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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathophysiology and Treatment of Congenital Neuromuscular Disorders

edited by Johan Lindqvist

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4168 | Submission Open

Keywords: nemaline myopathy; hereditary neuromuscular disorder; genetic mutations; pathogenesis; pathophysiology; therapy; myofilament dysfunction; congenital neuromuscular disorders; congenital muscular dystrophy; spinal muscular atrophy; Duchenne muscular dystrophy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies

edited by Lisa Lungaro

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4147 | Submission Open

Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hemophilia: From Pathophysiology to Novel Therapies

edited by

Mingching Shen

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4144 | Submission Open

Keywords: hemophilia; novel therapy in hemophilia; ultra-long half life clotting factor; clotting factor mimics; coagulation rebalancing agent; gene therapy; pathogenesis of hemophilia; molecular biology of hemophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bone Development and Regeneration—4th Edition

edited by

Kazuo Yudoh

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3914 | Submission Open

Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials

(This special issue belongs to the Section Molecular Biology)

Molecular Biology and Targeted Therapies in Leukemias

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3888 | Submission Open

Keywords: molecular biology; target therapy; leukemia; TKI; BCL-2; FLT3; CAR-T cells; CML

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Understanding Plant-Microbe Interactions

edited by

Tomislav Radić

and

Katarina Hančević

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3879 | Submission Open

Keywords: phytomicrobiome; symbiosis; pathogen resistance; microbial signalling

(This special issue belongs to the Section Molecular Plant Sciences)

Cell Envelope Biogenesis and, Molecular Strategies to Maintain Cellular Homeostasis in Bacteria

edited by

Satish Raina

and

Gracjana Klein

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3799 | Submission Open

Keywords: LpxC and the regulation of LPS; periplasmic protein folding; disulfide bond formation; BAM proteins and assembly of outer membrane proteins; periplasmic protease DegP (HtrA); lipopolysaccharide assembly; LPS modifications and diversity; LPS and phospholipid trafficking; bacterial virulence factors; antibiotic resistance; extracytoplasmic function sigma factors; regulatory RNAs; two-component systems; lipid A and its modification

(This special issue belongs to the Section Molecular Microbiology)

Chronic Lymphocytic Leukemia: Molecular Pathologies and Therapeutic Strategies

edited by Tang Her Jaing

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3754 | Submission Open

Keywords: chronic lymphocytic leukemia; genomic landscapes; precision medicine; clinical trials; biomarker

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lipid Peroxidation and Protein Carbonylation in Human Diseases

edited by

Galina Nikolova

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3708 | Submission Open

Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes

(This special issue belongs to the Section Biochemistry)

Advances in Clostridial and Related Neurotoxins, 3rd Edition

edited by

Sabine Pellett

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3559 | Submission Open

Keywords: botulinum neurotoxin; BoNT; toxicity; molecular mechanisms; recombinant; derivative; clostridium botulinum

(This special issue belongs to the Section Molecular Toxicology)

Wound Repair: From Basic Biology to Tissue Engineering

edited by

Magdalena Paczkowska-Walendowska

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3500 | Submission Open

Keywords: wound healing; tissue engineering; biomaterials; regenerative medicine; chronic wounds

(This special issue belongs to the Section Molecular Biology)

Hematologic Diseases: Molecular Insights and Novel Methods

edited by

Simona Soverini

and Samantha Bruno

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3467 | Submission Open

Keywords: hematologic malignancies; high-throughput technologies; omics data; biomarkers; drug resistance; minimal residual disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms: New Insights into the Pathogenesis of Neonatal Disorders

edited by

Rozeta Sokou

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3465 | Submission Open

Keywords: neonate; neonatal infections; molecular and cellular mechanisms; necrotizing enterocolitis; immature immune system; neonatal inflammation; epigenetic modification; regulatory RNAs; bronchopulmonary dysplasia; neonatal hypoxic– ischemic injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research of Cartilage: 2nd Edition

edited by

Laura Mangiavini

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3359 | Submission Open

Keywords: articular cartilage; cartilage lesions; tissue engineering; cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring New Field in Hydrocolloids Research and Applications

edited by

Mihaela Violeta Ghica

, Cristina Elena Dinu-Pirvu and

Lacramioara Popa

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3279 | Submission Open

Keywords: drug delivery systems; controlled-release; targeted delivery; wound healing; tissue engineering; bioadhesive agents; transdermal patches; mucoadhesive hydrogels; ophthalmic preparations; oral disintegrating films; gastroretentive systems; rheology modifiers; textural characteristics; stabilizing agents; encapsulation for protection and stability (drugs; probiotics and bioactive compounds); 3D bioprinting; nutraceutical delivery

