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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition
edited by and
submission deadline 28 Feb 2026 | Viewed by 20 | Submission Open
Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis
(This special issue belongs to the Section Materials Science)
Dermatological Perspectives on Connective Tissue Diseases
edited by Yoshihide Asano
submission deadline 28 Feb 2026 | Viewed by 8 | Submission Open
Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjö gren’ s syndrome; skin immunology; fibrosis; cytokines; targeted therapy
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Perspectives on Wound Healing submission deadline 20 Mar 2026 | 5 articles | Viewed by 11366 | Submission Open
Keywords: chronic wound healing; scarring; biomarkers; inflammation; angiogenesis; infection; extracellular matrix; biomaterials; tissue regeneration; therapeutic targets; innovative therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Unraveling the Molecular Mechanisms of Neurodegeneration
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 5813 | Submission Open
Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy
(This special issue belongs to the Section Molecular Neurobiology)
Protein Aggregation and Proteinopathies
edited by Hongyu Hu
submission deadline 20 Mar 2026 | 2 articles | Viewed by 4919 | Submission Open
Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy
(This special issue belongs to the Section Molecular Biology)
New Strategies to Improve the Detection of Human Papillomavirus (HPV) Persisting Infections submission deadline 20 Mar 2026 | 3 articles | Viewed by 4305 | Submission Open
Keywords: human papillomavirus; HPV; viral load; genotyping; oncogenic transcripts; biomarkers
(This special issue belongs to the Section Molecular Microbiology)
Inflammatory Bowel Disease and Microbiome
edited by Abigail Raffner Basson
submission deadline 20 Mar 2026 | 3 articles | Viewed by 4060 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker
(This special issue belongs to the Section Molecular Microbiology)
New Therapies and Strategies in the Treatment of Neurodegenerative Diseases submission deadline 20 Mar 2026 | 2 articles | Viewed by 3304 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders
edited by Thomas Paparrigopoulos
submission deadline 20 Mar 2026 | 2 articles | Viewed by 2445 | Submission Open
Keywords: addiction; alcohol use disorder; opioid use disorder; substance use disorders; physical exercise; physical activity; molecular mechanisms; neuroendocrine system
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 2254 | Submission Open
Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondria: Central Players in Cancer submission deadline 20 Mar 2026 | 2 articles | Viewed by 1638 | Submission Open
Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Inborn Errors of Immunity
edited by Aleksandra Szczawińska-Popłonyk
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1332 | Submission Open
Keywords: inborn errors of immunity; immune dysregulation; autoimmunity; autoinflammation; organ-specific immunopathology; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Hormones: Evolutionary and Functional Role
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1211 | Submission Open
Keywords: hormone action; brain organization; sexual behavior; endocrine tissue; receptor neuroexpression; endocrine control; endocrine disruption; climate change and reproduction; hormones and evolution
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cotton Molecular Genomics and Genetics (Third Edition)
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 883 | Submission Open
Keywords: cotton; biotic or abiotic stress; disease resistance; fiber yield and quality; gene editing; gene identification and function validation; genome-wide association study; QTL identification
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition submission deadline 20 Mar 2026 | 1 articles | Viewed by 756 | Submission Open
Keywords: cancer; natural bioactive molecules; natural products; tumor
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Autophagy and Programmed Cell Death in Plants and Algae
edited by
submission deadline 20 Mar 2026 | Viewed by 443 | Submission Open
Keywords: algal autophagy and PCD; autophagy-related (Atg) genes and proteins; biotic and abiotic stresses; caspase-like proteases; crop plant improvement; macro-; micro-; and mega-autophagy; metacaspases; selective autophagy; signaling; vacuolar processing enzymes (VPEs)
(This special issue belongs to the Section Molecular Plant Sciences)
Roles of Neutrophils in Autoimmune Diseases and Cancers
edited by
submission deadline 20 Mar 2026 | Viewed by 301 | Submission Open
Keywords: neutrophils; neutrophil extracellular traps (NETs); autoimmunity; autoimmune disease(s); cancer; oncology
(This special issue belongs to the Section Molecular Immunology)
Arthritis: From Molecular Basis to Therapy
edited by Cinzia Rotondo
submission deadline 20 Mar 2026 | Viewed by 32 | Submission Open
