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Advancements in Understanding Protein Misfolding Disorders and Cancer
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Advancements in Understanding Protein Misfolding Disorders and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 4249

Special Issue Editor

Prof. Dr. Marijn Speeckaert

E-Mail Website
Guest Editor
Department of Nephrology, Ghent University Hospital, 9000 Ghent, Belgium
Interests: biochemistry; biomarkers; hypertension; cardiovascular disease; kidney disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This special issue aims to bridge the knowledge between protein misfolding disorders such as amyloidosis and cancer by exploring the molecular pathways, diagnostic methodologies, and therapeutic strategies pertinent to these diseases. We invite investigators to submit original research articles, comprehensive reviews, and insightful commentaries that contribute to a deeper understanding of these distinct yet intersecting fields. Topics of interest include but are not limited to:

  • Molecular and genetic mechanisms underlying protein misfolding and aggregation in amyloidosis and oncogenesis.
  • Advances in diagnostic technologies and methodologies for early and accurate detection of amyloidosis and cancer.
  • Cross-talk between misfolded protein pathways and cancer signaling pathways.
  • Novel therapeutic strategies targeting common molecular pathways in protein misfolding disorders and cancer.
  • Multi-disciplinary approaches for managing patients with coexisting amyloidosis and cancer.
  • Patient-centric studies exploring the impact, management, and prognosis of amyloidosis and cancer.
  • Real-world evidence and clinical case studies highlighting diagnostic challenges and treatment outcomes in amyloidosis and cancer.

Prof. Dr. Marijn Speeckaert
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • protein misfolding
  • cancer
  • amyloidosis

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Published Papers (2 papers)

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Research

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17 pages, 2000 KB  
Article
Targeting Gliomas with Beta-Amyloid-Specific Dyes: A Novel Approach for In Vivo Staining and Potential Therapeutic Applications
by Lilia Kucheryavykh, Jescelica Ortiz Rivera, Boris Ermolinsky, Vassiliy Tsytsarev, Lynnette Cary, Janaina Alves, Adriana Reyes, Noelis de la Cruz-Rivera, Kevin Rosa Gonzalez, Felix Narvaez Irizarry, Tyrel R. Porter and Mikhail Inyushin
Int. J. Mol. Sci. 2025, 26(21), 10450; https://doi.org/10.3390/ijms262110450 - 28 Oct 2025
Viewed by 254
Abstract
Gliomas, the most common primary brain tumors, present significant diagnostic and treatment challenges due to their infiltrative nature and heterogeneity. Our previous research revealed that glioma tumors in both animals and humans accumulate beta-amyloid protein (Aβ), detectable through immunohistochemical methods or staining with [...] Read more.
Gliomas, the most common primary brain tumors, present significant diagnostic and treatment challenges due to their infiltrative nature and heterogeneity. Our previous research revealed that glioma tumors in both animals and humans accumulate beta-amyloid protein (Aβ), detectable through immunohistochemical methods or staining with amyloid-specific dyes. We hypothesize that beta-amyloid-specific dyes could serve as glioma markers, potentially enabling the delineation of glioma tumors or targeted therapeutics delivery. In this study, the specificity and blood-brain barrier permeability of two fluorescent beta-amyloid-specific dyes, Brilliant Blue G (BBG) and BODIPY-based Amyloid Probe-1 (BAP-1), were evaluated in C57Bl/6 mouse glioma implantation models using GL261 and KR158 glioma cells. The findings demonstrate that both BBG and BAP-1 selectively stain gliomas, providing a clear contrast from normal brain tissue. The study results open avenues for further development of glioma visualization methods and targeted therapeutic delivery strategies for clinical applications. Full article
(This article belongs to the Special Issue Advancements in Understanding Protein Misfolding Disorders and Cancer)
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Review

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18 pages, 931 KB  
Review
Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes
by Charlotte Delrue, Amélie Dendooven, Annelore Vandendriessche, Reinhart Speeckaert, Sander De Bruyne and Marijn M. Speeckaert
Int. J. Mol. Sci. 2024, 25(11), 5875; https://doi.org/10.3390/ijms25115875 - 28 May 2024
Cited by 3 | Viewed by 3176
Abstract
Renal amyloidosis is a set of complex disorders characterized by the deposition of amyloid proteins in the kidneys, which causes gradual organ damage and potential kidney failure. Recent developments in diagnostic methods, particularly mass spectrometry and proteome profiling, have greatly improved the accuracy [...] Read more.
Renal amyloidosis is a set of complex disorders characterized by the deposition of amyloid proteins in the kidneys, which causes gradual organ damage and potential kidney failure. Recent developments in diagnostic methods, particularly mass spectrometry and proteome profiling, have greatly improved the accuracy of amyloid typing, which is critical for disease management. These technologies provide extensive insights into the specific proteins involved, allowing for more targeted treatment approaches and better patient results. Despite these advances, problems remain, owing to the heterogeneous composition of amyloid proteins and the varying efficacy of treatments based on amyloid type. Access to sophisticated diagnostics and therapy varies greatly, highlighting the global difference in renal amyloidosis management. Future research is needed to investigate next-generation sequencing and gene-editing technologies, like clustered regularly interspaced short palindromic repeats (CRISPR), which promise more profound insights into the genetic basis of amyloidosis. Full article
(This article belongs to the Special Issue Advancements in Understanding Protein Misfolding Disorders and Cancer)
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