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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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DNA and mRNA-Based Vaccines Against Infectious Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 4592 | Submission Open
Keywords: mRNA vaccines; DNA vaccines; vaccine delivery; infectious disease; animal model
(This special issue belongs to the Section Molecular Immunology)
Advances in Polymers and Polysaccharides in Delivery Systems
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4525 | Submission Open
Keywords: polysaccharides; synthetic polymers; drug delivery systems; enzyme drugs; gene delivery; targeted release; controlled drug delivery systems
(This special issue belongs to the Section Molecular Pharmacology)
Advances in G Protein-Coupled Receptor Signaling
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 4518 | Submission Open
Keywords: G protein-coupled receptors (GPCRs)G蛋白偶联受体; seven transmembrane domain (7TM) receptors七跨膜结构域受体; metabotropic receptors代谢型受体; membrane receptors膜受体; GPCRs signalingGPCR信号; GPCRs signaling pathwaysGPCR信号通路; anti-inflammatory effects抗炎作用; inflammatory diseases炎性疾病; metabolic diseases代谢疾病; metabolic effects代谢效应; anti-inflammatory treatment抗炎治疗
(This special issue belongs to the Section Molecular Immunology)
TRP Channel, 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4365 | Submission Open
Keywords: TRP; TRPAnkyrin; TRPCanonical; TRPMelastatin; TRPPolycystin; TRPVanilloid
(This special issue belongs to the Section Molecular Pharmacology)
Genetic, Epigenetic and Microbiota Molecular Insights for Crop Resilience to Abiotic Stress
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4340 | Submission Open
Keywords: abiotic stress; tolerance; crop resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiota communities; microbiome
(This special issue belongs to the Section Molecular Plant Sciences)
Cellular Metabolism and Retinal Diseases: Unraveling Molecular Pathways and Therapeutic Targets submission deadline 20 Sep 2025 | 3 articles | Viewed by 4233 | Submission Open
Keywords: retina; metabolic dysfunction in retinal diseases; metabolism and retinal cell function; metabolism and oxidative stress; therapeutic targets; intracellular signaling; epigenetic modification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Perspectives in Nanomedicine
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 4194 | Submission Open
Keywords: nanomedicine; drug delivery; nano therapy and diagnostics; micro and nanofluidic tools; hybrid nanoparticles; CAR-T nanotechnologies
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Advances in Mental Health and Disorders
edited by Eva Christina Schulte
submission deadline 20 Sep 2025 | 3 articles | Viewed by 4153 | Submission Open
Keywords: molecular studies; mental health disorders; model systems; molecular epidemiology; omics   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified ChinesePRO Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Probiotics, Prebiotics and Postbiotics: The Secrets of Promoting Microbial Balance in the Gut
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4123 | Submission Open
Keywords: probiotics; prebiotics; postbiotics; gut microbiota; gut epithelial integrity
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Oxidative Stress in Kidney Disease
edited by Stefanos Roumeliotis
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4104 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; hemodialysis; peritoneal dialysis; oxidative stress; pro-oxidants; inflammation; atherosclerosis; cardiovascular disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Liver Disease: From Pathophysiology to Treatment
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 4084 | Submission Open
Keywords: nonalcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); type 2 diabetes (T2D)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Analysis and Applications of Comparative and Functional Genomic on Horticultural Plants: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 4076 | Submission Open
Keywords: horticultural plants; gene family; comparative genomics; genome evolution; gene function; gene expression; database construction; tool development
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms and Pathophysiology of Cystic Fibrosis
edited by and George M. Solomon
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4049 | Submission Open
Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeted Radioligand Therapy and Immunotherapy for Cancer Treatment submission deadline 20 Sep 2025 | 1 articles | Viewed by 3985 | Submission Open
Keywords: targeted radioligand therapy; immunotherapy; receptor targeting; tumor-specific antigens; immune checkpoint inhibitors; radiosensitization; tumor microenvironment; combination therapy
(This special issue belongs to the Section Molecular Oncology)
The Impact of Mitochondria on Human Disease and Health
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 3939 | Submission Open
Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer
(This special issue belongs to the Section Biochemistry)
Technical Developments and Recent Applications of Cellular Molecular Imaging
edited by Hanae Sato
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3931 | Submission Open
Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging
(This special issue belongs to the Section Molecular Biology)
Molecular Targets and Immunotherapy for Autoimmune Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3832 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; signaling pathway; molecular targets; antibody; T cells; B cells
(This special issue belongs to the Section Molecular Immunology)
Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3780 | Submission Open
Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution
(This special issue belongs to the Section Molecular Oncology)
Advances in Electrochemotherapy
edited by Jurij Novickij, and
