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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Enzymes in Metabolic Processes

edited by

Koichi Fujisawa

submission deadline 20 Dec 2025 | 4 articles | Viewed by 10550 | Submission Open

Keywords: enzyme; metabolism; glycolysis; mitochondria; kinase; cell growth; carcinogenesis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Recognition and Biosensing

edited by

Longjiao Zhu

submission deadline 20 Dec 2025 | 4 articles | Viewed by 10369 | Submission Open

Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity

(This special issue belongs to the Section Biochemistry)

Understanding and Treating Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases

edited by

Patrick Vourc'h

submission deadline 20 Dec 2025 | 3 articles | Viewed by 10226 | Submission Open

Keywords: neurodegenerative; ALS; motor neuron; genetics; molecular pathways; biomarkers; models; treatments

(This special issue belongs to the Section Molecular Neurobiology)

Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment

edited by

Stefania Grimaudo

and

Rosaria Maria Pipitone

submission deadline 20 Dec 2025 | 3 articles | Viewed by 10085 | Submission Open

Keywords: MAFLD; MASH; metabolic syndrome; steatosis; lipid droplets; SNPs; GWAS; therapeutc target; fatty liver; steatohepatitis; HCC; EpigEnetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lymphatic Disorders: From Molecular Mechanisms to Therapies

edited by

Laura Patton

submission deadline 20 Dec 2025 | 4 articles | Viewed by 10044 | Submission Open

Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

High Resolution Mass Spectrometry in Molecular Sciences: 2nd Edition

edited by

Laszlo Prokai

submission deadline 20 Dec 2025 | 4 articles | Viewed by 9970 | Submission Open

Keywords: antibodies; astrobiology; biomarkers; drug discovery; drug development; drug metabolism; Fourier transform; glycomics; imaging; ion cyclotron resonance; ion mobility; lipids; lipidomics; mass spectrometry; metabolomics; nucleic acids; Orbitrap; organometallics; polymers; peptides; proteins; proteomics; structural biology; structure elucidation; tandem mass spectrometry; time-of-flight

(This special issue belongs to the Section Biochemistry)

Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition

edited by

Veronica Esposito

and

Antonella Virgilio

submission deadline 20 Dec 2025 | 5 articles | Viewed by 9824 | Submission Open

Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex

(This special issue belongs to the Section Biochemistry)

Genetic Research in Neurological Diseases

edited by

Eva Bagyinszky

submission deadline 20 Dec 2025 | 2 articles | Viewed by 9820 | Submission Open

Keywords: neurodegenerative diseases; genetic risk factor; next-genetation sequencing; genome-wide association studies; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Diabetes: Advances in Molecular Research

edited by

Alexandra E. Butler

and

Stephen Atkin

submission deadline 20 Dec 2025 | 3 articles | Viewed by 9770 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; retinopathy; nephropathy; neuropathy; molecular pharmacology; cardiovascular disease; cerebrovascular disease; normal physiology; counter-regulatory hormones; hypoglycemia TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Therapeutic Approaches in Neuropsychiatric Disorders

edited by Marta Pardo

submission deadline 20 Dec 2025 | 2 articles | Viewed by 9632 | Submission Open

Keywords: neuropsychiatric disorders; pharmacogenomics; pathophysiology; molecular treatment mechanisms; molecular targets for novel drug development; neurotransmitters; synaptic plasticity; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Reviews in Molecular Plant Science 2025

edited by

Maoteng Li

and

Jinsong Bao

submission deadline 20 Dec 2025 | 4 articles | Viewed by 9514 | Submission Open

Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Insights into Redox Homeostasis and Oxidative Stress

edited by

Dimitrios Kouretas

, Zoi Vasiliki Skaperda and

Fotios Tekos

submission deadline 20 Dec 2025 | 4 articles | Viewed by 9317 | Submission Open

Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases

(This special issue belongs to the Section Molecular Pharmacology)

New Perspective on Inflammatory Diseases: Role of Natural Compounds

edited by

Floriana D'Angeli

Carlo Genovese

and

Cristina Russo

submission deadline 20 Dec 2025 | 4 articles | Viewed by 8845 | Submission Open

Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovations in Polymeric Materials: Exploring Advancements and Applications

edited by

Silvia Vasiliu

submission deadline 20 Dec 2025 | 3 articles | Viewed by 8777 | Submission Open

Keywords: eco-friendly polymers; nanocomposites; biodegradable polymers; smart materials; polymer recycling; drug delivery systems; biocompatible polymers; food industry; wastewater treatment

(This special issue belongs to the Section Materials Science)

