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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Brain-Body Interactions in Mental Disorders: Molecular Mechanisms and Therapeutics
edited by Yan-Xue Xue
submission deadline 20 Feb 2026 | 1 articles | Viewed by 5199 | Submission Open
Keywords: mental disorders; brain– body interactions; neural mechanisms; therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Cervical Cancer and Its Therapy
edited by Ilaria Cuccu and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 5158 | Submission Open
Keywords: cervical cancer; cervical cancer surgery; fertility-sparing techniques; targeted therapy; immunotherapy; immune checkpoint inhibitors; DNA damage repair inhibitors; antibody– drug conjugates; precision medicine; oncological outcomes
(This special issue belongs to the Section Molecular Oncology)
Drug Therapy of Systemic Lupus Erythematosus
edited by Dionysis Nikolopoulos
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5131 | Submission Open
Keywords: systemic lupus erythematosus; treatment; drugs; tailored strategies; precision medicine; biologics; cell therapy; randomized clinical trials
(This special issue belongs to the Section Molecular Pharmacology)
Osteoimmunology: Interactions of the Bone and Immune System submission deadline 20 Feb 2026 | 1 articles | Viewed by 5113 | Submission Open
Keywords: osteoimmunology markers; bone infection; inflammation and bone; immune response and bone; diagnostic and prognostic markers; bone remodeling; osteoclasts; immune-mediated bone diseases; bone– immune interface
(This special issue belongs to the Section Molecular Immunology)
Microbiome-Immunity Crosstalk and Its Role in Health and Disease
edited by and Sara Uceda
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5076 | Submission Open
Keywords: gut microbiota; immune system; nutrition; inflammatory processes; dysbiosis; neurodegenerative diseases
(This special issue belongs to the Section Molecular Microbiology)
Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers submission deadline 20 Feb 2026 | 5 articles | Viewed by 5075 | Submission Open
Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Osteoarthritis Pathways and Biomarker Research
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 4889 | Submission Open
Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus—Second Edition
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4830 | Submission Open
Keywords: systemic lupus erythematosus; lupus nephritis; neuropsychiatric lupus; autoimmunity; biomarkers; B lymphocyte; interferons
(This special issue belongs to the Section Molecular Immunology)
CRISPR/Cas Systems and Genome Editing—3rd Edition
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4776 | Submission Open
Keywords: CRISPR/Cas; bacterial argonauts; transcription regulation; genome editing; genome editing tools
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research on Micropollutants in Various Enviroments
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4772 | Submission Open
Keywords: airborne microorganisms; antibiotics; antibiotic resistance; circular economy of water; environmental bacteria and fungi; wastewater treatment; waterborne microorganisms; water quality
(This special issue belongs to the Section Molecular Toxicology)
Molecular and Cellular Aspects of Breast Cancer Metastasis
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4667 | Submission Open
Keywords: precision medicine; omics-based discovery research (genomics; proteomics; transcriptomics; and radiomics); non-invasive test; liquid biopsy; first-in-class medications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4567 | Submission Open
Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules
(This special issue belongs to the Section Molecular Oncology)
Aging: From Molecular Mechanisms and Pathophysiology to Novel Therapeutic Approaches (3rd Edition) submission deadline 20 Feb 2026 | 5 articles | Viewed by 4522 | Submission Open
Keywords: human aging; molecular clock; aging genes; epigenetics; nutrigenomics; inflammaging; stem cells; telomeres; mitochondria; brain-gut axis; brain-muscle axis; gut microbiota; chronodisruption
(This special issue belongs to the Section Molecular Biology)
Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4482 | Submission Open
Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Progress in the Use of Graphene and Graphene-Like Materials in Various Applications
edited by Piotr Kamedulski
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4449 | Submission Open
Keywords: graphene; porous carbons; carbon-based materials; 3D graphene; graphene exfoliation; nanotubes; nanomaterials; N-rich nano-porous carbon matrixes; N-rich activated carbons; carbon molecular sieves; hybrid materials; medical applications
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Targeted Regulation of Autoimmune Diseases
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4383 | Submission Open
Keywords: autoimmunity; autoimmune diseases; multiple sclerosis; rheumatoid arthritis; lupus; type 1 diabetes; inflammatory bowel disease; biomarkers; immune cells; signaling molecules
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Resistology: A New Approach in the Fight Against Antimicrobial Resistance
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4364 | Submission Open
