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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomedical Polymer Materials: Design, Synthesis or Applications
edited by Lourdes Franco
submission deadline 20 May 2026 | 2 articles | Viewed by 6439
Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles
(This special issue belongs to the Section Materials Science)
Host-Virus Interaction
edited by and
submission deadline 20 May 2026 | 4 articles | Viewed by 6374
Keywords: viral entry; viral replication; virus assembly and release; pro-viral factors; restriction factors; interferon pathway; viral immune evasion; antiviral strategies
(This special issue belongs to the Section Molecular Immunology)
Advances in the Translational Preclinical Research
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 6370
Keywords: translational preclinical research; drug discovery; cancer therapies; in vitro and in vivo experiments; biological mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 6255
Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Thermodynamic and Spectral Studies of Complexes
edited by Michał Zabiszak
submission deadline 20 May 2026 | 5 articles | Viewed by 6246
Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 6205
Keywords: metabolism pathway; signal pathway; animal development; animal behavior; animal disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception
edited by Gustavo G. Blanco
submission deadline 20 May 2026 | 2 articles | Viewed by 6190
Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbiome and Metabolome in the Gastrointestinal Tract, 3rd Edition submission deadline 20 May 2026 | 1 articles | Viewed by 6164
Keywords: microbiome; dysbiosis; microbiology; immunity; cytokine/chemokine networks; microbiota axes pathways; toxic substances; autoimmunity
(This special issue belongs to the Section Molecular Biology)
Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition
edited by and Mohammad G. Mostofa
submission deadline 20 May 2026 | 2 articles | Viewed by 6118
Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization
(This special issue belongs to the Section Molecular Plant Sciences)
Challenges of Immune Checkpoint Inhibitor Therapy
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 6092
Keywords: immune checkpoint inhibitor; ICI; safety of ICI drugs; irAE of ICI drugs; ultra-low-dose ICI; cost saving with ICI drugs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathology of the Placenta in Pregnancy Complications submission deadline 20 May 2026 | 5 articles | Viewed by 5897
Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Iodinated Compounds and Molecular Iodine in Human Disease
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 5891
Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement
(This special issue belongs to the Section Biochemistry)
Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 5847
Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers
(This special issue belongs to the Section Molecular Biology)
Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application submission deadline 20 May 2026 | 5 articles | Viewed by 5822
Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pain in Human Health and Disease
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 5710
Keywords: pain signaling; molecular pathways; chronic pain; neuropathic pain; inflammation neuro– immune interactions; epigenetics pharmacogenetics; precion medicine; sleep disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI
edited by and
submission deadline 20 May 2026 | 2 articles | Viewed by 5520
Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant– pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants
(This special issue belongs to the Section Molecular Informatics)
Advances in the Pathophysiology and Treatment of Eye Diseases
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 5487
Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Osteoarthritis: From Pathophysiology to Novel Therapy submission deadline 20 May 2026 | 3 articles | Viewed by 5419
Keywords: osteoarthritis; therapeutic targets; molecular mechanisms; biomarkers; bone degenerative disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnostics in Neurological Diseases submission deadline 20 May 2026 | 2 articles | Viewed by 5397
Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis
(This special issue belongs to the Section Molecular Neurobiology)
Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications
edited by Karim Daliri
submission deadline 20 May 2026 | 2 articles | Viewed by 5348
Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9
(This special issue belongs to the Section Molecular Biology)
Liposomes: Molecular Marvels in Drug Delivery
edited by and Juyang Huang
submission deadline 20 May 2026 | 1 articles | Viewed by 5322
Keywords: liposomal drug; targeted delivery; controlled release; hydrogen bonding; long-term stability; archaeosomes; cytotoxicity; lyophilized liposomal drugs
(This special issue belongs to the Section Molecular Biophysics)
Prostate Diseases: Focus on Hormone Therapies and Targeted Interventions
edited by Gabriel Campolina-Silva and Héctor Contreras
submission deadline 20 May 2026 | 2 articles | Viewed by 5246
Keywords: urinary disease; prostate cancer; hormone; therapeutic strategy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Characterization of Plant–Microbe Interactions submission deadline 20 May 2026 | 3 articles | Viewed by 5228
Keywords: phytopathogen; plant pathology; phytopathogen fungi; phytopathogen bacteria; phytoalexins; plant defense; allelopathy; fungicides
(This special issue belongs to the Section Molecular Plant Sciences)
Glial Cells in Neurodegenerative Disorders
edited by Daniel Souza Monteiro de Araujo
submission deadline 20 May 2026 | 3 articles | Viewed by 5086
Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders
(This special issue belongs to the Section Molecular Neurobiology)
RNA Editing/Modification in Health and Disease
edited by Valeriana Cesarini and
submission deadline 20 May 2026 | 2 articles | Viewed by 5026
Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs
