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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Surfactants: Design, Synthesis and Application
edited by
submission deadline 9 Oct 2025 | 1 articles | Viewed by 566 | Submission Open
Keywords: surfactants; adsorption phenomena; critical micellar concentration (CMC); hydrophilic– lipophilic balance (HLB); critical packing parameter (CPP); emulsion formulations; vesicular and non-vesicular origin nanocarriers; drug delivery; theranostics
(This special issue belongs to the Section Materials Science)
A Metabolomics Approach to Tackling Toxicological and Pharmacological Issues: 2nd Edition submission deadline 10 Oct 2025 | 2 articles | Viewed by 5685 | Submission Open
Keywords: metabolomics; metabolites; drugs; contaminants; xenobiotics; toxicity; pharmacology; toxicology
(This special issue belongs to the Section Molecular Toxicology)
Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design
edited by Aleksey E. Kuznetsov
submission deadline 10 Oct 2025 | 1 articles | Viewed by 1250 | Submission Open
Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design
(This special issue belongs to the Section Molecular Nanoscience)
Chlamydia trachomatis Pathogenicity and Disease (Third Edition) submission deadline 10 Oct 2025 | Viewed by 229 | Submission Open
Keywords: Chlamydia trachomatis; virulence factors; host susceptibility or resistance; innate and adaptive immune responses; genetic studies; cervico-vaginal microbiota; clinical outcomes with molecular study
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
MDSCs in Health and Disease submission deadline 10 Oct 2025 | Viewed by 170 | Submission Open
Keywords: MDSCs; inflammation; immune regulation; cancer; autoimmune diseases; pregnancy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Fundamental and Practical Perspectives in Regenerative Medicine: Proceedings of the VI National Congress of Regenerative Medicine (2024) submission deadline 15 Oct 2025 | 18 articles | Viewed by 21491 | Submission Open
Keywords: regenerative medicine; stem cell; gene therapy; cell therapy; tissue engineering
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetics of Human Disease: Emphasis on X-Linked Diseases and Clinical Practice
edited by Antonella La Russa
submission deadline 15 Oct 2025 | Viewed by 368 | Submission Open
Keywords: rare diseases; X-linked disease; X chromosome inactivation (XCI); mosaicism; epigenome; undiagnosed rare diseases; phenotype– genotype correlations; biomarkers; personalized medicine; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Synthesis and Molecular Research of Drugs for Skin Diseases and Cosmetic Ingredients
edited by and Paulina Mucha
submission deadline 20 Oct 2025 | 6 articles | Viewed by 41449 | Submission Open
Keywords: skin diseases; skin cancers; aging; pathogenesis; topical dermatological therapy; systemic dermatological therapy; cosmetic ingredients; molecular mechanism; drugs design and synthesis; molecular mechanism
(This special issue belongs to the Section Molecular Pharmacology)
Targeted Therapy for Immune Diseases
edited by
submission deadline 20 Oct 2025 | 15 articles | Viewed by 40496 | Submission Open
Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers
(This special issue belongs to the Section Molecular Immunology)
New Players in the Research of Oxidative Stress and Cancer submission deadline 20 Oct 2025 | 9 articles | Viewed by 40147 | Submission Open
Keywords: cancer; oxidative stress; biomarkes; redox signaling pathway; therapy resistance
(This special issue belongs to the Section Biochemistry)
Interactions Between Microbes and Hosts: Physiology, Pathology and Treatment
edited by
submission deadline 20 Oct 2025 | 19 articles | Viewed by 24335 | Submission Open
Keywords: microbial infection; microbes– host interaction; virulence factors; molecular and cell biology; antimicrobial therapy; antibiotics; antimicrobial peptides; resistance mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Mechanisms of Immune Tolerance and Autoimmune Diseases submission deadline 20 Oct 2025 | 3 articles | Viewed by 21572 | Submission Open
Keywords: immunological tolerance; autoimmune diseases; autoinflammatory diseases; inflammation; immune-mediated diseases
