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Citations	Article
1600	Pretreatment of Lignocellulosic Wastes to Improve Ethanol and Biogas Production: A Review by Mohammad J. Taherzadeh and Keikhosro Karimi
882	An Updated Review of Tyrosinase Inhibitors by Te-Sheng Chang
863	Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease by Un Ju Jung and Myung-Sook Choi
758	Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches by Xi-Feng Zhang, Zhi-Guo Liu, Wei Shen and Sangiliyandi Gurunathan
711	Green Extraction of Natural Products: Concept and Principles by Farid Chemat, Maryline Abert Vian and Giancarlo Cravotto
668	An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering by Piergiorgio Gentile, Valeria Chiono, Irene Carmagnola and Paul V. Hatton
667	Physiological, Biochemical, and Molecular Mechanisms of Heat Stress Tolerance in Plants by Mirza Hasanuzzaman, Kamrun Nahar, Md. Mahabub Alam, Rajib Roychowdhury and Masayuki Fujita
644	UV Radiation and the Skin by John D'Orazio, Stuart Jarrett, Alexandra Amaro-Ortiz and Timothy Scott
641	Inflammation, Oxidative Stress, and Obesity by Alba Fernández-Sánchez, Eduardo Madrigal-Santillán, Mirandeli Bautista, Jaime Esquivel-Soto, Ángel Morales-González, Cesar Esquivel-Chirino, Irene Durante-Montiel, Graciela Sánchez-Rivera, Carmen Valadez-Vega and José A. Morales-González
634	Impact of Dietary Polyphenols on Carbohydrate Metabolism by Kati Hanhineva, Riitta Törrönen, Isabel Bondia-Pons, Jenna Pekkinen, Marjukka Kolehmainen, Hannu Mykkänen and Kaisa Poutanen

Citations	Article
14	A Computational Framework Based on Ensemble Deep Neural Networks for Essential Genes Identification by Nguyen Quoc Khanh Le, Duyen Thi Do, Truong Nguyen Khanh Hung, Luu Ho Thanh Lam, Tuan-Tu Huynh and Ngan Thi Kim Nguyen
10	Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway by Nóra Török, Masaru Tanaka and László Vécsei
10	New Omics—Derived Perspectives on Retinal Dystrophies: Could Ion Channels-Encoding or Related Genes Act as Modifier of Pathological Phenotype? by Luigi Donato, Concetta Scimone, Simona Alibrandi, Ebtesam Mohamed Abdalla, Karim Mahmoud Nabil, Rosalia D’Angelo and Antonina Sidoti
10	Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2 by Elettra Barberis, Sara Timo, Elia Amede, Virginia V. Vanella, Chiara Puricelli, Giuseppe Cappellano, Davide Raineri, Micol G. Cittone, Eleonora Rizzi, Anita R. Pedrinelli, Veronica Vassia, Francesco G. Casciaro, Simona Priora, Ilaria Nerici, Alessandra Galbiati, Eyal Hayden, Marco Falasca, Rosanna Vaschetto, Pier Paolo Sainaghi, Umberto Dianzani, Roberta Rolla, Annalisa Chiocchetti, Gianluca Baldanzi, Emilio Marengo and Marcello Manfredi
10	Regulation of ROS Metabolism in Plants under Environmental Stress: A Review of Recent Experimental Evidence by Mirza Hasanuzzaman, M. H. M. Borhannuddin Bhuyan, Khursheda Parvin, Tasnim Farha Bhuiyan, Taufika Islam Anee, Kamrun Nahar, Md. Shahadat Hossen, Faisal Zulfiqar, Md. Mahabub Alam and Masayuki Fujita
8	Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer by Simone Patergnani, Alberto Danese, Esmaa Bouhamida, Gianluca Aguiari, Maurizio Previati, Paolo Pinton and Carlotta Giorgi
7	The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic by Jung-Hyun Won and Howard Lee
7	The Influence of Tumor Microenvironment on Immune Escape of Melanoma by Aleksandra Simiczyjew, Ewelina Dratkiewicz, Justyna Mazurkiewicz, Marcin Ziętek, Rafał Matkowski and Dorota Nowak
7	Effect of Prostanoids on Human Platelet Function: An Overview by Steffen Braune, Jan-Heiner Küpper and Friedrich Jung
7	In Silico Investigation of the New UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 Variants with a Focus at the ACE2–Spike RBD Interface by Bruno O. Villoutreix, Vincent Calvez, Anne-Geneviève Marcelin and Abdel-Majid Khatib

Citations	Article
81	COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males? by Donato Gemmati, Barbara Bramanti, Maria Luisa Serino, Paola Secchiero, Giorgio Zauli and Veronica Tisato
44	The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target by Mohamed Abu-Farha, Thangavel Alphonse Thanaraj, Mohammad G. Qaddoumi, Anwar Hashem, Jehad Abubaker and Fahd Al-Mulla
42	Potential Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 606 Million Compounds by André Fischer, Manuel Sellner, Santhosh Neranjan, Martin Smieško and Markus A. Lill
38	*Healthspan Enhancement by Olive Polyphenols in C. elegans* Wild Type and Parkinson’s Models** by Gabriele Di Rosa, Giovanni Brunetti, Maria Scuto, Angela Trovato Salinaro, Edward J. Calabrese, Roberto Crea, Christian Schmitz-Linneweber, Vittorio Calabrese and Nadine Saul
34	Investigation of Some Antiviral N-Heterocycles as COVID 19 Drug: Molecular Docking and DFT Calculations by Mohamed Hagar, Hoda A. Ahmed, Ghadah Aljohani and Omaima A. Alhaddad
33	Mechanisms of Multidrug Resistance in Cancer Chemotherapy by Karol Bukowski, Mateusz Kciuk and Renata Kontek
33	Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition by Aleix Gimeno, Júlia Mestres-Truyol, María José Ojeda-Montes, Guillem Macip, Bryan Saldivar-Espinoza, Adrià Cereto-Massagué, Gerard Pujadas and Santiago Garcia-Vallvé
32	Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity by Andrea Picchianti Diamanti, Maria Manuela Rosado, Claudio Pioli, Giorgio Sesti and Bruno Laganà
30	SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms by Manuela Pennisi, Giuseppe Lanza, Luca Falzone, Francesco Fisicaro, Raffaele Ferri and Rita Bella
28	SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment by Marcella Prete, Elvira Favoino, Giacomo Catacchio, Vito Racanelli and Federico Perosa

