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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Complex Orthopedic Trauma: Diagnosis, Treatment, Managing Complications and Rehabilitation
edited by Philip-Christian Nolte and Benedict Swartman
submission deadline 20 Nov 2025 | 6 articles | Viewed by 6935 | Submission Open
Keywords: orthopedic trauma; fracture; complications; infection; bone; rehabilitation
(This special issue belongs to the Section Orthopedics)
Pelvic Organ Prolapse: Current Progress and Clinical Challenges
edited by and Cosimo De Nunzio
submission deadline 20 Nov 2025 | 4 articles | Viewed by 6778 | Submission Open
Keywords: pelvic organ prolapse (POP); postmenopausal; urinary dysfunction; minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical mesh
(This special issue belongs to the Section Obstetrics & Gynecology)
New Clinical Advances in Chronic Asthma
edited by Vitaliano Nicola Quaranta
submission deadline 20 Nov 2025 | 5 articles | Viewed by 6255 | Submission Open
Keywords: chronic asthma; breathlessness; coughing; inhaled corticosteroids (ICS); long-acting beta-agonists (LABAs); personalized treatment; chronic rhinosinusitis; nasal polyps; bronchiectasis; endotypes; oral corticosteroids
(This special issue belongs to the Section Respiratory Medicine)
Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition) submission deadline 20 Nov 2025 | 6 articles | Viewed by 5873 | Submission Open
Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; dentistry; biological safety
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Sports Injury Treatment: Innovations in Pain Management, Recovery, and Performance Optimization
edited by Antonio P. Veloso and Javad Sarvestan
submission deadline 20 Nov 2025 | 2 articles | Viewed by 5821 | Submission Open
Keywords: sports injury treatment; pain management; recovery optimization; performance enhancement; advanced rehabilitation; injury prevention; biomechanics; neuromechanics; novel pain relief modalities; performance recovery strategies; wearable technology
(This special issue belongs to the Section Sports Medicine)
The Association Between Sleep Disorders and Metabolic and Mental Health submission deadline 20 Nov 2025 | 3 articles | Viewed by 4461 | Submission Open
Keywords: sleep medicine; sleep apnea; hypoxia; metabolism; mental health; women’ s health
(This special issue belongs to the Section Mental Health)
Advances in the Diagnosis and Treatment of Heart Failure submission deadline 20 Nov 2025 | 3 articles | Viewed by 3469 | Submission Open
Keywords: heart failure; diagnosis; treatment; elderly; pluripathology
(This special issue belongs to the Section Cardiology)
Current State of Breast Reconstruction
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 3010 | Submission Open
Keywords: breast reconstruction; silicone implant; autologous tissue; acellular dermal matrix; seroma; outcome; complication; patient satisfaction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Advances in Orthopedic Infections
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 2959 | Submission Open
Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management
(This special issue belongs to the Section Orthopedics)
Cardiopulmonary Resuscitation—from Research to Clinical Implementation
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 2534 | Submission Open
Keywords: cardiopulmonary resuscitation; cardiac arrest; basic life support; advanced life support; special circumstances; target temperature management; eCPR-ECLS; survival
(This special issue belongs to the Section Emergency Medicine)
Cardiac Imaging in the Diagnosis and Management of Heart Failure
edited by Mahi Lakshmi Ashwath and Allen S. Anderson
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2514 | Submission Open
Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain
(This special issue belongs to the Section Cardiology)
Clinical Updates in Lung Ultrasound
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2496 | Submission Open
Keywords: lung ultrasound; intensive care; imaging; ARDS; POCUS
(This special issue belongs to the Section Respiratory Medicine)
Updates on Cardiac Pacing and Electrophysiology
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2444 | Submission Open
Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation
(This special issue belongs to the Section Cardiology)