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3761 | Submission Open
Keywords: electrochemotherapy; drug delivery; pulsed electric fields; cancer; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Computational Methods for Studying the Effects of Radiation on Human Beings submission deadline 20 Sep 2025 | 2 articles | Viewed by 3751 | Submission Open
Keywords: DNA damage; biophysical models; DNA geometrical models; computational radiobiology; Monte Carlo simulations; ionizing radiation; heavy ions; DNA damage repair
(This special issue belongs to the Section Molecular Biophysics)
The Molecular Role of Platelets in Human Diseases submission deadline 20 Sep 2025 | 3 articles | Viewed by 3734 | Submission Open
Keywords: platelet; biomarkers; platelet membrane proteins; platelet-derived microparticles; platelet-related diseases; thrombosis; inflammatory diseases; cardiovascular disease; cancer; tumor growth and metastasis
(This special issue belongs to the Section Molecular Biology)
Compounds with Added Value from Marine Algae for Biomedical Applications submission deadline 20 Sep 2025 | 1 articles | Viewed by 3686 | Submission Open
Keywords: algae bioactive compounds; algal biotechnology for biomedical purposes; algal-derived biomedical materials; algal-based drug delivery systems; alginate; carrageenan; fucoidan; marine polysaccharides; marine peptides; marine polyphenols; marine antioxidants; marine bioactive compounds; marine glycosaminoglycans; marine biopolymers and biomaterials; marine lipids; marine-derived pharmaceuticals; marine-derived cosmeceuticals; marine-derived nutraceuticals; marine algae added-value products; marine drugs discovery; marine natural products; marine-derived anti-inflammatory agents; marine antimicrobial compounds; marine-derived anticancer agents; marine neuroprotective compounds; marine-derived anti-aging compounds; marine-based regenerative medicine; phycobiliproteins; seaweed-based tissue engineering materials; seaweed-derived bioactive molecules; seaweed extracts; seaweed-based wound healing materials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases
edited by , and
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3653 | Submission Open
Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Quadruplex DNA and Its Ligands for Disease Treatment
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3611 | Submission Open
Keywords: quadruplex; i-motif; transcriptional regulation; apoptosis; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Application of Artificial Intelligence in Molecular Sciences
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3600 | Submission Open
Keywords: artificial intelligence; deep learning; algorithms; molecular modeling and simulation; materials discovery; analysis of biological sequence data; computational chemistry; bioinformatics; genomics; protein structure prediction; molecular dynamics simulation
(This special issue belongs to the Section Molecular Informatics)
Current Trends in MOF (Metal–Organic Framework) and Metal X-ides Development, 2nd Edition
edited by Siwei Li
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3536 | Submission Open
Keywords: MOF; metal carbide; metal sulfide; metal phosphide; catalysis; biomedicine; electromagnetic absorption; energy conversion and storage
(This special issue belongs to the Section Materials Science)
Molecular Strategies to Overcome Antibiotic Resistance in Carbapenem-Producing Bacteria submission deadline 20 Sep 2025 | 2 articles | Viewed by 3511 | Submission Open
Keywords: antibiotic resistance; antimicrobial agents; bacterial pathogens; carbapenemases; genomics; molecular mechanisms; therapeutic targets
(This special issue belongs to the Section Molecular Biology)
Editorial Board Members’ Collection Series: Cancer Metabolism submission deadline 20 Sep 2025 | 2 articles | Viewed by 3506 | Submission Open
Keywords: cancer metabolism; metabolic pathway; glucose consumption and energy production; amino acid requirement
(This special issue belongs to the Section Molecular Oncology)
Rheumatoid Arthritis: Molecular Mechanisms and Immunotherapy
edited by Irena Manolova
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3460 | Submission Open
Keywords: rheumatoid arthritis; pathogenesis; innate immunity; adaptive immunity; inflammation; cytokines; autoantibodies; immunotherapy; clinical outcome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances and Challenges in Colorectal Cancer: From Molecular Research to Treatment submission deadline 20 Sep 2025 | 1 articles | Viewed by 3437 | Submission Open
Keywords: tumor biology; tumor heterogeneity; molecular mechanism involved in cancer initiation; progression; and metastasis; compensatory pathways; cancer screening; cancer biomarkers discovery; tumor molecular profiling methods; early cancer diagnosis; novel therapeutic strategies; targeted therapies; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Adapter CAR T Cells: From the Idea to the Clinic submission deadline 20 Sep 2025 | 1 articles | Viewed by 3403 | Submission Open
Keywords: CAR T cell therapy; chimeric antigen receptor; bispecific antibody; target module; autoimmune diseases; solid tumors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathophysiology and New Therapies of Alopecia
edited by Jong-Hyuk Sung
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3376 | Submission Open
Keywords: alopecia; pathophysiology; novel pharmacological treatments; regenerative medicines; gene therapy; cell therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroinflammation in the Pathogenesis of Alzheimer’s Disease and Related Dementias: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3339 | Submission Open
Keywords: Alzheimer’ s disease; neuroinflammation; drug development; microglia; astrocytes; cytokines; TREM2; risk factors; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Molecular Pathology, Diagnostics, and Therapeutics in Optic Neuropathies
edited by Tsz Kin Ng