Cancer Drug Treatment and Cancer Cell Drug Resistance

edited by

Juan Sebastian Yakisich

submission deadline 20 Dec 2025 | 3 articles | Viewed by 8620 | Submission Open

Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Synaptic Transmission and Plasticity

edited by

Manuela Dicarlo

submission deadline 20 Dec 2025 | 4 articles | Viewed by 8491 | Submission Open

Keywords: synaptic transmission; synapse; neurotransmitters; synaptic plasticity; memory; learning; neurodegenerative diseases; neuropsychiatric diseases

(This special issue belongs to the Section Molecular Neurobiology)

Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases

edited by

Caterina Gagliano

Marco Zeppieri

and

Mario Damiano Toro

submission deadline 20 Dec 2025 | 4 articles | Viewed by 8414 | Submission Open

Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Type 2 Diabetes: Molecular Pathophysiology and Treatment

edited by

Edit Szabó

submission deadline 20 Dec 2025 | 3 articles | Viewed by 8042 | Submission Open

Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research of Dystonia and Parkinson’s Disease

edited by

Ryoma Morigaki

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7954 | Submission Open

Keywords: dystonia; Parkinson’ s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition)

edited by

Qichang Yang

and

Byoung Ryong Jeong

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7892 | Submission Open

Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition

edited by

Nicoletta Cordani

and

Manfioletti Guidalberto

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7720 | Submission Open

Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations

(This special issue belongs to the Section Molecular Oncology)

The Role of Neurons in Human Health and Disease—3rd Edition

edited by

Yasemin M. Akay

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7579 | Submission Open

Keywords: brain; nervous system; neurons; immune system; human health and disease

(This special issue belongs to the Section Molecular Neurobiology)

Nanoparticles in Molecular Pharmaceutics

edited by

Qingxin Mu

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7436 | Submission Open

Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Targeting Macrophages in Immunotherapy

edited by Vinod Nadella

submission deadline 20 Dec 2025 | 1 articles | Viewed by 7333 | Submission Open

Keywords: tumor-associated macrophages; tumor microenvironment; tumor immunology; carcinogenesis; macrophage repolarization; checkpoint inhibitor; immunotherapy; nanomaterials; metabolic reprogramming; epigenetics

(This special issue belongs to the Section Molecular Immunology)

Regulatory Mechanisms of Development and Abiotic Stress Response by Transcriptional Regulators in Plants: 2nd Edition

edited by

Yong-Hwan Moon

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7258 | Submission Open

Keywords: transcriptional regulator; transcription activation; transcription factor; transcription repression; plant development; abiotic stress response; epigenetic regulation; genome-wide analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Multiple Sclerosis

edited by Yoshio Bando

submission deadline 20 Dec 2025 | 4 articles | Viewed by 6926 | Submission Open

Keywords: multiple sclerosis; molecular mechanism; pathogenesis; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Therapeutic Targets in Pancreatic Cancer: 2nd Edition

edited by

Dorota Lubgan

Nathalie Britzen-Laurent

and

Benjamin Frey

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6635 | Submission Open

Keywords: pancreatic cancer; translational research; therapeutic targets and novel interventional strategies; mechanisms of anti-tumor reactions; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Nanomedicine in Gene Therapy and Immunotherapy

edited by

Ruosen Xie

and Ruixuan Gao

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6601 | Submission Open

Keywords: nanomedicine; drug delivery; gene delivery; genome editing; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Cytochrome P450 Mechanism and Reactivity

edited by

Samuel De Visser

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6555 | Submission Open

Keywords: enzyme function; enzyme catalysis; bioengineering; inorganic reaction mechanisms; enzyme inhibition

(This special issue belongs to the Section Biochemistry)

Voltage-Gated Ion Channels and Human Diseases

edited by María A. Gandini

submission deadline 20 Dec 2025 | 5 articles | Viewed by 6417 | Submission Open

Keywords: channelopathies; voltage gated-ion channels; human diseases; mutations; calcium; sodium; potassium

(This special issue belongs to the Section Molecular Biophysics)

