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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Pulmonary Embolism Therapeutic

edited by

Jeisson Osorio

submission deadline 20 Aug 2026 | Viewed by 23 | Submission Open

Keywords: acute pulmonary embolism; chronic pulmonary embolism; chronic thromboembolic disease; chronic thromboem-bolic pulmonary hypertension; catheter-directed therapy; pulmonary endarterectomy; balloon pulmonary angio-plasty

(This special issue belongs to the Section Vascular Medicine)

Clinical Applications and Surgical Integration of Advanced Ophthalmic Imaging

edited by Katarzyna Nowomiejska

submission deadline 20 Aug 2026 | Viewed by 19 | Submission Open

Keywords: ophthalmic imaging; retina; intraoperative OCT; personalized treatment; clinical applications

(This special issue belongs to the Section Ophthalmology)

Cardiovascular Prevention and Epidemiology: Innovations and Insights Bridging Research and Practice for Effective Risk Reduction

edited by

Pasquale Palmiero

and Maria Maiello

submission deadline 20 Aug 2026 | Viewed by 18 | Submission Open

Keywords: cardiovascular prevention; risk reduction; epidemiology; innovations; risk stratification; population health

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Adult Deformities and Spinal Disorders: Surgical Treatment and Pre- and Post-Operative Re-Habilitation

edited by Laura Scaramuzzo

submission deadline 20 Aug 2026 | Viewed by 15 | Submission Open

Keywords: scoliosis; spine; kyphosis; degenerative spine; spine surgery

(This special issue belongs to the Section Orthopedics)

Managing Chronic Kidney Disease: Current Practices and Future Perspectives

edited by Maria L. Gonzalez-Suarez

submission deadline 20 Aug 2026 | Viewed by 13 | Submission Open

Keywords: chronic kidney disease; diabetic kidney disease; kidney failure; guideline-directed therapies; SLGT 2 inhibitors; GLP1 receptor agonists

(This special issue belongs to the Section Nephrology & Urology)

Future-Proof Care for Patients with Kidney Stones

edited by

Stijn Roemeling

and Oliver Wiseman

submission deadline 20 Aug 2026 | Viewed by 13 | Submission Open

Keywords: effectiveness; resilience; prevention; care pathways; urolithiasis; kidney stones; PCNL; URS; ESWL; quality of life

(This special issue belongs to the Section Nephrology & Urology)

Integrated Ozone Therapy and Physical Rehabilitation for Musculoskeletal Disorders: A Comprehensive Approach

edited by

Giovanni Ricevuti

and

Salvatore Chirumbolo

submission deadline 20 Aug 2026 | Viewed by 9 | Submission Open

Keywords: ozone therapy; physical rehabilitation; musculoskeletal disorders; integrative medicine; rehabilitation therapy; regenerative medicine; clinical outcomes

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life

edited by

Gloria Roberti

and

Manuele Michelessi

submission deadline 21 Aug 2026 | Viewed by 52 | Submission Open

Keywords: glaucoma surgery; visual acuity; intraocular pressure; surgical outcomes; trabeculectomy; microinvasive glaucoma surgery; postoperative complications; functional vision

(This special issue belongs to the Section Ophthalmology)

Advancements in Cardiomyopathies: Diagnosis, Treatment and Management—2nd Edition

edited by

Cinzia Forleo

and

Maria Cristina Carella

submission deadline 24 Aug 2026 | Viewed by 45 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases; risk stratification; genotype– phenotype correlations; rare variant interpretation; arrhythmias

(This special issue belongs to the Section Cardiology)

Current and Emerging Strategies in Ischemic Stroke: Diagnosis, Treatment, and Prevention

edited by

Dougho Park

Hyoung Seop Kim

and

Jong Hun Kim

submission deadline 25 Aug 2026 | Viewed by 64 | Submission Open

Keywords: diagnosis; digital medicine; epidemiology; ischemic stroke; machine learning; neurorehabilitation; prevention; stroke imaging; treatment

(This special issue belongs to the Section Clinical Neurology)

Knee Arthroplasty: Recent Advances and Future Challenges

edited by Matteo Marullo

submission deadline 25 Aug 2026 | Viewed by 64 | Submission Open

Keywords: knee arthroplasty; implant design; robotic surgery; revision surgery; biomechanics; clinical outcomes; perioperative care; fast-track surgery; digital orthopedics; partial knee replacement