Keywords: comorbidities; biomarkers; inflammation; autoimmune disease; systemic disease; arthritis; autoimmune disease; psoriasis; axial involvement; biological drugs; target synthetic DMARDs; pathogenesis; rheumatoid arthritis; spondyloarthritis; psoriatic arthritis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic Diversity, Founder Effects, and Migration in Neurodegeneration: Molecular and Population Perspectives submission deadline 20 Mar 2026 | Viewed by 10 | Submission Open
Keywords: neurodegeneration; population genetics; founder effects; genetic diversity; migration and disease risk; spinocerebellar ataxia; Alzheimer’ s disease; Parkinson’ s disease; genetic epidemiology; underrepresented populations
(This special issue belongs to the Section Molecular Neurobiology)
Functional Materials in Catalysis and Photocatalysis: From Design to Application submission deadline 20 Mar 2026 | Submission Open
Keywords: nanostructured materials  ; photocatalysis  ; catalysis  ; green synthesis  ; material design  ; surface engineering
(This special issue belongs to the Section Materials Science)
Molecular Engineering of Antimicrobial Agents: From Structure-Function Insights to Combinatorial Therapies
edited by Mingrui Liao
submission deadline 25 Mar 2026 | Viewed by 19 | Submission Open
Keywords: antimicrobial amphiphiles; antimicrobial resistance; structure– activity relationship; synergistic antimicrobial therapy; drug delivery systems
(This special issue belongs to the Section Molecular Biology)
Advances in Nasopharyngeal Carcinoma Immunology, Epigenetics, and Therapy
edited by
submission deadline 25 Mar 2026 | Viewed by 9 | Submission Open
Keywords: nasopharyngeal carcinoma (NPC); epstein– barr virus (EBV); cancer epigenomics; virus– host interaction; tumor microenvironment (TME); immunotherapy; targeted therapy; biomarker; metastasis; radiotherapy resistance  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Enzyme Inhibitors: Mechanisms, Applications, and Future Perspectives submission deadline 30 Mar 2026 | 5 articles | Viewed by 5607 | Submission Open
Keywords: enzyme inhibitors; drug design; drug discovery; drug therapy; resistance mechanisms; cancer; drug delivery systems; biocatalysts; enzymes in industrial applications
(This special issue belongs to the Section Biochemistry)
Immune Microenvironment and Tissue Remodeling in Oral Diseases and Oral Cancer
edited by
submission deadline 30 Mar 2026 | Viewed by 15 | Submission Open
Keywords: immune microenvironment; oral cancer; oral diseases; tissue remodeling; molecular signaling pathways
(This special issue belongs to the Section Molecular Immunology)
Unravelling the Intricate Link Between Microvascular Dysfunction and Cardiovascular Disease
edited by Róbert Pórszász
submission deadline 31 Mar 2026 | 1 articles | Viewed by 232 | Submission Open
Keywords: microvascular dysfunction; cardiovascular pathogenesis; endothelial dysfunction; oxidative stress; nitric oxide bioavailability; VEGF dysregulation; endothelin-1 overactivity; heart failure with preserved ejection fraction (HFpEF); pharmacological interventions; microcirculation-targeted therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mechanism Research on Listeria monocytogenes and Its Control submission deadline 31 Mar 2026 | Viewed by 177 | Submission Open
Keywords: Listeria monocytogenes; virulence; biofilm; pathogenicity; control; prevention; food safety
(This special issue belongs to the Section Molecular Microbiology)
Metabolic–Epigenetic Interplay in Healthy and Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 19 | Submission Open
Keywords: epigenetics; metabolism; TCA cycle; one-carbon cycle; aging; longevity; cancer; metabolic syndrome; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
ROS and Abiotic Stress in Plants, 3rd Edition submission deadline 31 Mar 2026 | Viewed by 16 | Submission Open
Keywords: chilling and freezing; drought stress; heat stress; heavy metals stress; nutrient and mineral stress; oxidative stress; resurrection plants and desiccation tolerance; salinity
(This special issue belongs to the Section Molecular Plant Sciences)
Synthetic Chemistry in Drug Discovery
edited by Kathiravan Suppan
submission deadline 20 Apr 2026 | Viewed by 566 | Submission Open
Keywords: late-stage functionalization; AI-driven synthesis; drug discovery; synthetic chemistry; transition metal catalysis
(This special issue belongs to the Section Molecular Pharmacology)
Research Progress of Orthopedic Materials
edited by Robert Karpiński
submission deadline 20 Apr 2026 | Viewed by 285 | Submission Open
Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings
(This special issue belongs to the Section Materials Science)
Fascial Anatomy and Histology: Advances in Molecular Biology
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 11087 | Submission Open
Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan
(This special issue belongs to the Section Molecular Biology)
Pancreatic Diseases: Molecular Pathology and Therapeutics
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 729 | Submission Open
Keywords: pancreatic cancer; acute pancreatitis; chronic pancreatitis; diabetes; inflammation; molecular markers; therapeutic strategies; genetic predispositions; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease
edited by
submission deadline 30 May 2026 | Viewed by 239 | Submission Open
Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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