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Current Advances and Future Perspectives in Cardiac Arrest and Cardiogenic...
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Current Advances and Future Perspectives in Cardiac Arrest and Cardiogenic Shock

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Emergency Medicine".

Deadline for manuscript submissions: closed (25 July 2026) | Viewed by 1024

Editor

Dr. Giulia Maj

E-Mail
Guest Editor
Cardiac Anesthesia Department, University Hospital “SS. Antonio e Biagio e C. Arrigo”, 15121 Alessandria, Italy
Interests: cardiogenic shock; left ventricular unloading; biomarkers; recovery; cardiac arrest

Special Issue Information

Dear Colleagues,

Cardiogenic shock and cardiac arrest remain among the most challenging and lethal emergencies in modern medicine, despite major advances in diagnosis, mechanical circulatory support, and critical care. In recent years, substantial progress has been made in understanding pathophysiological mechanisms, patient phenotyping, and outcome prediction, leading to more individualized therapeutic strategies. Moreover, the integration of advanced hemodynamic monitoring, biomarkers, and novel percutaneous technologies has opened up new perspectives for both early recognition and tailored interventions.

This Special Issue of Journal of Clinical Medicine will provide an up-to-date overview of current advances and future directions in the management of cardiogenic shock and cardiac arrest. We invite the submission of original research articles, clinical trials, registries, reviews, and expert opinions addressing topics such as early risk stratification, mechanical circulatory support, heart–lung interactions, ECMO/ECPR, post-resuscitation care, and neurological outcomes. Contributions exploring innovative pathways, precision medicine, and multidisciplinary “shock team” models are particularly welcome.

Our aim is to foster scientific dialogue and promote evidence-based strategies that can translate into improved survival and neurological recovery for these critically ill patients.

Dr. Giulia Maj
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiogenic shock
  • left ventricular unloading
  • biomarkers
  • recovery
  • cardiac arrest

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

12 pages, 2061 KB  
Article
Association Between Serum Potassium Levels and Cardiac Arrest Risk in Emergency Resuscitation Room Patients: A Retrospective Cohort Study
by Yongkai Li, Xialaibaitigu Saimaiti, Yingping Tian, Hengbo Gao and Jianzhong Yang
J. Clin. Med. 2026, 15(14), 5733; https://doi.org/10.3390/jcm15145733 - 22 Jul 2026
Viewed by 646
Abstract
Background: This study aimed to investigate the association between serum potassium levels and the risk of cardiac arrest in patients admitted to the emergency resuscitation room and to identify the optimal potassium range associated with the lowest risk. Methods: We conducted a retrospective [...] Read more.
Background: This study aimed to investigate the association between serum potassium levels and the risk of cardiac arrest in patients admitted to the emergency resuscitation room and to identify the optimal potassium range associated with the lowest risk. Methods: We conducted a retrospective cohort study of 784 adults (384 with cardiac arrest and 400 controls) admitted to the emergency resuscitation room of a tertiary academic medical center between January 2020 and July 2021. Using multivariable logistic regression and restricted cubic spline analysis with four knots, we examined the nonlinear relationship between serum potassium levels and cardiac arrest risk after adjusting for critical confounders including lactate levels and MEWS scores. Results: A robust J-shaped association was observed between serum potassium levels and cardiac arrest risk. The lowest risk occurred within the range of 3.1–4.0 mmol/L, with significantly increased risk both below and above this range. The association remained significant after adjustment for lactate alone (p-nonlinear < 0.001) and after simultaneous adjustment for the MEWS score and lactate (p-nonlinear < 0.05). Serum potassium demonstrated fair predictive accuracy for cardiac arrest with an AUC of 0.709 (95% CI: 0.672–0.747). At the optimal cut-off value of 4.45 mmol/L, specificity reached 87.5% and positive predictive value was 80.4%. Conclusions: This study reveals a consistent J-shaped distribution between serum potassium levels and cardiac arrest risk in emergency resuscitation room patients, with the safest range identified at 3.1–4.0 mmol/L. These findings suggest that maintaining potassium levels in the lower physiological range may be beneficial for preventing cardiac arrest in critically ill emergency patients. Serum potassium assessment provides a valuable tool for risk stratification in resuscitation settings. Full article
(This article belongs to the Special Issue Current Advances and Future Perspectives in Cardiac Arrest and Cardiogenic Shock)
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