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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Epilepsy: Exploring the Molecular Mechanisms and Potential Medications

edited by

Motohiro Okada

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1157 | Submission Open

Keywords: idiopathic epilepsy; genetic epilepsy; transmission; development; signaling; synaptic plasticity; pathophysiology; modulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Virus Infection, Resistance and Control

edited by

Carl Spetz

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1089 | Submission Open

Keywords: plant virus; host– pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Synthesis, Biosynthesis and Implications of Chalcones

edited by

Pal Perjesi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1030 | Submission Open

Keywords: chalcones; biosynthesis; biochemistry

(This special issue belongs to the Section Biochemistry)

Molecular Research in Functional Nanomaterials

edited by

Łukasz Laskowski

submission deadline 31 Jan 2026 | 1 articles | Viewed by 955 | Submission Open

Keywords: functional materials; nanomaterials; molecular structure; molecular materials; functional molecules; nanotechnology; self-assembly methods

(This special issue belongs to the Section Molecular Nanoscience)

Advances in the Molecular Pathogenesis of Gastrointestinal Malignancies with Implications for Diagnosis and Therapy

edited by Laura Necula

submission deadline 31 Jan 2026 | 1 articles | Viewed by 911 | Submission Open

Keywords: gastrointestinal cancers; biomarkers; early diagnosis; circulating molecules; non-invasive tests

(This special issue belongs to the Section Molecular Oncology)

Genetic and Metabolic Molecular Research of Lysosomal Storage Disease: 5th Edition

edited by

Grzegorz Wegrzyn

submission deadline 31 Jan 2026 | 1 articles | Viewed by 850 | Submission Open

Keywords: lysosomal storage diseases; molecular mechanisms of genetic disorders metabolic diseases; accumulation of macromolecules in cells; enzyme replacement therapy; hematopoietic stem cell transplantation gene therapy; substrate reduction therapy; translational research; novel therapies for genetic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrative Omics Strategies for Biomarker Discovery and Mechanistic Insights into Disease

edited by

Xinxin Song

submission deadline 31 Jan 2026 | 1 articles | Viewed by 764 | Submission Open

Keywords: integrative omics; biomarker discovery; cancer signaling networks; drug resistance; phosphoproteomics; multi-omics integration; systems biology; translational research

(This special issue belongs to the Section Molecular Informatics)

Molecular Design and Functional Applications of Polysaccharide Composites

edited by

Magdalena Krystyjan

Gohar Khachatryan

and

Karen Khachatryan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: polysaccharide composites; molecular design; functional applications

(This special issue belongs to the Section Materials Science)

Application of Nanomedicine in Cancer Targeting and Treatment

edited by

Kee Siang Lim

submission deadline 31 Jan 2026 | Viewed by 621 | Submission Open

Keywords: nanomedicine; nanoimaging/bioimaging; cancer biology; theranostics; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Breaking Barriers in Drug Discovery: Novel Methodologies and Mechanisms of Action

edited by Likun Gong,

Qiuping Qin

and Jing Chen

submission deadline 31 Jan 2026 | 1 articles | Viewed by 610 | Submission Open

Keywords: new approach methodologies (NAMs); in silico; in vitro; in vivo; in chemico; drug discovery; computational modeling; artificial intelligence (AI); high-throughput screening (HTS); high-throughput imaging (HTI); bioassay; omics; cell cultures; tissue engineering; organ engineering; therapeutic target; mechanism of drug action

(This special issue belongs to the Section Molecular Pharmacology)

Cardiomyocytes Among Physiology and Pathophysiology: Molecular Insights and Therapeutic Implications

edited by Rosetta Ragusa and

Chiara Caselli

submission deadline 31 Jan 2026 | 2 articles | Viewed by 584 | Submission Open

Keywords: sarcomere; metabolic stress; epigenetic mechanisms; exercise; aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Fibrosis and Oral Cancers: From Molecular Targets to Therapeutics

edited by Ila Pant

submission deadline 31 Jan 2026 | Viewed by 575 | Submission Open

Keywords: OSF; oral cancer; myofibroblast activation; collagen homeostasis; cancer stem cells; immunotherapy; monoclonal antibodies; DNA or RNA based targeted therapy; small molecule inhibitors; targeted nano-delivery systems; resistance to targeted therapies; molecular targets; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Medicinal Plants and Natural Products: Second Edition

edited by

Teresa Leszczyńska

Barbara Borczak

and

Joanna Kapusta-Duch

submission deadline 31 Jan 2026 | 1 articles | Viewed by 552 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in the Pathophysiology and Therapy of Cerebral Gliomas

edited by

Placido Bruzzaniti

submission deadline 31 Jan 2026 | 1 articles | Viewed by 496 | Submission Open

Keywords: mutant IDH1 3; EVs; Ki67; HSV1-TK; glioma; lipid vesicles; viral vectors; ATRX; EGFR; IDH1; MGMT; 1p/19q codeletion