(This special issue belongs to the Section Orthopedics)

Kidney Transplantation: From Donor Selection to Recipient Outcomes

edited by Basma Merhi and Reginald Gohh

submission deadline 25 Aug 2026 | Viewed by 40 | Submission Open

Keywords: kidney transplantation; end-stage renal disease (ESRD); living-donor kidney transplantation; deceased-donor kidney transplantation; organ shortage; dialysis waiting time; transplant candidate evaluation; immunosuppression

(This special issue belongs to the Section Nephrology & Urology)

Hand Surgery in Practice: Current Evidence and Emerging Techniques

edited by Guy Rubin

submission deadline 25 Aug 2026 | Viewed by 37 | Submission Open

Keywords: trauma; mallet; burn; nerve; tendon

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Motor Activity and Cognitive Development in Early Childhood: Clinical Implications

edited by

Michele Roccella

and

Daniela Smirni

submission deadline 25 Aug 2026 | Viewed by 36 | Submission Open

Keywords: motor activity; cognitive development; early childhood; neurodevelopmental disorders; autism spectrum disorder; attention-deficit/hyperactivity disorder; developmental coordination disorder; preterm birth

(This special issue belongs to the Section Clinical Neurology)

Advances in Percutaneous Coronary Intervention: Techniques, Tools and Outcomes

edited by Takashi Ashikaga

submission deadline 25 Aug 2026 | Viewed by 36 | Submission Open

Keywords: percutaneous coronary intervention; orbital atherectomy; coronary artery calcification; intravascular ultrasound (IVUS); optical coherence tomography (OCT)

(This special issue belongs to the Section Cardiovascular Medicine)

Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management—Second Edition

edited by Emelina Stambolliu and Antonios A. Argyris

submission deadline 25 Aug 2026 | Viewed by 31 | Submission Open

Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds

(This special issue belongs to the Section Vascular Medicine)

Gastrointestinal Cancer: Outcomes and Therapeutic Management—2nd Edition

edited by Maximos Frountzas

submission deadline 25 Aug 2026 | Viewed by 30 | Submission Open

Keywords: surgical oncology; gastrointestinal cancer; esophageal; gastric; hepatic; biliary; pancreatic; colon; rectal; neoplasm

(This special issue belongs to the Section Oncology)

Personalized Therapy and Clinical Outcome for Vasculitis

edited by

Giulia Cassone

submission deadline 25 Aug 2026 | Viewed by 27 | Submission Open

Keywords: immune-mediated systemic vasculitis; personalized therapy; treatment; outcome; biomarkers; risk factors; management; multidisciplinary care

(This special issue belongs to the Section Immunology & Rheumatology)

Etiology, Diagnosis, and Management of Upper Gastrointestinal Disorders: 2nd Edition

edited by

Hidekazu Suzuki

submission deadline 25 Aug 2026 | Viewed by 26 | Submission Open

Keywords: esophagus; stomach; duodenum; DGBI; FGIDs; helicobacter; eosinophilic esophagitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Updates of Pediatric Craniofacial Surgery

edited by Federica Tosi

submission deadline 25 Aug 2026 | Viewed by 25 | Submission Open

Keywords: pediatric craniofacial surgery; craniosynostosis; near-infrared spectroscopy; blood transfusion; perioperative monitoring; pediatric anesthesia; hemodynamic management; tissue oxygenation

(This special issue belongs to the Section Clinical Pediatrics)

Complications of Laparoscopic Cholecystectomy: Surgical Outcomes and Clinical Challenges

edited by

Roberto Cirocchi

submission deadline 25 Aug 2026 | Viewed by 24 | Submission Open

Keywords: laparoscopic cholecystectomy; bile duct injury; management of intraoperative injuries; surgical outcomes; postoperative infections

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Bariatric Surgery: Clinical Advances and Future Directions

edited by

Natalia Dowgiałło-Gornowicz

and

Mateusz Wityk

submission deadline 25 Aug 2026 | Viewed by 23 | Submission Open

Keywords: metabolic surgery; bariatric surgery; reflux; laparoscopy; conversion surgery; obesity

(This special issue belongs to the Section General Surgery)

