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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endometriosis: From Molecular Basis to Therapy
edited by Grzegorz Polak
submission deadline 31 Oct 2024 | 8 articles | Viewed by 10806 | Submission Open
Keywords: endometriosis; endometriosis diagnosis; infertility; novel strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into the Developmental Origins of Health and Disease submission deadline 31 Oct 2024 | 6 articles | Viewed by 10762 | Submission Open
Keywords: Developmental Origins of Health and Disease (DOHaD); fetal development; maternal nutrition; molecular programming; epigenetic modifications; environmental exposures; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Pathophysiology of Myocardial Disease submission deadline 31 Oct 2024 | 6 articles | Viewed by 10372 | Submission Open
Keywords: myocardiac disease; cardiomyopathy; fibrosis; heart failure; comorbidity; molecular mechanisms; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Haemorrhagic and Thrombotic Disorders submission deadline 31 Oct 2024 | 6 articles | Viewed by 8866 | Submission Open
Keywords: next-generation sequencing; whole-exome sequencing; haemorrhagia; thrombosis; molecular biology; diagnosis; genetics; blood coagulation disorders; inherited
(This special issue belongs to the Section Molecular Biology)
New Insights into Photosystem I submission deadline 31 Oct 2024 | 9 articles | Viewed by 8789 | Submission Open
Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Molecular Research in Tumors
edited by Keisaku Sato
submission deadline 31 Oct 2024 | 5 articles | Viewed by 8667 | Submission Open
Keywords: cancer biomarkers; cancer progression; cancer bioinformatics; immunotherapy; cancer organoids; nanoparticles; extracellular vesicles; patient-derived xenografts; artificial intelligence
(This special issue belongs to the Section Molecular Oncology)
Cancer Biology: From Genetic Aspects to Treatment
edited by
submission deadline 31 Oct 2024 | 7 articles | Viewed by 8603 | Submission Open
Keywords: cancer biology; cancer biomarker; cancer progression; cancer metastasis; genetic of cancer
(This special issue belongs to the Section Molecular Oncology)
Plant Omics: Sensing, Signaling, Regulation and Homeostasis submission deadline 31 Oct 2024 | 5 articles | Viewed by 7749 | Submission Open
Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology
(This special issue belongs to the Section Molecular Plant Sciences)
(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems
edited by , Milton Saier and Gabriel Moreno-Hagelsieb
submission deadline 31 Oct 2024 | 3 articles | Viewed by 7534 | Submission Open
Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Neurological and Psychiatric Disease: A Decade of Progress submission deadline 31 Oct 2024 | 5 articles | Viewed by 7424 | Submission Open
Keywords: Alzheimer's and Parkinson's diseases; epilepsy; migraine; essential tremors; stroke; depression; anxiety disorders; cognitive impairment
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Vitamin D in Human Health and Diseases 4.0 submission deadline 31 Oct 2024 | 4 articles | Viewed by 7382 | Submission Open
Keywords: vitamin D; vitamin D receptor; health; disease; inflammation; gene transcription; cell metabolism; differentiation; vitamin D deficiency; vitamin D supplementation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Coagulation and Anticoagulation
edited by
submission deadline 31 Oct 2024 | 4 articles | Viewed by 7233 | Submission Open
Keywords: coagulation; anticoagulation; procoagulant; anticoagulant; molecular mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathogenesis and Diagnostics of Lung Diseases
edited by
submission deadline 31 Oct 2024 | 4 articles | Viewed by 7192 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Potential Roles of Natural Active Products in Neurological Disorders
edited by Anna D. Serefko
submission deadline 31 Oct 2024 | 3 articles | Viewed by 7134 | Submission Open
