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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insight into Plant Bioactive Compounds submission deadline 20 Jul 2025 | 4 articles | Viewed by 12215 | Submission Open
Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Immune-Inflammatory and Oxidative Stress Signaling Pathways Involved in Human Disorders submission deadline 20 Jul 2025 | 3 articles | Viewed by 11987 | Submission Open
Keywords: inflammation; neuroinflammation; immune system; oxidative stress
(This special issue belongs to the Section Molecular Immunology)
Neurotrophins: Roles and Function in Human Diseases 2.0
edited by
submission deadline 20 Jul 2025 | 4 articles | Viewed by 11916 | Submission Open
Keywords: neuroinflammation; brain; toxicology; cell growth; neurogenesis
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into the Effects of Microbiome-Derived Metabolites on Health and Disease
edited by Kinga Jaworska
submission deadline 20 Jul 2025 | 5 articles | Viewed by 11789 | Submission Open
Keywords: bacterial metabolites; short-chain fatty acids; trimethylamine N-oxide; gut microbiome; molecular pathways; intestinal barrier
(This special issue belongs to the Section Molecular Microbiology)
Sphingolipid Metabolism and Signaling in Health and Diseases
edited by Gergana M. Deevska
submission deadline 20 Jul 2025 | 5 articles | Viewed by 11638 | Submission Open
Keywords: ceramide; ceramide-1-phosphate; sphingosine; sphingosine-1-phosphate; sphingomyelin; glycosphingolipids; metabolic syndrome; obesity; diabetes; cancer; neurodegeneration; neuroinflammation; autoimmunity
(This special issue belongs to the Section Molecular Biology)
Plant Hormone Signaling submission deadline 20 Jul 2025 | 9 articles | Viewed by 11566 | Submission Open
Keywords: hormonal regulation; cross-talk between phytohormones and other metabolites; signaling; gene expression; defense mechanisms; abiotic and biotic stress; plant growth and development
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Cell Signaling Pathways and Signal Transduction
edited by Katsuhiko Muraki and
submission deadline 20 Jul 2025 | 6 articles | Viewed by 11486 | Submission Open
Keywords: Ca2+ signaling; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell metabolism; cell senescence; protein phosphorylation/dephosphorylation; membrane trafficking; cell proliferation; differentiation; and apoptosis; cytokine/chemokine signaling
(This special issue belongs to the Section Biochemistry)
Challenges and Future Perspectives in Treatment for Lung Cancer
edited by Ilaria Marrocco and
submission deadline 20 Jul 2025 | 7 articles | Viewed by 11480 | Submission Open
Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery
(This special issue belongs to the Section Molecular Oncology)
Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 2nd Edition
edited by
submission deadline 20 Jul 2025 | 9 articles | Viewed by 11330 | Submission Open
Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor
(This special issue belongs to the Section Molecular Plant Sciences)
Research in iPSC-Based Disease Models
edited by
submission deadline 20 Jul 2025 | 6 articles | Viewed by 10967 | Submission Open
Keywords: iPSCs; disease model; organoid; gene editing; mutation correction; isogenic control
(This special issue belongs to the Section Molecular Biology)
Molecular Mediators of Exercise: Cross-Organ Communication Promoting Health and Combating Disease submission deadline 20 Jul 2025 | 4 articles | Viewed by 10873 | Submission Open
Keywords: exercise physiology; adipokines; myokines; hepatokines; inter-organ communication; inflammation; insulin sensitivity; obesity; type 2 diabetes; gastrointestinal system; cardiovascular system; sarcopenia; aging; osteogenic regulation; neurological health; nutraceuticals
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Glycobiology in Human Health and Disease
edited by Katrin Mani
submission deadline 20 Jul 2025 | 6 articles | Viewed by 10843 | Submission Open
Keywords: glycans and glycoconjugates; glycoproteins; proteoglycans; glycolipids; glycosylation including glycosyltransferases and glycosidases; carbohydrate and glycan metabolism; glycan structure; disease biomarkers; glycan signaling; glycoimmunology; glycomics
(This special issue belongs to the Section Macromolecules)
Advances in Research on Neurotransmitters
edited by , and Jing-Ning Zhu
submission deadline 20 Jul 2025 | 5 articles | Viewed by 10469 | Submission Open
Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis
(This special issue belongs to the Section Molecular Neurobiology)
Endothelial Dysfunction and Cardiovascular Diseases
edited by
submission deadline 20 Jul 2025 | 4 articles | Viewed by 10450 | Submission Open
Keywords: chemokines; cytokines; leukocyte trafficking; leukocyte attracting; leukocyte-derived cytokines; nitric oxide; prostacyclin; adhesion molecules; endothelium
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Kidney Injury and Repair
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 10404 | Submission Open
Keywords: kidney injury; renal repair; acute kidney injury (AKI); chronic kidney disease (CKD); sepsis; ischemia-reperfusion (I/R) injury; nephrotoxin exposition; adult renal progenitor cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 10362 | Submission Open