Emerging Trends and Therapeutic Innovations in Corneal and Ocular Surface Disorders

edited by

Zala Lužnik Marzidovšek

and Špela Štunf Pukl

submission deadline 25 Aug 2026 | Viewed by 9 | Submission Open

Keywords: corneal diseases; ocular surface disorders; regenerative medicine; stem cell therapy; gene therapy; nanomedicine and targeted drug delivery

(This special issue belongs to the Section Ophthalmology)

Recent Advances and Future Perspective of Subarachnoid Hemorrhage

edited by

Tihamer Molnar

submission deadline 26 Aug 2026 | Viewed by 15 | Submission Open

Keywords: subarachnoid bleeding; neuromonitoring; neuroimaging; delayed cerebral infarction; biomarkers; personalized medicine; AI-guided decision support; outcome

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Heart Failure: Innovations in Diagnosis, Therapy and Management

edited by Paolo Severino

submission deadline 28 Aug 2026 | Viewed by 39 | Submission Open

Keywords: heart failure; HFrEF therapy; HFpEF phenotyping; right ventricular dysfunction; renal congestion assessment; diuretic resistance; NT-proBNP dynamics; cardiac imaging; post-discharge management

(This special issue belongs to the Section Cardiology)

The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)

edited by Salvatore Giordano, Arturo Giordano and Nicola Corcione

submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); structural heart intervention; aortic stenosis; valve technology and durability; imaging and procedural optimization

(This special issue belongs to the Section Cardiovascular Medicine)

Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management—Second Edition

edited by

Maurizio Marvisi

and Alfredo Antonio Chetta

submission deadline 31 Aug 2026 | Viewed by 37 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); treatable traits; precision medicine; COPD comorbidities; COPD mortality

(This special issue belongs to the Section Respiratory Medicine)

Clinical Management of Type 1 Diabetes: 2nd Edition

edited by Carmen Quirós

submission deadline 31 Aug 2026 | Viewed by 30 | Submission Open

Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens

(This special issue belongs to the Section Endocrinology & Metabolism)

Advances in Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease: 2nd Edition

edited by

Giuseppe De Luca

submission deadline 31 Aug 2026 | Viewed by 28 | Submission Open

Keywords: platelet; anticoagulant therapy; antiplatelet therapy; coronary artery disease (CAD); atrial fibrillation (AF); thromboembolic events; myocardial ischemic; bleeding events; aspirin; clopidogrel; cardiovascular and cerebrovascular diseases; diagnosis and treatment; percutaneous coronary intervention; acute coronary syndrome

(This special issue belongs to the Section Cardiology)

Optimizing the Surgical Journey: From Abdominal Operation to Recovery

edited by

Alessio Giordano

and Carlo Bergamini

submission deadline 1 Sep 2026 | Viewed by 43 | Submission Open

Keywords: surgical complications; comanagement; comorbidities; elective surgical procedure; emergency surgery procedure; multidisciplinary approach; hospitalist

(This special issue belongs to the Section General Surgery)

Cardiac Intensive Care Units: Clinical Advances and Future Challenges

edited by Luca Baldetti

submission deadline 10 Sep 2026 | Viewed by 15 | Submission Open

Keywords: cardiac intensive care; heart failure; cardiogenic shock; mechanical circulatory support; invasive hemodynamic monitoring; acute cardiac care; shock; myocardial infarction

(This special issue belongs to the Section Cardiology)

Current Challenges in Clinical Dentistry: 3rd Edition

edited by

Eiji Tanaka

and

Susumu Abe

submission deadline 15 Sep 2026 | Viewed by 76 | Submission Open

Keywords: artificial intelligence; clinical dentistry; cutting-edge device and technology; dental material; challenging hypothesis; preventive dentistry; sleep medicine; digital dentistry; smart dentistry; stomatognathic function

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

State-of-the-Art of Lung Surgery: Modern Horizons in Lung Cancer Treatment

edited by

Alessio Mariolo

and Edouard Sage

submission deadline 15 Sep 2026 | Viewed by 17 | Submission Open

Keywords: lung-cancer-surgery; thoracic oncology; RATS; VATS; induction therapy; neoadjuvant-immunotherapy; non-intubated thoracic surgery; NITS; segmentectomy; lung-sparing surgery; 3D-reconstruction

(This special issue belongs to the Section General Surgery)