Keywords: antimicrobial resistance; resistology; ESBL; AmpC; carbapenem resistance; one health
(This special issue belongs to the Section Molecular Pharmacology)
Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4249 | Submission Open
Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Environmental Contributors to Oxidative Stress: Mechanisms and Effects
edited by Halina Tkaczenko and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4177 | Submission Open
Keywords: oxidative stress; environmental pollution; climate change; antioxidants; biological effects; toxicology; health risks; reactive oxygen species (ROS); public health; mitigation strategies; cellular damage in human and animal disorders; environmental stressors in human and animal health
(This special issue belongs to the Section Molecular Biology)
Advances in Stem Cell-Based Regenerative Medicine for Renal Disorders
edited by In-Yong Kim
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4140 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; stem cells; regenerative medicine; stem cell therapy; cellular reprogramming; cell transplantation
(This special issue belongs to the Section Molecular Biology)
Molecular Associations Between Adipose Tissue and Diseases submission deadline 20 Feb 2026 | 2 articles | Viewed by 4115 | Submission Open
Keywords: lipedema; adipose tissue; adipocyte; adipose organ; body fat; miRNA; ketogenic diet
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Forensics and the Genetic Foundations of Forensic Biology
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4093 | Submission Open
Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms Study of Functional Foods and Nutrients in Human Health Interventions
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4081 | Submission Open
Keywords: functional foods; molecular mechanisms; nutrient bioavailability; chronic disease prevention; health interventions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Biology of Periodontal Disease and Periodontal Pathogens
edited by Yago Leira and
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4017 | Submission Open
Keywords: periodontitis; general medicine; inflammation; bacteraemia; education
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Neuroscience: Molecular Biological Insights
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4012 | Submission Open
Keywords: neurodegenerative diseases; neurodevelopmental disorders; neurohiv; drug abuse; neuropharmacology; epigenetics; exosomes; inflammasomes; biomarkers; gene therapy; stem cell therapy; deep brain stimulation; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; autism spectrum disorder; ADHD; dyslexia; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Erythrocyte Cell Death: Molecular Insights
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3976 | Submission Open
Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death
(This special issue belongs to the Section Molecular Biology)
The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer submission deadline 20 Feb 2026 | 2 articles | Viewed by 3964 | Submission Open
Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Developments in Glioblastoma Research and Therapy: 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 3907 | Submission Open
Keywords: diagnostic; prognostic and predictive biomarkers of glioblastoma; ways to target glioma stem cells; targeting glioblastoma-related signaling pathways; epigenetics of glioblastoma; treatment resistance mechanisms; novel treatment options for glioblastoma; combinatorial therapies; immunotherapy; nanotherapy; the application of CRISPR/Cas9 in glioma research; molecular testing of long-term glioblastoma survivors
(This special issue belongs to the Section Molecular Neurobiology)
Crop Stress Biology and Molecular Breeding: 5th Edition
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3846 | Submission Open
Keywords: biotic and abiotic stress; variety improvement; crop stress biology; molecular breeding; biological basis; signal transduction pathway; agronomic traits; excellent germplasm
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Adsorbing Materials
edited by Mounia Achak
submission deadline 20 Feb 2026 | 4 articles | Viewed by 3825 | Submission Open
Keywords: adsorption process; adsorbing materials; bio-based adsorbents; regeneration and reusability; pollutant removal; wastewater treatment; industrial and environmental applications
(This special issue belongs to the Section Materials Science)
Molecular Studies of Bone Biology and Bone Tissue: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 3820 | Submission Open
Keywords: bone; stem cells; immunomodulation; biomaterials; bone regeneration; bone repair; bone diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Redox Systems in Humans, Animals, Plants and Aquatic Ecosystems and Their Microbiomes submission deadline 20 Feb 2026 | 1 articles | Viewed by 3749 | Submission Open
Keywords: redox systems; aging and disease; nutraceuticals; probiotics; animals; plants; aquatic ecosystems; microbiomes
(This special issue belongs to the Section Molecular Biology)
Acute Kidney Injury: Molecular Mechanism and Targeted Therapeutic Approaches
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3533 | Submission Open