Keywords: natural active products; phytochemicals; bioactive compounds; Neurological Disorders; depressive disorders; Parkinson's disease; depressive/epileptic episodes; antidepressants and antiepileptics; Alzheimer's disease; brain stroke; molecular mechanism; drug delivery; therapeutic potentials; structure-activity relationships; advanced therapies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cancer Stem Cells in Solid Tumors
edited by
submission deadline 31 Oct 2024 | 3 articles | Viewed by 7010 | Submission Open
Keywords: CSC characterization; genetic and epigenetic regulators of CSCs; tumor microenvironment; energy/oxidative metabolism; exosomes; microRNAs; treatment resistance; targeting CSCs; differentiation therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Progression of Genome-Related Diseases submission deadline 31 Oct 2024 | 6 articles | Viewed by 6762 | Submission Open
Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Ionic Liquids and Their Pharmaceutical Applications submission deadline 31 Oct 2024 | 3 articles | Viewed by 6729 | Submission Open
Keywords: ionic liquid; active pharmaceutical ingredient; drug delivery; human toxicity; environmental impact; pharmaceutical industry; pharmaceutical efficiency
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Research on Skeletal Muscle Biology
edited by
submission deadline 31 Oct 2024 | 6 articles | Viewed by 6448 | Submission Open
Keywords: skeletal muscle; muscular dystrophy; satellite cell; muscle regeneration; myofibrosis; exercise
(This special issue belongs to the Section Molecular Biology)
New Insights into Adipose Tissue Metabolic Function and Dysfunction, 3rd Edition
edited by
submission deadline 31 Oct 2024 | 5 articles | Viewed by 6172 | Submission Open
Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Redox Physiology in Biomedicine and Ecophysiology: The Influence of Various Substances on the Redox Regulation of Cell Metabolism, 2nd Edition
edited by
submission deadline 31 Oct 2024 | 3 articles | Viewed by 6091 | Submission Open
Keywords: redox-signalling pathways; antioxidative and hypoglicemic effects of plant extracts; prooxidant/antioxidant status in the cells; redox active trace metals; reproductive health of women and men: infertility/sterility; xenobiotics in aquatic organims; essential trace elements and immunological parameters in COVID/post-COVID patients
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Gene, Genomics, and Molecular Breeding in Cruciferae Plants (2nd Edition)
edited by
submission deadline 31 Oct 2024 | 8 articles | Viewed by 5621 | Submission Open
Keywords: Cruciferae plants; genome analysis; genetic dissection; gene function; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Non-coding RNA (ncRNA) in Cancer : 2nd Edition submission deadline 31 Oct 2024 | 3 articles | Viewed by 5523 | Submission Open
Keywords: non-coding RNA (ncRNA); cancer; oncogenes; tumor suppressor genes; microRNA; lncRNA; circRNA; cancer biomarkers
(This special issue belongs to the Section Molecular Oncology)
Heart Failure Mechanisms and Treatment Advances
edited by
submission deadline 31 Oct 2024 | 3 articles | Viewed by 5424 | Submission Open
Keywords: heart failure; cardiomyopathy; mechanisms; inflammation; oxidative stress; genetic susceptibility; microbiome; neurohormonal regulation; obesity and metabolic syndrome; targeted therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oncolytic Viruses for Cancer Immunotherapy submission deadline 31 Oct 2024 | 4 articles | Viewed by 5387 | Submission Open
Keywords: oncolytic viruses; anti-tumor immune responses; oncolytic immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Aspects of Autoimmune Diseases
edited by Raquel López Mejías
submission deadline 31 Oct 2024 | 3 articles | Viewed by 5352 | Submission Open
Keywords: genetics; epigenetics; molecules; cellules; autoimmune diseases; inflammation
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Organic Chemistry: Molecules Synthesis and Reactions submission deadline 31 Oct 2024 | 6 articles | Viewed by 5242 | Submission Open
Keywords: bioactive natural products; organocatalysis; photoredox reactions; free-radical reactions; organometallic reactions; organic synthesis
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Mechanisms and Novel Therapies of Liver Diseases
