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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition)

edited by

Qichang Yang

and

Byoung Ryong Jeong

submission deadline 20 May 2025 | 4 articles | Viewed by 4261 | Submission Open

Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake

(This special issue belongs to the Section Molecular Plant Sciences)

Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition

edited by

Balik Dzhambazov

submission deadline 20 May 2025 | 2 articles | Viewed by 4233 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovation in Biomaterials for Tissue Engineering and Regenerative Medicine

edited by

Helena Felgueiras

submission deadline 20 May 2025 | 1 articles | Viewed by 4129 | Submission Open

Keywords: natural and synthetic polymers; bioactive agents; antimicrobial activity; regenerative properties; tissue regeneration; biocompatibility; biodegradation; tissue integration

(This special issue belongs to the Section Materials Science)

Caenorhabditis elegans: A Model Organism for Human Health and Disease

edited by Andreia Teixeira-Castro

submission deadline 20 May 2025 | 4 articles | Viewed by 4096 | Submission Open

Keywords: human physiology; human disease; therapy; novel C. elegans methods; novel C. elegans models; disease models

(This special issue belongs to the Section Molecular Biology)

Recent Trends in Experimental Models for Cancer Research

edited by

Patrícia M. A. Silva

and

Cristina Pinto Ribeiro Xavier

submission deadline 20 May 2025 | 2 articles | Viewed by 4084 | Submission Open

Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models

(This special issue belongs to the Section Molecular Oncology)

Novel Molecular Research on Natural Bioactive Compounds in Human Health

edited by

Antonio Palumbo Piccionello

submission deadline 20 May 2025 | 2 articles | Viewed by 4015 | Submission Open

Keywords: aromatic heterocycles; bioactive compounds; drug design; natural bioactive plant products; biological and pharmacological activity; natural plant drug discovery and development; nutraceuticals; botanical dietary supplement

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on the Drug Toxicity

edited by

Annagiulia Di Trana

submission deadline 20 May 2025 | 2 articles | Viewed by 4002 | Submission Open

Keywords: drug toxicity; new psychoactive substances; toxicology; drug metabolism; drug intoxication

(This special issue belongs to the Section Molecular Toxicology)

Advances in Synaptic Transmission and Plasticity

edited by

Manuela Dicarlo

submission deadline 20 May 2025 | 2 articles | Viewed by 3916 | Submission Open

Keywords: synaptic transmission; synapse; neurotransmitters; synaptic plasticity; memory; learning; neurodegenerative diseases; neuropsychiatric diseases

(This special issue belongs to the Section Molecular Neurobiology)

FTIR Miscrospectroscopy: Opportunities and Challenges

edited by Simona Sabbatini

submission deadline 20 May 2025 | 2 articles | Viewed by 3824 | Submission Open

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Molecular Dynamics Simulation of Chemical and Biomedical Systems

edited by

Sandra Nunes

Tânia Cova

and

Carla Vitorino

submission deadline 20 May 2025 | 2 articles | Viewed by 3758 | Submission Open

Keywords: molecular dynamics simulation; chemical and biomedical systems; molecular-level processes; protein structures; drug binding mechanisms; biomolecular behavior; drug design; biomedicine materials

(This special issue belongs to the Section Molecular Informatics)

Extreme Biocatalysts: From Basic Research to Biotechnological Applications 2.0

edited by

Salvatore Fusco

submission deadline 20 May 2025 | 2 articles | Viewed by 3735 | Submission Open

Keywords: whole-cell biocatalysts; extremozymes; enzyme assays; protein engineering; extremophiles

(This special issue belongs to the Section Biochemistry)

Regulation and Activation of Immune Cells through the Mitochondria

edited by

Špela Konjar

submission deadline 20 May 2025 | 2 articles | Viewed by 3654 | Submission Open

Keywords: mitophagy in immune cells; autophagy and mitochondria in immune cells; fission and fusion of mitochondria in immune cells; oxphos and mitochondria in immune cells; glycolysis and mitochondria in immune cells; tissue residency of immune cells and their mitochondria; tumor infiltrating lymphocytes and their mitochondria; mitochondria in inflammation

(This special issue belongs to the Section Molecular Immunology)

Molecular Research on Nanotoxicology

edited by

Oleg Lunov

submission deadline 20 May 2025 | 2 articles | Viewed by 3648 | Submission Open

Keywords: nanotoxicology; nanodrugs; nanoparticles; adverse drug reactions; cytotoxicity

