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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomedical Polymer Materials: Design, Synthesis or Applications

edited by Lourdes Franco

submission deadline 20 May 2026 | 2 articles | Viewed by 6415 | Submission Open

Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles

(This special issue belongs to the Section Materials Science)

Molecular Research on Potential New Antidepressant Drugs

edited by

Marta Jóźwiak-Bębenista

and

Anna Stasiak

submission deadline 20 May 2026 | 3 articles | Viewed by 6394 | Submission Open

Keywords: antidepressant drug discovery; treatment-resistant depression; neuroinflammation; neuroplasticity; hallucinogens and psychedelics; CNS drug development; molecular targets for depression; neurotransmitter systems (serotonin; norepinephrine; dopamine); preclinical research (in vitro; in vivo; in silico); psychiatric disorders

(This special issue belongs to the Section Molecular Pharmacology)

Host-Virus Interaction

edited by

Xiaohui Ju

and

Xupeng Hong

submission deadline 20 May 2026 | 4 articles | Viewed by 6315 | Submission Open

Keywords: viral entry; viral replication; virus assembly and release; pro-viral factors; restriction factors; interferon pathway; viral immune evasion; antiviral strategies

(This special issue belongs to the Section Molecular Immunology)

Advances in the Translational Preclinical Research

edited by

Mariano Gabri

submission deadline 20 May 2026 | 4 articles | Viewed by 6306 | Submission Open

Keywords: translational preclinical research; drug discovery; cancer therapies; in vitro and in vivo experiments; biological mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thermodynamic and Spectral Studies of Complexes

edited by Michał Zabiszak

submission deadline 20 May 2026 | 5 articles | Viewed by 6214 | Submission Open

Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy

edited by

Mariusz Chabowski

submission deadline 20 May 2026 | 4 articles | Viewed by 6207 | Submission Open

Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception

edited by Gustavo G. Blanco

submission deadline 20 May 2026 | 2 articles | Viewed by 6175 | Submission Open

Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior

edited by

Runxiang Zhang

submission deadline 20 May 2026 | 4 articles | Viewed by 6172 | Submission Open

Keywords: metabolism pathway; signal pathway; animal development; animal behavior; animal disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Microbiome and Metabolome in the Gastrointestinal Tract, 3rd Edition

edited by

Ioannis Alexandros Charitos

submission deadline 20 May 2026 | 1 articles | Viewed by 6145 | Submission Open

Keywords: microbiome; dysbiosis; microbiology; immunity; cytokine/chemokine networks; microbiota axes pathways; toxic substances; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 May 2026 | 2 articles | Viewed by 6082 | Submission Open

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

Challenges of Immune Checkpoint Inhibitor Therapy

edited by

Tibor Bakacs

submission deadline 20 May 2026 | 2 articles | Viewed by 6073 | Submission Open

Keywords: immune checkpoint inhibitor; ICI; safety of ICI drugs; irAE of ICI drugs; ultra-low-dose ICI; cost saving with ICI drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Iodinated Compounds and Molecular Iodine in Human Disease

edited by

Carmen Aceves

submission deadline 20 May 2026 | 2 articles | Viewed by 5878 | Submission Open

Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement

(This special issue belongs to the Section Biochemistry)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 20 May 2026 | 5 articles | Viewed by 5858 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Molecular Pathology of the Placenta in Pregnancy Complications

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 20 May 2026 | 5 articles | Viewed by 5855 | Submission Open

Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap

edited by

Oliver Seifert

submission deadline 20 May 2026 | 2 articles | Viewed by 5801 | Submission Open

Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers

(This special issue belongs to the Section Molecular Biology)

Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application

edited by

Jelena Vekic

and

Aleksandra Zeljkovic

submission deadline 20 May 2026 | 5 articles | Viewed by 5773 | Submission Open

Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pain in Human Health and Disease

edited by

Daniel Pozza

submission deadline 20 May 2026 | 2 articles | Viewed by 5681 | Submission Open

Keywords: pain signaling; molecular pathways; chronic pain; neuropathic pain; inflammation neuro– immune interactions; epigenetics pharmacogenetics; precion medicine; sleep disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI

edited by

Yuriy L. Orlov

and

Ming Chen

submission deadline 20 May 2026 | 2 articles | Viewed by 5484 | Submission Open

Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant– pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants

