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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancer Immunotherapy Biomarkers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Apostolos Zaravinos

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2325 | Submission Open

Keywords: tumor microenvironment; tumor immunology; cancer biomarkers; immunotherapy; immunohistochemistry; pathology; personalized medicine; omics technologies; prognosis and therapy; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biological Determination of Physical Injury

edited by

Sorin Hostiuc

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2153 | Submission Open

Keywords: molecular markers; physical injury; micro-RNA; dating of traumatic injuries

(This special issue belongs to the Section Molecular Biology)

Advanced Oxidation Processes for the Decontamination of Emerging Contaminants and Disinfection of Pathogenic Microorganisms

edited by

Chengdu Qi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2118 | Submission Open

Keywords: advanced oxidation processes; emerging contaminants; pathogenic microorganisms; disinfection; hydroxyl radical; sulfate radical; organic radical

(This special issue belongs to the Section Molecular Microbiology)

Molecular Toxicity Research of Biological Venoms

edited by

Karla De Castro Figueiredo Bordon

and Suely Vilela Sampaio

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1991 | Submission Open

Keywords: neurotoxicity assays; insect models; electrophysiology; screening assays; ion channels; therapeutic molecules; animal venoms; antitumoral activity; enzyme activity; biotechnological application

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Brain Cancers: Second Edition

edited by

Monika Gudowska-Sawczuk

and

Karolina Orywal

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1762 | Submission Open

Keywords: brain tumors; malignant brain tumor; advanced cancer biology

(This special issue belongs to the Section Molecular Oncology)

The Biogenesis, Structure, Function and Division of Plastids

edited by

Xiaomin Liu

and Li'na Yin

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1678 | Submission Open

Keywords: plastid; chloroplast; chlorophyll; endosymbiotic cyanobacteria; photosynthesis; genetic engineering

(This special issue belongs to the Section Biochemistry)

Significance and Challenges of Plant-Derived Natural Compounds in Cancers

edited by Ba Vinh Le

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1278 | Submission Open

Keywords: metabolomic; bioactive compound; pharmacognosy; oriental medicine; drug discovery; pharmacology; anti-cancer; pharmacological effects

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Epigenetics of Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1260 | Submission Open

Keywords: epigenetics; metabolic diseases; DNA methylation; histone modifications; non-coding RNAs; obesity; diabetes; metabolic syndrome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Unravelling Functional Biology in Retinal Dystrophies and Eye Disease

edited by

Luigi Donato

and

Simona Alibrandi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1236 | Submission Open

Keywords: precision ophthalmology; inherited retinal diseases; functional genomics; multi-omics approaches; photoreceptor degeneration; retinal organoids and iPSC models; bioinformatics and systems biology; genotype– phenotype correlations; RNA therapeutics and gene editing; early and late biomarkers of retinal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Updates and Advances in Molecular Toxicology

edited by

Marco E. M. Peluso

submission deadline 30 Jan 2026 | 2 articles | Viewed by 1162 | Submission Open

Keywords: molecular toxicology; biomarkers; mechanisms of toxicity; xenobiotics; cancer diagnosis

(This special issue belongs to the Section Molecular Toxicology)

Plant Cell/Organ Structure and Function Research

edited by

Bartosz Płachno

submission deadline 30 Jan 2026 | 2 articles | Viewed by 1157 | Submission Open

Keywords: leaf development; root development; plant cell ultrastructure; plant morphogenesis; plant organs and bacteria; fungi and animal interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Dialogues in the Tumor Microenvironment: Mechanisms, Methods and Therapeutic Implications

edited by

José M. Muñoz-Félix

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1136 | Submission Open

Keywords: tumor microenvironment; blood vessels; immune cells; spatial transcriptomics; histology

(This special issue belongs to the Section Molecular Oncology)

Exosomes and Non-Coding RNA Research in Health and Disease—2nd Edition

edited by

Stergios Boussios

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1127 | Submission Open

Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Spectral Control of Stress Response in Plants

edited by

Gábor Kocsy

and Zsolt Gulyás

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1075 | Submission Open

Keywords: spectral control; stress response; light spectrum; photoreceptor; reactive oxygen; plant hormone; antioxidant; plant growth and development