Citations	Article
290	The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation by Nathan Kelley, Devon Jeltema, Yanhui Duan and Yuan He
239	A Review of SARS-CoV-2 and the Ongoing Clinical Trials by Yung-Fang Tu, Chian-Shiu Chien, Aliaksandr A. Yarmishyn, Yi-Ying Lin, Yung-Hung Luo, Yi-Tsung Lin, Wei-Yi Lai, De-Ming Yang, Shih-Jie Chou, Yi-Ping Yang, Mong-Lien Wang and Shih-Hwa Chiou
151	Cytokines in Inflammatory Disease by Shinwan Kany, Jan Tilmann Vollrath and Borna Relja
150	Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications by Michele Longo, Federica Zatterale, Jamal Naderi, Luca Parrillo, Pietro Formisano, Gregory Alexander Raciti, Francesco Beguinot and Claudia Miele
139	TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis by Yang Hao, David Baker and Peter ten Dijke
123	Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases by Fabrice Collin
106	Vascular Endothelial Cell Biology: An Update by Anne Krüger-Genge, Anna Blocki, Ralf-Peter Franke and Friedrich Jung
101	A Comprehensive Review on Current Advances in Peptide Drug Development and Design by Andy Chi-Lung Lee, Janelle Louise Harris, Kum Kum Khanna and Ji-Hong Hong
99	Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues by Doralicia Casares, Pablo V. Escribá and Catalina Ana Rosselló
82	Sex-Specific SARS-CoV-2 Mortality: Among Hormone-Modulated ACE2 Expression, Risk of Venous Thromboembolism and Hypovitaminosis D by Sandro La Vignera, Rossella Cannarella, Rosita A. Condorelli, Francesco Torre, Antonio Aversa and Aldo E. Calogero

Citations	Article
290	The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation by Nathan Kelley, Devon Jeltema, Yanhui Duan and Yuan He
251	Silver Nanoparticles: Synthesis and Application for Nanomedicine by Sang Hun Lee and Bong-Hyun Jun
239	A Review of SARS-CoV-2 and the Ongoing Clinical Trials by Yung-Fang Tu, Chian-Shiu Chien, Aliaksandr A. Yarmishyn, Yi-Ying Lin, Yung-Hung Luo, Yi-Tsung Lin, Wei-Yi Lai, De-Ming Yang, Shih-Jie Chou, Yi-Ping Yang, Mong-Lien Wang and Shih-Hwa Chiou
234	Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer by Priyanka Singh, Santosh Pandit, V.R.S.S. Mokkapati, Abhroop Garg, Vaishnavi Ravikumar and Ivan Mijakovic
232	Role of Extracellular Matrix in Development and Cancer Progression by Cameron Walker, Elijah Mojares and Armando Del Río Hernández
209	Role of Human Macrophage Polarization in Inflammation during Infectious Diseases by Chiraz Atri, Fatma Z. Guerfali and Dhafer Laouini
205	Targeting Tumor Microenvironment for Cancer Therapy by Catarina Roma-Rodrigues, Rita Mendes, Pedro V. Baptista and Alexandra R. Fernandes
200	Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery by Nicholas Ekow Thomford, Dimakatso Alice Senthebane, Arielle Rowe, Daniella Munro, Palesa Seele, Alfred Maroyi and Kevin Dzobo
173	The Roles of Autophagy in Cancer by Chul Won Yun and Sang Hun Lee
160	Psoriasis Pathogenesis and Treatment by Adriana Rendon and Knut Schäkel

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3706	Dual mTOR/DNA-PK Inhibitor CC-115 Induces Cell Death in Melanoma Cells and Has Radiosensitizing Potential by Felix Bürkel, Tina Jost, Markus Hecht, Lucie Heinzerling, Rainer Fietkau and Luitpold Distel
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3008	Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases by Nicole Jacqueline Jensen, Helena Zander Wodschow, Malin Nilsson and Jørgen Rungby
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2534	Possible Receptor Mechanisms Underlying Cannabidiol Effects on Addictive-like Behaviors in Experimental Animals by Ewa Galaj and Zheng-Xiong Xi
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2441	The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic by Jung-Hyun Won and Howard Lee
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35216	Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation by Elena Campione, Terenzio Cosio, Luigi Rosa, Caterina Lanna, Stefano Di Girolamo, Roberta Gaziano, Piera Valenti and Luca Bianchi
12965	Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics by Chase M. Walton, Samuel M. Jacobsen, Blake W. Dallon, Erin R. Saito, Shantelle L. H. Bennett, Lance E. Davidson, David M. Thomson, Robert D. Hyldahl and Benjamin T. Bikman
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7843	*Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema* by Sandro Michelini, Pietro Chiurazzi, Valerio Marino, Daniele Dell’Orco, Elena Manara, Mirko Baglivo, Alessandro Fiorentino, Paolo Enrico Maltese, Michele Pinelli, Karen Louise Herbst, Astrit Dautaj and Matteo Bertelli
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