International Journal of Molecular Sciences

Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders

edited by Thomas Paparrigopoulos

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1649 | Submission Open

Keywords: addiction; alcohol use disorder; opioid use disorder; substance use disorders; physical exercise; physical activity; molecular mechanisms; neuroendocrine system

(This special issue belongs to the Section Molecular Neurobiology)

Ischemia–Reperfusion Syndrome: A Complex Puzzle in Physiopathology, Pharmacology and Therapeutic Advances

edited by René Ferrera,

Thierry Hauet

,

Joan Roselĺo-Catafau

and

Arnau Panisello-Roselló

submission deadline 10 Jul 2025 | Viewed by 269 | Submission Open

Keywords: ischemia– reperfusion injury; graft dysfunction and organ preservation; solid organ transplantation; machine perfusion strategies (HOPE/NMP); mitochondria dysfunction; cell signaling pathways; organ preconditioning/postconditioning; therapeutic surgical and drug strategies; redox stress and inflammation mediators; cell lines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer

edited by

Daniel Gabriel Pons

submission deadline 10 Jul 2025 | Viewed by 197 | Submission Open

Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Molecular Updates and Applications in Forensic Medicine

edited by

Eugenia Carnevali

submission deadline 15 Jul 2025 | 3 articles | Viewed by 4132 | Submission Open

Keywords: forensic genetics; forensic transcriptomics; mitochondrial DNA (mtDNA); next-generation sequencing (NGS); body fluid identification; environmental DNA analysis; forensic entomology; animal and plant forensics; forensic microbiology; paternity testing; time of death; advanced molecular autopsy; disaster victim identification (DVI); ancient DNA; biological age prediction; DNA phenotyping; ancestry; investigative genetic genealogy; ethics in forensic genetics; criminal database; DNA mixture interpretation; activity level; forensic bioinformatics; artificial intelligence; quality assurance

(This special issue belongs to the Section Molecular Biology)

Molecular Paradigm Iconoclasm

edited by

Vance G. Nielsen

submission deadline 15 Jul 2025 | 1 articles | Viewed by 581 | Submission Open

Keywords: paradigm shift; biochemistry; cell signaling; coagulation; toxinology

(This special issue belongs to the Section Biochemistry)

Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes

edited by Maria Victoria Preciado

submission deadline 15 Jul 2025 | Viewed by 190 | Submission Open

Keywords: virus evolution; immune response; host– virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics

(This special issue belongs to the Section Molecular Immunology)

Skin Microbiome and Skin Health: Molecular Interactions

edited by

Terenzio Cosio

submission deadline 15 Jul 2025 | Viewed by 166 | Submission Open

Keywords: skin microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis

(This special issue belongs to the Section Molecular Immunology)

New Insights in Natural Bioactive Compounds: 3rd Edition

edited by

Letteria Minutoli

and

Giovanni Pallio

submission deadline 20 Jul 2025 | 22 articles | Viewed by 59805 | Submission Open

Keywords: inflammation; cytokines; ROS; oxidative stress; natural products; flavonoids; cannabinoids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Agents and Novel Drugs Use for the Oncological Diseases Treatment

edited by

Alexandra L. Zakharenko

and

Nadezhda S. Dyrkheeva

submission deadline 20 Jul 2025 | 20 articles | Viewed by 42844 | Submission Open

Keywords: anti-proliferative; cancer; molecular oncology; novel agents; off-label use; target therapy

(This special issue belongs to the Section Molecular Pharmacology)

Focus on Cartilage Biology

edited by

Jácome Bruges-Armas

submission deadline 20 Jul 2025 | 5 articles | Viewed by 24601 | Submission Open

Keywords: cartilage biology; signaling pathways; molecular genetics; osteoarthritis; inflammatory arthropaty; cartilage repair; microbioma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Paroxysmal Nocturnal Hemoglobinuria: Pathophysiology and Novel Therapeutic Approaches

edited by Jun-Ichi Nishimura

submission deadline 20 Jul 2025 | 7 articles | Viewed by 22437 | Submission Open

Keywords: paroxysmal nocturnal hemoglobinuria; complement; intravascular hemolysis; extravascular hemolysis; breakthrough hemolysis; terminal complement inhibitor; proxymal complement inhibitor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microalgal Molecules and Enzymes: 2nd Edition

edited by

Assunta Saide

and

Chiara Lauritano

submission deadline 20 Jul 2025 | 5 articles | Viewed by 18863 | Submission Open

Keywords: microalgae; bioactive molecules; gene expression; drug discovery; molecular mechanism; gene mining; enzymes; industrial applications