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Recent Research in Composite Materials

edited by Aboulfazl Barati

submission deadline 31 Jan 2026 | Viewed by 473 | Submission Open

Keywords: composite materials; molecular-level structure– property relationships; polymer nanocomposites; interfacial interactions; sustainable and biodegradable composites; hybrid organic– inorganic systems

(This special issue belongs to the Section Materials Science)

Advances in Melanoma Immunotherapy and Molecular Mechanisms of Drug Resistance, Second Edition

edited by Antonino Guerrisi and

Italia Falcone

submission deadline 31 Jan 2026 | Viewed by 468 | Submission Open

Keywords: melanoma; targeted therapy; immunotherapy; precision medicine; biomarkers; omics technologies; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

New Advances in Functional Nanomaterials, Nanomedicines and Biosensors Based on Nucleic Acids

edited by

Yuancong Xu

and Peng Cao

submission deadline 31 Jan 2026 | 1 articles | Viewed by 398 | Submission Open

Keywords: nucleic acids; functional nanomaterials; nanomedicine; biosensors; DNA nanotechnology; delivery systems; self-assembly; biomedical imaging; clinical applications; diagnostics

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 31 Jan 2026 | Viewed by 304 | Submission Open

Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics; metabolomics; proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Brain Tumor Research and Treatment

edited by

Daniele Armocida

and

Davide Barbagallo

submission deadline 31 Jan 2026 | Viewed by 283 | Submission Open

Keywords: brain tumor; gliomas; brain metastases; translational research; molecular biology

(This special issue belongs to the Section Molecular Oncology)

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 31 Jan 2026 | Viewed by 262 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biochemistry)

Advances in Research of Estrogen Receptors in Health and Diseases

edited by

Maciej Iek Skrzypczak

submission deadline 31 Jan 2026 | Viewed by 238 | Submission Open

Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders

(This special issue belongs to the Section Biochemistry)

Macrophage Metabolic Reprogramming in Inflammation

edited by

Ricardo Sánchez-Rodríguez

and

Roberta Angioni

submission deadline 31 Jan 2026 | Viewed by 234 | Submission Open

Keywords: inflammation; immunometabolism; metabolic rewiring; glycolysis; krebs cycle; glutaminolysis; innate immune response; macrophages

(This special issue belongs to the Section Molecular Immunology)

Emerging Therapeutic Potential of Organic Compound in Diseases

edited by

Katarzyna Kotwica-Mojzych

submission deadline 31 Jan 2026 | Viewed by 230 | Submission Open

Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Health-Promoting Benefits of Natural Products and Functional Foods, 2nd Edition

edited by

Emad Al-Dujaili

submission deadline 31 Jan 2026 | Viewed by 209 | Submission Open

Keywords: natural products; functional foods; health promotion; nutrigenomics; evidence-based preventive healthcare; phytochemicals; biomarkers; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Long COVID Biology and Epidemiology: Predisposition, Molecular Mechanisms and Diagnostics

edited by Eduardo José Melo dos Santos

submission deadline 31 Jan 2026 | Viewed by 207 | Submission Open

Keywords: long COVID; genetic predisposing; long COVID epidemiology; pathogenesis; immunology of long COVID; long COVID etiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Angiogenesis Research: From Novel Compounds to Mechanistic Insights and Therapeutic Strategies

edited by Juliana Luporini Dreyfuss

submission deadline 31 Jan 2026 | Viewed by 201 | Submission Open

Keywords: angiogenesis; vascular endothelial growth factor (VEGF); novel compounds; endothelial cells; drug development; advanced molecular biology; omics technologies; innovation

(This special issue belongs to the Section Molecular Biology)

