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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3107 | Submission Open
Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; stargardt disease; cone– rod dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds, Smart Polymers and Functionalised Materials for Drug Delivery
edited by Emilia Szymańska
submission deadline 20 Aug 2025 | 1 articles | Viewed by 3094 | Submission Open
Keywords: drug delivery system; bioactive compound; drug carrier; pharmacological activity; polymer
(This special issue belongs to the Section Materials Science)
Advancements in Understanding Protein Misfolding Disorders and Cancer
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 3079 | Submission Open
Keywords: protein misfolding; cancer; amyloidosis
(This special issue belongs to the Section Molecular Oncology)
Research on Transcriptional Regulation in Reproductive Biology
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3045 | Submission Open
Keywords: reproductive biology; molecular research; transcriptional regulations; signaling pathways; gene expression; cell biology
(This special issue belongs to the Section Molecular Biology)
Oral Squamous Cell Carcinoma: Insights into Molecular Pathways and Emerging Therapeutic Approaches
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3029 | Submission Open
Keywords: oral squamous cell carcinoma; epigenetics; molecular genetics; gene expression targeted therapy; molecular biomarkers
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Regulation in Blood-Brain Barrier
edited by Rajkumar Vutukuri
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2921 | Submission Open
Keywords: blood brain barrier (BBB); tight junctions; NVU cell types; neurodegenerative diseases; neuro-inflammation
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Pro-Inflammatory and Anti-Inflammatory Cytokines
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2920 | Submission Open
Keywords: pro-inflammation cytokine; anti-inflammation cytokine; chemotherapy; radiotherapy; signal transduction; microbiome– host response; sepsis; bone marrow; GI; brain
(This special issue belongs to the Section Molecular Immunology)
Advance in Plant Abiotic Stress: 3rd Edition
edited by and
submission deadline 20 Aug 2025 | 6 articles | Viewed by 2867 | Submission Open
Keywords: abiotic stress; cold; drought; salt; heat; nutrient deficiency; secondary metabolism; stress resistance; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Research on CAR-T Cell Therapy
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2766 | Submission Open
Keywords: CAR T cell therapy; T cell activation; memory lymphocyte differentiation; cancer vaccine; antigen spread
(This special issue belongs to the Section Molecular Immunology)
Rheumatoid Arthritis: From Molecular Basis to Therapies
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 2740 | Submission Open
Keywords: rheumatoid arthritis; autoimmune; intracellular signaling pathways; targeted therapy; inflammation; immunometabolic reprogramming; CD40; CD40 ligand; GM-CSF; PD-1; inhibitors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancements in Perovskite and Tandem Solar Cell Technologies
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2717 | Submission Open
Keywords: perovskite solar cells; tandem photovoltaics; charge transporting materials; interfacial engineering; optoelectronic properties
(This special issue belongs to the Section Materials Science)
Biological Research of Rhythms in the Nervous System
edited by Bernát Kocsis and Andreas Draguhn
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2639 | Submission Open
Keywords: mechanisms of rhythmic synchronization; rhythmic firing; neural network oscillations; rhythmic components in EEG; oscillopathy; theta and gamma rhythm; sleep spindle; rhythmic activity and cognition; pathology of rhythmic synchronization in the nervous system; altered rhythmic activity in neuropsychiatric disorders
(This special issue belongs to the Section Molecular Neurobiology)
Pathogenic Microorganisms, Viruses and Therapeutic Strategies submission deadline 20 Aug 2025 | 1 articles | Viewed by 2620 | Submission Open
Keywords: medicinal chemistry; pathogenic microorganisms; bacteria; fungi; viruses; pathogen; therapeutic
(This special issue belongs to the Section Molecular Microbiology)
MicroRNAs and Other Non-Coding RNAs as Regulators, Biomarkers, and Therapeutic Targets, 2nd Edition
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2462 | Submission Open
Keywords: non-coding RNAs; microRNA; lncRNA; circRNA; piRNA; biomarker; therapeutic target
(This special issue belongs to the Section Molecular Biology)
Design, Synthesis and Applications of the Task-Specific Molecules
edited by and
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2418 | Submission Open
Keywords: task-specific molecules; molecular design and synthesis; physical/chemical absorption; catalysis (including electrocatalysis; photocatalysis; etc.); mechanism on the molecular level; molecular dynamic simulations; optical materials; optoelectronic devices; photoelectric detection; semiconductors
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular and Cellular Research on the Glioma and Tumor Microenvironment submission deadline 20 Aug 2025 | 2 articles | Viewed by 2417 | Submission Open
Keywords: tumour microenvironment; immune cells; cell siganling; tumor niche; tumor heterogeneity; TMZ resistance; new therapeutic strategies; endothelial cells; fibroblasts; extracellular matrix
