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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Chromatin Remodelers as Players and Drivers in Pathological States
edited by Matteo De March
submission deadline 20 May 2026 | 4 articles | Viewed by 11163 | Submission Open
Keywords: protein structure/function; chromatin remodelers; DNA repair; oncogene/oncosuppressor; cancer
(This special issue belongs to the Section Molecular Biology)
Regulatory Network of Bone Metabolism
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 11094 | Submission Open
Keywords: osteoblasts; osteoclasts; osteocytes; mesenchymal stem cells; bone metabolism; bone formation; bone resorption
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Fish Immunology, 5th Edition submission deadline 20 May 2026 | 4 articles | Viewed by 10888 | Submission Open
Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms in Organ Transplantation
edited by Hirofumi Hirao
submission deadline 20 May 2026 | 6 articles | Viewed by 10888 | Submission Open
Keywords: organ transplantation; cellular-specific response to perioperative stress; cold/warm ischemia; innate/adaptive immunity; microcirculatory disturbance
(This special issue belongs to the Section Molecular Biology)
Pulmonary Hypertension: Molecular Diagnosis, Pathogenesis, Biomarkers and Therapies
edited by Michele Correale
submission deadline 20 May 2026 | 3 articles | Viewed by 10778 | Submission Open
Keywords: pulmonary hypertension; pulmonary arterial hypertension; pulmonary vascular disease; pulmonary circulation; cor pulmonale; chronic lung disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Development and Abiotic Stress Response Regulation via Alternative Splicing
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 10774 | Submission Open
Keywords: plants; development; abiotic stress responses; alternative splicing; transcriptional regulation; signaling; splicing factors
(This special issue belongs to the Section Molecular Plant Sciences)
Diagnosis and Treatment of Osteoporosis
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 10693 | Submission Open
Keywords: osteoporosis; diagnosis; dual X-rays absorptiometry; DXA; bone turnover markers; secondary osteoporosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Organic Synthesis in Drug Discovery submission deadline 20 May 2026 | 3 articles | Viewed by 10450 | Submission Open
Keywords: organic synthesis; drug design; heterocyclic chemistry; functionalization
(This special issue belongs to the Section Molecular Pharmacology)
Pharmacology and Toxicology of Synthetic and Natural Products
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 10427 | Submission Open
Keywords: pharmacology and toxicology; pharmacodynamics and pharmacokinetics; synthetic drugs; natural products; drug interactions; molecular mechanisms; therapeutic potential; adverse effects; dose– response relationship; drug safety and efficacy
(This special issue belongs to the Section Molecular Pharmacology)
Host Responses to Virus Infection
edited by and Yoshinao Kubo
submission deadline 20 May 2026 | 4 articles | Viewed by 10310 | Submission Open
Keywords: viral infection; host reactions; interferon alpha and beta; interferon gamma; cytokines; vaccine; cytokine storm
(This special issue belongs to the Section Molecular Microbiology)
New Advances in Opioid Research
edited by Matthew E. Layton
submission deadline 20 May 2026 | 5 articles | Viewed by 10035 | Submission Open
Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms and Treatment of Migraine
edited by Noboru Imai
submission deadline 20 May 2026 | 1 articles | Viewed by 9834 | Submission Open
Keywords: migraine; nitric oxide synthase (NOS); neuropeptides; calcitonin gene-related peptide (CGRP); pituitary adenylate cyclase activating polypeptide (PACAP); molecular pathways; therapeutic targets; neurovascular condition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurological Diseases: From Physiology to Therapy submission deadline 20 May 2026 | 2 articles | Viewed by 9547 | Submission Open
Keywords: neurophysiology; genetics; Alzheimer’ s disease; neurological diseases; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Studies of Monogenic Diseases: Diagnostics, Mechanisms and Therapeutics
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 9490 | Submission Open
Keywords: cell death pathways; DNA sequencing; drug discovery; gene expression; gene mutation; genetic diagnosis; molecular signaling; molecular therapy; monogenic disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in G Protein-Coupled Receptor Signaling
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 9489 | Submission Open
Keywords: G protein-coupled receptors (GPCRs)G蛋白偶联受体; seven transmembrane domain (7TM) receptors七跨膜结构域受体; metabotropic receptors代谢型受体; membrane receptors膜受体; GPCRs signalingGPCR信号; GPCRs signaling pathwaysGPCR信号通路; anti-inflammatory effects抗炎作用; inflammatory diseases炎性疾病; metabolic diseases代谢疾病; metabolic effects代谢效应; anti-inflammatory treatment抗炎治疗
(This special issue belongs to the Section Molecular Immunology)
Biophysical Perspectives on Bone Physiology and Pathology
edited by Atsuhiko Ichimura and Yohei Ueda