(This special issue belongs to the Section Molecular Genetics and Genomics)
Biological Study of Plant Bioactive Compounds submission deadline 20 May 2026 | 6 articles | Viewed by 4922
Keywords: plants’ biological activity; analysis of plant and plant preparations; interactions between plants and drugs; drugs inspired by plant actives; misuse of plant preparations
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Biology of Host and Pathogen Interactions: 3rd Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 4881
Keywords: microbe; pathogen; virus; bacteria; parasite; fungi; infection; disease; interaction; host response
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research in Epilepsy and Epileptogenesis—2nd Edition
edited by and Barbara Miziak
submission deadline 20 May 2026 | 3 articles | Viewed by 4864
Keywords: epilepsy; antiseizure; anti-epileptogenic drugs; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Evolution and Genomics: Relevance to Current Issues
edited by and Sally Lloyd
submission deadline 20 May 2026 | 2 articles | Viewed by 4854
Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights into Chemotherapeutic Agents in Cancer Treatment
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 4779
Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics
(This special issue belongs to the Section Molecular Pharmacology)
Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies
edited by and Bohan Yin
submission deadline 20 May 2026 | 2 articles | Viewed by 4736
Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release
(This special issue belongs to the Section Macromolecules)
Peptides and Peptidomimetics for Targeting Protein-Protein Interactions submission deadline 20 May 2026 | 1 articles | Viewed by 4657
Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC
(This special issue belongs to the Section Biochemistry)
Advancements in Regenerative Medicine Research
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 4513
Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Computational Research in Pharmacological Structure–Efficacy
edited by and Jerônimo Lameira
submission deadline 20 May 2026 | 2 articles | Viewed by 4504
Keywords: molecular modeling; structure– activity relationship (SAR); pharmacological efficacy; quantum chemistry; molecular dynamics; free energy calculations; drug design; enzyme inhibition; ligand– receptor interactions; computational pharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition submission deadline 20 May 2026 | 2 articles | Viewed by 4480
Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Primary Colorectal Cancer and Liver Metastases
edited by Alexandros E. Giakoustidis
submission deadline 20 May 2026 | 2 articles | Viewed by 4475
Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics submission deadline 20 May 2026 | 4 articles | Viewed by 4446
Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Flower Gene Regulation
edited by Wen‑Chieh Tsai
submission deadline 20 May 2026 | 2 articles | Viewed by 4197
Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination
(This special issue belongs to the Section Molecular Plant Sciences)
Cyclodextrins for Drug/iRNA Co-Delivery
edited by and
submission deadline 20 May 2026 | 1 articles | Viewed by 4101
Keywords: advanced therapies; antibody-based therapies; active and passive tumor targeting; cancer; conventional chemotherapy; immune system; immunotherapy; immunotoxicity; nanomedicine; nanoparticles; nanotoxicity; tumor immune microenvironment (TIME); tumor microenvironment (TME); cyclodextrins
(This special issue belongs to the Section Macromolecules)
The Role of Lipoprotein in Cardiovascular Disease submission deadline 20 May 2026 | 2 articles | Viewed by 3938
Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Heart Failure: From Pathogenesis to Innovative Treatments
edited by Volker Adams and
submission deadline 20 May 2026 | 2 articles | Viewed by 3911
Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in the Synthesis and Medical Application of Biomaterials
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 3751
Keywords: nanostructured biomaterials; bioceramics; bioactive; biodegradable; resorbable materials; biomimetic materials; biocompatibility
(This special issue belongs to the Section Materials Science)
New Research on Bioactive Natural Products: 2nd Edition submission deadline 20 May 2026 | 1 articles | Viewed by 3714
Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure– activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Lymphedema: From Mechanism to Treatment
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 3680
Keywords: lymphedema; lymphatic dysfunction; molecular mechanisms; cell signaling; diagnostic imaging; biomarkers; therapeutic interventions; inflammation; adipose tissue accumulation; fibrosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Life’s Thermodynamics: Cells and Evolution
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 3654
Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 3646
Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry
(This special issue belongs to the Section Materials Science)
Heart Failure and Cardiac Remodeling: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 3592
Keywords: heart failure; cardiac remodeling; molecular mechanisms; therapeutic strategies; cardiomyopathy; biomarkers; gene therapy; regenerative medicine; pharmacology; inflammation; fibrosis; signal transduction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition
edited by Sanja Dabelić
submission deadline 20 May 2026 | 3 articles | Viewed by 3568
Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics
(This special issue belongs to the Section Macromolecules)
DNA Virus Infection: HPV-Related Cancers, Pathology, Biomarkers and Immunotherapy submission deadline 20 May 2026 | 1 articles | Viewed by 3528
Keywords: HPV; molecular diagnostics; HPV ctDNA; cancer; mutations; viral oncogenicity; immunotherapy; biomarkers; oncology; cancer treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 3512
Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer
(This special issue belongs to the Section Molecular Oncology)
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