(This special issue belongs to the Section Molecular Immunology)
Potential Health Benefits of Resveratrol: Laboratory-Confirmed Mechanisms of Action
edited by
submission deadline 20 Oct 2025 | 9 articles | Viewed by 20693 | Submission Open
Keywords: resveratrol; polyphenol; phytoalexin; phytoestrogen; natural compound; reactive oxygen species; antioxidant effects; anti-inflammatory effects; antiaging properties; antidiabetic properties; cardioprotective effects; neuroprotective effects; anticancer properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Nanoparticles in Nanobiotechnology and Nanomedicine: 2nd Edition
edited by
submission deadline 20 Oct 2025 | 8 articles | Viewed by 19055 | Submission Open
Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanism in DNA Replication and Repair
edited by Ryszard Maciejewski
submission deadline 20 Oct 2025 | 8 articles | Viewed by 18647 | Submission Open
Keywords: DNA replication; genome stability; DNA repair mechanisms; mismatch repair mechanism; nucleotide excision repair; cancer risk
(This special issue belongs to the Section Molecular Biophysics)
Phytochemicals and Nutrients in Cancer Prevention and Treatment: Recent Trends and Advances, 2nd Edition submission deadline 20 Oct 2025 | 5 articles | Viewed by 18640 | Submission Open
Keywords: phytochemicals; polyphenols; cancer; antioxidant; pro-oxidant; DNA damage; dietary supplements; signaling pathways; epigenetic; metabolism; immune system; chemoprevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Application of Biotechnology to Dental Treatment submission deadline 20 Oct 2025 | 12 articles | Viewed by 18569 | Submission Open
Keywords: biotechnology; implant material; titanium; zirconia; PEEK; in vitro; in vivo
(This special issue belongs to the Section Materials Science)
Neural Crest Development in Health and Disease (Volume 2)
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 17899 | Submission Open
Keywords: animal models; cellular models; cell fate determination; cell metabolism; cell migration; cell signaling; disease modeling; evolution; gene– environment interactions; gene regulatory networks; neural-crest-related congenital malformations; neural-crest-related cancers; molecular genetics; molecular therapies; pathogenic mechanisms; stem-cell-based therapies
(This special issue belongs to the Section Molecular Neurobiology)
Plant-Sourced Functional and Bioactive Compounds—Nature’s Blueprint for Improving Human Well-Being submission deadline 20 Oct 2025 | 5 articles | Viewed by 17484 | Submission Open
Keywords: plants; antioxidants; phytochemicals; phyto-nutrition; natural products; health enhancing
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Novel Therapeutic Strategies for Neurodegenerative Disease submission deadline 20 Oct 2025 | 3 articles | Viewed by 17181 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; therapy
(This special issue belongs to the Section Molecular Neurobiology)
Rare Genetic Diseases: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 20 Oct 2025 | 6 articles | Viewed by 16408 | Submission Open
Keywords: rare genetic disease; innate metabolic errors; neurodegenerative diseases; therapeutic; molecular diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Research on Cancer Biology and Therapeutics: Third Edition submission deadline 20 Oct 2025 | 8 articles | Viewed by 15533 | Submission Open
Keywords: antiangiogenic; anticancer therapy; antimetastatic; apoptosis; antiproliferative; cancer; peptides; signaling molecules; transcription factors; tumor
(This special issue belongs to the Section Molecular Oncology)
Advances in Cell Metabolism in Endocrine Diseases
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 15509 | Submission Open
Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms of Allergy and Asthma: 3rd Edition submission deadline 20 Oct 2025 | 8 articles | Viewed by 15282 | Submission Open
Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology
(This special issue belongs to the Section Molecular Biology)
Viral Infections and Cancer: Recent Advances and Future Perspectives
edited by
submission deadline 20 Oct 2025 | 8 articles | Viewed by 15109 | Submission Open
