Sepsis: Current Updates and Perspectives

Dear Colleagues,

Despite the remarkable progress and technical developments in intensive care medicine, sepsis remains a major global health challenge with a high mortality rate. Nowadays, the rise of antibiotic resistance mandates a more judicious approach to antibiotics; therefore, antimicrobial stewardship is crucial. Rapid diagnostic tools for pathogen identification are being integrated into care, enabling timely de-escalation of broad-spectrum antibiotics and helping prevent resistance.

Recent advancements in sepsis management emphasize early detection, timely intervention, and personalized treatment for patients with sepsis. It became evident that "one size does not fit all" in sepsis. Early diagnosis and outcome prediction with novel biomarkers and AI are transforming sepsis management and aiding in decision-making. AI and machine learning are valuable tools for identifying sepsis patients' unique immune response profiles and for the future development of targeted therapies that can more precisely modulate immune responses. The future perspectives hold promises for developing even more personalized treatment options by integrating complex data from genomics, proteomics, and metabolomics.

In this Special Issue, we invite researchers and clinicians to submit their work, which may include original clinical research studies, as well as narrative and systematic reviews. We seek contributions that provide additional insights into recent advancements in understanding sepsis pathophysiology, innovations in diagnostics, and personalized medicine for patients with sepsis. We also welcome perspectives on future strategies for the diagnosis and treatment of sepsis, aiming to improve patient outcomes.

Dr. Ecaterina Scarlatescu
Guest Editor

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