PET Imaging in Bone and Non-Bone Diseases
edited by and
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2234 | Submission Open
Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Perspectives in Reconstructive Urethral Surgery
edited by Krishnan Venkatesan
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2183 | Submission Open
Keywords: urethral reconstruction; urethroplasty; urethral stricture; bladder neck stenosis; urinary fistula
(This special issue belongs to the Section Nephrology & Urology)
Prostate Cancer: Diagnosis, Clinical Management and Prognosis
edited by Giovanni Muto
submission deadline 20 Nov 2025 | 3 articles | Viewed by 1786 | Submission Open
Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments
(This special issue belongs to the Section Nephrology & Urology)
Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1452 | Submission Open
Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment
(This special issue belongs to the Section Ophthalmology)
State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy
edited by Marco Mercieri
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1414 | Submission Open
Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets
(This special issue belongs to the Section Clinical Neurology)
Future Directions in Imaging-Guided Glaucoma Diagnosis and Therapy
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1321 | Submission Open
Keywords: optical coherence tomography; optical coherence tomography angiography; visual field testing; glaucoma surgery; MIGS; structure– function relationship in glaucoma
(This special issue belongs to the Section Ophthalmology)
New Advances in Uterus and Ovarian Transplantation: 2nd Edition submission deadline 20 Nov 2025 | 2 articles | Viewed by 1216 | Submission Open
Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Challenges and Opportunities in Geriatric Nephrology and Urology
edited by Giulio Romano
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1133 | Submission Open
Keywords: kidney disease; elderly patient; epidemiology; pharmacological therapy; lifestyle diet
(This special issue belongs to the Section Nephrology & Urology)
Latest Advances in Glaucoma, Cataract and Refractive Surgery: Expert Views, 2nd Edition submission deadline 20 Nov 2025 | 1 articles | Viewed by 1114 | Submission Open
Keywords: refractive surgery; glaucoma; cataract; intraocular lenses; diagnostic imaging
(This special issue belongs to the Section Ophthalmology)
Aortic Valve Implantation: Recent Advances and Future Prospects
edited by Suvitesh Luthra and Richard Jabbour
submission deadline 20 Nov 2025 | 1 articles | Viewed by 893 | Submission Open
Keywords: aortic valve replacement; aortic stenosis; paravalvular leak; coronary and structural interventional cardiology; percutaneous coronary artery interventions
(This special issue belongs to the Section Cardiology)
Arthritis: From Diagnosis to Treatment
edited by Andrea Di Matteo and
submission deadline 20 Nov 2025 | 1 articles | Viewed by 831 | Submission Open
Keywords: rheumatoid arthritis; psoriatic arthritis; imaging; ultrasound; DMARDs; differential diagnosis; difficult to treat rheumatoid arthritis; prevention
(This special issue belongs to the Section Immunology)
Challenges in Fertility Preservation
edited by and Guido Ambrosini
submission deadline 20 Nov 2025 | 1 articles | Viewed by 820 | Submission Open
Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy
(This special issue belongs to the Section Reproductive Medicine & Andrology)
State-of-the-Art Research on Thoracic Surgery submission deadline 20 Nov 2025 | 1 articles | Viewed by 703 | Submission Open
Keywords: 3D imaging; surgical process optimization; robotic surgery; immunotherapy and targeted therapy; novel cancer detection methods; personalized treatment
(This special issue belongs to the Section General Surgery)
Research Progress in Pediatric Endocrinology
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 574 | Submission Open
Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening
(This special issue belongs to the Section Clinical Pediatrics)
Current Status and Future Directions in Cardiac Surgery
edited by Marie-Elisabeth Stelzmüller and Randolph H.L. Wong
submission deadline 20 Nov 2025 | Viewed by 496 | Submission Open
Keywords: innovations; AI; minimally invasive; endoscopic; novel technologies in electrophysiology; hybrid procedures; inno-vative approaches in cardiac surgery and patient care
