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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Polygenic Risk Scores for Complex Traits in the Genome-Wide Association Study (GWAS) Era
edited by
submission deadline 29 Apr 2024 | 1 articles | Viewed by 803 | Submission Open
Keywords: precision medicine; genetic; gene– gene; gene– environment
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Molecular Dynamics Simulation of Chemical and Biomedical Systems submission deadline 29 Apr 2024 | 1 articles | Viewed by 478 | Submission Open
Keywords: molecular dynamics simulation; chemical and biomedical systems; molecular-level processes; protein structures; drug binding mechanisms; biomolecular behavior; drug design; biomedicine materials
(This special issue belongs to the Section Molecular Informatics)
Synthesis and Applications of Photoactive Molecules and Photovoltaic Materials submission deadline 29 Apr 2024 | Viewed by 254 | Submission Open
Keywords: photochemistry; chromophores; light-activated systems; donor– acceptor structures; covalent and noncovalent chemistry; solar cells
(This special issue belongs to the Section Materials Science)
The Human Fetal Membranes: A Versatile Tissue Important for Pregnancy Health and Regenerative Therapies
edited by Claire E. Kendal-Wright and Lauren Richardson
submission deadline 29 Apr 2024 | Viewed by 248 | Submission Open
Keywords: fetal membranes; tissue strength; inflammation; parturition; preterm premmature rupture of the membrane (PPROM); infection; stem cells; regenerative surgery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Physiological Benefits of Dietary Selenium
edited by and Hugh Harris
submission deadline 29 Apr 2024 | Viewed by 221 | Submission Open
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Materials for Emerging Solar Cells
edited by and Francesco Pattini
submission deadline 29 Apr 2024 | Viewed by 208 | Submission Open
Keywords: photovoltaics; materials; solar cells; perovskite; thin film; efficiency; electrical characterization; absorber; transparent conductive oxide; charge transport layer
(This special issue belongs to the Section Materials Science)
The Role of Metals in Biomedicine: Diagnosis and Therapy
edited by
submission deadline 29 Apr 2024 | Viewed by 200 | Submission Open
Keywords: synthesis of basic metal compounds and bioactives metal nano-objects; biomedical applications; metal-based biosensors; biocatalysis delivers; metal-based drugs; nanomedicine; metal toxicity
(This special issue belongs to the Section Biochemistry)
New Aspects of Bioenergetics in Cancer
edited by
submission deadline 29 Apr 2024 | Viewed by 192 | Submission Open
Keywords: cancer metabolism; bioenergetics; mitochondria; redox
(This special issue belongs to the Section Molecular Oncology)
The Application of Nanoparticles in Biomedicine
edited by
submission deadline 29 Apr 2024 | Viewed by 145 | Submission Open
Keywords: nanoparticle; nanomaterial; biomedicine; imaging; therapy; contrast agent; therapeutic agent
(This special issue belongs to the Section Molecular Nanoscience)
Biochemical Insight into Skin Regeneration and Inflammation
edited by
submission deadline 29 Apr 2024 | Viewed by 132 | Submission Open
Keywords: skin regeneration; inflammation; extracellular matrix in wound healing; cell proliferation; self-renewal and differentiation
(This special issue belongs to the Section Molecular Biology)
Molecular Insight on Nanoparticle Toxicity
edited by Fátima Brandão
submission deadline 29 Apr 2024 | Viewed by 122 | Submission Open
Keywords: nanoparticles; toxicity; mechanisms; safe-by-design; molecular pathways; 3R principles
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Biology of Sulfatase
edited by
submission deadline 29 Apr 2024 | Viewed by 114 | Submission Open
Keywords: chondroitin sulfatases; sulfotransferases; steroid; tyrosine; and other sulfatases; metabolic pathways affected by sulfation; impact of changes in sulfation on disease
(This special issue belongs to the Section Molecular Biology)
Strategies to Counteract Oxidative Stress and Inflammation in Chronic-Degenerative Diseases 3.0 submission deadline 29 Apr 2024 | Viewed by 106 | Submission Open