submission deadline 20 May 2026 | 1 articles | Viewed by 9311 | Submission Open
Keywords: bone formation; bone disorders; physiology; pathology; stem cells; osteoblasts; osteoclasts
(This special issue belongs to the Section Molecular Biophysics)
Molecular Mechanisms, Biomarkers, and Therapeutic Targets for Endometriosis
edited by Katharina Proestling and
submission deadline 20 May 2026 | 5 articles | Viewed by 9271 | Submission Open
Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 9206 | Submission Open
Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut– liver axis; spleen– liver axis; alcoholic liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanism in Multiple Sclerosis and Related Disorders: 3rd Edition
edited by and Kazuo Fujihara
submission deadline 20 May 2026 | 5 articles | Viewed by 9173 | Submission Open
Keywords: neurodegeneration; multiple sclerosis; NMOSD; MOGAD; disease-modifying treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Perspectives of Molecular Genetics and Genomics in Human Mendelian Diseases
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 9149 | Submission Open
Keywords: functional genomics; omics; genetic disease; human; molecular mechanisms; genome editing; biomarkers; computational genomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Polymeric Biomaterials
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 8880 | Submission Open
Keywords: biopolymers; biocomposites; nanomaterials; applications
(This special issue belongs to the Section Materials Science)
p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell
edited by Przemyslaw Bozko
submission deadline 20 May 2026 | 4 articles | Viewed by 8638 | Submission Open
Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Calcium Homeostasis of Cells in Health and Disease: Third Edition submission deadline 20 May 2026 | 6 articles | Viewed by 8603 | Submission Open
Keywords: Ca2+; calcium homeostasis; calcium-binding proteins; aging; disease
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms Linked to Exercise
edited by Igor Zubrzycki
submission deadline 20 May 2026 | 1 articles | Viewed by 8425 | Submission Open
Keywords: molecular mechanisms; exercise adaptations; translational health
(This special issue belongs to the Section Molecular Biology)
Extraction, Identification and Quantification of Bioactive Molecules
edited by and Rosario Mare
submission deadline 20 May 2026 | 2 articles | Viewed by 8393 | Submission Open
Keywords: extracts; botanicals; nutraceuticals; bioactive molecules; spectrometry; spectrophotometer; chromatography; western blotting; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Technical Developments and Recent Applications of Cellular Molecular Imaging
edited by Hanae Sato
submission deadline 20 May 2026 | 3 articles | Viewed by 8203 | Submission Open
Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging
(This special issue belongs to the Section Molecular Biology)
New Anti-cancer Agents: Design, Synthesis and Applications submission deadline 20 May 2026 | 2 articles | Viewed by 8169 | Submission Open
Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity
(This special issue belongs to the Section Molecular Pharmacology)
From Nature to Medicine: Exploring Natural Products for New Therapies
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 8124 | Submission Open
Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate
(This special issue belongs to the Section Molecular Pharmacology)
Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 8056 | Submission Open
Keywords: dementia with Lewy bodies; Alzheimer’ s disease; dementing disorders in advanced age
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeted Therapies and Molecular Methods in Cancer, 3rd Edition
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 8054 | Submission Open
Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Pathogenesis and Treatment of Pregnancy Complications
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 8030 | Submission Open
Keywords: hypertensive disorders of pregnancy; preeclampsia; molecular biology; biomarker; prevention; therapeutics; placenta
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Targets in Cardiovascular Health and Cardiotoxicity
edited by
submission deadline 20 May 2026 | 5 articles | Viewed by 8022 | Submission Open
Keywords: cardiovascular; ischemia; heart failure; arrhythmogenesis; myocardial remodeling; endothelial dysfunction; cardiology; cardio-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions submission deadline 20 May 2026 | 2 articles | Viewed by 7954 | Submission Open
Keywords: atopic dermatitis; contact dermatitis; psoriasis; urticaria; eczema; acne; rosacea; seborrheic dermatitis; drug-induced reaction; prurigo nodularis; lichen; hidradenitis suppurativa; alopecia; chronic urticaria; skin tumor; angioedema; venous ulcer; HPV skin manifestations; skin infection; vitiligo
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Isolation and Biological Activities of Natural Products: Focus on Molecular Advance
edited by Pedro Ferreira and
submission deadline 20 May 2026 | 4 articles | Viewed by 7803 | Submission Open