Natural Products and Compounds in Anticancer Drug Discovery

edited by

Diana I. Ivanova

submission deadline 31 Jan 2026 | Viewed by 196 | Submission Open

Keywords: antitumor plant compounds; antitumor plant-derived products; cellular pathways for natural drug apoptosis induction; chromatography of antitumor plant metabolites; modern technologies for recovery of plant anticancer substances; nanotechnology based natural anticancer drug products; plant-derived antitumor drug-protein interactions

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Animal Nutrition and Muscle Biology

edited by Usuk Jung

submission deadline 31 Jan 2026 | Viewed by 195 | Submission Open

Keywords: animal nutrition; metabolic regulation; molecular biology; molecular mechanisms; skeletal muscle; intramusculuar fat; skeletal muscle fibrosis

(This special issue belongs to the Section Molecular Biology)

The Placental Barrier: From Fundamental Mechanisms to Clinical Implications

edited by

Ricardo Emilio Fretes

and María I. De La Calle

submission deadline 31 Jan 2026 | Viewed by 191 | Submission Open

Keywords: placental barrier; maternal– fetal interface; pregnancy pathologies; vertical transmission

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Peripheral Nerve Regeneration—2nd Edition

edited by

Cinzia Fabrizi

submission deadline 31 Jan 2026 | Viewed by 188 | Submission Open

Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth

(This special issue belongs to the Section Molecular Neurobiology)

Unraveling Cell–Cell and Cell–Matrix Interactions: Novel Morphological and Molecular Insights

edited by

José Freni

submission deadline 31 Jan 2026 | Viewed by 180 | Submission Open

Keywords: DGC; sarcoglycans; cell– cell interactions; cell– matrix interactions; morphological analysis; molecular analysis; molecular pathogenesis; translational studies

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Supramolecular Structure

edited by Massoud Kaykhaii

submission deadline 31 Jan 2026 | Viewed by 178 | Submission Open

Keywords: supramolecular chemistry; molecular self-assembly; host– guest interactions; molecular recognition; non-covalent interactions; dynamic supramolecular systems; stimulus-responsive materials; nanostructures; supramolecular therapeutics; structural characterization

(This special issue belongs to the Section Materials Science)

3D Scaffolds for Tissue Engineering: Challenges and Breakthroughs

edited by

Akkouch Adil

submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open

Keywords: 3D scaffolds; tissue engineering; biomaterials

(This special issue belongs to the Section Materials Science)

Nutrition from Cereal Foods: Molecular Perspectives

edited by

Yakindra Timilsena

submission deadline 31 Jan 2026 | Viewed by 174 | Submission Open

Keywords: cereal nutrition; molecular bioavailability; plant proteins; foodomics; grain processing; bioactive compounds; gut microbiome; nutraceuticals; food matrices; sustainable foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Cardiac Repairs and Regeneration

edited by William C.W. Chen

submission deadline 31 Jan 2026 | Viewed by 174 | Submission Open

Keywords: cardiac regeneration; cardioprotection; molecular cardiology; regenerative signaling pathways; metabolic reprogramming; protein quality control; post‑translational modifications; single‑cell and spatial omics; multi-omics; CRISPR‑based genome and epigenome editing; high‑resolution molecular imaging; synthetic and systems biology; artificial intelligence and machine learning

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tau Pathology Mechanisms and Therapeutic Interventions

edited by

Claudia Marino

submission deadline 31 Jan 2026 | Viewed by 173 | Submission Open

Keywords: tau; misfolding; neurodegeneration; Alzheimer’ s disease; oligomer; tauopathies; therapies; hyperphorphorylation; frontotemporal lobe dementia; synapses; spreading

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Host–Oral Bacterial Interaction in Periodontal Pathogenesis

edited by Felice Roberto Grassi

submission deadline 31 Jan 2026 | Viewed by 173 | Submission Open

Keywords: periodontitis; oral microbiome; host– pathogen interaction; inflammation; dysbiosis; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Technologies in Musculoskeletal Research: From Molecular Mechanisms to Translational Innovation

edited by

Javad Tavakoli

submission deadline 31 Jan 2026 | Viewed by 170 | Submission Open

Keywords: musculoskeletal tissue; cell mechanobiology; biofabrication; tissue regeneration; organ-on-a-chip; disease mechanism and screening; molecular and cellular diagnostics; AI and machine learning; omics technology; wearable technologies; implant technologies; biomarkers; predictive modelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights and Therapeutic Advances in Cerebral and Spinal Tumors