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3328 | Submission Open
Keywords: optic neuropathies; glaucoma; optic nerve; retinal ganglion cells; neuroprotection; biomarkers; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
False-Positive and False-Negative Laboratory Biomarkers
edited by Michela Salvatici and Lorenzo Drago
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3306 | Submission Open
Keywords: biomarkers; false positives/negatives; protein biomarkers; nucleic acid markers; multi-omics; single-cell sequencing; liquid biopsy
(This special issue belongs to the Section Biochemistry)
Drug Discovery and Development Focusing on Natural Products submission deadline 20 Sep 2025 | 1 articles | Viewed by 3248 | Submission Open
Keywords: natural products; drug R& D; herbal medicine; gut microbiota; mechanism of action; therapeutic targets
(This special issue belongs to the Section Molecular Pharmacology)
New Anti-cancer Agents: Design, Synthesis and Applications submission deadline 20 Sep 2025 | 2 articles | Viewed by 2993 | Submission Open
Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity
(This special issue belongs to the Section Molecular Pharmacology)
Type 1 Diabetes: Molecular Mechanisms and Therapeutic Approach
edited by Preeti Chhabra
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2930 | Submission Open
Keywords: type 1 diabetes; microbiome; proteomics; immunotherapy; β -cell replacement; single-cell sequencing; stem cells; gene editing technologies; tolerance
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Roles of Mesenchymal Stem/Stromal Cells in Tumor Therapies
edited by Francesco Agostini
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2901 | Submission Open
Keywords: mesenchymal stem cells; tumor; cancer patients; ex vivo cell modification; cell and gene therapy; targeted drug delivery; homing; migration; current regulatory guidelines; MSC therapeutic potential
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research on Cardiac Troponins submission deadline 20 Sep 2025 | 2 articles | Viewed by 2881 | Submission Open
Keywords: cardiac troponin; gene mutations; post-translational modifications; therapy; high-sensitivity (hs) immunoassays; mechanisms of release; biomarkers; cardiovascular disease
(This special issue belongs to the Section Molecular Biology)
Research of Hydroxyapatite-Based Materials and Their Applications
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2859 | Submission Open
Keywords: hydroxyapatite; nanobiocomposite; biomedical applications; coatings; environment remediation; biological properties; drug delivery; pollutant adsorption efficiency; morphology and structural features
(This special issue belongs to the Section Materials Science)
Novel Technologies in the Study of the Pathogenesis of Cardiac Diseases submission deadline 20 Sep 2025 | 1 articles | Viewed by 2828 | Submission Open
Keywords: artificial Intelligence; multi-omics; organoids; engineered heart tissue; advanced imaging; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Utilizing Induced Pluripotent Stem Cells and Cardiomyocytes: From Basic Research to Disease Modeling
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2828 | Submission Open
Keywords: induced pluripotent stem cells; cardiomyocytes; disease modeling; basic research; translational applications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Parvovirus
edited by Zahra Kadri
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2826 | Submission Open
Keywords: parvovirus structure; parvovirus replication; parvovirus proteome; cell signaling pathways; transcription; translation and post-translational modification; host restriction factor; host/parvovirus interaction; recombinant virus and VLP; immune evasion and/or activation; host tropism (cell type and species); new experimental models and approaches
(This special issue belongs to the Section Molecular Microbiology)
Emerging Heterocycles submission deadline 20 Sep 2025 | 1 articles | Viewed by 2808 | Submission Open
Keywords: synthesis; reactions; applications; biological activity; medicinal chemistry; natural products; alkaloids; new methodology
(This special issue belongs to the Section Biochemistry)
Molecular Advances in Olive and Its Derivatives
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2792 | Submission Open
Keywords: olive; structural and functional genomics; genomic variation; breeding; biotechnologies; next-generation sequencing
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Retinal Neurobiology
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2673 | Submission Open
Keywords: retina; vision; disease; ganglion cells; amacrine cells; bipolar cells; horizontal cells; photoreceptors; astrocytes; microglia; Mü ller cells
(This special issue belongs to the Section Molecular Neurobiology)
The Blood–Brain Barrier and Neuroprotection
edited by Aruna Sharma and Hari Shanker Sharma
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2662 | Submission Open
Keywords: blood– brain barrier; neurodegenerative diseases; nanoformulations; drug development; delivery systems
(This special issue belongs to the Section Molecular Neurobiology)
Microbiota’s Role in Respiratory Disorders and Diseases
edited by and Mauro Carone
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2629 | Submission Open
Keywords: microbiota; microbiome; metabolome; transcriptome; microbiota gut/lung axis; microbiota gut/oral axis; respiratory disorders; respiratory diseases; respiratory rehabilitation
(This special issue belongs to the Section Molecular Microbiology)
Molecular Dimensional Design, Synthesis Modification and Application of Sustainable Polymer Materials
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2604 | Submission Open
Keywords: sustainable polymeric materials; 3D printing; sustainability; environmental impact; molecular modifications
(This special issue belongs to the Section Materials Science)
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