Keywords: chronic-degenerative diseases; oxidative stress; inflammation; nutrition; nutraceuticals; stem cell therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Novel Biological Molecules for Cancer Treatments 2.0
edited by
submission deadline 30 Apr 2024 | 16 articles | Viewed by 23579 | Submission Open
Keywords: cancer treatment; cancer biology; biological molecule; cancer cell; new molecules or antibodies
(This special issue belongs to the Section Molecular Biology)
Biomechanics and Molecular Research on Glioblastoma
edited by
submission deadline 30 Apr 2024 | 9 articles | Viewed by 19220 | Submission Open
Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Trends in Neuroscience: From Molecular Mechanisms to Innovative Therapeutics submission deadline 30 Apr 2024 | 15 articles | Viewed by 17750 | Submission Open
Keywords: neurodevelopment; neurodegeneration; cognitive capacities; invertebrate and vertebrate ani-mals; transcriptomic analysis; proteomic analysis; genetic and epigenetic factors; signalling pathways; bioinformatics; neuroengineering
(This special issue belongs to the Section Molecular Neurobiology)
Microbiota and Cancer 3.0 submission deadline 30 Apr 2024 | 8 articles | Viewed by 17381 | Submission Open
Keywords: gut microbiota; cancer; hematopoietic stem cell transplantation; human microbiome; immune system; colon cancer; carcinogenesis; nutrition; short-chain fatty acids; metagenomic; dysbiosis
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Therapies of Myeloid Leukaemia 2.0
edited by
submission deadline 30 Apr 2024 | 8 articles | Viewed by 16675 | Submission Open
Keywords: acute leukaemia; myeloid leukaemia; paediatric leukaemia; adult leukaemia; targetted therapy; antigens
(This special issue belongs to the Section Molecular Oncology)
Genetic Variations in Human Diseases
edited by
submission deadline 30 Apr 2024 | 16 articles | Viewed by 14112 | Submission Open
Keywords: polymorphism; mutation; length variation; functional analysis; association study; monogenic disorders; complex disorders
(This special issue belongs to the Section Molecular Genetics and Genomics)
Developmental Biology: Computational and Experimental Approaches submission deadline 30 Apr 2024 | 11 articles | Viewed by 13957 | Submission Open
Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations; fertilization; zygote; cell cycle; stem cell; meristem; cell layer; tissue; embryo; multicellular organism; ontogenesis; morphogenesis; life cycle; molecular mechanism; signal transduction; gene regulation; gene-networks; cellular process; differentiation; migration; segmentation; high-resolution 3D-map; real-time in silico simulator; developmental hourglass; transcriptome ontogenetic switch; developmental abnormality; premature aging; neurodegeneration; tumorigenesis; atherogenesis; autoimmunity; induced pluripotent cell; wound healing; regeneration; assisted reproductive technologies; epigenetic reprogramming; predictive preventive personalized participatory (4P) medicine
(This special issue belongs to the Section Molecular Biology)
Insights in Multiple Sclerosis (MS) and Neuroimmunology
edited by
submission deadline 30 Apr 2024 | 9 articles | Viewed by 13854 | Submission Open
Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis
(This special issue belongs to the Section Molecular Immunology)
Roles and Function of Extracellular Vesicles in Diseases 2.0
edited by
submission deadline 30 Apr 2024 | 8 articles | Viewed by 12484 | Submission Open
Keywords: extracellular vesicle; exosome; disease; roles and function
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Extracellular Vesicles and Nanoparticles
edited by
submission deadline 30 Apr 2024 | 7 articles | Viewed by 11810 | Submission Open
Keywords: extracellular vesicles; exosomes; bacterial toxins; viruses; biomarkers; signal transduction; targeted therapy; exososmes in cancer; exosomes and extracellular vesicles host-pathogen interaction; extracellular vesicles of gram positive bacteria; extracellular vesicles of gram negative bacteria; extracellular vesicles and biofilm formation
(This special issue belongs to the Section Biochemistry)
Diabetes: From Molecular Basis to Therapy
edited by
submission deadline 30 Apr 2024 | 6 articles | Viewed by 11666 | Submission Open
Keywords: diabetes; obesity; autoimmunity; insulin resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Plant Abiotic Stress Tolerance
