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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)

edited by

Mario A. Pagnotta

submission deadline 28 Jun 2025 | 1 articles | Viewed by 1514

Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes

(This special issue belongs to the Section Molecular Plant Sciences)

Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches

edited by

Whi-An Kwon

submission deadline 28 Jun 2025 | Viewed by 169

Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Oncology)

Exploring the Molecular, Physiological, and Biochemical Responses of Crops to Stress

edited by

Hakim Manghwar

submission deadline 29 Jun 2025 | 4 articles | Viewed by 2904 | Submission Open

Keywords: molecular signaling pathways in response to biotic stresses (e.g.; bacteria; viruses; fungi; and insects); plant responses to abiotic stresses (e.g.; salinity; cold; drought; waterlogging; heat; heavy metals; and UV light); mechanisms of stress adaptation and tolerance; stress adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis

edited by

Regina M. Day

and Jeffrey R. Koenitzer

submission deadline 29 Jun 2025 | 1 articles | Viewed by 284 | Submission Open

Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins

(This special issue belongs to the Section Molecular Biology)

Rare Diseases and Neuroscience

edited by

Michelangelo Mancuso

and

Filippo Drago

submission deadline 30 Jun 2025 | 8 articles | Viewed by 20413 | Submission Open

Keywords: neurogenetics; rare diseases; rare neurological diseases; cerebellar ataxia; rare movement disorders; mitochondrial diseases; innovative treatments in rare neurological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetics and Novel Techniques for Soybean Pivotal Characters

edited by

Qingshan Chen

and

Dawei Xin

submission deadline 30 Jun 2025 | 11 articles | Viewed by 19596 | Submission Open

Keywords: QTL mapping and marker-assisted selection; GWAS and genomic selection/prediction; molecular breeding by design; germplasm application; domestication and selection signatures; genotype x environment interaction; improvement of seed quality and/or nutritional quality traits; nitrogen efficiency modification; symbiosis mechanism detection; breeding for tolerance to biotic stresses; soybean– pathogen interaction; increasing the adaptation to the environment

(This special issue belongs to the Section Molecular Plant Sciences)

G Protein-Coupled Receptors

edited by

Dorota Latek

submission deadline 30 Jun 2025 | 7 articles | Viewed by 19244 | Submission Open

Keywords: biased signaling; activation microswitches; allosteric ligands; drug design; GPCR-targeted assays; compound profiling; orphan receptors; viral hijacking of GPCRs; cellular response; live-cell imaging

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Molecular Neurobiology in Poland

edited by

Irena Nalepa

submission deadline 30 Jun 2025 | 6 articles | Viewed by 18602 | Submission Open

Keywords: neurobiology; neurochemistry; neuropathology; neurophysiology; neuropharmacology; neurogenetics; neurodegeneration; aging neuroscience; neurogenesis; neuroplasticity; signalling pathways; signalling networks; systems biology; stress-related processes

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Retinal Diseases

edited by Hsiaoming Chao, Robert Casson and Hsi-Kung Kuo

submission deadline 30 Jun 2025 | 8 articles | Viewed by 17915 | Submission Open

Keywords: faricimab; modified cerebrolysin; acupuncture; stem cells; gene therapy; retinal chip; femtosecond; artisan aphakia; artiflex; exozyme; silicon oil; amniotic membrane; EOG; multifocal ERG; flash ERG; VEP; microperimetry; OCT-A

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Molecular Science of Fragile X Syndrome and Associated Disorders

edited by Flora Tassone and Randi Hagerman

submission deadline 30 Jun 2025 | 13 articles | Viewed by 14514 | Submission Open

Keywords: FMR1; fragile X syndrome; FXPOI; FXTAS; FXAND; FXPAC; molecular studies

(This special issue belongs to the Section Molecular Biology)