edited by
submission deadline 31 Oct 2024 | 3 articles | Viewed by 5193 | Submission Open
Keywords: acute and chronic liver diseases (CLDs); hepatocellular carcinoma (HCC); post-translational modification (PTM); autophagy; potential therapeutic approaches; preclinical mouse models  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0 submission deadline 31 Oct 2024 | 4 articles | Viewed by 5077 | Submission Open
Keywords: oxidative stress; inflammation; metabolism; plant bioactive compounds; functional food; nutraceuticals; natural extracts; human health; nutrition; metabolic syndrome; chronic diseases; cardiovascular diseases; cancer
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Reprogramming the Tumor Microenvironment in Pancreatic Cancer
edited by
submission deadline 31 Oct 2024 | 2 articles | Viewed by 4984 | Submission Open
(This special issue belongs to the Section Molecular Oncology)
Integration of Meta-Multi-Omics Data: Unraveling Impact and Therapeutic Potential
edited by
submission deadline 31 Oct 2024 | 3 articles | Viewed by 4828 | Submission Open
Keywords: integration meta-multiomics data; impact; aging; exercise; skeletal muscle; mitochondrial; heart; cancer; therapeutic; prevention; proteomics; omnibus; metabolite; metabolomic; repository dataset; public data
(This special issue belongs to the Section Molecular Informatics)
Skin Diseases: From Molecular Mechanisms to Pathology submission deadline 31 Oct 2024 | 4 articles | Viewed by 4662 | Submission Open
Keywords: skin diseases; immunology; genetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Prostate Cancer: Novel Research and Innovative Therapeutic Strategies submission deadline 31 Oct 2024 | 3 articles | Viewed by 4643 | Submission Open
Keywords: prostate cancer; therapeutic strategy; castration-resistant PCa
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetics and Molecular Breeding of Cucurbitaceous Crops
edited by Younghoon Park
submission deadline 31 Oct 2024 | 6 articles | Viewed by 4568 | Submission Open
Keywords: Cucurbitaceae; melon; watermelon; cucumber; pumpkins; zucchini; gourd; evolution; genetic diversity; genetic resources; conventional breeding; molecular breeding; genomics-assisted breeding; precison breeding; genome editing; genome selection
(This special issue belongs to the Section Molecular Plant Sciences)
Biodegradable Polymer: Structure, Properties and Applications submission deadline 31 Oct 2024 | 3 articles | Viewed by 4233 | Submission Open
Keywords: biodegradable polymers; synthesis; structure; properties; applications
(This special issue belongs to the Section Materials Science)
Plant Pathogen Interactions: 2nd Edition submission deadline 31 Oct 2024 | 3 articles | Viewed by 4057 | Submission Open
Keywords: pathogenicity; plant immunity; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); effectors; avirulent; virulent; biotroph; necrotroph; interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Nutritional and Hormonal Control of Glucose Metabolism submission deadline 31 Oct 2024 | 2 articles | Viewed by 3826 | Submission Open
Keywords: glucose; lipids; amino acids; insulin resistance; obesity; NAFLD; hormones; metabolic syndrome; diabetes
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Research on Fruit Crop Breeding and Genetics: 3rd Edition submission deadline 31 Oct 2024 | 4 articles | Viewed by 3618 | Submission Open
Keywords: fruit breeding; genetic; genomic; transcriptomic; proteomic; epigenetic
(This special issue belongs to the Section Molecular Plant Sciences)
Medical Imaging Technology in Molecular Pathological Mechanisms and Disease Therapies
edited by Howard J. Halpern
submission deadline 31 Oct 2024 | 2 articles | Viewed by 3616 | Submission Open
Keywords: medical imaging; fluorescent probe; molecular imaging;oxygen; redox; cancer therapy; resistance; electron paramagnetic resonance; imaging reconstruction; tumor/cancer microenvironment; pathological mechanisms; bioinformatics; genomics analysis; anti-cancer drug discovery; toxin delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immunopathology, Vaccine Development and Treatment of Viruses