(This special issue belongs to the Section Molecular Microbiology)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes

edited by

Daniela Miricescu

submission deadline 20 Jul 2025 | 7 articles | Viewed by 18649 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β ; Ras/Raf/MEK/ERK; Wnt/β -catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

Alcohol and Inflammation

edited by

María Candelaria Martín-González

and Emilio González-Reimers

submission deadline 20 Jul 2025 | 7 articles | Viewed by 18347 | Submission Open

Keywords: alcohol; inflammation; alcohol use disorder; alcoholic liver disease; liver disease; alcoholic hepatitis; liver injury; oxidative damage

(This special issue belongs to the Section Molecular Immunology)

Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 Jul 2025 | 6 articles | Viewed by 17248 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

State-of-the-Art Molecular Pharmacology in USA

edited by

Anastasios Lymperopoulos

,

William C. (Trey) Putnam

,

Khosrow Kashfi

,

Kamyar Zahedi

and

Gaetano Santulli

submission deadline 20 Jul 2025 | 4 articles | Viewed by 17136 | Submission Open

Keywords: signal transduction; receptor; animal models; preclinical; pharmacodynamics; pharmacokinetics; drug development; drug metabolism

(This special issue belongs to the Section Molecular Pharmacology)

Pro-inflammatory and Anti-inflammatory Interleukins in Various Diseases 2.0

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 20 Jul 2025 | 7 articles | Viewed by 16167 | Submission Open

Keywords: cytokines; inflammation; interleukins; IL-1; IL-2; IL-3; IL-4; IL-5; IL-6; IL-7; IL-8; IL-9; IL-10; IL-11; IL-12; IL-17; IL-18; IL-22; IL-37; IL-38; IFN-α ; IFN-β ; IFN-γ ; TGF-β ; TNF-α ; TNF-β ; allergy; TNF-α ; chemokines; interferon; gut inflammation; systemic inflammation; infection

(This special issue belongs to the Section Molecular Immunology)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases 2.0

edited by

Yasemin M. Akay

submission deadline 20 Jul 2025 | 7 articles | Viewed by 15937 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Therapies of Chronic Obstructive Pulmonary Disease

edited by

Marija Stankovic

submission deadline 20 Jul 2025 | 6 articles | Viewed by 15778 | Submission Open

Keywords: COPD; molecular mechanism; inflammation; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Dysbiosis in Chronic Diseases

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Jul 2025 | 5 articles | Viewed by 15751 | Submission Open

Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; microorganism; metabolites; clinical practices; prebiotics; probiotics

(This special issue belongs to the Section Molecular Microbiology)

Tumor Microenvironments: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression

edited by Sonam Mittal

submission deadline 20 Jul 2025 | 6 articles | Viewed by 15723 | Submission Open

Keywords: tumor microenvironment; metastasis; metabolism; cytokines; cancer-derived extracellular vesicles; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Lung Cancers: An Update on Molecular Diagnostics and Therapy

edited by

Mariusz Chabowski

submission deadline 20 Jul 2025 | 6 articles | Viewed by 15333 | Submission Open

Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Peripheral Nerve Regeneration

edited by

Cinzia Fabrizi

submission deadline 20 Jul 2025 | 7 articles | Viewed by 15062 | Submission Open

Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth

(This special issue belongs to the Section Molecular Neurobiology)

Network Pharmacology: An Emerging Field in Drug Discovery

edited by

Weiwei Han

submission deadline 20 Jul 2025 | 10 articles | Viewed by 15000 | Submission Open

Keywords: network pharmacology; machine learning; databases; drug discovery; computer-aided drug design (CADD); data mining

(This special issue belongs to the Section Molecular Pharmacology)