Breast Cancer: Molecular Pathology, Diagnosis, and Therapeutic Strategies

edited by Rodrigo Sánchez-Bayona

submission deadline 30 Jun 2025 | 5 articles | Viewed by 11298 | Submission Open

Keywords: biomarker; breast; molecular assays; molecular characterization; molecular-driven treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Omics: Sensing, Signaling, Regulation and Homeostasis

edited by

Margherita-Gabriella De Biasi

submission deadline 30 Jun 2025 | 5 articles | Viewed by 11260 | Submission Open

Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology

(This special issue belongs to the Section Molecular Plant Sciences)

Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration 4.0

edited by

Alessandra Pelagalli

and

Heba Abdelrazik

submission deadline 30 Jun 2025 | 5 articles | Viewed by 9725 | Submission Open

Keywords: mesenchymal stem cells (MSCs); regenerative medicine; tissue engineering; tissue repair; cell differentiation; cell behaviour and cell fate; traslational medicine; animal sources; MSC vesicles; MSC secretome; MSCs as genetic vectors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding the Genetics of Complex Traits in Plants: Association Analysis and Genomic Selection Methods

edited by

Wenxin Liu

submission deadline 30 Jun 2025 | 10 articles | Viewed by 9040 | Submission Open

Keywords: association analysis; genomic selection; plant; complex trait; genetic architecture; molecular biology; molecular breeding; genotype– environment interaction

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanisms of Heavy Metal Toxicity: 3rd Edition

edited by

Toshiyuki Kaji

submission deadline 30 Jun 2025 | 6 articles | Viewed by 8720 | Submission Open

Keywords: heavy metal; metal compound; metallothionein; cellular defense mechanism; metal transporter

(This special issue belongs to the Section Molecular Toxicology)

Synthesis, Characterization and Phyto-Function of Nanophotocatalysts

edited by

Maria G. P. M. S. Neves

Carla Isabel Madeira dos Santos

and

Nuno M. M. Moura

submission deadline 30 Jun 2025 | 4 articles | Viewed by 8396 | Submission Open

Keywords: nanophotocatalysts; green synthesis; hydrogen generation; pollutants; fine chemistry; photoinactivation; cancer; microorganisms

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Structure and Function of Intermediate Filaments in Health and Disease

edited by

Cecilia Bucci

Roberta Romano

and

Flora Guerra

submission deadline 30 Jun 2025 | 4 articles | Viewed by 7931 | Submission Open

Keywords: intermediate filaments; vimentin; peripherin; lamins; keratins; neurofilaments; mechanics; migration; signaling; autophagy; organelle positioning; organelle function; inflammation; neurodegenerative diseases; cancer; gene expression; epigenetics; post-translational modifications

(This special issue belongs to the Section Molecular Biology)

The Role of Lipids in Health and Diseases

edited by

Yutang Wang

submission deadline 30 Jun 2025 | 3 articles | Viewed by 7625 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

RNA Biology and Regulation

edited by

Naoyuki Kataoka

submission deadline 30 Jun 2025 | 6 articles | Viewed by 7454 | Submission Open

Keywords: RNA processing; RNA transport; RNA localization; RNA editing; RNA synthesis; RNA stability; RNA modification; translation; transcription; RNA metabolism; human diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Potential Prevention and Treatment of Neurodegenerative Disorders

edited by

Maria Paola Bertuccio

submission deadline 30 Jun 2025 | 4 articles | Viewed by 6643 | Submission Open

Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Glioblastoma Pathogenesis: Focus on Progenitor Cells, Microglia and Noncoding RNA

edited by

Imran Khan

submission deadline 30 Jun 2025 | 2 articles | Viewed by 6602 | Submission Open

Keywords: glioblastoma; tumor microenvironment; microglia; tumor-infiltrating lymphocytes; astrocytes; progenitor cells; driver mutations

(This special issue belongs to the Section Molecular Oncology)