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Endothelial Cells in Health and Disease

edited by

Alessia Ricci

and

Amelia Cataldi

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3270 | Submission Open

Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair

(This special issue belongs to the Section Molecular Biology)

Microbial Resistance Mechanisms in Biotechnology: From Extremes to Applications

edited by Giovanni Gallo and

Martina Aulitto

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3186 | Submission Open

Keywords: microorganism resistance systems; extreme environments; molecular adaptation; genetic pathways; biotechnological applications; industrial biotechnology; environmental remediation; extremophiles; stress tolerance; evolutionary adaptations

(This special issue belongs to the Section Molecular Microbiology)

Structure, Function and Dynamics in Proteins: 3rd Edition

edited by

Luigi Russo

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3089 | Submission Open

Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray

(This special issue belongs to the Section Molecular Biology)

Innovative Strategies in the Design and Development of Anticancer Agents

edited by Sanjay Kumar

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3084 | Submission Open

Keywords: chemotherapy; biomimetic; natural product analogs; prodrugs; nanodrugs; drug release

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Research on the Physiology and Toxicology of Aquatic Animals

edited by Xin Zhang

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3067 | Submission Open

Keywords: aquatic ecosystem; physiology of aquatic animals; toxicology of aquatic animals; environmental adaptability; environmental pollutants; ecotoxicology; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Biology)

Dysregulation of Bone Health–a Matter of Several Culprits

edited by Ana Gomes

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3053 | Submission Open

Keywords: bone metabolism; osteoporosis; osteopenia; low-impact fractures; osteoimmunology; leptin; lung disorders; cancer; renal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Advances in Nanoparticles for Modern Biomedicine (2nd Edition)

edited by

Sebastian Schwaminger

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3026 | Submission Open

Keywords: nanoparticles; nanotherapeutics; nanomedicine; biomedicine; selective targeting of nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Autophagy and Kidney Diseases

edited by Francesco Reggiani

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2863 | Submission Open

Keywords: autophagy; kidney diseases; cellular homeostasis; molecular signaling; autophagy biomarkers; renal homeostasis; autophagy modulators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Multiple Faces of Non-Small Cell Lung Cancer: Targeted Therapies and Recent Developments

edited by Angelo Delmonte and Alberto Verlicchi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2835 | Submission Open

Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Bone Injury and Bone Tissue Regeneration

edited by Nasim Golafshan

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2801 | Submission Open

Keywords: bone formation; osteoblast diffrentiation; cell-based materials

(This special issue belongs to the Section Materials Science)

Protein Networks and Their Signaling

edited by

Ashok Kumar

and

Vladimir N. Uversky

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2731 | Submission Open

Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design

(This special issue belongs to the Section Molecular Biology)

Precision Medicine Approaches to Antifibrotic Therapy

edited by Karim Daliri

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2691 | Submission Open

Keywords: fibrotic diseases; antifibrotic therapy; antifibrotic drug; multi-omics data; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Cell Metabolism in Cancer Biology

edited by

Silvia Filippi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2618 | Submission Open

Keywords: cancer cells metabolism; target therapy; PI3K/Akt/mTOR pathway; hypoxia

(This special issue belongs to the Section Molecular Oncology)

Modulating the Function of the Immune System by Thyrotropin and Thyroid Hormones

edited by Graciela Alicia Cremaschi and Claudia Gabriela Pellizas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2454 | Submission Open

Keywords: thyrotropin (TSH); thyroid hormones (THs); immune modulation; immunology; immune; autoimmune; immunoendocrinology; hypothalamic-pituitary-thyroid axis; antitumor immune response

(This special issue belongs to the Section Molecular Immunology)

Protein Signal Transduction in the Nucleus

edited by Jaekyung Shim

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2449 | Submission Open

Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Animal Nutrition

edited by Jie Fu

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2330 | Submission Open

Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host– microbiome interaction; metabolic reprogramming

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by

Mrigya Babuta

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2312 | Submission Open

Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Tumor Suppressor Proteins

edited by Jie Liu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2312 | Submission Open

Keywords: DNA repair; genome stability; tumor suppressor; BRCA1; BRCA2; PALB2; RAD51C

(This special issue belongs to the Section Molecular Oncology)

The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment

edited by Fabricio Figueiro

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2181 | Submission Open

Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research in Photocatalysis

edited by

María Teresa Colomer

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2130 | Submission Open

Keywords: design; simulation; synthesis; properties; functionalities; reactions; photocatalysis

(This special issue belongs to the Section Biochemistry)

