by

Harald Krentel

and

Rudy Leon De Wilde

submission deadline 30 Sep 2025 | Viewed by 159 | Submission Open

Keywords: robotic-assisted surgery; MR imaging; radiomics; transvaginal ultrasound; deep endometriosis; ovarian endometriosis; fluorescence-guided surgery; artificial intelligence; adhesions in endometriosis; infertility; classification systems

(This special issue belongs to the Section Obstetrics & Gynecology)

Latest Advances in Ocular Surface Diseases

edited by Barbara Burgos-Blasco

submission deadline 30 Sep 2025 | Viewed by 139 | Submission Open

Keywords: cornea; keratitis; ocular surface disease; dry eye; corneal ulcer; keratoplasty; conjunctival disease

(This special issue belongs to the Section Ophthalmology)

Clinical Diagnosis and Therapeutic Approaches for Acute and Chronic Coronary Syndromes

edited by Rocco Antonio Montone

submission deadline 30 Sep 2025 | Viewed by 135 | Submission Open

Keywords: coronary artery disease; clinical diagnosis; therapeutic approaches; atherosclerosis; risk factors; percutaneous cor-onary intervention; acute coronary syndrome; MINOCA; INOCA

(This special issue belongs to the Section Cardiology)

Thrombosis and Haemostasis: Clinical Advances

edited by Hui Yin Lim

submission deadline 30 Sep 2025 | Viewed by 134 | Submission Open

Keywords: venous thrombosis; biomarkers; bleeding; direct oral anticoagulants; pulmonary embolism; factor XI inhibitors; factor XII inhibitors; endovascular treatment

(This special issue belongs to the Section Vascular Medicine)

Modern Concepts on Acoustic Neuroma

edited by Alessia Rubini and Davide Soloperto

submission deadline 30 Sep 2025 | Viewed by 129 | Submission Open

Keywords: neurotology; neurosurgery; vestibular schwannoma; acoustic neuroma; middle cranial fossa approach; retrosigmoid approach; translabirynthine approach; gammaknife; wait and scan policy

(This special issue belongs to the Section Otolaryngology)

Systemic Autoimmune Disorder with Pulmonary Involvement: Novel Insights from Underlying Mechanisms of Drug Development and Intervention

edited by

Fabio Perrotta

submission deadline 30 Sep 2025 | Viewed by 127 | Submission Open

Keywords: rheumatic diseases; pulmonary involvement; connective tissue disorders; systemic autoimmune disorders (SARDs); diagnosis; innovative treatments

(This special issue belongs to the Section Respiratory Medicine)

Risk Prediction in Mechanical Circulatory Support (MCS) and Cardiac Transplantation

edited by

Nandini Nair

submission deadline 30 Sep 2025 | Viewed by 125 | Submission Open

Keywords: advanced heart failure; mechanical circulatory support (MCS); cardiac transplantation; heart transplantation; risk prediction

(This special issue belongs to the Section Cardiology)

Breast Cancer: Advances in Clinical and Personalized Practices

edited by Massimo Lodi and Sébastien Molière

submission deadline 30 Sep 2025 | Viewed by 120 | Submission Open

Keywords: breast cancer; radiology; surgical oncology; breast reconstruction; personalized medicine; quality of life; multidisci-plinary approach; new technologies

(This special issue belongs to the Section Oncology)

Esophageal and Upper Interventional Endoscopy and Surgery: Latest Advances and Prospects

edited by Giulia Gibiino

submission deadline 30 Sep 2025 | Viewed by 119 | Submission Open

Keywords: gastric preneoplastic and neoplastic lesions; endoscopic submucosal dissection (ESD); endoscopic full-thickness resection (EFTR); subepithelial upper GI lesions; duodenal adenomas; esophageal stenting

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Myeloid-Derived Suppressor and Innate Immune Cells in Hematologic, Malignant and Chronic Diseases

edited by

Helen A. Papadaki

submission deadline 30 Sep 2025 | Viewed by 101 | Submission Open

Keywords: myeloid-derived suppressor cells (MDSCs); macrophages; monocytes; eosinophils; neutrophils; malignancy; cancer; autoimmunity; infection; chronic inflammation; therapeutic target; biomarker; precision medicine; molecular pathways; bone marrow microenvironment