edited by
submission deadline 30 Apr 2024 | 10 articles | Viewed by 11589 | Submission Open
Keywords: acclimation; drought; salinity; pesticides; high– low temperature; high– low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in the Physiology of Primary and Secondary Plant Metabolism under Abiotic and Biotic Stress submission deadline 30 Apr 2024 | 9 articles | Viewed by 11471 | Submission Open
Keywords: in vitro plant cultures; plants; abiotic stress (drought; heat; salinity; cold; flooding); biotic stress (bacteria; viruses; fungi; parasites; insects; weeds); physiological/biochemical stress responses; oxidative stress; genes and proteins; breeding and agronomy; primary components (carbohydrates; lipids; proteins); secondary components (polyphenols; terpenoids; alkaloids); metabolome; proteome
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Compounds from Natural Products for the Prevention and Treatment of Chronic Diseases 2.0
edited by
submission deadline 30 Apr 2024 | 9 articles | Viewed by 10933 | Submission Open
Keywords: natural products; natural products isolation; bioactive natural compounds; inflammation; neurodegenerative diseases; skin diseases; cancer; metabolic syndrome; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Deep Learning in Bioinformatics and Biological Data Analysis
edited by
submission deadline 30 Apr 2024 | 7 articles | Viewed by 10434 | Submission Open
(This special issue belongs to the Section Molecular Informatics)
Advances of Plant Aquaporins submission deadline 30 Apr 2024 | 5 articles | Viewed by 9588 | Submission Open
Keywords: plant aquaporins; cellular localisations; transport selectivity; cellular functions lipid environmental; gating; expression and subcellular trafficking
(This special issue belongs to the Section Molecular Plant Sciences)
Plant Responses to Heavy Metals: From Deficiency to Excess submission deadline 30 Apr 2024 | 9 articles | Viewed by 9440 | Submission Open
Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis
(This special issue belongs to the Section Molecular Plant Sciences)
Polyamines in Aging and Disease submission deadline 30 Apr 2024 | 6 articles | Viewed by 9437 | Submission Open
Keywords: polyamines; bioactive amines; aging; senility; old people; spermine; spermidine; polyamine metabolism; polyamine oxidase; polyamine analogues; metabolic diseases in the elderly
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus submission deadline 30 Apr 2024 | 7 articles | Viewed by 9274 | Submission Open
(This special issue belongs to the Section Molecular Immunology)
New Targeted Therapies in Cancer-2024
edited by
submission deadline 30 Apr 2024 | 6 articles | Viewed by 9162 | Submission Open
Keywords: targeted therapy; personalized medicine; side effects; molecular targets; cancer treatment; mutations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Kinase in Disease submission deadline 30 Apr 2024 | 6 articles | Viewed by 9074 | Submission Open
Keywords: protein kinases; phosphorylation; cancers; inflammatory diseases; protein kinase inhibitors; anticancer drugs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathogenesis of Diseases of the Central Nervous System 2.0
edited by and Beatriz Bermudez
submission deadline 30 Apr 2024 | 5 articles | Viewed by 9069 | Submission Open
(This special issue belongs to the Section Molecular Neurobiology)
Cells and Molecules in Bone Remodeling and Repair
edited by
submission deadline 30 Apr 2024 | 3 articles | Viewed by 8972 | Submission Open
Keywords: osteoblast; osteoclast; mesenchymal stem cell; hematopoietic stem cell; bone remodeling; bone repair; bone pathophysiology; bone microenvironment
(This special issue belongs to the Section Molecular Biology)
Skeletal Muscle Function and Metabolism: Molecular Mechanisms and Treatment
edited by
submission deadline 30 Apr 2024 | 6 articles | Viewed by 8928 | Submission Open
Keywords: skeletal muscle; metabolism; mitochondria; epigenetics; exercise; signalization
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Central and Local Modulators of Reproduction and Fertility: An Update 3.0 submission deadline 30 Apr 2024 | 8 articles | Viewed by 8637 | Submission Open
Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular and Therapeutic Research in Rheumatoid Arthritis submission deadline 30 Apr 2024 | 9 articles | Viewed by 8462 | Submission Open