Computational Genomics and Bioinformatics in Microbiology

edited by

Andreas Martin Lisewski

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2064 | Submission Open

Keywords: computational microbial genomics; comparative genomics; structural genomics; functional genomics; genomic data bioinformatics

(This special issue belongs to the Section Molecular Informatics)

Advances in Plant Nematology Research

edited by

Sergei A. Subbotin

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2055 | Submission Open

Keywords: DNA barcoding; Molecular evolution; Genomes; Molecular systematics; Phylogenetics; Plant– nematode interactions; Transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

Coagulation Factors and Natural Anticoagulants in Health and Disease

edited by

Zsuzsanna Bereczky

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2011 | Submission Open

Keywords: coagulation factor; natural anticoagulant; hemostasis; thrombosis; molecular studies; molecular interactions; structure; functional studies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights and Regulation Mechanisms of Tea Quality

edited by

Xujun Zhu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2005 | Submission Open

Keywords: molecular ecology; spectroscopic techniques; tea quality; tea plant growth

(This special issue belongs to the Section Molecular Plant Sciences)

Oxidative Stress in Dermatology, Aesthetics and Regenerative Medicine

edited by

Eugenio Luigi Iorio

submission deadline 20 Jan 2026 | Viewed by 1980 | Submission Open

Keywords: oxidative stress; redox system; antioxidant chemical species; dermatology; aesthetics; regenerative medicine; inflammatory; degenerative skin diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Studies on Oral Disease and Treatment

edited by

Daniela Adamo

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1905 | Submission Open

Keywords: oral cancer; oral mucosal lesions; chronic pain; temporomandibular joint disorders; periodontal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Progress in Adipokines Research in Cardiovascular Health and Diseases

edited by

Morris Karmazyn

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1900 | Submission Open

Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function; structure; and integrity; adipokines and cardiovascular inflammation; adipokines; adiposity; and cardiovascular disease in obesity

(This special issue belongs to the Section Molecular Biology)

Fibrotic Disease: From Pathophysiology to Treatment

edited by Galina S. Bogatkevich

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1893 | Submission Open

Keywords: lung; liver; heart; kidney; fibrosis; systemic sclerosis; mechanisms; pathophysiology; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances and Applications in Molecular Enzymology

edited by

Gustavo Molina

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1880 | Submission Open

Keywords: microbial enzymes; biosynthesis and bioengineering; drug development and targets; enzymes in the environment; engineered enzymes; enzymes in agri-food; enzymatic formulations; enzyme engineering; enzymes in biomedical sciences; green chemistry/technology; glycans; molecular evolution; nanocatalyst and nanotechnology; pharma enzymes; recombinant proteins production and purification; system and synthetic biology

(This special issue belongs to the Section Biochemistry)

The Role of Extracellular Histones in Patho(physio)logical Hemostasis

edited by Fabrizio Semeraro and

Mauro Coluccia

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1722 | Submission Open

Keywords: extracellular histones; hemostasis; platelets; coagulation; fibrinolysis; thrombosis; inflammation; extracellular traps

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Radiolabeled Compounds for Theranostic Applications in Oncology

edited by

Cyril Fersing

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1719 | Submission Open

Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling

(This special issue belongs to the Section Molecular Oncology)

Unraveling the Enigma of Colorectal Cancer: From Mechanisms to Therapeutic Advances

edited by Valentina Belli and

Vincenza Ciaramella

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1718 | Submission Open

Keywords: Colorectal cancer; tumour microenvironment; epigenetics; diagnostic molecules; immune evasion; biomarkers; drug resistance; precision medicine; targeted

(This special issue belongs to the Section Molecular Oncology)

Studying Multi-Target Drug Approaches and Posttranslational Modification (PTM) Therapies

edited by

Guo-Ping Zhou

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1695 | Submission Open

Keywords: multi-target therapy; network analysis tools; multi-label proteins; web-server predictor; posttranslational modifications (PTMs); 3D structures; rational drug design

(This special issue belongs to the Section Molecular Informatics)

Protein Design and Engineering in Biochemistry

edited by Om Prakash Narayan

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1692 | Submission Open

Keywords: protein engineering; molecular biology; biochemical tools; computational protein design; directed evolution; CRISPR/Cas9; synthetic biology; biomaterials; protein therapeutics; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Research Progress and Therapeutic Targets of Chronic Kidney Disease

edited by

Stefanos Roumeliotis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1675 | Submission Open

Keywords: blood pressure; cardiovascular disease; chronic kidney disease; diabetes; hypertension; inflammation; oxidative stress; sodium glucose transporter-2; vascular calcification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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