Multifunctional Application of Biopolymers and Biomaterials 2.0

edited by

Valentina Siracusa

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5814 | Submission Open

Keywords: biopolymers; nanomaterials; biomaterials; functional materials; bioactive natural compounds; essential oil emulsion; natural colorant; plant extract; bioactive compounds; nanocomposite; functional composite; composite film and coatings

(This special issue belongs to the Section Materials Science)

Editorial Board Members’ Collection Series: “Bacterial Enzymes as Targets”

edited by

Clemente Capasso

and

Alicja Wegrzyn

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5684 | Submission Open

Keywords: enzymes; cell wall biosynthesis; DNA replication; metabolic pathway; vital bacterial function; enzyme inhibition; antibacterial agents; antibiotic resistance

(This special issue belongs to the Section Biochemistry)

Protein Aggregation and Proteinopathies

edited by Hongyu Hu

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4652 | Submission Open

Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy

(This special issue belongs to the Section Molecular Biology)

Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition

edited by

Hsinjung Ho

submission deadline 30 Jun 2025 | 4 articles | Viewed by 3921 | Submission Open

Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic

(This special issue belongs to the Section Biochemistry)

Metal Oxide Nanomaterial Properties: Molecular Electrochemistry and Biomedical Applications

edited by

Carmen Lǎzǎu

and

Cornelia Bandas

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3243 | Submission Open

Keywords: inorganic binding biomolecules; nanostructured materials; metal oxide nanoparticles; metal oxide– polymer nanocomposites; active surface sites

(This special issue belongs to the Section Materials Science)

Synthesis and Applications of Photoactive Molecules and Photovoltaic Materials

edited by

Leandro M. O. Lourenço

and

Carlos Monteiro

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3205 | Submission Open

Keywords: photochemistry; chromophores; light-activated systems; donor– acceptor structures; covalent and noncovalent chemistry; solar cells

(This special issue belongs to the Section Materials Science)

Fabrication and Application of Photocatalytically Active Materials

edited by

Imre Miklós Szilágyi

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3063 | Submission Open

Keywords: semiconductor oxides; photocatalysis; materials science; nanotechnology; activity; catalyst preparation; nanomaterials; environmental applications

(This special issue belongs to the Section Materials Science)

Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition)

edited by

David Martín-Hernández

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3023 | Submission Open

Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Plant and Environmental Interactions (Abiotic Stress)

edited by

Lixin Li

submission deadline 30 Jun 2025 | 5 articles | Viewed by 2672 | Submission Open

Keywords: stress response; signal transduction; metabolism and secondary metabolism; material/vesicle transportation; rhizospheric microorganism; interactions between plants and microorganisms

(This special issue belongs to the Section Molecular Plant Sciences)

Translational Research in Ophthalmic Pathology

edited by

Robert M. Verdijk

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2264 | Submission Open

Keywords: eye; ophthalmology; immunohistochemistry; molecular biology; pathophysiology; translational science; anatomy; histology; pathology; orbit

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Imaging for Cancer Theranostics

edited by

Hak Soo Choi

and Kai Bao

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2255 | Submission Open

Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanocrystals, Nanoclusters, Nanoparticles: Synthesis and Optical Properties

edited by

Sebastian Maćkowski

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2047 | Submission Open

Keywords: nanocrystals; nanoclusters; nanoparticles; synthesis; optical properties

(This special issue belongs to the Section Molecular Nanoscience)

New Research Insights in Cystic Fibrosis and CFTR-Related Diseases

edited by Judith A. Coppinger

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1735 | Submission Open

Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developmental Biology: Computational and Experimental Approaches, 2nd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 30 Jun 2025 | 4 articles | Viewed by 1729 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress and Autophagy in Cancer Cells

edited by

Abdelhabib Semlali

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1530 | Submission Open

Keywords: oxidative stress; autophagy; apoptosis; cancer cells; cancer cell signaling pathways

(This special issue belongs to the Section Molecular Biology)

Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Tomasz Chorągiewicz

and

Joanna Dolar-Szczasny

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1458 | Submission Open

Keywords: eye diseases; genetic; biochemical; proteomic; cellular and physiological level; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Algae Molecular Biology and Biotechnology

edited by

Paolo Gualtieri

and

Laura Barsanti

submission deadline 30 Jun 2025 | Viewed by 1396 | Submission Open

Keywords: molecular techniques; microscopy; microspectrophotometry; molecular biology and phylogenetics; processing and pattern recognition in alga images; molecular processes in photoreception; nutraceuticals and functional food production; toxicity; bioremediation; industrial exploitation; health care importance; environmental sustainability

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances and Insights in Cancer Genomics

edited by

Masa Tsuchiya

Alessandro Giuliani

and

Kenichi Yoshikawa

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1291 | Submission Open

Keywords: biochemistry; biophysics; cancer genomics; cell biology; complex networks; complex systems; data science; development and differentiation; epigenomics; genome computing; higher-order structure of chromatin; multi-omics integration; next-generation sequencing; proteomics; single-cell CRISPR screens; single-cell genomics; transcriptomics; tumor biology

(This special issue belongs to the Section Molecular Oncology)

Brain-Body Interactions in Mental Disorders: Molecular Mechanisms and Therapeutics

edited by Yan-Xue Xue

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1281 | Submission Open

Keywords: mental disorders; brain– body interactions; neural mechanisms; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomics of Human Disease

edited by

Sungkyoung Choi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1257 | Submission Open

Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Inborn Errors of Immunity

edited by Aleksandra Szczawińska-Popłonyk

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1221 | Submission Open

Keywords: inborn errors of immunity; immune dysregulation; autoimmunity; autoinflammation; organ-specific immunopathology; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Latest Reviews in Molecular Plant Science 2025

edited by

Maoteng Li

and

Jinsong Bao

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1188 | Submission Open

Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Aquatic Biotechnology and Its Application in Genetic Breeding—2nd Edition

edited by

Hui Qiao

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1134 | Submission Open

Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Batteries and Electrochemical Sensors: Design, Development and Application

edited by Zhengkun Xie

submission deadline 30 Jun 2025 | Viewed by 1109 | Submission Open

Keywords: novel electrodes and electrolytes; high-energy density batteries; characterization techniques; advanced electrochemical sensor; key analytes

(This special issue belongs to the Section Materials Science)

Plant Metabolism and Natural Product Biosynthesis

edited by

Andrej Frolov

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1058 | Submission Open

Keywords: plant metabolism; natural product; biosynthesis; metabolomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Cardiovascular Diseases: Molecular Mechanism and Therapeutic Strategies

edited by

Tzong-Shyuan Lee

submission deadline 30 Jun 2025 | 1 articles | Viewed by 916 | Submission Open

Keywords: cardiovascular diseases; vascular; atherosclerosis; heart failure; stroke; oxidative stress; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cutting-Edge Advances in Breast Cancer

edited by

Ľuba Hunáková

submission deadline 30 Jun 2025 | 1 articles | Viewed by 649 | Submission Open

Keywords: cancer progression and metastasis (dissemination; extravasation; angiogenesis; innervation; and metabolic reprogramming); immunity and inflammation; targeted therapies; early detection and screening; genetics; epigenetics; mi-RNA; tumour microenvironment

(This special issue belongs to the Section Molecular Oncology)

Molecular Insight into Skeletal Muscle Atrophy and Regeneration, 2nd Edition

edited by

Elena Nebot

Teresa Priego Cuadra

and

Ana Isabel Martín Velasco

submission deadline 30 Jun 2025 | 1 articles | Viewed by 641 | Submission Open

Keywords: muscle atrophy; muscle regeneration; sarcopenia; cachexia; satellite cells; autophagy; proteolytic system; growth factors; myokines; physical exercise; nutrition; bone metabolism

(This special issue belongs to the Section Molecular Biology)

Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies

edited by Lisa Lungaro

submission deadline 30 Jun 2025 | 1 articles | Viewed by 635 | Submission Open

Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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