Keywords: natural products; sustainable isolation; biological activities; therapeutic potential; structure-activity relationships; omics technologies; bioavailability; functional foods; green chemistry; molecular docking
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Molecular Basis of Extracellular Vesicles in Health and Diseases—2nd Edition
edited by Taral R. Lunavat
submission deadline 20 May 2026 | 5 articles | Viewed by 7740 | Submission Open
Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
FTIR Miscrospectroscopy: Opportunities and Challenges
edited by Simona Sabbatini
submission deadline 20 May 2026 | 4 articles | Viewed by 7661 | Submission Open
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Applications of Technologies and Techniques for the Extraction of Simple Molecules and Compounds
edited by
submission deadline 20 May 2026 | 6 articles | Viewed by 7463 | Submission Open
Keywords: sample preparation; natural product extraction; purification; pollutant extraction; nutraceutical extraction; extraction of environmental indicators; magnetic extraction; green analytical chemistry; liquid– liquid (micro)extraction; cloud point (micro)extraction; solid phase (micro)extraction; pressurized liquid extraction; ultrasound-assisted extraction; microwave-assisted extraction; deep eutectic solvents; supercritical fluid extraction; molecularly imprinted polymers; QuEChERS (quick; easy; cheap; effective; rugged and safe)
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
New Insights in Artificial Intelligence for Drug Design and Target Discovery
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 7352 | Submission Open
Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations
(This special issue belongs to the Section Molecular Pharmacology)
The Effects of Dietary Supplements, Functional Foods and Nutraceuticals in the Immune System
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 7327 | Submission Open
Keywords: dietary supplements; functional foods; immune system; immunomodulation; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Biology of Fish Stress
edited by , and
submission deadline 20 May 2026 | 4 articles | Viewed by 7308 | Submission Open
Keywords: fish stress; molecular biology; omics; apoptosis; inflammation
(This special issue belongs to the Section Molecular Biology)
Medical Applications of Polymer Materials
edited by Zhen Zhang
submission deadline 20 May 2026 | 4 articles | Viewed by 7292 | Submission Open
Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics
(This special issue belongs to the Section Macromolecules)
Biomaterials for Tissue Regeneration: Current Progress and Future Directions
edited by and Horia Barbu
submission deadline 20 May 2026 | 3 articles | Viewed by 7267 | Submission Open
Keywords: biomaterials; biocompatibility; tissue engineering; tissue defect; rehabilitation; scaffolds; regenerative medicine; angiogenesis; stem cells; antimicrobial
(This special issue belongs to the Section Materials Science)
Arthritis: Focus on Pathologies, Symptoms and Therapy submission deadline 20 May 2026 | 2 articles | Viewed by 7210 | Submission Open
Keywords: rheumatoid arthritis; autoimmune; pathogenesis; strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets
edited by Jue Wang
submission deadline 20 May 2026 | 3 articles | Viewed by 7173 | Submission Open
Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular Oncology)
Ceramides and Ceramide Kinase
edited by Antonio Gomez-Muñoz
submission deadline 20 May 2026 | 3 articles | Viewed by 7081 | Submission Open
Keywords: cancer; cell survival; ceramides; ceramide 1-phosphate; inflammation
(This special issue belongs to the Section Biochemistry)
Current Advance in Infectious and Inflammatory Diseases submission deadline 20 May 2026 | 2 articles | Viewed by 7025 | Submission Open
Keywords: inflammatory diseases; infectious diseases; host– pathogen interactions; antimicrobial resistance; immune modulation; cytokine signaling
(This special issue belongs to the Section Molecular Microbiology)
Redox Enzymes: Molecular Mechanisms, Structural Features, Physiological Roles submission deadline 20 May 2026 | 2 articles | Viewed by 6628 | Submission Open
Keywords: metalloenzyme; terminal oxidase; cytochrome; heme; respiratory chain; photosynthesis; enzyme activation and inhibition; ROS scavenging enzyme; reactive oxygen species; ROS defense mechanism; molecular bioenergetics; drug target
(This special issue belongs to the Section Molecular Biophysics)
Computational Approaches for Protein Design
edited by Livija Jakaite and
submission deadline 20 May 2026 | 4 articles | Viewed by 6567 | Submission Open
Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction  
(This special issue belongs to the Section Molecular Biophysics)
Whole-Cell System and Synthetic Biology, 2nd Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 6513 | Submission Open
Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomedical Polymer Materials: Design, Synthesis or Applications
edited by Lourdes Franco
submission deadline 20 May 2026 | 2 articles | Viewed by 6333 | Submission Open
Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles
(This special issue belongs to the Section Materials Science)
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