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Biomedical Application of Polymeric Micelles submission deadline 20 Aug 2025 | 1 articles | Viewed by 2341 | Submission Open
Keywords: polymeric micelles; nanomedicine; drug delivery; amphiphilic compounds; therapeutic applications
(This special issue belongs to the Section Macromolecules)
Materials for Bioengineering and Biotechnology 2.0 submission deadline 20 Aug 2025 | 1 articles | Viewed by 2334 | Submission Open
Keywords: biomaterials; nanomaterials; nanocarriers; extracellular vesicles; intercellular communication; tissue engineering; scaffolds
(This special issue belongs to the Section Materials Science)
Pathogenesis of Preeclampsia: From a Molecular Perspective
edited by Jezid Miranda
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2327 | Submission Open
Keywords: preeclampsia; immune system; molecular mechanisms in preeclampsia; angiogenic factors; gene regulation; epigenetics; transcription factors in preeclampsia; translational research in preeclampsia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Non-Coding RNA in Physiology and Pathophysiology: Second Edition
edited by Maria Rosaria Tumolo
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2323 | Submission Open
Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; musculoskeletal pain; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging
(This special issue belongs to the Section Molecular Biology)
Biological Role of Oxidative Stress in Inflammatory Diseases: 2nd Edition
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2271 | Submission Open
Keywords: oxidative stress; inflammation; endogenous antioxidant enzymes
(This special issue belongs to the Section Molecular Immunology)
Eustress: Molecular Events Underlying the Usefulness of Moderate Oxidative Stress in Prevention and Therapy
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2228 | Submission Open
Keywords: eustress; medical ozone; Nrf2; aging
(This special issue belongs to the Section Biochemistry)
Roles of Lipid Rafts in the Regulation of Cellular Processes and Diseases
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2155 | Submission Open
Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease
(This special issue belongs to the Section Biochemistry)
Molecular Research of Ocular Pathologies, 2nd Edition submission deadline 20 Aug 2025 | 1 articles | Viewed by 2147 | Submission Open
Keywords: ocular pathologies; dry eye; glaucoma; retinal diseases; oxidative stress; inflammation; molecular treatments; molecular biomarkers  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Redox Enzymes of Bacteria and Parasites as Potential Drug Targets submission deadline 20 Aug 2025 | 1 articles | Viewed by 2115 | Submission Open
Keywords: bacteria and parasite electron transport chains; membrane and cell wall component synthesis; dioxygenases; nitroreductases; antibacterial and antiparasitic agents
(This special issue belongs to the Section Biochemistry)
The Role of Long Non-Coding RNAs in Stress and Diseases submission deadline 20 Aug 2025 | 2 articles | Viewed by 2108 | Submission Open
Keywords: long non-coding RNAs (lncRNAs); human health; core stress response; genotoxic stress; exosomes; biomarkers; stress-related diseases; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Targeted Regulation of Autoimmune Diseases
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1995 | Submission Open
Keywords: autoimmunity; autoimmune diseases; multiple sclerosis; rheumatoid arthritis; lupus; type 1 diabetes; inflammatory bowel disease; biomarkers; immune cells; signaling molecules
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Two- and Three-Dimensional Nanostructured Materials for Biosensing Applications
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1912 | Submission Open
Keywords: biosensors; biomimetics; nanoparticles; nanoclusters; quantum dots; nanostructured carbon; self-assembled structures
(This special issue belongs to the Section Materials Science)
New Insights into Autophagy and Retinal Degeneration
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1771 | Submission Open
Keywords: autophagy; retinal degeneration; retinal inflammation; oxidative stress; retinal alterations; age-related macular degeneration; retinal damage; inflammatory processes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanism and Therapeutic Approach of Metal Toxicity
edited by Grażyna Gromadzka
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1762 | Submission Open
Keywords: metal toxicity; neurodegenerative disease; cancer; stroke; myocardial infarct; atherosclerosis; cardiovascular disease; metal chelators; therapeutic approach of metal toxicity; cobalt toxicity; copper toxicity; iron toxicity; aluminum toxicity; manganese toxicity; molybdenum toxicity; nickel toxicity; zinc toxicity; lead toxicity
(This special issue belongs to the Section Molecular Toxicology)
Advances in Genetics and Breeding Research in Horticultural Crops
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 1753 | Submission Open
Keywords: horticultural crops; genomic sequencing; multi-omics technologies; molecular biology; gene editing; plant breeding; function of genes; molecular marker
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Innovations in Synthetic Organic Chemistry
edited by Anand H. Shinde
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1747 | Submission Open
Keywords: organic synthesis; catalysis; material applications; bioactive molecules; active pharmaceutical ingredients; green chemistry
(This special issue belongs to the Section Biochemistry)
