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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Insights into Mitochondrial Iron Metabolism: Connections to Cancer and Other Pathologies

edited by Michael Petronek

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3201 | Submission Open

Keywords: iron metabolism; mitochondrial iron; cellular homeostasis; iron– sulfur cluster biogenesis; heme synthesis; mitochondrial ferritin; cancer biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3163 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

Advances in the Pathogenesis and Treatment of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2844 | Submission Open

Keywords: heart failure; biomarkers; pathways of heart failure; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition

edited by

Edyta Zbroch

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2822 | Submission Open

Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Cancer Stem Cell Research: 2nd Edition

edited by

Tomoyasu Sugiyama

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2780 | Submission Open

Keywords: cancer stem cell; biomarker; signaling; cancer-associated fibroblast; artificial intelligence; cell therapy; antibody therapy; cell therapy; gene expression

(This special issue belongs to the Section Molecular Oncology)

Plant Stress Biology

edited by Rui Li

submission deadline 30 Dec 2025 | 3 articles | Viewed by 2691 | Submission Open

Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanisms of Diabetic Cardiomyopathy

edited by Martin Michel

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2552 | Submission Open

Keywords: diabetes; cardiomyopathy; animal models; novel treatments; pathophyiology; SGLT2 inhibitors; neprilysin inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Anti-Cancer Drugs, 2nd Edition

edited by

Christiana Neophytou

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2386 | Submission Open

Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Luisa M. P. F. Amaral

and

Romeu A. Videira

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2372 | Submission Open

Keywords: natural bioactive compounds; discovery and isolation; chemical characterization; biological activities; mechanisms of action; pharmaceuticals; nutraceuticals; agricultural applications; cosmetic innovations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences

edited by

Andrei Smertenko

submission deadline 30 Dec 2025 | 4 articles | Viewed by 2336 | Submission Open

Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential

edited by

Rachel Shukrun

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2010 | Submission Open

Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

Stroke: Novel Molecular Mechanisms and Therapeutic Approaches

edited by Kang-Ho Choi

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1982 | Submission Open

Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dietary Antioxidants in Human Health

edited by

Marika Cordaro

Roberta Fusco

and

Rosanna Di Paola

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1974 | Submission Open

Keywords: diet; functional food; oxidative stress; mitochondrial disfunction; human health; animal models; nutrition; molecular pathways; human pathology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Forensic Science: Integrating Innovation and Investigation

edited by

Aniello Maiese

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1733 | Submission Open

Keywords: DNA profiling; artificial intelligence; trace evidence analysis; immunohistochemical markers; molecular biology techniques; super-resolution microscopy; integrated forensic approach; new bioinformatics techniques; digital pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics

edited by

Myrna Gloria Candelaria

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1596 | Submission Open

Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

New Challenges of Parkinson’s Disease, 2nd Edition

edited by

Franca Rosa Guerini

and

Cristina Agliardi

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1405 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Leptin Biology

edited by

Víctor Sánchez-Margalet

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1373 | Submission Open

Keywords: leptin; leptin expression; leptin receptor; leptin action

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Myocardial Injury and Ventricular Dysfunction: Pathways and Therapeutic Targets

edited by

Antonio Lax

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1348 | Submission Open

Keywords: myocardial injury; ventricular dysfunction; drug development; gene therapy; molecular modulators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Cell-Free Nucleic Acids and Cancers: 3rd Edition

edited by

Bruna Scaggiante

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1114 | Submission Open

Keywords: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next-generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing

(This special issue belongs to the Section Molecular Oncology)

Gene-Level Pharmacological Research on Natural Products

edited by

Wansu Park

submission deadline 30 Dec 2025 | Viewed by 958 | Submission Open

Keywords: natural products; gene-level pathways; pharmacological efficacy

(This special issue belongs to the Section Molecular Pharmacology)

Novel Multifunctional Materials with Electrical, Catalytic, and Biological Properties

edited by

Jana Pisk

and

Luka Pavic

submission deadline 30 Dec 2025 | Viewed by 864 | Submission Open

Keywords: novel multifunctional materials; innovative design and synthesis; electrical properties; catalytic properties; biological properties

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Cell Adhesion

edited by

Surajit Bhattacharjya

submission deadline 30 Dec 2025 | Viewed by 790 | Submission Open

Keywords: cell adhesion; cell– cell communication; structures; drug discovery; integrins; cadherins; selectins

(This special issue belongs to the Section Molecular Biophysics)

