The Role of Macrophages in Tumors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 1375
Special Issue Editor
Interests: transcriptional, epigenetic, and metabolic programming of macrophages and their precoursors—corculating monocytes; tumor immunometabolism; macrophage biomarkers of therapy resistance; new molecular targets for TAM reprogramming in solid tumors
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Special Issue Information
Dear Colleagues,
Tumor-associated macrophages (TAMs) are key innate immune cells in the tumor microenvironment (TME) that regulate growth of primary tumors, anti-tumor adaptive immune response, tumor angiogenesis, extracellular matrix remodeling, intravasation in the vasculature, and extravasation in metastatic sites. TAMs can establish beneficial conditions for metastatic cells in the secondary organs. TAMs interfere with the actions of a number of classical chemotherapeutic agents and are critical for the success of new immunotherapeutic tools. Scavenging, signaling, intracellular vesicular transport, transcriptional, epigenetic, and metabolic mechanisms cooperate to form functional TAM phenotypes and, at the same time, offer new options to develop TAM anti-tumor programming agents.
We are pleased to invite you to contribute original papers (full size or brief definite reports) as well as review articles in all fields of tumor-associated macrophages: basic biology and functions, their interaction with cancer cells and other cells in the TME, their role in hematogenous and lymphatic metastasis, TAM interactions with therapeutic agents, as well as TAM biomarkers and functions in cancer patients.
The aim of this Special Issue is to identify critical mechanisms in TAMs that interfere with the success of already developed therapeutic agents and to identify new options for targeting TAMs and reprogramming them to the potent anti-tumor effectors.
Research areas may include (but are not limited to) the following:
- Molecular mechanisms of TAM functions.
- TAMs epigenetics.
- TAMs metabolism.
- Phagocytosis and endocytosis in TAMs.
- Monocyte programming that defines TAM differentiation.
- Roles of cancer-related pathogenesis in TAM programming.
- TAMs and chemotherapy.
- TAMs and radiotherapy.
- TAMs in immunotherapy
- Biomarkers of TAMs for patients’ stratification.
- New targets for TAM programming.
- Translational research on TAMs and clinical applications.
We look forward to receiving your contributions.
Prof. Dr. Julia Kzhyshkowska
Guest Editor
Manuscript Submission Information
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Keywords
- tumor-associated macrophages
- transcriptome
- metabolome
- epigenetics
- angiogenesis
- metastasis
- immunotherapy
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