The Interplay Between Cellular Stress and Human Diseases
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1611 | Submission Open
Keywords: cellular stress; DNA damage response; unfolded protein response; autophagy; senescence; apoptosis; repair pathways; mitochondrial stress; nutrient deprivation; oxidative stress
(This special issue belongs to the Section Biochemistry)
Endothelial Function and Cardiovascular Disease: Molecular Advances and Challenges
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 1589 | Submission Open
Keywords: endothelium; heart; protection; therapeutic strategies; vascular system; vesicles
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Embryonic Development
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1586 | Submission Open
Keywords: embryonic development; molecular mechanisms; cellular mechanisms; model embryos; genetic
(This special issue belongs to the Section Molecular Biology)
Cardioprotection in Drug-Induced Cardiotoxicity
edited by Roisin Kelly-Laubscher
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1586 | Submission Open
Keywords: cardioprotection; cardiotoxicity; anthracycline; cardiac dysfunction; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microsatellite Instability (MSI) and Mismatch Repair Deficient (dMMR)-Related Diseases: From Detection Methods to Practice
edited by Federica Zito Marino
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1572 | Submission Open
Keywords: microsatellite instability (MSI); mismatch repair deficient (dMMR); immunotherapy; next-generation sequencing (NGS); immunohistochemistry (IHC); polymerase chain reaction (PCR); MSI-positive tumors
(This special issue belongs to the Section Molecular Biology)
The Role of Macrophages in Tumors
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1554 | Submission Open
Keywords: tumor-associated macrophages; transcriptome; metabolome; epigenetics; angiogenesis; metastasis; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants
edited by Wajid Zaman
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1549 | Submission Open
Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Neurodegeneration and Neuroprotection for Retinal and Optic Nerve Diseases
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 1541 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research
(This special issue belongs to the Section Molecular Neurobiology)
Modulation of the Immune System and Oxidative Stress in Liver Illnesses
edited by and Dan Ionuț Gheonea
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1538 | Submission Open
Keywords: oxidative stress; liver illnesses; immune system; inflammatory
(This special issue belongs to the Section Molecular Immunology)
Molecular Pathology and Novel Therapies for Lymphoma
edited by Fulvio Massaro
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1489 | Submission Open
Keywords: Hodgkin lymphoma; non-Hodgkin lymphoma; hematopathology; biomarker; new therapeutic approaches
(This special issue belongs to the Section Molecular Oncology)
Plant Bioactive Compounds in Human Diseases
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1462 | Submission Open
Keywords: plant extracts; plant-derived compounds; secondary metabolites; mechanism of action; bioavailability; human health and disease; computer-aided drug design; machine learning and artificial Intelligence
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Toxicity Research of Biological Venoms
edited by and Suely Vilela Sampaio
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1461 | Submission Open
Keywords: neurotoxicity assays; insect models; electrophysiology; screening assays; ion channels; therapeutic molecules; animal venoms; antitumoral activity; enzyme activity; biotechnological application
(This special issue belongs to the Section Molecular Toxicology)
Revolutionizing Antifungal Therapeutics: From Understanding to Intervention submission deadline 20 Aug 2025 | 2 articles | Viewed by 1423 | Submission Open
Keywords: fungi; antifungal; biofilm; Candida; Aspergillus; Trichoderma
(This special issue belongs to the Section Molecular Microbiology)
Advanced Spectroscopy Research: New Findings and Perspectives
edited by
submission deadline 20 Aug 2025 | Viewed by 1383 | Submission Open
Keywords: molecular spectroscopy; atomic spectroscopy; chemical analysis; molecular interaction; IR/FT-IR/ATR; Raman and SERS spectroscopy and imaging; UV-Vis; XRD; computational methods
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
edited by David Rohde
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1344 | Submission Open
Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights in Hepatic Disease and Hepatocellular Carcinoma
edited by and Jong-Young Choi
submission deadline 20 Aug 2025 | 2 articles | Viewed by 1261 | Submission Open
Keywords: hepatology; viral hepatitis; liver cirrhosis; hepatocellular carcinoma; liver transplantation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research on Luminescent Materials and Their Luminescence Mechanism submission deadline 20 Aug 2025 | 1 articles | Viewed by 1214 | Submission Open
Keywords: luminescence; molecular/ionic level; mechanism
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms of Phytochemicals in Antioxidation, Antimicrobial, and Cytoprotective Properties
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1203 | Submission Open
Keywords: phytochemicals; antioxidant; antimicrobial; cytoprotective; in vitro screening; in vivo evaluation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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