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Advances in Aquatic Genetic Improvement

edited by Jun Qiang,

Yifan Tao

and Wenjing Tao

submission deadline 30 Jan 2026 | 1 articles | Viewed by 897 | Submission Open

Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence

(This special issue belongs to the Section Molecular Genetics and Genomics)

KRAS-Mutant Cancers: From Basic Biology to Clinical Translation

edited by

Mirela Sedić

Sérgia Velho

and Luka Bočkor

submission deadline 30 Jan 2026 | Viewed by 852 | Submission Open

Keywords: KRAS mutations; KRAS signalling; cancer; KRAS inhibitors; drug resistance; tumour microenvironment; cellular metabolism

(This special issue belongs to the Section Molecular Oncology)

Experimental Models and Applications in Muscle Regeneration

edited by

Daiva Bironaite

submission deadline 30 Jan 2026 | 1 articles | Viewed by 813 | Submission Open

Keywords: stem cells; internal and external stimuli; scaffolds; signaling systems; muscle regeneration mechanisms

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence Advancing Computer-Aided Drug Discovery

edited by

Raju Dash

submission deadline 30 Jan 2026 | 1 articles | Viewed by 660 | Submission Open

Keywords: machine learning; deep learning; computer-aided drug design; target identification; AI-assisted molecular diagnosis; AI-driven pharmacokinetic profiling; virtual screening; network pharmacology; drug repurposing; molecular dynamics simulation; computational chemistry; AI in nanotechnology

(This special issue belongs to the Section Molecular Informatics)

Chemoinformatics and Bioinformatics Tools in Structure-Activity Modelling in Molecular Sciences: 3rd Edition

edited by

Bono Lučić

submission deadline 30 Jan 2026 | Viewed by 631 | Submission Open

Keywords: chemoinformatics tools and models; bioinformatics tools and models; structure– activity modeling; structure– property modeling; QSAR; QSPR; drug/structure identification in bioprospecting research; molecular docking; molecular interactions; protein– protein interactions; development of algorithms; databases and web servers; data mining in chemoinformatics and bioinformatics; structure representation and optimization; molecular descriptors; modeling of health and environmentally relevant endpoints (activities; properties); toxicity modeling and prediction; carcinogenicity modeling and prediction; computational methods in molecular sciences; model validation approaches; multivariate modeling; predictive modeling; descriptive modeling; continuous data modeling; classification data modeling; machine learning in molecular sciences; deep learning in molecular sciences; structure visualization tools

(This special issue belongs to the Section Molecular Informatics)

Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies

edited by Osha Roopnarine

submission deadline 30 Jan 2026 | Viewed by 615 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies

(This special issue belongs to the Section Molecular Pharmacology)

Protease and Carbonic Anhydrase Inhibitors: 3rd Edition

edited by

Alessio Nocentini

submission deadline 30 Jan 2026 | Viewed by 582 | Submission Open

Keywords: carbonic anhydrase; protease; inhibitor; antiviral drug; antitumor drug; drug design; serine protease; metalloprotease; aspartic protease

(This special issue belongs to the Section Biochemistry)

Autoimmune and Inflammatory Diseases: Latest Advances and Prospects

edited by

Paola Galozzi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 578 | Submission Open

Keywords: autoimmunity; autoimmune disease; inflammation; inflammatory disease; cellular pathways; molecular mechanisms; pathogenesis; therapy

(This special issue belongs to the Section Molecular Immunology)

Insights into Neurological and Psychiatric Diseases from Invertebrate Models

edited by

Efthimios M. C. Skoulakis

submission deadline 30 Jan 2026 | Viewed by 507 | Submission Open

Keywords: disease model development; disease model validation; GWAS validation; ameliorative approaches; pharmacogenetics; pharmacoproteomics; disease mechanisms; suppressor/enhancer genetic screens; synthetic lethality screens; biomarker screens and validation

(This special issue belongs to the Section Molecular Neurobiology)