Keywords: vascular permeability; atherosclerosis; blood– brain barrier; endothelial adhesion molecules; vasodilation; thrombosis
(This special issue belongs to the Section Molecular Immunology)
Organic/Inorganic Nanocomposites on the Basis of 'Three Pillars' (Organic Compounds, Metal Nanoparticles, and Carbon Nanomaterials)
edited by
submission deadline 20 Jul 2025 | 7 articles | Viewed by 10360 | Submission Open
Keywords: organic/inorganic composites; hybrid materials; composite materials; organic films; polymers; aromatic molecules; metal nanoparticles; carbon nanomaterials; carbon nanotubes; graphene
(This special issue belongs to the Section Molecular Nanoscience)
Advances in Head and Neck and Skin Cancer
edited by , and Iorio Giuseppe Carlo
submission deadline 20 Jul 2025 | 3 articles | Viewed by 10351 | Submission Open
Keywords: head and neck cancer; melanoma; nonmelanoma skin cancer; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
A Molecular Perspective on Reproductive Health, 2nd Edition submission deadline 20 Jul 2025 | 6 articles | Viewed by 10140 | Submission Open
Keywords: reproductive function; molecular bases; male; female; reproductive pathology; reproductive physiology
(This special issue belongs to the Section Biochemistry)
Cardiovascular Diseases: Histopathological and Molecular Diagnostics
edited by
submission deadline 20 Jul 2025 | 7 articles | Viewed by 9889 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Functional Roles of Epithelial and Endothelial Cells submission deadline 20 Jul 2025 | 7 articles | Viewed by 9820 | Submission Open
Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier
(This special issue belongs to the Section Biochemistry)
Natural Products in Cancer Prevention and Treatment submission deadline 20 Jul 2025 | 8 articles | Viewed by 9647 | Submission Open
Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy
edited by and Emma Folch-Puy
submission deadline 20 Jul 2025 | 5 articles | Viewed by 9516 | Submission Open
Keywords: hepatopancreatic diseases; intestine diseases; molecular basis; therapy; pathogenesis; molecular pathways; pharmacological interventions; surgical techniques; immunotherapies; regenerative medicine approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery
edited by Fei Guo
submission deadline 20 Jul 2025 | 8 articles | Viewed by 9447 | Submission Open
Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications
(This special issue belongs to the Section Molecular Informatics)
Metal-Based Drugs and Research on Mechanisms of Action submission deadline 20 Jul 2025 | 3 articles | Viewed by 9389 | Submission Open
Keywords: transition metals; metal complexes; metallodrugs; drug development; synthesis; imaging agents; structure– activity ratio
(This special issue belongs to the Section Molecular Pharmacology)
Versatility of Protein Synthesis in a Test Tube
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 9366 | Submission Open
Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation
(This special issue belongs to the Section Molecular Biology)
Viral Infections and Host Immune Responses
edited by and Maria Teresa Maggiorella
submission deadline 20 Jul 2025 | 5 articles | Viewed by 9357 | Submission Open
Keywords: virus infections; virus– host interaction; innate immunity; adaptive immunity; host factors; co-infections; acute and chronic infections; restriction factors; therapeutic strategies
(This special issue belongs to the Section Molecular Microbiology)
Role of Proteomics in Human Diseases and Infections
edited by and Kevin Coombs
submission deadline 20 Jul 2025 | 5 articles | Viewed by 9335 | Submission Open
Keywords: proteomics; human diseases; infections; biomarkers; therapeutic targets; disease pathogenesis; host– pathogen interactions; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Function in Human Health and Disease: 2nd Edition
edited by
submission deadline 20 Jul 2025 | 6 articles | Viewed by 9324 | Submission Open
Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Biochemistry)
Advances in Biomedical and Tissue Engineering Strategies to Cross the Blood–Brain Barrier for Next-Generation Treatments Against Neurodegenerative Diseases
edited by and Livia La Barbera
submission deadline 20 Jul 2025 | 5 articles | Viewed by 9301 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease; CNS; blood– brain barrier; drug delivery systems; nanocarriers; nanomedicine; tissue engineering; theranostics
(This special issue belongs to the Section Molecular Neurobiology)
Novel Insight into Epigenomic Studies of Human Disease
edited by and Takashi Ito
submission deadline 20 Jul 2025 | 5 articles | Viewed by 9203 | Submission Open
Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease
(This special issue belongs to the Section Molecular Genetics and Genomics)
A Molecular Perspective on the Genetics of Kidney Diseases
edited by Joaquim Calado
submission deadline 20 Jul 2025 | 5 articles | Viewed by 9185 | Submission Open
Keywords: kidney; genetics; solute transport; genomics; inflammation; dysmetabolism
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Breakthroughs in Molecular Diagnostic Tools for Human Diseases submission deadline 20 Jul 2025 | 8 articles | Viewed by 9135 | Submission Open