edited by

Alexandru Vladimir Ciurea

submission deadline 31 Jan 2026 | Viewed by 169 | Submission Open

Keywords: central nervous system tumors; molecular oncology; gliomas and spinal cord neoplasms; targeted therapy and precision medicine; neuro-oncology biomarkers; tumor microenvironment; immunotherapy; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Stress-Related Disorders and Depression: From Molecular Basis to Therapy (3rd Edition)

edited by

Irena Nalepa

and

Agnieszka Zelek-Molik

submission deadline 31 Jan 2026 | Viewed by 169 | Submission Open

Keywords: psychobiology of stress; depression; posttraumatic stress disorder; anxiety disorders; animal models; biogenic monoamines; glucocorticoids; inflammation; antidepressant and anxiolytic drugs

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Research on Immune Cells and Cytokines (3rd Edition)

edited by

Athanasia Mouzaki

submission deadline 31 Jan 2026 | Viewed by 168 | Submission Open

Keywords: immune cells; cytokines; immunomodulatory treatments; immune diseases; immune system

(This special issue belongs to the Section Molecular Immunology)

Nanomedicine for Cancer Diagnosis and Therapy

edited by

Suresh Thangudu

submission deadline 31 Jan 2026 | Viewed by 168 | Submission Open

Keywords: nanomaterials; multifunctional properties; anticancer nanotechnology; image guided nano platforms; in vivo evaluation; delivery approaches; immune-nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Genetics, Epigenetics and Genomics of Neurodegenerative Diseases

edited by

Simone Agostini

submission deadline 31 Jan 2026 | Viewed by 166 | Submission Open

Keywords: epigenetics; microRNA; genetics; genomics; methylation; histone modification; neurodegenerative diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Pathways and Pathogenesis in Orthopedic Diseases

edited by

Angelos Kaspiris

and

Elias Vasiliadis

submission deadline 31 Jan 2026 | Viewed by 166 | Submission Open

Keywords: intracellular interactions during fracture healing; molecular signaling of degenerative orthopedic diseases; growth factor expression in musculoskeletal disorders and deformities; pathophysiology of primary bone tumors and metastasis; clinical and molecular basis of orthopedic infections; biomarkers; molecular-driven treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Horizons in Structure and AI-Based Drug Design

edited by

Huiyong Sun

submission deadline 31 Jan 2026 | Viewed by 159 | Submission Open

Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms in Postharvest Biology

edited by

Kangdi Hu

submission deadline 31 Jan 2026 | Viewed by 158 | Submission Open

Keywords: postharvest biology; fruit ripening; senescence; stress tolerance; disease resistance; molecular biology; gene regulatory networks; genomics; synthetic biology; nanotechnology; controlled atmosphere; biostimulants

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Regulation of Glycoproteins in Cancer Biology

edited by

Josiah Ochieng

submission deadline 31 Jan 2026 | Viewed by 154 | Submission Open

Keywords: glycoprotein; metastasis; glycosylation; tumor progression

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Aquatic Animal Reproduction, Breeding Strategies and Genetic Improvement

edited by

Jixing Zou

submission deadline 31 Jan 2026 | Viewed by 152 | Submission Open

Keywords: reproductive biology; aquaculture genetics; fish breeding; genomic selection; marker-assisted selection; genome editing; hybridization; genetic improvement; molecular breeding; sustainable animal production

(This special issue belongs to the Section Molecular Biology)

Therapeutic Advances in Vaccines

edited by Dorota Kopciuch

submission deadline 31 Jan 2026 | Viewed by 139 | Submission Open

Keywords: therapeutic vaccines; mRNA vaccines; DNA-based vaccines; viral vector vaccines; protein-based vaccines; peptide vaccines; personalized cancer vaccines; antigen persistence; immune activation mechanisms

(This special issue belongs to the Section Molecular Immunology)

New Insights into the Tumor Microenvironment of Pleural Mesothelioma and Opportunities for Novel Treatments

edited by

Marcella Barbarino

submission deadline 31 Jan 2026 | Viewed by 139 | Submission Open

Keywords: mesothelioma; tumor-associated stromal cells; immunotherapy; tumor microenvironment; cancer-associated fibroblast; mesenchymal stem cells; endothelial cells; cancer-associated adipocytes

(This special issue belongs to the Section Molecular Oncology)

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