Current Challenges and Perspectives in Aortic Valve Replacement
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".
Deadline for manuscript submissions: 10 August 2026 | Viewed by 1259
Editors
Interests: TAVR; structural heart disease; prosthesis–patient mismatch; valve-in-valve; multimodality imaging
Interests: TAVR; structural heart disease; prosthesis–patient mismatch; valve-in-valve; multimodality imaging
Interests: TAVR; structural heart disease; prosthesis–patient mismatch; valve-in-valve; multimodality imaging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aortic valve replacement (AVR) has undergone a profound transformation over the past two decades, driven by rapid advances in transcatheter technologies, imaging, procedural techniques, and patient selection strategies. What was once a treatment reserved for high-risk or inoperable patients has evolved into a first-line therapy for a broad spectrum of risk profiles, ages, and anatomical scenarios.
Despite these advances, several important clinical, anatomical, and technological challenges remain. Issues such as prosthesis–patient mismatch, the durability of transcatheter valves, coronary access after TAVI, optimal treatment of bicuspid valves, management of small annuli, and valve-in-valve strategies continue to generate intense scientific debate. In parallel, surgical aortic valve replacement (SAVR) remains an essential benchmark, particularly for younger patients and complex anatomies, and its integration with transcatheter approaches is reshaping contemporary Heart Team decision-making.
This Special Issue will provide a comprehensive and state-of-the-art overview of current challenges, emerging evidence, and future perspectives in aortic valve replacement, encompassing both surgical and transcatheter therapies. The scope of this Special Issue is fully aligned with the mission of the Journal of Clinical Medicine, which emphasizes clinically relevant research and multidisciplinary cardiovascular care.
In this Special Issue, we welcome original research articles and narrative reviews addressing topics including, but not limited to, transcatheter and surgical valve technologies, patient selection, procedural planning, imaging, complications, long-term outcomes, and implications of AVR for health systems.
We look forward to receiving your valuable contributions.
Dr. Leonardo Guimaraes
Dr. Quentin Fischer
Dr. David Del Val
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aortic valve replacement
- transcatheter aortic valve implantation (TAVI)
- surgical aortic valve replacement
- prosthesis–patient mismatch
- structural heart disease
- heart team
- valve durability
- coronary access
- valve-in-valve
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