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

edited by

Miguel Hueso

and

Alfredo Vellido

submission deadline 20 May 2025 | 1 articles | Viewed by 3646 | Submission Open

Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning

(This special issue belongs to the Section Molecular Informatics)

Arteriogenesis, Angiogenesis and Vascular Remodeling, 2nd Edition

edited by

Paul Quax

and

Elisabeth Deindl

submission deadline 20 May 2025 | 2 articles | Viewed by 3589 | Submission Open

Keywords: arteriogenesis; angiogenesis; collateral formation; peripheral arterial disease; vascular remodeling; atherosclerosis; restenosis; intimal hyperplasia; vein grafting; cardiovascular diseases; cell and gene therapy; critical limb ischemia; therapeutic angiogenesis; collateral circulation; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Mitochondria in Cancer

edited by Hirofumi Arakawa, Takeshi Uchiumi and

Manabu Futamura

submission deadline 20 May 2025 | 2 articles | Viewed by 3550 | Submission Open

Keywords: metabolism; apoptosis; fusion and fission; mitochondrial DNA; mitochondrial RNA; mitochondrial proteins; mitophagy; lipid; cardiolipin; phase separation; oxidative phosphorylation; proteostasis; mitochondrial quality control; TFAM; anti-cancer drug; imaging; cancer therapy; cancer diagnosis; Warburg effect

(This special issue belongs to the Section Molecular Oncology)

Molecular Research and New Therapy in Melanoma and Other Skin Cancers: 2nd Edition

edited by

Rüdiger Greinert

submission deadline 20 May 2025 | 2 articles | Viewed by 3498 | Submission Open

Keywords: epigenetics; cancer stem cells; noncoding RNA (miRNA); personalized diagnostic (medicine); personalized medicine; DNA repair; skin cancer biomarker; skin cancer prevention; genomics; transcriptomics; immunomodulation; ctDNA; circulating tumor cells; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances and Perspectives in Rheumatic Diseases

edited by

Luciana Breda

submission deadline 20 May 2025 | 2 articles | Viewed by 3458 | Submission Open

Keywords: rheumatic diseases; molecular biology; inflammatory pathways; cytokines; molecular diagnostics; biologics; drug development; genetic factors; epigenetics; environmental influences

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Melanoma Therapy

edited by

Terrence Piva

submission deadline 20 May 2025 | 1 articles | Viewed by 3414 | Submission Open

Keywords: melanoma; anti-cancer; immunotherapy; targeted therapy; signaling pathway; Polyphenolic compounds; cannabinoids; pharmacotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Bioactive Compounds: Antioxidant, Anti-inflammatory and Anticancer Effects

edited by

Dana Maria Copolovici

submission deadline 20 May 2025 | 2 articles | Viewed by 3350 | Submission Open

Keywords: anticancer; antioxidant; anti-inflammatory; bioactive compounds; chemical biology; molecular biology; metabolic diseases; nutrition.

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathology and Treatment of Neuromuscular Disease

edited by Christopher Nelke and Christina B. Schroeter

submission deadline 20 May 2025 | 1 articles | Viewed by 3319 | Submission Open

Keywords: complements; myasthenia gravis; neuromuscular diseases; neuromuscular junction; hereditary disorders; amyotrophic lateral sclerosis; personalized treatments

(This special issue belongs to the Section Molecular Neurobiology)

Editorial Board Members’ Collection Series: “Protein Biophysics”

edited by

Vladimir N. Uversky

and

Assaf Friedler

submission deadline 20 May 2025 | 2 articles | Viewed by 3218 | Submission Open

Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics)

Hypertension: Mechanisms of Oxidative Stress and Antioxidant Regulation

edited by Rossana Scuri

submission deadline 20 May 2025 | 2 articles | Viewed by 3210 | Submission Open

Keywords: arteriolar networks organization; blood flow supply; cardiovascular disease; endothelial dysfunction; eNOS regulatory activity; oxidative stress; polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Alzheimer’s Disease Treatment: Exploring Novel Approaches and Strategies

edited by

Sunmin Park

submission deadline 20 May 2025 | 2 articles | Viewed by 3197 | Submission Open

Keywords: Alzheimer’ s disease; bioinformatics; novel compounds; in vitro; in vivo; clinical study; Alzheimer’ s disease models