(This special issue belongs to the Section Molecular Informatics)

Advances in the Pathophysiology and Treatment of Eye Diseases

edited by

Georgios Panos

submission deadline 20 May 2026 | 3 articles | Viewed by 5450 | Submission Open

Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 20 May 2026 | 2 articles | Viewed by 5371 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Osteoarthritis: From Pathophysiology to Novel Therapy

edited by

Paloma Guillem-Llobat

submission deadline 20 May 2026 | 3 articles | Viewed by 5351 | Submission Open

Keywords: osteoarthritis; therapeutic targets; molecular mechanisms; biomarkers; bone degenerative disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liposomes: Molecular Marvels in Drug Delivery

edited by

Parkson Lee-Gau Chong

and Juyang Huang

submission deadline 20 May 2026 | 1 articles | Viewed by 5312 | Submission Open

Keywords: liposomal drug; targeted delivery; controlled release; hydrogen bonding; long-term stability; archaeosomes; cytotoxicity; lyophilized liposomal drugs

(This special issue belongs to the Section Molecular Biophysics)

Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications

edited by Karim Daliri

submission deadline 20 May 2026 | 2 articles | Viewed by 5307 | Submission Open

Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9

(This special issue belongs to the Section Molecular Biology)

Prostate Diseases: Focus on Hormone Therapies and Targeted Interventions

edited by Gabriel Campolina-Silva and Héctor Contreras

submission deadline 20 May 2026 | 2 articles | Viewed by 5235 | Submission Open

Keywords: urinary disease; prostate cancer; hormone; therapeutic strategy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Characterization of Plant–Microbe Interactions

edited by

Cristina Pinedo-Rivilla

submission deadline 20 May 2026 | 3 articles | Viewed by 5206 | Submission Open

Keywords: phytopathogen; plant pathology; phytopathogen fungi; phytopathogen bacteria; phytoalexins; plant defense; allelopathy; fungicides

(This special issue belongs to the Section Molecular Plant Sciences)

Glial Cells in Neurodegenerative Disorders

edited by Daniel Souza Monteiro de Araujo

submission deadline 20 May 2026 | 3 articles | Viewed by 5047 | Submission Open

Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders

(This special issue belongs to the Section Molecular Neurobiology)

RNA Editing/Modification in Health and Disease

edited by Valeriana Cesarini and

Piergiorgio La Rosa

submission deadline 20 May 2026 | 2 articles | Viewed by 5016 | Submission Open

Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Antisense Oligonucleotides: Versatile Tools with Broad Applications

edited by

Suxiang Chen

submission deadline 20 May 2026 | 2 articles | Viewed by 4972 | Submission Open

Keywords: antisense oligonucleotide; RNase H; splice switching; exon skipping; therapeutics; pesticide

(This special issue belongs to the Section Molecular Biology)

Biological Study of Plant Bioactive Compounds

edited by

Anna Weronika Sobańska

submission deadline 20 May 2026 | 6 articles | Viewed by 4856 | Submission Open

Keywords: plants’ biological activity; analysis of plant and plant preparations; interactions between plants and drugs; drugs inspired by plant actives; misuse of plant preparations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Biology of Host and Pathogen Interactions: 3rd Edition

edited by

Ana Paula Arez

submission deadline 20 May 2026 | 4 articles | Viewed by 4853 | Submission Open

Keywords: microbe; pathogen; virus; bacteria; parasite; fungi; infection; disease; interaction; host response

(This special issue belongs to the Section Molecular Microbiology)

Evolution and Genomics: Relevance to Current Issues

edited by

Roger Dawkins

and Sally Lloyd

submission deadline 20 May 2026 | 2 articles | Viewed by 4843 | Submission Open

Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research in Epilepsy and Epileptogenesis—2nd Edition

edited by

Stanisław Jerzy Czuczwar

and Barbara Miziak

submission deadline 20 May 2026 | 3 articles | Viewed by 4809 | Submission Open

Keywords: epilepsy; antiseizure; anti-epileptogenic drugs; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Chemotherapeutic Agents in Cancer Treatment

edited by

Eleni Stamoula

submission deadline 20 May 2026 | 1 articles | Viewed by 4772 | Submission Open

Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics

(This special issue belongs to the Section Molecular Pharmacology)

Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies

edited by

Siu Hong Dexter Wong

and Bohan Yin

submission deadline 20 May 2026 | 2 articles | Viewed by 4704 | Submission Open

Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release

(This special issue belongs to the Section Macromolecules)

Peptides and Peptidomimetics for Targeting Protein-Protein Interactions

edited by

Giacomo Rossino

and

Pasquale Linciano

submission deadline 20 May 2026 | 1 articles | Viewed by 4638 | Submission Open

Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC

(This special issue belongs to the Section Biochemistry)

Molecular Computational Research in Pharmacological Structure–Efficacy

edited by

José Rogério A. Silva

and Jerônimo Lameira

submission deadline 20 May 2026 | 2 articles | Viewed by 4488 | Submission Open

Keywords: molecular modeling; structure– activity relationship (SAR); pharmacological efficacy; quantum chemistry; molecular dynamics; free energy calculations; drug design; enzyme inhibition; ligand– receptor interactions; computational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Advancements in Regenerative Medicine Research

edited by

Rosa V. Ventrella

submission deadline 20 May 2026 | 3 articles | Viewed by 4470 | Submission Open

Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine

(This special issue belongs to the Section Molecular Biology)

Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition

edited by

François Chevalier

submission deadline 20 May 2026 | 2 articles | Viewed by 4466 | Submission Open

Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Primary Colorectal Cancer and Liver Metastases

edited by Alexandros E. Giakoustidis

submission deadline 20 May 2026 | 2 articles | Viewed by 4431 | Submission Open

Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics

edited by

Myrna Gloria Candelaria

submission deadline 20 May 2026 | 3 articles | Viewed by 4410 | Submission Open

Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Gastrointestinal Inflammation: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Nikolett Bódi

submission deadline 20 May 2026 | 3 articles | Viewed by 4296 | Submission Open

Keywords: gastrointestinal tract; inflammation; gastroenteritis; infection; microbiome; mucosal epithelium; immune cells; enteric nervous system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Flower Gene Regulation

edited by Wen‑Chieh Tsai

submission deadline 20 May 2026 | 2 articles | Viewed by 4183 | Submission Open

Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination

(This special issue belongs to the Section Molecular Plant Sciences)

Cyclodextrins for Drug/iRNA Co-Delivery

edited by

Ivana Jarak

and

Ana Figueiras

submission deadline 20 May 2026 | 1 articles | Viewed by 4097 | Submission Open

Keywords: advanced therapies; antibody-based therapies; active and passive tumor targeting; cancer; conventional chemotherapy; immune system; immunotherapy; immunotoxicity; nanomedicine; nanoparticles; nanotoxicity; tumor immune microenvironment (TIME); tumor microenvironment (TME); cyclodextrins

(This special issue belongs to the Section Macromolecules)

Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition

edited by

Mattia Mori

and

Ilaria Vicenti

submission deadline 20 May 2026 | 3 articles | Viewed by 4012 | Submission Open

Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 20 May 2026 | 2 articles | Viewed by 3921 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 20 May 2026 | 2 articles | Viewed by 3876 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in the Synthesis and Medical Application of Biomaterials

edited by

Csaba Balázsi

submission deadline 20 May 2026 | 2 articles | Viewed by 3739 | Submission Open

Keywords: nanostructured biomaterials; bioceramics; bioactive; biodegradable; resorbable materials; biomimetic materials; biocompatibility

(This special issue belongs to the Section Materials Science)

New Research on Bioactive Natural Products: 2nd Edition

edited by

Alexandros Tsoupras

submission deadline 20 May 2026 | 1 articles | Viewed by 3703 | Submission Open

Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure– activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Lymphedema: From Mechanism to Treatment

edited by

Florent Morfoisse

submission deadline 20 May 2026 | 1 articles | Viewed by 3672 | Submission Open

Keywords: lymphedema; lymphatic dysfunction; molecular mechanisms; cell signaling; diagnostic imaging; biomarkers; therapeutic interventions; inflammation; adipose tissue accumulation; fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 May 2026 | 2 articles | Viewed by 3643 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

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