(This special issue belongs to the Section Hematology)

Advances in Treatment and Prognosis for Acute Type A and Type B Aortic Dissections

edited by

Katsuhiko Oda

submission deadline 30 Sep 2025 | Viewed by 100 | Submission Open

Keywords: acute aortic dissection; stent graft; false lumen expansion; thoracic endovascular aortic repair; initial surgery for Type A acute aortic dissection; frozen elephant trunk

(This special issue belongs to the Section Cardiovascular Medicine)

Gastrointestinal Perforations: Diagnosis and Management to Reduce Morbidity and Mortality

edited by

Rossella Reddavid

submission deadline 30 Sep 2025 | Viewed by 97 | Submission Open

Keywords: gastrointestinal perforation; diagnosis; surgery; acute peritonitis; sepsis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Minimally Invasive Evolutions in Advanced Oncologic Visceral Surgery

edited by

Philipp Horvath

submission deadline 30 Sep 2025 | Viewed by 81 | Submission Open

Keywords: minimally invasive; oncologic surgery; robotic; laparoscopic; outcome

(This special issue belongs to the Section Oncology)

Clinical Advances in Cartilage Repair and Regeneration

edited by Akira Tsujii and Kazunori Shimomura

submission deadline 1 Oct 2025 | 1 articles | Viewed by 1404 | Submission Open

Keywords: cartilage; regenerative therapy; stem cell therapy; scaffold; orthobiologics; osteoarthritis

(This special issue belongs to the Section Orthopedics)

Targeted Diagnosis and Treatment of Maladaptive Developmental Trajectories and Psychopathological Manifestations in Children and Adolescents

edited by

Monia Vagni

, Andrea Baroncelli and Valeria Giostra

submission deadline 1 Oct 2025 | 1 articles | Viewed by 734 | Submission Open

Keywords: maladaptive developmental trajectories; developmental psychopathology; predictors and correlates of distress in children and adolescents; new forms of social-emotional difficulties and distress; clinical and social interventions and preventions; cognitive; affective; expressive and social improvement of children and adolescents; conduct problems; evidence-based practices; early interventions

(This special issue belongs to the Section Mental Health)

Urinary Tract Infection: Current Treatment and Future Options

edited by

Biagio Barone

submission deadline 1 Oct 2025 | Viewed by 476 | Submission Open

Keywords: urinary tract infections (UTIs); antibiotic resistance; probiotics and alternative therapies; diagnostic advancements; urinary infection management

(This special issue belongs to the Section Nephrology & Urology)

Point of Care Sonography, an Essential Tool for Anesthesiology and Acute Care

edited by

Stefan U. Weber

and Se-Chan Kim

submission deadline 1 Oct 2025 | Viewed by 332 | Submission Open

Keywords: ultrasound; anesthesia; acute care; critical care; regional anesthesia; vascular access; lung ultrasound; echocardiography; gastric ultrasound; point of care

(This special issue belongs to the Section Anesthesiology)

Mitral Valve Surgery: Current Status and Future Challenges

edited by Antonio Lio and Marco Russo

submission deadline 5 Oct 2025 | 8 articles | Viewed by 6935 | Submission Open

Keywords: mitral valve; mitral valve repair; mitral valve replacement; minimally invasive surgery; robotic surgery

(This special issue belongs to the Section Cardiology)

Endovascular Surgery: State of the Art and Clinical Perspectives

edited by

Andrea Xodo

and Francesco Squizzato

submission deadline 9 Oct 2025 | 1 articles | Viewed by 576 | Submission Open

Keywords: complex aortic endovascular repair; aortic arch endovascular surgery; endoleaks; PMEG; spinal cord ischemia; endograft-related adverse events

(This special issue belongs to the Section Vascular Medicine)

Current Measures for Diagnosis, Monitoring, and Outcome Assessment in Orthopedics, Traumatology, and Hand Surgery

edited by