Role of Mitochondria in Neurodegenerative Diseases

edited by Małgorzata Wojtkowska

submission deadline 30 Dec 2025 | 1 articles | Viewed by 706 | Submission Open

Keywords: mitochondria; ccfDNA; Parkinson’ s disease’ Alzheimer’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms in Learning and Memory

edited by

Giovanna Traina

submission deadline 30 Dec 2025 | Viewed by 678 | Submission Open

Keywords: learning; memory; animal models; conditioning; molecular mechanisms; genetic mechanisms; epigenetic mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms of Genotoxicity

edited by

Bernd Kaina

submission deadline 30 Dec 2025 | Viewed by 637 | Submission Open

Keywords: DNA damage; gene instab; genetic instab; DNA methyl; genotoxic; gene mutation; DNA repair; genotoxicity; toxicogenetic; toxicogenomic

(This special issue belongs to the Section Molecular Toxicology)

Diabetic Retinopathy—Innovation in Diagnosis and Treatment

edited by

Peter Koulen

submission deadline 30 Dec 2025 | Viewed by 621 | Submission Open

Keywords: diabetes mellitus; diabetic macular edema; diagnostics; drug development; neovascularization; neurodegeneration; neuroprotection; retina; therapeutics; vascular disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cell Innovations and Reproductive Biotechnologies

edited by

Marcin Samiec

submission deadline 30 Dec 2025 | Viewed by 612 | Submission Open

Keywords: mammals; birds; stem cell research; pluri-/multipotency; differentiation/dedifferentiation; assisted reproductive technologies (ARTs); transgenic research; biomedicine

(This special issue belongs to the Section Molecular Biology)

Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies

edited by

Piotr Sobolewski

submission deadline 30 Dec 2025 | 1 articles | Viewed by 591 | Submission Open

Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Advancements in Genomic Technologies for Molecular Safety Assessment

edited by

Eric Blomme

submission deadline 30 Dec 2025 | Viewed by 585 | Submission Open

Keywords: gene expression; safety assessment; genomic technologies; genomic tools; molecular toxicology; toxicity; predictive safety assessments; proteomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Pathophysiology of Multiple Sclerosis and Neuroinflammation

edited by

Fabrizio Michetti

submission deadline 30 Dec 2025 | Viewed by 521 | Submission Open

Keywords: multiple sclerosis (MS); autoimmune diseases; encephalomyelitis; neuroinflammation; central nervous system (CNS); autoimmunity and neurodegeneration; molecular basis of immune mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Metal-Based Compounds: Molecular Mechanisms of Pharmacological Action and Toxicity

edited by

Danijela Z. Krstić

submission deadline 30 Dec 2025 | Viewed by 513 | Submission Open

Keywords: metal elements and ions; metal complexes; metal nanoclusters; pharmacology andpharmacokinetics; in vitro toxicity; in vivo toxicity; toxicity biomarkers; enzymes as pharmacological and toxicity targets; toxicity mechanisms; metallodrugs

(This special issue belongs to the Section Molecular Toxicology)

Electromagnetic Field Interactions with Biomolecules

edited by Samina Masood

submission deadline 30 Dec 2025 | Viewed by 398 | Submission Open

Keywords: magnetic field; biomolecules; medicine; drug delivery; protective methods; disease control

(This special issue belongs to the Section Biochemistry)

Brain Ischemia: From Molecular Mechanisms to Innovative Therapies

edited by

Ryszard Pluta

submission deadline 30 Dec 2025 | Viewed by 398 | Submission Open

Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Antimicrobial Resistance

edited by

Dan-Alexandru Țoc

and

Carmen Costache

submission deadline 30 Dec 2025 | Viewed by 391 | Submission Open

Keywords: antimicrobial resistance; MRSA; ESBL-producing bacteria; carbapenem-resistant enterobacterales (CRE); vancomycin-resistant enterococci (VRE); linezolid resistance; novel antibiotic combinations; resistance mechanisms; horizontal gene transfer; molecular epidemiology

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Regenerative Medicine, Organ Bioengineering and Transplantation

edited by

Dorota Latek

submission deadline 30 Dec 2025 | Viewed by 375 | Submission Open

Keywords: regenerative medicine; organ bioengineering; transplantation; allografting; stem cells; drug discovery; immunosuppression; xenotransplantation; organogenesis; biomaterials

(This special issue belongs to the Section Molecular Immunology)

Neuroimmune Regulation of Acute and Chronic Pain

edited by Karen M. Wagner

submission deadline 30 Dec 2025 | Viewed by 344 | Submission Open

Keywords: acute pain; chronic pain; central sensitization; neuroinflammation; neuroimmunity; neurovascular coupling; cytokines; chemokines; catacholamines; stress

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Obesity Research: Metabolic Pathways and Pathophysiological Factors

edited by Aleksandra Stefanović

submission deadline 30 Dec 2025 | Viewed by 278 | Submission Open

Keywords: obesity; inflammation; oxidative stress; obesity-related diseases; adypocitokines