Keywords: kidney injury; repair; immunoresponse; biomarker; targeted therapy; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Member's Collection Series: The Memory of the Immune Cells submission deadline 20 Feb 2026 | 2 articles | Viewed by 3510 | Submission Open
Keywords: immunological memory; innate immune memory; dendritic cells; natural killer cells; macrophage memory
(This special issue belongs to the Section Molecular Immunology)
Drug-Induced Neurotoxicity and Neurodegeneration: Mechanisms, Models and Implications submission deadline 20 Feb 2026 | 2 articles | Viewed by 3505 | Submission Open
Keywords: drugs of abuse; pharmaceutical drugs; environmental toxins; drug exposure; neurotoxicity; neurodegeneration; brain health; substance use disorders; therapeutic interventions; in vivo models; in vitro models; in silico models; biomarkers of damage; translational studies
(This special issue belongs to the Section Molecular Neurobiology)
Intestinal 3D Culture, Organoids and Gut-on-Chip in Intestinal Disorders submission deadline 20 Feb 2026 | 2 articles | Viewed by 3475 | Submission Open
Keywords: 3D cultures; gut-on-chip; intestinal organoids; spheroids; organotypic cultures; morphological studies; pharmacological studies; intestinal cancer; inflammatory bowel disease; intestinal functional disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathophysiological Insights, Biomarkers and New Therapeutic Strategies in Immune-Mediated Disorders and Neurodegenerative Diseases
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3432 | Submission Open
Keywords: neurodegeneration; neuroimmunology; inflammation; biomarkers; treatment; pathophysiology; multiple sclerosis; myasthenia gravis; neurodegenerative disease
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Phytochemicals in Antioxidation, Antimicrobial, and Cytoprotective Properties
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3421 | Submission Open
Keywords: phytochemicals; antioxidant; antimicrobial; cytoprotective; in vitro screening; in vivo evaluation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Micro(nano) Plastics as Endocrine Disruptors in Human Diseases submission deadline 20 Feb 2026 | 1 articles | Viewed by 3416 | Submission Open
Keywords: micro(nano) plastics; estrogens; endocrine disruptors; female reproductive system; breast; colon
(This special issue belongs to the Section Molecular Biology)
Zebrafish: A Model Organism for Human Health and Disease: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3391 | Submission Open
Keywords: zebrafish; drug discovery; high-throughput screens; genome editing/CRISPR mutants; cancer; neuronal disorders; drug toxicity; drug effect mechanisms; developmental disorders
(This special issue belongs to the Section Molecular Biology)
Advanced Molecular Research in Brain Tumors
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3360 | Submission Open
Keywords: targeted therapy; blood– brain barrier; GBM; glioma; immune checkpoint blockers; TME
(This special issue belongs to the Section Molecular Oncology)
Molecular Research and Applications of Nanomaterials
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3324 | Submission Open
Keywords: molecular research; application; functionality of nanomaterials; catalysis; environmental science
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition
edited by , María José Cuevas-González and Chun-Jung Huang
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3202 | Submission Open
Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Immune Response to Virus Infection and Vaccines
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3140 | Submission Open
Keywords: immunogenicity; emerging pathogen vaccination; molecular and cellular determinants of vaccine responses in immunocompromised individuals; predictive markers of immune response; laboratory methods to dissect immune responses to infections and vaccinations
(This special issue belongs to the Section Molecular Immunology)
Exploring the Genetics in Rare Diseases: A Genomic Odyssey
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3079 | Submission Open
Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders
edited by Massimiliano M. Corsi Romanelli and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3044 | Submission Open
Keywords: atherosclerosis; angiotensin; endothelial cell; inflammation; biomarkers; gLP-1; sT-2
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advancing Liver Health: State of the Art and Recent Research Advances
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3036 | Submission Open
Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Towards Complex Molecular Cancer Therapies
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2998 | Submission Open
Keywords: precision medicine; immune system harnessing; targeted therapies TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Heart Failure: From Bench to Bedside
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2945 | Submission Open
Keywords: heart failure; cardiac biomarkers; medical therapy; molecular pathways; prognosis; target therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nucleic Acid Recognition and Pharmaceutical Ligand Design submission deadline 20 Feb 2026 | 1 articles | Viewed by 2936 | Submission Open
Keywords: nucleic acid recognition; ligand design; analytical techniques; computational chemistry; therapeutics
(This special issue belongs to the Section Macromolecules)
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