New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 3rd Edition

edited by

Yutang Wang

and

Dianna Magliano

submission deadline 20 Jul 2025 | 7 articles | Viewed by 14710 | Submission Open

Keywords: cardiovascular disease; myocardial infarction; stroke; transient ischaemic attack; hypertension; diabetes mellitus; atherosclerosis; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Aryl Hydrocarbon Receptor in Immune Modulation

edited by

Jörg Lehmann

submission deadline 20 Jul 2025 | 5 articles | Viewed by 14181 | Submission Open

(This special issue belongs to the Section Biochemistry)

Mitochondrial Dysfunction in Autoimmune Diseases

edited by

Biji Theyilamannil Kurien

submission deadline 20 Jul 2025 | 1 articles | Viewed by 13976 | Submission Open

Keywords: autoimmune diseases; autoantibodies; autophagy; mitophagy; mitochondrial hyperpolarization; mitochondrial dysfunction; oxidative phosphorylation; oxidative damage; fatigue; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Medicinal Plants and Natural Products

edited by

Ana Paula Coelho Duarte

and

Ângelo Luís

submission deadline 20 Jul 2025 | 7 articles | Viewed by 13830 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Tomato Breeding and Molecular Research

edited by Silvana Grandillo,

Gianfranco Diretto

and

Maria Cammareri

submission deadline 20 Jul 2025 | 6 articles | Viewed by 13329 | Submission Open

Keywords: tomato; natural and induced variation; genetics; genomics; omics; molecular breeding; physiology and development; fruit quality; biochemistry and metabolism; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic and Metabolic Molecular Research of Lysosomal Storage Disease: 4th Edition

edited by

Grzegorz Wegrzyn

submission deadline 20 Jul 2025 | 8 articles | Viewed by 13296 | Submission Open

Keywords: lysosomal storage diseases; molecular mechanisms of genetic disorders metabolic diseases; accumulation of macromolecules in cells; enzyme replacement therapy; hematopoietic stem cell transplantation gene therapy; substrate reduction therapy; translational research; novel therapies for genetic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Steroid Biosynthesis and Metabolism

edited by Amanda C. Swart

submission deadline 20 Jul 2025 | 6 articles | Viewed by 13081 | Submission Open

Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cell Division: A Focus on Molecular Mechanisms

edited by Stefano Sechi and Antonino Colanzi

submission deadline 20 Jul 2025 | 9 articles | Viewed by 12947 | Submission Open

Keywords: cell cycle; cell division; post-translational modification (PTM); mitosis/meiosis; cell organelles; cytokinesis; membrane trafficking; disease; therapeutic target; model organisms

(This special issue belongs to the Section Molecular Biology)

Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?

edited by

Dimitrios Kanakis

submission deadline 20 Jul 2025 | 5 articles | Viewed by 12909 | Submission Open

Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD）; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Neurometabolic Disorders in the Adults

edited by

Klary Niezen-Koning

and

Tom J. de Koning

submission deadline 20 Jul 2025 | 4 articles | Viewed by 12853 | Submission Open

Keywords: Neurometabolic; Metabolic/biochemical pathways; Genetic defects; Pathological phenotypes

(This special issue belongs to the Section Molecular Neurobiology)

Liver Diseases: From Molecular Basis to Potential Therapy

edited by

Giuliano Ramadori

submission deadline 20 Jul 2025 | 5 articles | Viewed by 12780 | Submission Open

Keywords: TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gene Doping Control

edited by

Teruaki Tozaki

submission deadline 20 Jul 2025 | 6 articles | Viewed by 12608 | Submission Open

Keywords: cell therapy; cell doping; gene doping; gene editing; gene silencing; gene therapy; transgene; CRISPR; therapeutic oligonucleotide

(This special issue belongs to the Section Molecular Genetics and Genomics)

Exploring Molecular Mechanisms of Inflammatory Diseases

edited by

Vlatka Sotosek

submission deadline 20 Jul 2025 | 4 articles | Viewed by 12471 | Submission Open

Keywords: immunity; inflammation; inflammatory disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Translational Research in Cardiovascular Endocrinology, Cardio-Metabolic Diseases and Non-Alcoholic Fatty Liver Disease (NAFLD): 2nd Edition

edited by

Eva Kassi

,

Ioannis Kyrou

and

Harpal S. Randeva

submission deadline 20 Jul 2025 | 7 articles | Viewed by 12315 | Submission Open

Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Plant Bioactive Compounds

edited by

Karolina Wojtunik-Kulesza

submission deadline 20 Jul 2025 | 4 articles | Viewed by 12224 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Immune-Inflammatory and Oxidative Stress Signaling Pathways Involved in Human Disorders

edited by

Alessio Ardizzone

and

Emanuela Esposito

submission deadline 20 Jul 2025 | 3 articles | Viewed by 11993 | Submission Open

Keywords: inflammation; neuroinflammation; immune system; oxidative stress

(This special issue belongs to the Section Molecular Immunology)

