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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Therapies Barriers and Opportunities

edited by

O’neil W. Guthrie

submission deadline 15 Aug 2025 | Viewed by 194 | Submission Open

Keywords: gene therapy; gene editing; RNA therapy; RNA editing; protein therapy; stem cells; cell therapy; genomics; proteomics; molecular pathology

(This special issue belongs to the Section Molecular Biology)

Novel Therapeutic Strategies for Gynecological Cancer

edited by

Masayuki Sekine

submission deadline 15 Aug 2025 | Viewed by 133 | Submission Open

Keywords: gynecological cancer; therapeutic strategies; genomic medicine; multimodality treatment; biomarker; molecular targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

edited by

Elisa Oltra

submission deadline 20 Aug 2025 | 6 articles | Viewed by 40101 | Submission Open

Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Targeted Therapies of Breast Cancer

edited by

Piotr Dzięgiel

, Karolina Jabłońska and

Katarzyna Nowińska

submission deadline 20 Aug 2025 | 9 articles | Viewed by 31208 | Submission Open

Keywords: breast cancer; cancer progression; cancer metastasis; tumor microenvironment; molecular mechanisms; molecular markers; epigenetics; genomics; transcriptomics; EMT; targeted therapies; signaling pathways; exosomes; EMT; hormonal regulation; drugs; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Bioactive Nutrients Promoting Human Health

edited by

Baojun Xu

submission deadline 20 Aug 2025 | 11 articles | Viewed by 23708 | Submission Open

Keywords: bioactive nutrients; antioxidants; anti-inflammatory; disease prevention; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Retinal Degenerative Diseases: 2nd Edition

edited by

Diego García-Ayuso

and

Johnny Di Pierdomenico

submission deadline 20 Aug 2025 | 6 articles | Viewed by 22950 | Submission Open

Keywords: retina; photoreceptor degenerative diseases; inherited retinal degenerations; glaucoma; retinal pigment epithelial cells; retinal ganglion cells (RGCs); neuronal degeneration; glial activation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Trace Elements in Nutrition and Health

edited by Jie Feng

submission deadline 20 Aug 2025 | 8 articles | Viewed by 21309 | Submission Open

Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research of Skin Inflammation and Related Diseases

edited by

Filomena Napolitano

and

Valentina Giudice

submission deadline 20 Aug 2025 | 9 articles | Viewed by 21022 | Submission Open

Keywords: skin; inflammation; molecular target; inflammatory skin diseases; psoriasis; urticaria; atopic dermatitis; systemic sclerosis; skin fibrosis; immune system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neurodegenerative Diseases Research and Therapy—Third Edition

edited by

Sumonto Mitra

submission deadline 20 Aug 2025 | 8 articles | Viewed by 18848 | Submission Open

Keywords: neurodegenerative diseases; therapy; molecular mechanisms; neuron; astrocytes; microglia; inflammation; brain; drug delivery

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Skin Cancer Pathology: From Pathogenesis to Precision Therapies

edited by

Ovidiu Simion Cotoi

submission deadline 20 Aug 2025 | 4 articles | Viewed by 18181 | Submission Open

Keywords: skin cancer; melanoma; non-melanoma; immunotherapy; cutaneous malignancies; targeted therapy; early detection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics and Genomics of Tumors

edited by

Petra Korać

submission deadline 20 Aug 2025 | 14 articles | Viewed by 17901 | Submission Open

Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Cytokines in Inflammatory Signaling: 2nd Edition

edited by

Waipo Chong

Daniela Novick

and

Rosalinda Sorrentino

submission deadline 20 Aug 2025 | 8 articles | Viewed by 17260 | Submission Open

Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Links between Sensory Nerves, Inflammation, and Pain 3.0

edited by

Zsuzsanna Helyes

and

Szőke Éva

submission deadline 20 Aug 2025 | 5 articles | Viewed by 15567 | Submission Open

Keywords: sensory neuropeptides; inflammation; neurogenic inflammation; pain; arthritis; colitis; neuropathy; migraine; novel drug targets; TRP channels; neuroinflammation