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Catalytic Materials (Second Edition)

edited by

Julio Macedo

submission deadline 20 May 2025 | 3 articles | Viewed by 3164 | Submission Open

Keywords: synthetic routes; nanomaterials; catalysis; sustainability; biomass; biofuel; photocatalysis; fine chemistry

(This special issue belongs to the Section Materials Science)

Advanced Molecular Research on Chronic Heart Failure

edited by

Marco Tana

submission deadline 20 May 2025 | 2 articles | Viewed by 3156 | Submission Open

Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products in Drug Discovery and Development

edited by Tian-Le Gao

submission deadline 20 May 2025 | 4 articles | Viewed by 3150 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

New Perspective on Inflammatory Diseases: Role of Natural Compounds

edited by

Floriana D'Angeli

Carlo Genovese

and

Cristina Russo

submission deadline 20 May 2025 | 2 articles | Viewed by 3113 | Submission Open

Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cytokines in Inflammation and Health

edited by

Jörg Hermann Fritz

submission deadline 20 May 2025 | 3 articles | Viewed by 3097 | Submission Open

Keywords: cytokines; inflammation; ageing; cancer; obesity; novel therapies

(This special issue belongs to the Section Molecular Immunology)

Food Science and Molecular Nutrition

edited by

Hsinjung Ho

submission deadline 20 May 2025 | 1 articles | Viewed by 3093 | Submission Open

Keywords: food science; antioxidants; bioactive compounds; mitochondria; nutrigenomics; metabolomics

(This special issue belongs to the Section Biochemistry)

Cell and Molecular Perspectives in Breast Cancer

edited by Seungbaek Lee

submission deadline 20 May 2025 | 1 articles | Viewed by 3078 | Submission Open

Keywords: breast cancer; molecular biology; cell biology; biomarker; novel therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroplasticity Unveiled: Mechanisms across Neural Networks

edited by Irina I. Stoyanova

submission deadline 20 May 2025 | 1 articles | Viewed by 3077 | Submission Open

Keywords: neuroplasticity; extended reality; cognitive neuroscience; molecular neurobiology; neurodegeneration; brain development; neural networks; synaptic plasticity; neurorehabilitation; neuroadaptive changes

(This special issue belongs to the Section Molecular Neurobiology)

Natural and Synthetic Biomaterials in Biomedical Applications

edited by

Adina Magdalena Musuc

submission deadline 20 May 2025 | 2 articles | Viewed by 3069 | Submission Open

Keywords: biocompatibility; biodegradability; tissue engineering; regenerative medicine; drug delivery systems; nanostructured biomaterials; hybrid and composite biomaterials; smart biomaterials; innovative fabrication techniques

(This special issue belongs to the Section Materials Science)

Neuro-Molecular Pathogenetic Mechanisms of Sudden Infant Death Syndrome (SIDS) and Other Infant Neurodevelopmental Disorders

edited by

Anna Maria Lavezzi

submission deadline 20 May 2025 | 2 articles | Viewed by 3059 | Submission Open

Keywords: congenital central hypoventilation syndrome (CCHS); cyclin-dependent kinase-like 5 (CDKL5)) deficiency disorder; GRIN1-related neurodevelopmental disorder ; SIDS; neuropathology; neurodevelopmental alterations; genetic polymorphisms; mutations; pollutants; Pitt-Hopkins syndrome; Rett syndrome; risk factors

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in Thrombosis: 3rd Edition

edited by

Isabella Russo

submission deadline 20 May 2025 | 5 articles | Viewed by 3056 | Submission Open

Keywords: thrombosis; platelets; coagulation; diabetes; obesity; insulin resistance; metabolic disease; cardiovascular diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Adsorption Mechanism of Novel Porous Materials in Wastewater Treatment, 2nd Edition

edited by

Anna Deryło-Marczewska

submission deadline 20 May 2025 | 3 articles | Viewed by 2996 | Submission Open

Keywords: porous materials; nanominerals; adsorption mechanism; metal– organic framework materials; heavy metals; organic contaminants; pharmaceuticals; molecular simulation; morphology

(This special issue belongs to the Section Materials Science)

Quantum Dots for Biomedical Applications

edited by

Shanmugavel Chinnathambi

submission deadline 20 May 2025 | 2 articles | Viewed by 2976 | Submission Open

Keywords: quantum dots; molecular imaging; tissue imaging: biosensing; medical diagnosis; drug delivery