Keywords: virus; infection; cancer; immune response
(This special issue belongs to the Section Molecular Oncology)
Research and Application of Platelet-Rich Plasma (PRP)
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 14830 | Submission Open
Keywords: platelet-rich plasma; platelet-rich fibrin; platelets; exosome; mitochondria; growth factors; tissue regeneration
(This special issue belongs to the Section Molecular Biology)
The Applicability of Graphene-Based Materials in the Pharmaceutical, Biological and Biomedical Sectors
edited by and Pogacean Florina
submission deadline 20 Oct 2025 | 6 articles | Viewed by 14489 | Submission Open
Keywords: graphene; graphene-based composites; graphene-based sensors; biomedical applications; tissue engineering; drug delivery
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms of Cancer Invasion and Metastasis
edited by
submission deadline 20 Oct 2025 | 6 articles | Viewed by 13865 | Submission Open
Keywords: cancer; cancer invasion; metastasis; tumor microenvironment; molecular basis of cancer; immunotherapy; cell motility; cancer genetics; cancer development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular and Molecular Mechanisms of Autoimmune Disorders
edited by
submission deadline 20 Oct 2025 | 3 articles | Viewed by 13111 | Submission Open
Keywords: autoimmune diseases; self-tolerance; immune cells; autoantibodies; autoantigens; pathomechanisms
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in RNA Drug Development
edited by Hidenori Tani
submission deadline 20 Oct 2025 | 3 articles | Viewed by 13109 | Submission Open
Keywords: RNA therapeutics; drug development; antisense oligonucleotides; siRNA; miRNA; aptamers; CRISPR-Cas9; delivery systems; clinical applications; emerging technologies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications
edited by Jung-Hyun Lee
submission deadline 20 Oct 2025 | 7 articles | Viewed by 13030 | Submission Open
Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Therapeutic Targets in Skin Diseases
edited by Hanna Mys̈liwiec
submission deadline 20 Oct 2025 | 6 articles | Viewed by 13012 | Submission Open
Keywords: inflammatory skin diseases; systemic inflammation; infectious skin diseases; comorbidity; pathogenesis; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic Mutations in Health and Disease
edited by
submission deadline 20 Oct 2025 | 8 articles | Viewed by 12988 | Submission Open
Keywords: genetic diseases; mutations; genetic screening; structure prediction; haploinsufficeincy; germline mutations; somatic mutations; gene enviroment interaction; gene-gene interations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Targeting RNA Molecules submission deadline 20 Oct 2025 | 3 articles | Viewed by 12820 | Submission Open
Keywords: riboswitch; noncoding RNA; antibiotics; resistance; bacteria; antimicrobial resistance
(This special issue belongs to the Section Molecular Biology)
Editorial Board Members’ Collection Series: Human Traits and Genomics submission deadline 20 Oct 2025 | 5 articles | Viewed by 12757 | Submission Open
Keywords: genetic data analysis; genomic profiling; trait inheritance; DNA and RNA sequencing approaches; deep learning methods
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Role of Extracellular Matrix Proteins in Pathogenesis: 2nd Edition
edited by
submission deadline 20 Oct 2025 | 10 articles | Viewed by 12634 | Submission Open
Keywords: extracellular matrix proteins; autoimmune disease; cancer; cardiovascular diseases; inflammation; chronic diseases; human diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition submission deadline 20 Oct 2025 | 2 articles | Viewed by 12136 | Submission Open
Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mesenchymal Stem Cells and Cancer
edited by Krisztián Németh and Balazs Mayer
submission deadline 20 Oct 2025 | 4 articles | Viewed by 12046 | Submission Open
Keywords: cancer; microenvironment; tumor stroma; cancer-associated fibroblast; mesenchymal stem cell; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR-T cells; immunotherapy; signal transduction; small molecules
(This special issue belongs to the Section Molecular Oncology)