(This special issue belongs to the Section Molecular Biology)

Photodynamic Therapy and Photodetection, 2nd Edition

edited by

Petras Juzenas

submission deadline 20 Aug 2025 | 11 articles | Viewed by 15187 | Submission Open

Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser; photochemical internalization (PCI); quantum dots; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Targeted Therapies and Drugs in Cancer

edited by

Maria Teresa Vietri

submission deadline 20 Aug 2025 | 6 articles | Viewed by 14714 | Submission Open

Keywords: targeted therapies; genetic mutation; PARP inhibitors; immunotherapy; drug development; cancer molecular analysis; drug response; molecular-targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd Edition

edited by

Claudia Ricci

submission deadline 20 Aug 2025 | 7 articles | Viewed by 14442 | Submission Open

Keywords: neurodegenerative diseases; molecular biology; neurogenetics; pathogenesis; therapy; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pathophysiology of Lung Diseases

edited by

Theodoros Karampitsakos

and Brenda M. Juan-Guardela

submission deadline 20 Aug 2025 | 6 articles | Viewed by 14380 | Submission Open

Keywords: biomarkers; asthma; COPD; pulmonary fibrosis; post-COVID-19 interstitial lung disease; pathogenesis; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exercise and Health: Cellular and Molecular Perspectives

edited by

Annamaria Mancini

submission deadline 20 Aug 2025 | 4 articles | Viewed by 14243 | Submission Open

Keywords: promoting health; anti-inflammatory action; anti-ageing action; mental health; mitochondrial adaptation; cellular function; regulation of gene expression; metabolic response to exercise

(This special issue belongs to the Section Molecular Biology)

Plant Responses to Abiotic and Biotic Stresses

edited by

Longxing Tao

and

Tingting Chen

submission deadline 20 Aug 2025 | 15 articles | Viewed by 13950 | Submission Open

Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Application of Mass Spectrometry and Chromatography in Biomedicine

edited by

Giovanni Ventura

submission deadline 20 Aug 2025 | 8 articles | Viewed by 13865 | Submission Open

Keywords: mass spectrometry; chromatography; LC-MS; GC-MS; biomarker discovery; pharmaceuticals; metabolimics; proteomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Biomedical Applications of Mesenchymal Stem Cells

edited by

Giuliana Mannino

and

Debora Lo Furno

submission deadline 20 Aug 2025 | 7 articles | Viewed by 13847 | Submission Open

Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage

(This special issue belongs to the Section Molecular Pharmacology)

Computational Molecular Biology of Metabolic Pathways and Signal Transduction Pathways

edited by Ralf Herwig

submission deadline 20 Aug 2025 | 8 articles | Viewed by 13672 | Submission Open

Keywords: computational genomics; computational structural and molecular biology; molecular dynamics simulations; artificial intelligence; AI-driven drug design and development; molecular modeling; computer-aided drug design; computational proteomics; computational and theoretical chemistry

(This special issue belongs to the Section Molecular Biology)

Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease

edited by

Marco Ragusa

and

Cristina Barbagallo

submission deadline 20 Aug 2025 | 10 articles | Viewed by 13621 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; polymorphisms; cancer; degenerative diseases; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Innovative Strategies to Target Metabolism, Inflammation, and Oxidative Stress in Human Diseases

edited by

Kota V. Ramana

submission deadline 20 Aug 2025 | 11 articles | Viewed by 13140 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; aging; cardiovascular diseases; gene editing; stem cell therapy; next-generation sequencing; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Therapeutic Targets in Cancers: 3rd Edition

edited by

Elena Levantini

submission deadline 20 Aug 2025 | 6 articles | Viewed by 12858 | Submission Open

Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

Viral Infection and Virology Methods

edited by

Letizia Santinelli

submission deadline 20 Aug 2025 | 6 articles | Viewed by 12836 | Submission Open

Keywords: acute and chronic viral infection; molecular mechanism; new methodologies; emerging disease; innate and adaptive immunity