Inflammation and Metabolic Response in Mitochondrial Diseases

edited by

Guido Primiano

submission deadline 30 Jan 2026 | Viewed by 456 | Submission Open

Keywords: mitochondrial diseases; mitochondria; mtDNA; metabolic remodeling; inflammation; immunity; cell death; neurodegenration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence in Human Disease: Current and Future Perspectives in Digital Medicine

edited by

Dumache Raluca-Oana

submission deadline 30 Jan 2026 | Viewed by 433 | Submission Open

Keywords: molecular genetics; artificial intelligence; pharmacogenomics; internet of things; molecular pathology; genomic medicine

(This special issue belongs to the Section Molecular Informatics)

New Insights in Nanomaterials and Electroactive Molecules—in Memory of Prof. Royce W. Murray

edited by

Zeev Porat

submission deadline 30 Jan 2026 | 1 articles | Viewed by 401 | Submission Open

Keywords: nanomaterials; organic electrochemistry; macromolecules and polymers; analytical chemistry

(This special issue belongs to the Section Molecular Nanoscience)

Nutritional Modulators of Healthy Longevity: Mechanisms and Interventions

edited by

Shaokang Wang

submission deadline 30 Jan 2026 | Viewed by 357 | Submission Open

Keywords: aging; healthspan; nutrient signaling; oxidative stress; inflammation; autophagy; sarcopenia; bioactive compounds; molecular nutrition; protein metabolism

(This special issue belongs to the Section Molecular Biology)

Photosensitizers for Photodynamic Therapy: From Molecular Design to Application

edited by

Carlos Monteiro

M. Amparo F. Faustino

and

Leandro M. O. Lourenço

submission deadline 30 Jan 2026 | Viewed by 314 | Submission Open

Keywords: photodynamic therapy (PDT); photosensitizers (PS); reactive oxygen species (ROS); molecular design; nanocarriers; porphyrins and analogs; targeted drug delivery; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Endometriosis Pathophysiology and Pharmacological Treatment (2nd Edition)

edited by

René Wenzl

submission deadline 30 Jan 2026 | Viewed by 206 | Submission Open

Keywords: endometriosis; pathophysiology; pharmacological treatment; estrogen

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Immune Mechanisms in Kidney Disease

edited by Niels Olsen Saraiva Câmara

submission deadline 30 Jan 2026 | Viewed by 199 | Submission Open

Keywords: kidney disease; molecular sensors; kidney metabolism; immunity; AKI to CKD transition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Interaction of Gut Microbiota and Food Bioactive Compounds

edited by

Yiming Feng

and

Xiaohong Sun

submission deadline 30 Jan 2026 | Viewed by 193 | Submission Open

Keywords: gut microbiome; molecular mechanisms; metabolomics; transcriptomics; bioactive compounds; microbial enzymes; host– microbe signaling; personalized nutrition; systems biology; functional genomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cellular and Molecular Pathogenesis of Gynecologic Diseases: Focus on Uterine and Ovarian Dysfunction

edited by

Seung-Yup Ku

submission deadline 30 Jan 2026 | Viewed by 189 | Submission Open

Keywords: molecular pathogenesis; uterine diseases; ovarian dysfunction; cellular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances of Osteomuscolar Conditions

edited by

Nicola Veronese

submission deadline 30 Jan 2026 | Viewed by 184 | Submission Open

Keywords: osteomuscular conditions; musculoskeletal disorders; bone; cartilage; and muscle degeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Therapy for Human Haemoglobinopathy

edited by Alex Felice and

Joseph Borg

submission deadline 30 Jan 2026 | Viewed by 179 | Submission Open

Keywords: haemoglobin (Hb); hemoglobinopathy (Hbpy); globin; thalassaemia; sickle cell; stem cell; gene therapy/editing; therapeutics; HbF inducing agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant–Rhizobium Interaction

edited by Rujin Chen

submission deadline 30 Jan 2026 | Viewed by 172 | Submission Open

Keywords: legume; rhizobia; symbiotic nitrogen fixation

(This special issue belongs to the Section Molecular Plant Sciences)

Cardiovascular Diseases: From Molecular Diagnosis to Treatment

edited by

Li Wang

submission deadline 30 Jan 2026 | Viewed by 163 | Submission Open

Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Environmental Carcinogenesis

edited by Grażyna Gromadzka

submission deadline 30 Jan 2026 | Viewed by 119 | Submission Open

Keywords: environmental carcinogenesis; molecular mechanisms; gene– environment interaction; endocrine disruptors; oxidative stress; epigenetics; cancer biomarkers; environmental pollutants; molecular epidemiology; cancer prevention; cancer treatment

