Eustress: Molecular Events Underlying the Usefulness of Moderate Oxidative Stress in Prevention and Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 1194
Special Issue Editor
Interests: medical ozone; system medicine; Nrf2; oxidative stress; clinical pharmacology
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Special Issue Information
Dear Colleagues,
Many scientists are paying increasing attention to biochemical mechanisms capable of controlling and probably correcting many functions of the human organism, mainly linked to oxidative stress.
It is interesting to note how over the last two decades, thousands of works have been published on a transcription factor called Nrf2, emphasizing its clinical importance and adding to the complexity of the definition of its activity, which can undoubtedly be considered evolutionary of the species.
It is now clear that this path is of enormous importance, even if we are still far from understanding its supposed potential in terms of clinical utility or therapeutic benefits, especially in relation to the inevitable damage of aging.
Among the countless and prestigious works published, it is not yet clear whether the effect of this transcription factor can be activated in a gradual or binary manner.
We believe the time has come for medical science to make an effort to study the cellular and molecular mechanisms underlying the action of adequate oxidative stimuli (eustress) capable of modulating the Nrf2 metabolic pathway.
To date, we know that like other pharmacological agents or xenobiotic stimuli, molecules such as medical ozone are also able to interact with the Kep1–Nrf2 complex, initiating a cascade of events which, through complex epigenetic mechanisms, can represent a formidable resource for the regulation of pathological processes resulting from aging, including immune, vascular and neurological functions, and many others.
The aim of this Special Issue will be to stimulate research aimed at understanding the pharmacological and molecular mechanisms not yet completely defined in their complexity.
Dr. Lamberto Re
Guest Editor
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Keywords
- eustress
- medical ozone
- Nrf2
- aging
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