Anticancer and Chemopreventive Activity of Natural Products and Its Derivatives

edited by

Magdalena Bartnik

submission deadline 20 Dec 2025 | 2 articles | Viewed by 6328 | Submission Open

Keywords: coumarins; coumarin derivatives; anticancer activity; chemopreventive activity; therapy adjuvant; mechanism of action; in vitro and in vivo studies; molecular research; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Targeting Metabolic Reprogramming: From Pathogenesis to Therapeutic Strategies

edited by

Beatriz García-Díaz

Alejandro Escamilla

and

Raquel Sanchez-Varo

submission deadline 20 Dec 2025 | 2 articles | Viewed by 6172 | Submission Open

Keywords: metabolism; therapy; mitochondria; pathogenesis; bioenergetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition)

edited by

David Martín-Hernández

submission deadline 20 Dec 2025 | 2 articles | Viewed by 6122 | Submission Open

Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

The Molecular Link Between Nutrition and Obesity

edited by

Elena Azzini

submission deadline 20 Dec 2025 | 2 articles | Viewed by 6021 | Submission Open

Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insight into Extracellular Vesicles in Proliferative Diseases

edited by Sergio Esquivel-Ruiz

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5991 | Submission Open

Keywords: proliferation; extracellular vesicles; intercellular communication; vesicle cargo; therapeutic applications; biomarkers

(This special issue belongs to the Section Molecular Immunology)

A Commemorative Issue in Honor of Professor Peter A. Ward: World Expert in Sepsis

edited by Peter Ward

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5986 | Submission Open

Keywords: sepsis; neutrophils; macrophages; histones; chemical modifications; apoptosis; complement factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Neurological Disorders via Computational Neuroscience and Neural Networks

edited by

Elnaz Pashaei

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5977 | Submission Open

Keywords: neurological disorders; neuroimaging analysis; biomarker identification; computational neuroscience; machine learning; brain aging

(This special issue belongs to the Section Molecular Informatics)

New Molecular Insights into Ischemia/Reperfusion: 2nd Edition

edited by

Moo-Ho Won

submission deadline 20 Dec 2025 | 5 articles | Viewed by 5942 | Submission Open

Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lipid Metabolism and Biomarkers in Neural and Cardiometabolic Health

edited by

Elena Vianello

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5936 | Submission Open

Keywords: lipid species; cardiovascular health; neural health; inflammation; cardiac biomarkers; neural biomarkers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Gastrointestinal Disease: Exploring the Interplay Between Inflammation, Autoimmunity, and Cancer

edited by Spyridon Siakavellas and

Stavros P. Papadakos

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5876 | Submission Open

Keywords: gastrointestinal disease; inflammation; autoimmunity; gut microbiota

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research on Antifungal Resistance

edited by Anna Tomova

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5845 | Submission Open

Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

From Nature to Medicine: Exploring Natural Products for New Therapies

edited by

Alejandro Madrid

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5698 | Submission Open

Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate

(This special issue belongs to the Section Molecular Pharmacology)

Allergic Diseases: Molecular Insights into Immunotherapy

edited by Stefania Nicola

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5631 | Submission Open

Keywords: component resolved diagnosis; allergen immunotherapy; molecular diagnostic; basophil activation test; anaphylaxis; allergy diagnosis; in vitro tests; in vivo tests; skin prick test

(This special issue belongs to the Section Molecular Immunology)

Antifungal Drug Discovery: Progresses, Challenges, Opportunities, 2nd Edition

edited by

Bernhard Biersack

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5450 | Submission Open

Keywords: antifungal drugs; fungal infections; drug design; drug discovery; targeted therapy; drug resistance; fungal drug targets; neglected tropical diseases

(This special issue belongs to the Section Molecular Pharmacology)

Current Research on Plant Hormones Affecting Crop Yield and Fruit Quality

edited by

María Serrano

and

Daniel Valero

submission deadline 20 Dec 2025 | 1 articles | Viewed by 5277 | Submission Open

Keywords: auxins; gibberellins; citokynis; ethylene; yield; quality; antioxidant; storage

(This special issue belongs to the Section Molecular Plant Sciences)

Systemic Sclerosis: New Insight into Pathogenesis, Molecular and Immune Mechanisms

edited by

Przemysław Kotyla

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5266 | Submission Open

Keywords: systemic sclerosis; autoimmunity; inflammation; fibrosis; pathophysiology and treatment; profibrotic signaling; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers for Cardiovascular Risk Prediction

edited by

Sanja Stankovic

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5252 | Submission Open

Keywords: biomarker; cardiovascular disease; risk stratification; inflammation; vascular damage; micro-RNA; therapy; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Nanomaterials: Approaches, Strategies and Applications

edited by

Andrea Bernardos

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5133 | Submission Open

Keywords: nanotechnology; biocides; antimicrobials; controlled release; drug delivery; antimicrobial agents; antimicrobial resistance; infection; nanoparticles

(This special issue belongs to the Section Materials Science)

p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell

edited by Przemyslaw Bozko

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5053 | Submission Open

Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Biology of Fish Stress

edited by