Treatment and Clinical Management of Necrotizing Pancreatitis

edited by

Apostolos Gaitanidis

submission deadline 20 Sep 2026 | Viewed by 61 | Submission Open

Keywords: necrotizing pancreatitis; infected necrosis; step-up approach; necrosectomy; minimally invasive surgery; artificial intelligence; lumen-apposing metal stent; pancreatic necrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Management in Dry Eye Disease: Current Strategies and Emerging Protocols

edited by Sunil Shah and Raquel Gil-Cazorla

submission deadline 20 Sep 2026 | Viewed by 51 | Submission Open

Keywords: dry eye disease; ocular surface; diagnostics; inflammation; biomarkers; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Perinatal and Postnatal Mental Health: State of the Art

edited by Adriana Mihai

submission deadline 20 Sep 2026 | Viewed by 40 | Submission Open

Keywords: peripartum depression; post-partum depression; parental– infant well-being; early detection; perinatal mental health; postnatal mental health; psychotherapy interventions

(This special issue belongs to the Section Mental Health)

Current Challenges and Approaches to Post-Traumatic Stress Disorder (PTSD)

edited by

Aron Tendler

submission deadline 20 Sep 2026 | Viewed by 24 | Submission Open

Keywords: PTSD treatment; implementation; prevention; prevalence; risk factors

(This special issue belongs to the Section Mental Health)

Advances in the Diagnosis and Management of Sarcoidosis

edited by

Carlos Feijoo-Massó

, Pilar Brito-Zerón and Miriam Akasbi Montalvo

submission deadline 25 Sep 2026 | Viewed by 60 | Submission Open

Keywords: sarcoidosis; diagnosis; biomarkers; imaging; immunopathogenesis; biologic therapy; prognosis; interstitial lung disease

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Advances in Hepatology

edited by

Dimitrios S. Karagiannakis

and

Theodoros Androutsakos

submission deadline 30 Sep 2026 | Viewed by 53 | Submission Open

Keywords: cirrhosis; portal hypertension; non-invasive tests; viral hepatitis; MASLD; HCC

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Interplay of Motility, Microbiota, and Function: New Insights into GI Disorders, IBS, and SIBO

edited by Tsachi Tsadok Perets

submission deadline 30 Sep 2026 | Viewed by 47 | Submission Open

Keywords: gastrointestinal motility; irritable bowel syndrome (IBS); small intestinal bacterial overgrowth (SIBO); gut microbiota; functional gastrointestinal disorders

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Fibromyalgia: Diagnostic Progress and Therapeutic Advances

edited by

Casandra Isabel Montoro Aguilar

submission deadline 17 Nov 2026 | Viewed by 86 | Submission Open

Keywords: fibromyalgia; chronic pain; central sensitization; diagnostic biomarkers; advanced imaging; molecular markers; autonomic nervous system; cardiovascular regulation; emotional processing; cognitive dysfunction; fatigue; pain modulation; neuromodulation; tDCS

(This special issue belongs to the Section Clinical Neurology)

Clinical Outcomes and Emerging Strategies in Neovascualr Age-Related Macular Degeneration

edited by

Raziyeh Mahmoudzadeh

submission deadline 15 Dec 2026 | Viewed by 23 | Submission Open

Keywords: neovascular age-related macular degeneration; exudative retinal disease; anti-VEGF therapy; tyrosine kinase inhibitors; angiopoietin/Tie-2 modulation; gene therapy; sustained-release platforms; complement pathway inhibition; real-world clinical outcomes

(This special issue belongs to the Section Ophthalmology)

Dental Care: Oral and Systemic Disease Prevention: 2nd Edition

edited by

Kacper Nijakowski

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1683 | Submission Open

Keywords: oral health; oral diseases; oral manifestations; systemic diseases; oral care; dental prevention; dental caries; periodontal disease; oral medicine; dentistry; oral microbiome; salivary diagnostics; AI-assisted tools

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications

edited by

Petroula N. Nana

, Tilo Kölbel and José Ignacio F. Torrealba

submission deadline 20 Jul 2027 | Viewed by 158 | Submission Open

Keywords: aortic aneurysm; aortic dissection; genetic aortic disease; acute aortic syndromes; endovascular repair; complica-tions; outcomes

(This special issue belongs to the Section Vascular Medicine)

Insights into Urological Surgery: Evolving Practices, Trends, and Emerging Challenges

edited by