The Interplay Between Cellular Stress and Human Diseases

Dear Colleagues,

Mammalian cells are subjected to a variety of stress conditions that significantly influence cellular responses. These adaptive mechanisms ensure the maintenance of cellular and systemic homeostasis. Overall, cellular stress response has a physiological and patho- physiological significance. The loss of these control mechanisms can lead to cellular senescence or regulated cell death, or trigger the onset of several human pathologies including cancer and neurodegenerative diseases. In cancer, these stress response mechanisms can increase tumor growth and progression. Therefore, strategies aimed at modulating these pathways have a potential clinical implications.

In this special issue, we welcomes reviews and original articles in the cellular stress response field. Potential topics include, but are not limited to: biological pathways and molecular mechanisms activated after a cellular stress response; the clinical impact of stress response mechanisms; acute or chronic perturbations that activate stress responses; stress factors that are responsible for changes in the transcriptome or the proteome; mechanisms of cell death; mechanisms of cell adaptation; stress signaling pathways and stress signaling markers.

Dr. Daniele Vergara
Guest Editor

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