edited by Courtney B. Woolsey
submission deadline 31 Oct 2024 | 3 articles | Viewed by 3607 | Submission Open
Keywords: virus; immunopathology; vaccines; treatments; therapeutics; pathogenesis; molecular virology; emerging viruses
(This special issue belongs to the Section Molecular Immunology)
Design and Application of Organic Superbases—from Theory to Experiment submission deadline 31 Oct 2024 | 3 articles | Viewed by 3338 | Submission Open
Keywords: organic superbases; computational study; synthesis; structrue-function relationship; catalysis
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Atherosclerosis: From Molecular Basis to Therapy
edited by Massimiliano Ruscica
submission deadline 31 Oct 2024 | 2 articles | Viewed by 3337 | Submission Open
Keywords: atherosclerosis; molecular basis; cardiovascular disease; artery disease; vascular dementia
(This special issue belongs to the Section Molecular Biology)
Editorial Board Members’ Collection Series: “Molecular Dynamics” submission deadline 31 Oct 2024 | 2 articles | Viewed by 3246 | Submission Open
Keywords: quantum mechanics; classical mechanics; hybrid QM/MM; molecular dynamics at the atomic level; steered molecular dynamics; coarse-graining; docking(protein– protein; protein– ligand); the molecular dynamics of protein– ligand interactions; drug design; virtual screening
(This special issue belongs to the Section Molecular Biophysics)
Immune Modulation of Macrophages: 2nd Edition
edited by and Yan Chen
submission deadline 31 Oct 2024 | 3 articles | Viewed by 3244 | Submission Open
Keywords: macrophages; treatment; phenotype change; pathway analysis
(This special issue belongs to the Section Molecular Immunology)
Genetic Basis and Molecular Mechanisms of Heart Failure submission deadline 31 Oct 2024 | 1 articles | Viewed by 3234 | Submission Open
Keywords: heart failure; cardiomyopathies; genetics; molecular pathways; epigenetics; gene mutations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
RNA Function and Structure
edited by Anna Wacker
submission deadline 31 Oct 2024 | 1 articles | Viewed by 3188 | Submission Open
Keywords: RNA architecture; molecular motions; structural dynamics; NMR spectroscopy; RNA– RNA interaction; RNA-binding proteins; RNA– ligand complex; RNA recognition; RNA modifications; RNA targeting
(This special issue belongs to the Section Molecular Biology)
Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition) submission deadline 31 Oct 2024 | 2 articles | Viewed by 3075 | Submission Open
Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
New Advances in Protein Structure, Function and Design
edited by
submission deadline 31 Oct 2024 | 2 articles | Viewed by 3018 | Submission Open
Keywords: AI applications in molecular structure; molecular simulations; new bioinformatics tools; protein structure; protein function; protein– protein interaction; online resources
(This special issue belongs to the Section Molecular Informatics)
Multiple Sclerosis at the Crossroads of Autoimmunity and Neurodegeneration 2.0
edited by
submission deadline 31 Oct 2024 | 2 articles | Viewed by 2929 | Submission Open
Keywords: neurodegeneration; multiple sclerosis; autoimmunity; T lymphocytes; B lymphocytes; demyelination; axonal loss; synaptic pruning; microglia; astrocytes
(This special issue belongs to the Section Molecular Immunology)
The Lysosome in Human Health and Diseases
edited by , and Marisa Encarnação
submission deadline 31 Oct 2024 | 2 articles | Viewed by 2839 | Submission Open
Keywords: lysosomal storage disorders; lysosomal hub; lysosomal signalling; lysosomal trafficking; nutrient sensing; cell death; disease models; biomarkers; RNA-therapeutics
(This special issue belongs to the Section Molecular Biology)
Unravelling Interactions between Amyloid Beta (Aβ) and Key Pathological Features of Alzheimer’s Disease
edited by Athanasios Metaxas
submission deadline 31 Oct 2024 | 1 articles | Viewed by 2832 | Submission Open
Keywords: Alzheimer’ s disease; amyloid; tau; neuroinflammation; synapses; metabolism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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