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Basis for Sustainable Management of Migratory Insects

edited by

Xingfu Jiang

submission deadline 30 Dec 2025 | Viewed by 242 | Submission Open

Keywords: migrant insects; molecular basis of population growth; migration and reproduction; migration and immunity; migration and diapause; migration and orientation; molecular regulation of migration

(This special issue belongs to the Section Molecular Biology)

Role of Immune and Inflammatory Cells in Pulmonary Diseases

edited by Remo C. Russo

submission deadline 30 Dec 2025 | Viewed by 236 | Submission Open

Keywords: idiopathic pulmonary fibrosis (IPF); pulmonary immunology; precision medicine; single-cell RNA sequencing (scRNA-seq); spatial transcriptomics sequencing; animal model of pulmonary fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Immune-Modulating Therapies and Cutting-Edge Technologies for Immune-Related Diseases

edited by

Xingxing Fan

submission deadline 30 Dec 2025 | Viewed by 225 | Submission Open

Keywords: immune heomostasis; immune related diseases; small molecules; cell therapy; bacteria and virus; antibodies

(This special issue belongs to the Section Molecular Immunology)

Synthesis, Characterization and Applications of Advanced Polymer Materials

edited by Namil Kim

submission deadline 30 Dec 2025 | Viewed by 219 | Submission Open

Keywords: synthesis methodologies; molecular architecture; functional polymers; characterization techniques; cutting-edge applications

(This special issue belongs to the Section Macromolecules)

Cellular Physiology and Aging: Membrane Dynamics, Intracellular Environment and Signaling Pathways

edited by

Alessia Remigante

Rossana Morabito

and Sara Spinelli

submission deadline 30 Dec 2025 | Viewed by 191 | Submission Open

Keywords: aging; oxidative stress; ion channels; antioxidant molecules; membrane transport systems; redox signaling; cellular senescence; inflammation; intracellular signaling pathways; mitochondrial dysfunction; bioactive compounds; cell physiology; homeostasis; longevity; age-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Biology of Pregnancy Complications

edited by Elżbieta Poniedziałek-Czajkowska and Radzisław Mierzyñski

submission deadline 30 Dec 2025 | Viewed by 184 | Submission Open

Keywords: molecular biology of pregnancy complications; maternal pregnancy complications; neonatal pregnancy complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Telocytes: Unraveling Their Roles in Health and Disease

edited by

Sanda Cretoiu

submission deadline 30 Dec 2025 | Viewed by 180 | Submission Open

Keywords: telocytes; telopodes; intercellular communication; stem cell niche; extracellular vesicles; regenerative medicine; tissue remodelling; stromal cells

(This special issue belongs to the Section Molecular Biology)

Epigenetic Regulation in Cell Development, Differentiation and Cell Fate

edited by Gang Ren

submission deadline 30 Dec 2025 | Viewed by 177 | Submission Open

Keywords: 3D genome; myogenesis; transgenerational inheritance; enhancer– promoter interaction; histone modification; epigenetic variation; complex traits

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Products in Immune Regulation

edited by

Wansu Park

submission deadline 30 Dec 2025 | Viewed by 166 | Submission Open

Keywords: natural products; immune responses; immunomodulatory therapies

(This special issue belongs to the Section Molecular Immunology)

Recent Research in RNA–Protein Networks

edited by Hidenori Tani

submission deadline 30 Dec 2025 | Viewed by 163 | Submission Open

Keywords: machine learning; bioinformatics; ribonucleoprotein; RNA– protein complex; alternative splicing; RNA stability; RNA localization

(This special issue belongs to the Section Molecular Biology)

Evolutionary Drivers and Adaptive Mechanisms in Algal Organellar Genomes

edited by

Feng Liu

submission deadline 30 Dec 2025 | Viewed by 152 | Submission Open

Keywords: organellar genome of algae; molecular evolution; secondary structure of intron; evolutionary driving force; horizontal gene transfer

(This special issue belongs to the Section Molecular Plant Sciences)

New Breakthroughs in Molecular Diagnostic Tools for Human Diseases, 2nd Edition

edited by

Vittorio Fineschi

submission deadline 30 Dec 2025 | Viewed by 147 | Submission Open

Keywords: molecular pathology; molecular diagnostics; genetics; epigenetics; proteomics; immunohistochemistry; thrombo-embolic disease; sudden cardiac death; the molecular pathology of traumatic injuries; hypoxic– ischemic brain damage; the experimental models of injury and diseases; the targeted therapy of injuries and diseases; drug abuse; histological diagnosis; the epigenetics of organs injuries; miRNA and the prognosis of diseases; novel approaches and proofs of principle in therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Crossroads in Cardiac Pathophysiology

edited by

Robert J. Chilton

submission deadline 30 Dec 2025 | Viewed by 141 | Submission Open

Keywords: cardiometabolic disease; cardiac metabolism; heart failure; mitochondrial dysfunction; insulin resistance; cardiometabolic therapies; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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