(This special issue belongs to the Section Molecular Microbiology)

Molecular Approach to Fern Development

edited by

Helena Fernández

submission deadline 20 Aug 2025 | 5 articles | Viewed by 12659 | Submission Open

Keywords: apomixis; apogamy; asexual reproduction; fern; proteomics; genomics; plant development; evo-devo; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Regulation in Chronic Kidney Diseases

edited by

Marijn Speeckaert

submission deadline 20 Aug 2025 | 5 articles | Viewed by 12300 | Submission Open

Keywords: chronic kidney disease; pathophysiology; genetic and epigenetic factors; metabolic and inflammatory pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetic Genes, Biomarkers and Immunotherapy in Cancers

edited by

Urszula Oleksiewicz

and

Andrzej Mackiewicz

submission deadline 20 Aug 2025 | 5 articles | Viewed by 12215 | Submission Open

Keywords: epigenetics; epigenetic modifications; immunotherapies; immune checkpoint; DNA methylation; histone modifications; epigenetic biomarkers; epidrugs; endogenous retroviruses

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Advances in Endometriosis Research: 3rd Edition

edited by

Antonio Simone Laganà

submission deadline 20 Aug 2025 | 3 articles | Viewed by 12103 | Submission Open

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neurological Disorders: Molecular Pathology and Therapeutic Approaches

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Aug 2025 | 5 articles | Viewed by 12073 | Submission Open

Keywords: The following topics are proposed for this SI:Intracellular signalling networks in neurological disorders.Identification of new therapeutic targets.Genetics of neurological disorders: identification and treatment of mutations.Mitochondrial diseases and neurodegeneration.Gene therapy in neurological diseases: recent advances.Neuroinflammation in autoimmune disorders of the central nervous system.Impact of the microbiome on neurological health.

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Glycosaminoglycans in Human Diseases

edited by

Darko Kero

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11939 | Submission Open

Keywords: glycosaminoglycans; inflammation; infectious disease; cancer

(This special issue belongs to the Section Biochemistry)

Antioxidant, Anti-Inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights

edited by

Ramona Suharoschi

Oana Lelia Pop

and

Adriana Fodor

submission deadline 20 Aug 2025 | 3 articles | Viewed by 11935 | Submission Open

Keywords: phytochemicals; antioxidant activities; anti-inflammatory properties; antimicrobial effects; molecular mechanisms; clinical applications; traditional medicine; bioavailability; safety and toxicology and regulatory aspects of phytochemicals; pharmacological interaction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Molecular Targets and Prognostic Markers Focused on Improving Quality in Healthcare

edited by

Ion Cristóbal

submission deadline 20 Aug 2025 | 8 articles | Viewed by 11916 | Submission Open

Keywords: prognostic markers; molecular targets; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into CKD and Age-Related Bone and Mineral Disorders

edited by

Natalia Carrillo-López

Sara Panizo

and

Cristina Alonso-Montes

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11742 | Submission Open

Keywords: chronic kidney disease; CKD; CKD-MBD; mineral and bone disorder

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Epigenetic Modifications

edited by

Marco Miceli

, Mariella Cuomo and

Rosa Della Monica

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11708 | Submission Open

Keywords: epigenetic modifications; chromatin remodeling; transcription factors; RNA modification; histones; methylation; diseases; epigenetic drugs development

(This special issue belongs to the Section Molecular Genetics and Genomics)