(This special issue belongs to the Section Materials Science)

Roles of Migration and Invasion in Cancer Metastasis

edited by

Kyung-Chul Choi

submission deadline 20 May 2025 | 1 articles | Viewed by 2955 | Submission Open

Keywords: cancer; metastasis; invasion; migration; tumor microenviornment; epithelial– mesenchymal transition; mesenchymal– epithelial transition; intravasation; extravasation

(This special issue belongs to the Section Molecular Oncology)

Embryonic Development and Differentiation: 2nd Edition

edited by

László Márk

submission deadline 20 May 2025 | 2 articles | Viewed by 2903 | Submission Open

Keywords: blastocyte; embryogenesis; endometrium; implantation; in vitro fertilization (IFV); ICSI; oocyte; pregnancy; seminal plasma; sperm

(This special issue belongs to the Section Molecular Biology)

The Molecular Link Between Nutrition and Obesity

edited by

Elena Azzini

submission deadline 20 May 2025 | 2 articles | Viewed by 2879 | Submission Open

Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Antioxidants in Human Health and Disease, 2nd Edition

edited by

María Herranz-López

submission deadline 20 May 2025 | 1 articles | Viewed by 2862 | Submission Open

Keywords: ROS; oxidative disorders; molecular pathways; inflammation; biotransformation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Multiple Sclerosis

edited by Yoshio Bando

submission deadline 20 May 2025 | 3 articles | Viewed by 2827 | Submission Open

Keywords: multiple sclerosis; molecular mechanism; pathogenesis; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Materials: State-of-the-Art Research and Development Prospects

edited by

Alina Maria Holban

submission deadline 20 May 2025 | 3 articles | Viewed by 2809 | Submission Open

Keywords: nanobiomaterials; antibacterial materials; anticancer nanomaterials; wound dressings; coatings for bioactive implants; molecular imaging; nanosensors

(This special issue belongs to the Section Materials Science)

Brain Metastasis 2025

edited by

Dario Marchetti

submission deadline 20 May 2025 | 1 articles | Viewed by 2784 | Submission Open

Keywords: brain metastasis; brain microenvironment; pathology; circulating tumor cells; tumor-normal cell crosstalks; new biomarkers and therapies for brain metastasis; cerebral spinal fluid/liquid biopsy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biopolymers for Enhanced Health Benefits—2nd Edition

edited by

Leonard-Ionut Atanase

submission deadline 20 May 2025 | 2 articles | Viewed by 2718 | Submission Open

Keywords: nanocomposites; biomedical materials; stimuli-responsive materials; wound healing; biomaterials; tissue engineering; regenerative medicine; targeted and controlled drug delivery; in vitro and in vivo biological activities; polymers for biomedical application; surface modification and their characterization; antibacterial & antiviral; microbial biofilms; medical-related antimicrobial/antiviral polymers

(This special issue belongs to the Section Macromolecules)

Plant Development and Abiotic Stress Response Regulation via Alternative Splicing

edited by

Yong-Hwan Moon

submission deadline 20 May 2025 | 2 articles | Viewed by 2643 | Submission Open

Keywords: plants; development; abiotic stress responses; alternative splicing; transcriptional regulation; signaling; splicing factors

(This special issue belongs to the Section Molecular Plant Sciences)

Pathophysiology and Treatment of Alzheimer's Disease

edited by

Jeffrey Fessel

submission deadline 20 May 2025 | 1 articles | Viewed by 2553 | Submission Open

Keywords: Alzheimer's disease; Alzheimer’ s dementia; neurodegeneration; AD; pathogenesis; cure for AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Mechanisms and Markers in Inflammatory Disorders, 3rd Edition

edited by

Elena Vianello

submission deadline 20 May 2025 | 4 articles | Viewed by 2544 | Submission Open

Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling

(This special issue belongs to the Section Molecular Immunology)

Editorial Board Members’ Collection Series: “Emerging Progress in Nanomedicine”

edited by Hamed Laroui and

Federico D’Agata

submission deadline 20 May 2025 | 1 articles | Viewed by 2507 | Submission Open

Keywords: nanomedicine; nanoparticles; nanotechnology; targeted drug delivery; pharmaceutical nanoimaging; nanoengineering; nanotoxicology

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Research on Antifungal Resistance

edited by Anna Tomova

submission deadline 20 May 2025 | 3 articles | Viewed by 2492 | Submission Open

Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

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