Molecular Mechanisms of Neurodegeneration and Neuroprotection for Retinal and Optic Nerve Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 790
Special Issue Editor
Interests: neuroprotection; neuroprotective therapy; diabetic retinopathy; optic nerve
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuronal cell death is an irreversible change and associated with the pathogenesis of all retinal and optic nerve diseases. Because neuronal cell death is directly related to vision loss, neuronal cell death must be protected before the point of no return. A variety of types of cell death, such as necrosis, apoptosis, pyroptosis, autophagic cell death, ferroptosis, or necroptosis, can be associated with the pathogenesis of retinal and optic nerve diseases. Thus, multiple neuroprotective therapies against various types of cell death may be required for retinal and optic nerve diseases. To establish neuroprotective therapies, the precise mechanism of neuronal cell death must be elucidated. Otherwise, we cannot identify where the point of no return is.
This Special Issue focuses on the molecular mechanisms of neuronal cell death as well as neuroprotective and regenerative therapies for retinal and optic nerve diseases. This Special Issue covers all studies from bench to bed, and thus clinical studies and trials for neuroprotective therapies are also welcome. We hope that this Special Issue contributes to the development of medical science more than a little.
Prof. Dr. Toshiyuki Oshitari
Guest Editor
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Keywords
- neuroprotection
- neurodegeneration
- neuronal cell death
- regeneration
- cell death and survival pathways
- neurovascular unit
- oxidative stress
- inflammation
- advanced glycation end products
- ischemia
- optic nerve injuries
- glaucoma
- optic neuritis
- retinitis pigmentosa
- diabetic retinopathy
- age-related macular degeneration
- retinal vein/artery occlusion
- gene therapy
- cell plantation
- nutrients
- neuroprotectants
- drug delivery
- translational research
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