State-of-the-Art Cancer Immunotherapies—2nd Edition

edited by

Takayuki Yoshimoto

Takuma Kato

and

Hisashi Nagase

submission deadline 20 Aug 2025 | 5 articles | Viewed by 11668 | Submission Open

Keywords: immune checkpoint inhibitors; antibody therapy; cytokines/chemokines; CAR-T and TCR-T cells; iPS cell-derived cells; dendritic cell therapy; vaccine; inflammation; mesenchymal stem cells; immunosuppressive tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Calcium Metabolism and Regulation

edited by Hermann Salmhofer and

Michael Lichtenauer

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11067 | Submission Open

Keywords: pathologic calcification; calcification inhibitors; calciprotein particles; Runx-2; apatite; matrix Gla protein; fetuin-A; vitamin D; parathyroid hormone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Research on Protein Structure and Protein Dynamics

edited by

Robert T. Youker

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10971 | Submission Open

Keywords: allostery; receptor; kinase; protein folding; simulations; X-ray crystallography; NMR; super-resolution imaging; fluorescence fluctuation techniques; thermodynamic; enzyme; catalysis; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Gastrointestinal Cancer: From Pathophysiology to Novel Therapeutic Approaches

edited by

Marlena Brzozowa-Zasada

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10854 | Submission Open

Keywords: gastrointestinal cancer; molecular pathology; innovative therapies; targeted therapy; immunotherapy; cancer resistance

(This special issue belongs to the Section Molecular Oncology)

Advances in Rare Diseases Biomarkers: 2nd Edition

edited by

Andrea Bernini

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10803 | Submission Open

Keywords: orphan diseases; rare diseases; inborn errors of metabolism; mitochondrial disorders; biomarker discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular and Cellular Research in Ophthalmology

edited by

Zala Lužnik Marzidovšek

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10599 | Submission Open

Keywords: eye disease; ophthalmology; molecular mechanisms; cellular mechanism; stem cell therapy; tissue engineering; gene therapy

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress and Inflammation in Health and Disease

edited by Fabio Vivarelli and

Donatella Canistro

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10398 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; risk factors; prevention

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Derived Food Products in the Prevention of Chronic Non-Communicable Diseases

edited by

Teresa Leszczyńska

Barbara Borczak

and

Joanna Kapusta-Duch

submission deadline 20 Aug 2025 | 7 articles | Viewed by 10359 | Submission Open

Keywords: plant foods; plant-derived foods; oxidative stress; bioactive compounds; antioxidative substances; chronic non-communicable diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Na, K-ATPase in Health and Disease

edited by

Liora Shoshani

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10310 | Submission Open

Keywords: Na+; K+-ATPase; α -subunit; β -subunit; γ subunits; FXYD

(This special issue belongs to the Section Molecular Biology)

Molecular Study and Treatment of Motor Neuron Diseases

edited by Simona Rossi and

Savina Apolloni

submission deadline 20 Aug 2025 | 3 articles | Viewed by 10182 | Submission Open

Keywords: motor neuron; amyotrophic lateral sclerosis; neuronal degeneration; pathogenic mechanisms; molecular therapy

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Immunology and Inflammation During and After Infectious Diseases

edited by

Manuela Ceccarelli

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10127 | Submission Open

Keywords: bacterial infections; fungi infections; HIV; COVID-19; immune response; inflammation

(This special issue belongs to the Section Molecular Immunology)

Recent Advances of Natural Products in Chemical and Biological Aspects

edited by

Francisco Les

Marta Sofía Valero

and

María Pilar Arruebo

submission deadline 20 Aug 2025 | 6 articles | Viewed by 9926 | Submission Open

Keywords: bioactive compounds; polyphenols; antioxidants; natural products; phytochemicals; molecular research; chemical composition; therapeutic targets; action mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neurodegenerative Diseases: New Insights into Mechanisms, Prevention, Markers, and Therapeutic Targets

edited by

Katarzyna Kaczyńska

submission deadline 20 Aug 2025 | 6 articles | Viewed by 9843 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; molecular targets; biomarkers; disease modeling; therapeutic strategies; prevention; drug design

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Treatments in Neurodegenerative Diseases

edited by