Keywords: molecular pathology; molecular diagnostics; genetics; epigenetics; proteomics; immunohistochemistry; thrombo-embolic disease; sudden cardiac death; molecular pathology of traumatic injuries; hypoxic– ischemic brain damage; experimental models of injury and diseases; targeted therapy of injuries and diseases; drug abuse; histological diagnosis; epigenetics of organs injuries; miRNA and prognosis of diseases; novel approaches and proofs of principle in therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cutting-Edge Research and Applications of Extracellular Microvesicles in Disease Management
edited by María Isabel Torres
submission deadline 20 Jul 2025 | 5 articles | Viewed by 8991 | Submission Open
Keywords: extraccellular microvesicles; exosome; ectosoma; biomarkers; cargoes of extracellular vesicles; therapeutics; diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hormone Signaling in Human Health and Diseases, 2nd Edition
edited by
submission deadline 20 Jul 2025 | 6 articles | Viewed by 8939 | Submission Open
Keywords: hormone; cell receptor; endocrine signaling; cancer; insulin; oestrogen; testosterone; angiotensin; gonadotropin; thyroid hormone
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Prostate Cancer: Novel Research and Innovative Therapeutic Strategies submission deadline 20 Jul 2025 | 4 articles | Viewed by 8897 | Submission Open
Keywords: prostate cancer; therapeutic strategy; castration-resistant PCa
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Progress of Opioid Research, 2nd Edition submission deadline 20 Jul 2025 | 5 articles | Viewed by 8660 | Submission Open
Keywords: opioids; opioid crisis; pain; analgesic; addiction; dependence; stress; reward; opioid peptides; opioid use disorder
(This special issue belongs to the Section Molecular Pharmacology)
Recent Advances in Lung Cancer
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 8611 | Submission Open
Keywords: lung cancer; immunotherapy; molecular diagnostic; next-generation sequencing
(This special issue belongs to the Section Molecular Oncology)
Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways
edited by
submission deadline 20 Jul 2025 | 4 articles | Viewed by 8419 | Submission Open
Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways
(This special issue belongs to the Section Molecular Immunology)
Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition submission deadline 20 Jul 2025 | 4 articles | Viewed by 8413 | Submission Open
Keywords: biogenic amines (histamine; dopamine; serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Protein–Ligand Interactions
edited by Dong-Jun Yu
submission deadline 20 Jul 2025 | 4 articles | Viewed by 8309 | Submission Open
Keywords: drug design; binding specificity; molecular docking; ligand screening; structural biology; protein– protein interactions; protein– ligand interactions; protein– lipid complexes; protein– nucleic acid interactions
(This special issue belongs to the Section Macromolecules)
Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases
edited by
submission deadline 20 Jul 2025 | 4 articles | Viewed by 8258 | Submission Open
Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen
(This special issue belongs to the Section Molecular Immunology)
Molecular Research and Cellular Biology of Breast Cancer submission deadline 20 Jul 2025 | 8 articles | Viewed by 8217 | Submission Open
Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor immune responses; conventional and biological therapies; blood and tissue biomarkers
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Molecular Mechanisms Underlying Kidney Diseases: Pathophysiology and Therapeutic Targets, 2nd Edition submission deadline 20 Jul 2025 | 4 articles | Viewed by 8200 | Submission Open
Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic and Epigenetic Influences on Personality Traits and Athletic Performance submission deadline 20 Jul 2025 | 1 articles | Viewed by 8182 | Submission Open
Keywords: genetics; epigenetics; personality traits; athletic performance; polymorphisms; microbiome; neurotransmitters; molecular mechanisms; metabolic health; injury susceptibility
(This special issue belongs to the Section Molecular Genetics and Genomics)
Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition
edited by
submission deadline 20 Jul 2025 | 6 articles | Viewed by 8067 | Submission Open
Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Metabolisms in Cartilage Health and Diseases: 3rd Edition
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 7926 | Submission Open
Keywords: cartilage; chondrocytes; growth; regeneration; endochondral ossification; arthritis; joint; growth factors; mechanical stress; nutrition
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology
edited by Ernesto Alejandro Aiello
submission deadline 20 Jul 2025 | 5 articles | Viewed by 7855 | Submission Open
Keywords: heart; vascular; signaling; cardiovascular disease; mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders
edited by Marta Pardo
submission deadline 20 Jul 2025 | 3 articles | Viewed by 7653 | Submission Open
Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition
edited by and
submission deadline 20 Jul 2025 | 6 articles | Viewed by 7650 | Submission Open
Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies
(This special issue belongs to the Section Molecular Immunology)
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