(This special issue belongs to the Section Cardiology)
Clinical Insights in Maternal–Fetal Medicine
edited by Moti Gulersen
submission deadline 20 Nov 2025 | 1 articles | Viewed by 378 | Submission Open
Keywords: preterm birth; antenatal corticosteroids; preeclampsia; ultrasound; fetal growth; congenital anomalies; infection; maternal morbidity; diabetes; multiple gestation
(This special issue belongs to the Section Obstetrics & Gynecology)
Challenges and Future Trends in Bariatric Surgery
edited by Maurizio L. de Luca and Amanda Belluzzi
submission deadline 20 Nov 2025 | Viewed by 361 | Submission Open
Keywords: metabolic and bariatric surgery; SADI-S; LSG; RYGB; SASI; OAGB; complications after MBS; long-term outcomes; malnutrition
(This special issue belongs to the Section General Surgery)
Acute Ischemic Stroke Management Strategies
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 286 | Submission Open
Keywords: mechanical thrombectomy; leptomeningeal collateral circulation; neuroprotection; reperfusion injury; ischemic penumbra
(This special issue belongs to the Section Clinical Neurology)
Clinical Therapeutic and Management Strategies of Epilepsy—Social and Neuropsychological Aspects
edited by
submission deadline 20 Nov 2025 | Viewed by 250 | Submission Open
Keywords: quality of life (QOL); cognition; behavior; stigma; seizure severity; interictal epileptiform discharge (IED); social
(This special issue belongs to the Section Clinical Neurology)
Skin Wound Healing: Clinical Updates and Perspectives
edited by and Norbert Kiss
submission deadline 20 Nov 2025 | Viewed by 160 | Submission Open
Keywords: dermatology; wound care; diagnosis; biomaterials; negative pressure wound therapy
(This special issue belongs to the Section Dermatology)
Minimally Invasive Techniques in Digestive Pathologies
edited by
submission deadline 20 Nov 2025 | Viewed by 152 | Submission Open
Keywords: minimally invasive surgery; laparoscopic techniques; robotic surgery; endoscopic interventions; hybrid surgical approaches; digestive oncology; AI in surgery; surgical innovation; gastrointestinal disorders
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Therapies for Diabetic Foot Ulcer Management submission deadline 20 Nov 2025 | Viewed by 147 | Submission Open
Keywords: diabetic foot disease; diabetic foot ulcers; wound healing; biomarkers; telemedicine; artificial intelligence; preven-tive strategies; advanced therapies; amputation prevention; diabetes complications; novel treatments
(This special issue belongs to the Section Endocrinology & Metabolism)
Diagnosis and Treatment of Ocular Surface Diseases submission deadline 20 Nov 2025 | Viewed by 140 | Submission Open
Keywords: dry eye disease; ocular surface; anterior segment imaging; biomarkers; artificial intelligence; diagnostic tools; novel therapeutic agents; anterior eye care
(This special issue belongs to the Section Ophthalmology)
Low Back Pain: Clinical Treatment and Management submission deadline 20 Nov 2025 | Viewed by 137 | Submission Open
Keywords: exercise; rehabilitation; weight loss; telerehabilitation; pain; physical therapy; treatment; conservative treatment; intervertebral disk displacement; low back pain; sciatica
(This special issue belongs to the Section Clinical Neurology)
Advances in Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis
edited by
submission deadline 20 Nov 2025 | Viewed by 124 | Submission Open
Keywords: pulmonary hypertension; interstitial lung disease; idiopathic pulmonary fibrosis; heart failure; mitral valve disease
(This special issue belongs to the Section Respiratory Medicine)
Cardiac MRI: Current Techniques and Future Directions
edited by
submission deadline 20 Nov 2025 | Viewed by 117 | Submission Open
Keywords: cardiac magnetic resonance imaging; technology; sequences; applications; acute coronary syndrome; intravascular imaging; CT-scanner
(This special issue belongs to the Section Cardiology)
Clinical Research in Management of Corneal Diseases
edited by Massimo Busin and Angeli Christy Yu
submission deadline 20 Nov 2025 | Viewed by 102 | Submission Open
Keywords: corneal surgery; corneal transplant; lamellar keratoplasty; deep anterior lamellar keratoplasty; descemet membrane endothelial keratoplasty; descemet stripping automated endothelial keratoplasty; corneal neurotization