(This special issue belongs to the Section Molecular Toxicology)

The Regulation of Metabolism by Sugars During Plant Responses to Environmental Factors and Their Function During Development

edited by

Iwona Morkunas

submission deadline 30 Jan 2026 | Viewed by 111 | Submission Open

Keywords: plant metabolism; sugar signalling; enzymes of sucrose metabolism; environmental factors; plant defense responses; developmental regulation; phytohormones; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Roles of Epithelial and Endothelial Cells

edited by

Lucie Germain

and

Stéphanie Proulx

submission deadline 31 Jan 2026 | 9 articles | Viewed by 20129 | Submission Open

Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier

(This special issue belongs to the Section Biochemistry)

Developmental Biology: Computational and Experimental Approaches, 2nd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 31 Jan 2026 | 5 articles | Viewed by 12284 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations

(This special issue belongs to the Section Molecular Biology)

Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches

edited by

Dimitrios Kanakis

submission deadline 31 Jan 2026 | 3 articles | Viewed by 8352 | Submission Open

Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma

(This special issue belongs to the Section Molecular Oncology)

Cytokines and Other Biomarkers of Health Status

edited by Anna Cywińska and

Ewelina Maculewicz

submission deadline 31 Jan 2026 | 5 articles | Viewed by 6710 | Submission Open

Keywords: cytokine concentration; cytokine gene expression; cytokine receptors; biomarkers; pathogenesis; adaptation; homeostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research into Chronic Heart Failure

edited by

Velia Cassano

submission deadline 31 Jan 2026 | 2 articles | Viewed by 6691 | Submission Open

Keywords: heart failure; oxidative stress; cardiac remodeling; cardiomyopathy; proteomic; molecular science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition

edited by Xiaogang Li

submission deadline 31 Jan 2026 | 5 articles | Viewed by 4727 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Oxidative and Redox Signalling in Neurological Diseases

edited by

Malamati Kourti

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3728 | Submission Open

Keywords: gasotransmitters; neurological diseases; oxidative stress; redox signalling; reactive oxygen species (ROS); neuroinflammation; mitochondrial dysfunction; cell death/apoptosis; nitrosative stress; endogenous gas signalling; neuromodulation; neurovascular coupling; therapeutic strategies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Th2-Mediated Inflammation in Dermatology: Mechanistic and Therapeutic Perspectives

edited by

Luca Mastorino

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2997 | Submission Open

Keywords: Th2 inflammation; inflammatory skin disease; immunology of the skin; type 2 inflammatory diseases; immunophenotype

(This special issue belongs to the Section Molecular Immunology)

25th Anniversary of IJMS: Updates and Advances in Molecular Biology

edited by

Irmgard Tegeder

Antonio Ieni

and

Costantino Balestra

submission deadline 31 Jan 2026 | 7 articles | Viewed by 2912 | Submission Open

Keywords: next-generation sequencing (NGS); CRISPR-Cas9; liquid biopsy; molecular diagnostics; personalized medicine; genome-wide association studies (GWAS)

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Pancreatic Diseases

edited by

Wasif Saif

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2388 | Submission Open

Keywords: pancreatic cancer; pancreatic neuroendocrine tumors; KRAS; KRAS inhibitors; KRASG12D inhibitor in pancreatic ductal adenocarcinoma; XPO1 inhibitor; PNET

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Target and Anti-Cancer Therapies

edited by Laura Denisa Dragu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1554 | Submission Open

Keywords: cancer; conventional therapy; targeted therapy; immunotherapy; natural compounds; combinatorial therapy; molecular target; molecular mechanism; drug design; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Voltage-Gating and Modulation in Ion Channels

edited by Joao Carvalho de Souza

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1550 | Submission Open

Keywords: voltage-gated ion channels; voltage sensing; voltage sensor coupling; new modulators; ion channel modulation; cell excitability

(This special issue belongs to the Section Molecular Biophysics)

Displaying special issue 51-100 on page 2 of 66.

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