Keywords: rheumatoid arthritis; inflammation; cytokines; autoimmunity; microRNAs
(This special issue belongs to the Section Molecular Immunology)
Lipid Metabolism and Signaling in Tumors and Cerebrovascular Diseases 2.0 submission deadline 30 Apr 2024 | 4 articles | Viewed by 8134 | Submission Open
Keywords: lipids; sphingolipids; phospholipids; cholesterol; fatty acids; solid tumors; hematological tumors; cerebrovascular diseases
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Application of Advanced Molecular Methods to Study Infections 2.0 submission deadline 30 Apr 2024 | 8 articles | Viewed by 8014 | Submission Open
Keywords: molecular epidemiology; genotyping; novel screening and diagnostic methods; epidemic tracing through molecular characterization; next-generation sequencing; metagenomics; molecular ecology and evolution of microbes; molecular mechanisms of pathogenicity; mechanisms of pathogen-host interactions; infectious disease emergence; cross-species transmission; phylogeny; phylodynamics; microbiome/virome/infectome
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Animal Toxins, Venoms and Antivenoms 2.0 submission deadline 30 Apr 2024 | 5 articles | Viewed by 7963 | Submission Open
Keywords: venom; toxin; antitoxin; antivenom; neurotoxin; cytotoxin; hemotoxin; conotoxin; snake; scorpion; spider
(This special issue belongs to the Section Molecular Toxicology)
Immunotherapy for Cancer 2023
edited by and Donald J. Buchsbaum
submission deadline 30 Apr 2024 | 4 articles | Viewed by 7800 | Submission Open
Keywords: cancer immunotherapy; immunotherapy; photothermal therapy; immunomodulators; drug delivery
(This special issue belongs to the Section Molecular Immunology)
Organic Compounds: Design, Synthesis and Biological Application
edited by
submission deadline 30 Apr 2024 | 5 articles | Viewed by 7502 | Submission Open
Keywords: organic compounds; design; synthesis; biological activity; pesticide discovery; medicine discovery; mechanisms of action; natural compounds; active screening; structure– activity relationships (SAR); risk assessment
(This special issue belongs to the Section Macromolecules)
The Role of Neutrophils in Inflammatory Diseases
edited by Akrivi Chrysanthopoulou
submission deadline 30 Apr 2024 | 3 articles | Viewed by 7472 | Submission Open
Keywords: neutrophils/NETs; inflammation; innate immunity; trained immunity; cytokines; infection; neutrophil plasticity; neutrophil subsets; resolution; recruitment; reverse migration
(This special issue belongs to the Section Molecular Immunology)
Rising of New Signatures in Skeletal Muscle Pathologies and Their Possible Role in Disease Pathogenesis
edited by
submission deadline 30 Apr 2024 | 4 articles | Viewed by 7332 | Submission Open
Keywords: muscular dystrophies  ; inflammation  ; immune system activation  ; disease biomarkers  ; disease targets  ; tdark genes  ; gut microbiota
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metals and Cancer submission deadline 30 Apr 2024 | 6 articles | Viewed by 7107 | Submission Open
Keywords: cancer; metal; cell metabolism; mitochondria; cell proliferation
(This special issue belongs to the Section Molecular Oncology)
Raman Spectroscopy and Machine Learning in Human Disease
edited by
submission deadline 30 Apr 2024 | 6 articles | Viewed by 7024 | Submission Open
Keywords: Raman spectroscopy; machine learning; disease; molecular diagnostics; optical biopsy; liquid biopsy
(This special issue belongs to the Section Molecular Biophysics)
Peptides as Biochemical Tools and Modulators of Biological Activity
edited by
submission deadline 30 Apr 2024 | 3 articles | Viewed by 6994 | Submission Open
Keywords: peptides; phage display; stem cells; mesenchymal stromal cells; cancer; leukemia; tumor targeting; drug delivery
(This special issue belongs to the Section Molecular Biology)
Novel Hypotheses for Dementia and Neurodegenerative Diseases: From Molecular Mechanisms to Therapies
edited by
submission deadline 30 Apr 2024 | 6 articles | Viewed by 6643 | Submission Open
Keywords: neurodegenerative diseases; dementia; bioinformatics; neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
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