Neurotrophins: Roles and Function in Human Diseases 2.0

edited by

Marco Fiore

submission deadline 20 Jul 2025 | 4 articles | Viewed by 11916 | Submission Open

Keywords: neuroinflammation; brain; toxicology; cell growth; neurogenesis

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into the Effects of Microbiome-Derived Metabolites on Health and Disease

edited by Kinga Jaworska

submission deadline 20 Jul 2025 | 5 articles | Viewed by 11793 | Submission Open

Keywords: bacterial metabolites; short-chain fatty acids; trimethylamine N-oxide; gut microbiome; molecular pathways; intestinal barrier

(This special issue belongs to the Section Molecular Microbiology)

Sphingolipid Metabolism and Signaling in Health and Diseases

edited by Gergana M. Deevska

submission deadline 20 Jul 2025 | 5 articles | Viewed by 11638 | Submission Open

Keywords: ceramide; ceramide-1-phosphate; sphingosine; sphingosine-1-phosphate; sphingomyelin; glycosphingolipids; metabolic syndrome; obesity; diabetes; cancer; neurodegeneration; neuroinflammation; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Plant Hormone Signaling

edited by

Ewa Muszyńska

and

Kinga Dziurka

submission deadline 20 Jul 2025 | 9 articles | Viewed by 11567 | Submission Open

Keywords: hormonal regulation; cross-talk between phytohormones and other metabolites; signaling; gene expression; defense mechanisms; abiotic and biotic stress; plant growth and development

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Cell Signaling Pathways and Signal Transduction

edited by Katsuhiko Muraki and

Susumu Ohya

submission deadline 20 Jul 2025 | 6 articles | Viewed by 11486 | Submission Open

Keywords: Ca2+ signaling; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell metabolism; cell senescence; protein phosphorylation/dephosphorylation; membrane trafficking; cell proliferation; differentiation; and apoptosis; cytokine/chemokine signaling

(This special issue belongs to the Section Biochemistry)

Challenges and Future Perspectives in Treatment for Lung Cancer

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 20 Jul 2025 | 7 articles | Viewed by 11480 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery

(This special issue belongs to the Section Molecular Oncology)

Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 2nd Edition

edited by

Shanfa Lu

submission deadline 20 Jul 2025 | 9 articles | Viewed by 11331 | Submission Open

Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor

(This special issue belongs to the Section Molecular Plant Sciences)

Research in iPSC-Based Disease Models

edited by

Eric Deneault

submission deadline 20 Jul 2025 | 6 articles | Viewed by 10967 | Submission Open

Keywords: iPSCs; disease model; organoid; gene editing; mutation correction; isogenic control

(This special issue belongs to the Section Molecular Biology)

Molecular Mediators of Exercise: Cross-Organ Communication Promoting Health and Combating Disease

edited by

Jan Bilski

and

Tomasz Brzozowski

submission deadline 20 Jul 2025 | 4 articles | Viewed by 10873 | Submission Open

Keywords: exercise physiology; adipokines; myokines; hepatokines; inter-organ communication; inflammation; insulin sensitivity; obesity; type 2 diabetes; gastrointestinal system; cardiovascular system; sarcopenia; aging; osteogenic regulation; neurological health; nutraceuticals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glycobiology in Human Health and Disease

edited by Katrin Mani

submission deadline 20 Jul 2025 | 6 articles | Viewed by 10848 | Submission Open

Keywords: glycans and glycoconjugates; glycoproteins; proteoglycans; glycolipids; glycosylation including glycosyltransferases and glycosidases; carbohydrate and glycan metabolism; glycan structure; disease biomarkers; glycan signaling; glycoimmunology; glycomics

(This special issue belongs to the Section Macromolecules)

Journal Menu

Journal Browser

Special Issues

Further Information

Guidelines

MDPI Initiatives

Follow MDPI