Innovative Antimicrobial Therapies: Overcoming Virulence of Microorganisms and Drug Resistance
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 11742 | Submission Open
Keywords: antibiotics; antimicrobial resistance; antivirals; commensal; pathogenesis; virulence
(This special issue belongs to the Section Molecular Microbiology)
Ion Channels as a Potential Target in Pharmaceutical Designs 2.0
edited by
submission deadline 20 Oct 2025 | 9 articles | Viewed by 11621 | Submission Open
Keywords: ion currents; current kinetics; gating properties; voltage-dependent hysteresis; frequency-dependent regulation; small-molecule modulator
(This special issue belongs to the Section Molecular Biology)
Gut Microbiota in Disease and Health 3.0 submission deadline 20 Oct 2025 | 3 articles | Viewed by 11457 | Submission Open
Keywords: microbiota; microbiome; gut metabolites; short-chain fatty acids; secondary bile acids; microRNA; microvesicles; cell signaling; prebiotics/probiotics; nutrition; fecal transplantation; bacteriophages; gene editing
(This special issue belongs to the Section Molecular Microbiology)
Depression: From Molecular Basis to Therapy—2nd Edition
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 11371 | Submission Open
Keywords: depression; neurobiology; molecular basis; neurotransmitters; genetic factors; psychopharmacology; psychotherapy; genetic markers
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Cellular Research in Pregnancy-Related Complications, 2nd Edition submission deadline 20 Oct 2025 | 4 articles | Viewed by 11289 | Submission Open
Keywords: pregnancy loss/miscarriage; pregnancy complications; pre-eclampsia; maternal– placental– fetal interactions; trophoblast; immune cells; immune tolerance; red blood cells; oxidative stress; blood and fetal proteins; DNA; RNA; stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application
edited by
submission deadline 20 Oct 2025 | 7 articles | Viewed by 11181 | Submission Open
Keywords: miRNA; ncRNA; biomarkers; therapeutics; microarray; NGS
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetics- and Genomics-Based Crop Improvement and Breeding: 3rd Edition
edited by Jian Ma
submission deadline 20 Oct 2025 | 6 articles | Viewed by 11036 | Submission Open
Keywords: crop; germplasm; genetics; genomics; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Exosomes—3rd Edition
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 10730 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes; cancer; sleep cardiovascular diseases; lung disease and upper airways; obesity; sleep and end-organ morbidity
(This special issue belongs to the Section Molecular Biology)
Spinocerebellar Ataxias: Uncovering Their Molecular Mechanisms, Biomarker Development, and Therapies
edited by Anna Sulek
submission deadline 20 Oct 2025 | 5 articles | Viewed by 10556 | Submission Open
Keywords: spinocerebellar ataxia; biomarker; neurodegeneration; preclinical models; transcriptomics; proteomics; microRNA; iPSC; dynamic mutations
(This special issue belongs to the Section Molecular Neurobiology)
New Advances in Epigenetics and Epigenomics
edited by Vicki Maltby
submission deadline 20 Oct 2025 | 4 articles | Viewed by 9493 | Submission Open
Keywords: epigenetics; epigenomics; multi-omics; epitranscriptomics; single cell
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Molecular Insights into Antimicrobial Photo-Treatments
edited by Pietro Delcanale
submission deadline 20 Oct 2025 | 5 articles | Viewed by 9270 | Submission Open
Keywords: photodynamic inactivation; photo-thermal therapy; photosensitization; antimicrobials; reactive oxygen species; photo-treatments; antibiotic resistance; singlet oxygen; antivirals
(This special issue belongs to the Section Molecular Microbiology)
Chronic Kidney Disease: The State of the Art and Future Perspectives
edited by Alberto Rosati
submission deadline 20 Oct 2025 | 5 articles | Viewed by 9206 | Submission Open
Keywords: glomerulonephritis; chronic kidney disease; prevention; screening; cardiovascular mortality; patient outcomes; CKD progression
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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