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Bioactive Compounds, Smart Polymers and Functionalised Materials for Drug Delivery

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 310

Special Issue Editor


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Guest Editor
Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland
Interests: fibres

Special Issue Information

Dear Colleagues,

Multifunctional drug carriers represent attractive approach to improve drug bioavailability e.g. by modulating the release profile or by site-specific delivery of active agents. Basically, drug delivery systems are composed of excipients that serve as the vehicle for active agent. Much attention has been recently paid to bioactive compounds or materials from natural or synthetic origin which exhibit adjunctive biological activity (e.g., anti-inflammatory, antimicrobial, immunomodulating) and may therefore act as an active part of the therapy. At the same time the structural functionalization of these compounds have been extensively studied to improve the physicochemical properties of the drug carrier or to facilitate the pharmacological activity of embedded active agents. This special issue aims to highlight the current advances and the latest developments in the application of bioactive ingredients including plants compounds, polysaccharides, proteins and lipids in technology of drug delivery systems. Full research articles and reviews covering design concept, optimization process and characterization of multifunctional drug carriers intended for topical, oral or parenteral applications with the use of bioactive compounds, smart polymers and functionalized materials are welcome.

Dr. Emilia Szymańska
Guest Editor

Manuscript Submission Information

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Keywords

  • drug delivery system
  • bioactive compound
  • drug carrier
  • pharmacological activity
  • polymer

Published Papers (1 paper)

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Research

18 pages, 2065 KiB  
Article
Medicinal Anti-Inflammatory Patch Loaded with Lavender Essential Oil
by Karolina Zyburtowicz, Paulina Bednarczyk, Anna Nowak, Anna Muzykiewicz-Szymańska, Łukasz Kucharski, Aneta Wesołowska and Paula Ossowicz-Rupniewska
Int. J. Mol. Sci. 2024, 25(11), 6171; https://doi.org/10.3390/ijms25116171 - 4 Jun 2024
Viewed by 176
Abstract
Transdermal drug delivery offers a promising alternative for administering medications like ibuprofen, known for its analgesic and anti-inflammatory properties, with reduced gastrointestinal side effects compared to oral administration. This study explored the potential synergistic effects of combining ibuprofen with lavender essential oil (LEO) [...] Read more.
Transdermal drug delivery offers a promising alternative for administering medications like ibuprofen, known for its analgesic and anti-inflammatory properties, with reduced gastrointestinal side effects compared to oral administration. This study explored the potential synergistic effects of combining ibuprofen with lavender essential oil (LEO) in transdermal patches. The composition of LEO was analyzed, revealing predominant compounds such as linalyl acetate and linalool, which are known for their analgesic and anti-inflammatory properties. The physicochemical properties of the patches were investigated, indicating improved cohesion with the addition of LEO. Additionally, thermal stability assessments demonstrated enhanced stability with LEO incorporation with an increase in onset decomposition temperature from 49.0 to 67.9 °C. The antioxidant activity of patches containing LEO was significantly higher with a free radical scavenging ability of 79.13% RSA compared to 60% RSA in patches without LEO. Release and permeation studies showed that patches with LEO exhibited an increased permeation of ibuprofen through the skin with 74.40% of the drug released from LEO-containing patches compared to 36.29% from patches without LEO after 24 h. Moreover, the permeation rate was notably faster with LEO, indicating quicker therapeutic effects. The inclusion of LEO in transdermal patches containing ibuprofen holds promise for enhancing drug delivery efficiency and therapeutic effectiveness, offering a potential strategy for improved pain management with reduced side effects. Full article
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