(This special issue belongs to the Section Ophthalmology)
Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition submission deadline 20 Nov 2025 | Viewed by 100 | Submission Open
Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses
(This special issue belongs to the Section Orthopedics)
Diagnosis and Treatment of Scoliosis and Spinal Deformity
edited by Anna Rienmueller and Kenny Yat Hong Kwan
submission deadline 20 Nov 2025 | Viewed by 94 | Submission Open
Keywords: scoliosis; spinal deformity; adolescent idiopathic scoliosis (AIS); early onset scoliosis (EOS); neuromuscular scoliosis; adult spinal deformity (ASD); operative treatment; spinal fusion; neuromonitoring in scoliosis and deformity surgery; perioperative risk factors; conservative treatment; bracing therapy; physiotherapy scoliosis-specific exercises (PSSE) and Schroth therapy; spinal biomechanics; scoliosis imaging; low-dose radiation imaging; artificial intelligence in scoliosis; 3D modelling in spinal deformity including surgical planning; predictive modelling in scoliosis progression; biomechanics of spinal curvature; growth modulation; patient-reported outcomes in scoliosis treatment
(This special issue belongs to the Section Orthopedics)
High-Risk Neuroblastoma and Rhabdoid Tumors: New Clinical Insights and Challenges (Second Edition)
edited by and Johannes Hubertus Schulte
submission deadline 20 Nov 2025 | Viewed by 94 | Submission Open
Keywords: neuroblastoma; rhabdoid tumor; autologous stem cell transplantation; allogeneic stem cell transplantation immunotherapy; anti-GD2 antibody; targeted therapy; CAR T-cells
(This special issue belongs to the Section Oncology)
Novel Approaches in Cataract and Refractive Surgery
edited by Stephen T. Armenti
submission deadline 20 Nov 2025 | Viewed by 85 | Submission Open
Keywords: cataract surgery; complex cataract surgery; secondary intraocular lens surgery; refractive surgery (LASIK; PRK; SMILE); astigmatism correction; multifocal intraocular lenses; femtosecond laser; dropless cataract surgery
(This special issue belongs to the Section Ophthalmology)
Clinical Procedures for Diagnosis and Treatment of Cardiovascular Diseases
edited by Ahmad Jabri, Mohammad Alqarqaz, Qais Radaideh and Ahmad Al-Abdouh
submission deadline 20 Nov 2025 | Viewed by 85 | Submission Open
Keywords: cardiovascular disease; diagnostic imaging; minimally invasive procedures; precision medicine; artificial intelligence; interventional cardiology; surgical innovations; patient outcomes; preventive cardiology
(This special issue belongs to the Section Cardiovascular Medicine)
Effect of Long-Term Insomnia on Mental Health—2nd Edition submission deadline 21 Nov 2025 | 1 articles | Viewed by 1527 | Submission Open
Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress
(This special issue belongs to the Section Mental Health)
Research Advances in Coagulation Disorders
edited by Alberto Maino
submission deadline 21 Nov 2025 | Viewed by 110 | Submission Open
Keywords: coagulation; bleeding disorders; thrombosis; hemophilia; clotting disorders; hematology
(This special issue belongs to the Section Hematology)
Clinical Features and Management of Psychosis
edited by , and Michael Hadjulis
submission deadline 23 Nov 2025 | 3 articles | Viewed by 2003 | Submission Open
Keywords: psychosis; clinical features of psychosis; diagnosis of psychosis; schizophrenia; psychotic depression; affective disorder with psychotic features; psychosis in substance use disorders; psychosis in neurological disorders; psychosis in medical conditions; management of psychosis; treatment of psychosis
(This special issue belongs to the Section Mental Health)
Clinical Management of Type 1 Diabetes
edited by Carmen Quirós
submission deadline 25 Nov 2025 | 6 articles | Viewed by 19136 | Submission Open
Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens
(This special issue belongs to the Section Endocrinology & Metabolism)
The “Orthogeriatric Fracture Syndrome”—Issues and Perspectives submission deadline 25 Nov 2025 | 14 articles | Viewed by 12707 | Submission Open
Keywords: geriatric trauma; fragility fracture; orthogeriatric; co-management; assessment; integrated care; osteoporosis; sarcopenia; frailty; gait disturbance; fall; rehabilitation; prehabilitation; prevention; ehealth; digitalization
(This special issue belongs to the Section Orthopedics)
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