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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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State-of-the-Art Molecular Oncology in Brazil 3.0 submission deadline 29 Jun 2024 | Viewed by 159 | Submission Open
Keywords: apoptosis; autophagy; calcium; cancer; cell death; chemotherapy; metabolism; mitochondria; drug resistance; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Advances in Understanding Molecular Mechanisms Involved in Chronic Kidney Injury and Repair
edited by
submission deadline 29 Jun 2024 | Viewed by 139 | Submission Open
Keywords: kidney disease; ischemic kidney injury; renal fibrosis; obesity; inflammation; oxidative stress; autophagy; senescence; cell death; small ncRNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Endothelial Glycocalyx: Physiological, Pathological and Therapeutic “Holy Grail”
edited by
submission deadline 29 Jun 2024 | Viewed by 129 | Submission Open
Keywords: atherogenesis; endothelial dysfunction; disordered microvascular function; glycocalyx; vascular
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Therapeutic Targets and Approaches to Manage Inflammation: Disappointing Past, Current Efforts and Faint Hopes
edited by Natasha Irrera
submission deadline 29 Jun 2024 | Viewed by 102 | Submission Open
Keywords: inflammation; inflammatory pathways; resolution of inflammation; inflammasome; molecular pathways; anti-inflammatory response
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Tumor Necrosis Factor and Inflammatory Diseases
edited by Salah Amasheh
submission deadline 29 Jun 2024 | Viewed by 96 | Submission Open
Keywords: tumor necrosis factor; inflammatory chronic disease; experimental biomedicine; epithelium; pathophysiology; immunology; therapeutic stategies
(This special issue belongs to the Section Molecular Oncology)
Biomarkers in Metabolic Syndrome
edited by
submission deadline 29 Jun 2024 | Viewed by 92 | Submission Open
Keywords: biomarkers; metabolic syndrome; cardiovascular disease; chronic degenerative pathologies; neurological diseases; oncological diseases
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
23rd Anniversary of IJMS: Advances in Biochemistry
edited by
submission deadline 30 Jun 2024 | 189 articles | Viewed by 597572 | Submission Open
(This special issue belongs to the Section Biochemistry)
Molecular Research in Fruit Crop
edited by
submission deadline 30 Jun 2024 | 15 articles | Viewed by 22850 | Submission Open
(This special issue belongs to the Section Molecular Plant Sciences)
21st Century Enzymology: Further Advances in Identification and Characterization of Enzymes submission deadline 30 Jun 2024 | 14 articles | Viewed by 18532 | Submission Open
Keywords: enzyme functional assignment; drug discovery and development; enzyme kinetics; enzyme mechanisms; enzyme structure; enzyme dynamics; allosteric enzyme regulation; microbial biosynthesis and bioengineering
(This special issue belongs to the Section Biochemistry)
The Role of Neurons in Human Health and Disease 2.0
edited by
submission deadline 30 Jun 2024 | 7 articles | Viewed by 18171 | Submission Open
Keywords: brain; nervous system; neurons; immune system; human health and disease
(This special issue belongs to the Section Molecular Neurobiology)
Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases 2.0
edited by
submission deadline 30 Jun 2024 | 9 articles | Viewed by 14934 | Submission Open
Keywords: cardiovascular diseases; metabolic diseases; cellular and molecular mechanisms
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research on Depression submission deadline 30 Jun 2024 | 7 articles | Viewed by 13732 | Submission Open
Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Biomarkers in Cancers: Advances and Challenges submission deadline 30 Jun 2024 | 6 articles | Viewed by 13501 | Submission Open
Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value
(This special issue belongs to the Section Molecular Oncology)
Pregnancy Complicated by Hypertension—New Horizons in the Pathomechanism, Diagnosis, and Treatment
edited by
submission deadline 30 Jun 2024 | 7 articles | Viewed by 12936 | Submission Open
Keywords: molecular markers; molecular pathway; pre-eclampsia; pregnancy-induced hypertension; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Neurobiology of Migraine 2.0
edited by , Yasuo Terayama and
submission deadline 30 Jun 2024 | 7 articles | Viewed by 12880 | Submission Open
Keywords: migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; TRP channels; PACAP
(This special issue belongs to the Section Molecular Neurobiology)
Recent Advance on Iron Metabolism, Ferritin and Hepcidin Research 2.0
edited by
submission deadline 30 Jun 2024 | 6 articles | Viewed by 12781 | Submission Open
Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis 2.0
edited by
submission deadline 30 Jun 2024 | 7 articles | Viewed by 12690 | Submission Open
Keywords: enzyme; enzyme inhibitor; drug target; enzyme deficiency; enzyme overexpression; biomarker; drugs; diagnosis; therapy
(This special issue belongs to the Section Molecular Pharmacology)
Retinal Degenerative Diseases 2.0 submission deadline 30 Jun 2024 | 3 articles | Viewed by 12278 | Submission Open
Keywords: retina; photoreceptor degenerative diseases; inherited retinal degenerations; glaucoma; retinal pigment epithelial cells; retinal ganglion cells (RGCs); neuronal degeneration; glial activation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Machine Learning and Bioinformatics in Human Health and Disease
edited by Ramin Ranjbarzadeh and
submission deadline 30 Jun 2024 | 11 articles | Viewed by 12186 | Submission Open
Keywords: machine learning; bioinformatics; deep learning; multi-omics approaches; genetic risk factors; drug interactions; precision medicine; neurodegenerative diseases; disease diagnosis; epidemic prediction
(This special issue belongs to the Section Molecular Informatics)
Mitochondria in Human Health and Disease 2.0
edited by
submission deadline 30 Jun 2024 | 9 articles | Viewed by 12169 | Submission Open
Keywords: OXPHOS; mitochondrial transcription; mitochondrial– nuclear interactions; mitochondrial– ER interactions; mitochondrial bioenergetics; mitochondrial fusion/fission; apoptosis; mitophagy; ROS– mitochondrial oxidative defense systems; neurodegenerative diseases; mitochondrial myopathies; mitochondrial diseases; mitochondrial disorders in cancer; mitochondria and inflammation; Ca2+ signaling
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Autoimmune and Autoinflammatory Disorders: Current Issue and Future Perspectives submission deadline 30 Jun 2024 | 5 articles | Viewed by 11281 | Submission Open
Keywords: spondyloarthritis; innate immunity; adaptive immunity; interleukin-1; IL-1-mediated diseases; inflammasome; precision medicine; gender medicine
(This special issue belongs to the Section Molecular Immunology)
Targeted Therapies and Molecular Methods in Cancer 2.0
edited by
submission deadline 30 Jun 2024 | 7 articles | Viewed by 11200 | Submission Open
Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI
(This special issue belongs to the Section Molecular Oncology)
Advances in Stem Cells and Organoid Development: Exploring Molecular, Metabolic and Electro-Synaptic Mechanisms Using Systems Approach submission deadline 30 Jun 2024 | 4 articles | Viewed by 10143 | Submission Open
Keywords: stem cells; genome; proteomics; organoids; systems
(This special issue belongs to the Section Molecular Biology)
Crop Biotic and Abiotic Stress Tolerance 3.0
edited by
submission deadline 30 Jun 2024 | 7 articles | Viewed by 9575 | Submission Open
Keywords: biotic and abiotic stress tolerance; QTL/gene mapping and clones; gene editing; marker-assisted selection; genomic breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Research on Immune Cells and Cytokines
edited by
submission deadline 30 Jun 2024 | 9 articles | Viewed by 9342 | Submission Open
(This special issue belongs to the Section Molecular Immunology)
New Insights into Aquaporins submission deadline 30 Jun 2024 | 8 articles | Viewed by 8916 | Submission Open
Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target
(This special issue belongs to the Section Molecular Biology)
The Promising Future of CAR-Based Therapies: A Matter of Molecular Details submission deadline 30 Jun 2024 | 4 articles | Viewed by 8876 | Submission Open
Keywords: CAR; genetic engineering; T; NK; CIK; ATMP; GMP manufacturing; off-the-shelf; TME; cell exhaustion
(This special issue belongs to the Section Molecular Immunology)
Sphingolipid Metabolism and Signaling: Role in Health and Diseases
edited by
submission deadline 30 Jun 2024 | 7 articles | Viewed by 8068 | Submission Open
Keywords: sphingolipids; sphingosine-1-phosphate; ceramide; glycosphingolipids; sphingolipid-mediated signaling; cancer; neurodegenerative diseases; inflammatory diseases; diabetes
(This special issue belongs to the Section Biochemistry)
Novel Mechanisms of Bacterial Antibiotic Resistance and Strategies to Fight Them submission deadline 30 Jun 2024 | 5 articles | Viewed by 7876 | Submission Open
Keywords: molecular mechanisms of antibacterial resistance; essential bacterial processes; bacterial tolerance to antibiotics; emerging antibiotic targets; screening procedures; antimicrobials; target validation; drug discovery; drug repurposing; medicinal chemistry
(This special issue belongs to the Section Molecular Pharmacology)
Therapeutic Potential of Antioxidants in the Prevention of Human Diseases
edited by
submission deadline 30 Jun 2024 | 3 articles | Viewed by 7611 | Submission Open
Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research for Cereal Grain Quality 2.0
edited by
submission deadline 30 Jun 2024 | 6 articles | Viewed by 7595 | Submission Open
Keywords: cereal; rice; wheat; maize; barley; sorghum; millet; molecular markers; genome-wide association studies; genome editing; genome selection; sequencing; molecular selection; transcriptomics; omics; post-translational regulation; starch; protein; lipids; vitamin; phenolics; processing quality; eating quality
(This special issue belongs to the Section Molecular Plant Sciences)
Virus Engineering and Applications: 2nd Edition
edited by
submission deadline 30 Jun 2024 | 4 articles | Viewed by 7496 | Submission Open
Keywords: virus engineering; oncolytic virotherapy; immunovirotherapy; viral biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Advance in Targeted Cancer Therapy and Mechanisms of Resistance—2nd Edition submission deadline 30 Jun 2024 | 5 articles | Viewed by 7396 | Submission Open
Keywords: targeted therapy; drug resistance; tumor microenvironment; cancer progression; molecular profiling; immunosurveillance; immunotherapy; gene therapy; biomarker
(This special issue belongs to the Section Molecular Oncology)
Molecular Computer Science and Artificial Intelligence for Drug Discovery
edited by Enkelejda Miho
submission deadline 30 Jun 2024 | 4 articles | Viewed by 7091 | Submission Open
Keywords: artificial intelligence; computer science; drug discovery; computational modeling; drug target identification; drug design; machine learning; deep learning; drug interactions
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insight into Retinal Diseases
edited by Hsiaoming Chao, Robert Casson and Hsi-Kung Kuo
submission deadline 30 Jun 2024 | 6 articles | Viewed by 6953 | Submission Open
Keywords: faricimab; modified cerebrolysin; acupuncture; stem cells; gene therapy; retinal chip; femtosecond; artisan aphakia; artiflex; exozyme; silicon oil; amniotic membrane; EOG; multifocal ERG; flash ERG; VEP; microperimetry; OCT-A
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Applications of Fluorescence Microscopy in Molecular Biology
edited by
submission deadline 30 Jun 2024 | 3 articles | Viewed by 6839 | Submission Open
Keywords: single and two-photon fluorescence microscopy; super-resolution microscopy; 3D deconvolution microscopy; light-sheet microscopy; molecular imaging; organoids; brain imaging; drug screening; optical clearing; protocol
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Human Liver Diseases 2.0
edited by
submission deadline 30 Jun 2024 | 5 articles | Viewed by 6778 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); alcoholic steatohepatitis (ASH) Wilson’ s disease; hemochromatosis; viral hepatitis; autoimmune hepatitis; hepatocellular carcinoma; signaling pathways; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Chaperones: Protein Folding, Proteostasis, and Diseases
edited by
submission deadline 30 Jun 2024 | 5 articles | Viewed by 6725 | Submission Open
(This special issue belongs to the Section Biochemistry)
Molecular and Cellular Research on Adipose Tissue Development and Functions
edited by
submission deadline 30 Jun 2024 | 5 articles | Viewed by 6499 | Submission Open
Keywords: adipose tissue; development; expansion; white adipose tissue; brown adipose tissue; beige adipose tissue; adipocytes; adipogenesis; lipogenesis; peroxisome proliferator-activated receptor gamma (PPAR-γ ); CCAAT enhancer binding proteins (CEBP-α ; CEBP-β ; and CEBP-δ ); carbohydrate response element binding protein (ChREBP)
(This special issue belongs to the Section Molecular Biology)
Identification of New Molecular Subgroups in Breast Cancer submission deadline 30 Jun 2024 | 3 articles | Viewed by 6471 | Submission Open
Keywords: breast cancer; molecular subgroups; gene expression profiles; molecular tests; targeted agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic Modifiers of Hemoglobinopathies: Recent Advances and Future Directions
edited by Alex Felice, and
submission deadline 30 Jun 2024 | 6 articles | Viewed by 6377 | Submission Open
Keywords: hemoglobinopathies; genetic modifiers; thalassemia; sickle cell disease; association studies; biomarkers; GWAS
(This special issue belongs to the Section Molecular Biology)
Acid–Base Metabolism, and Human Physiology and Pathophysiology submission deadline 30 Jun 2024 | 6 articles | Viewed by 6370 | Submission Open
Keywords: ammoniagenesis; FGF-23-Klotho axis; growth hormone– IGF axis; hormones; kidney physiology and function; NAE; nutrition; potassium balance; PRAL; renin– angiotensin aldosterone system
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into the Developmental Origins of Health and Disease submission deadline 30 Jun 2024 | 5 articles | Viewed by 6174 | Submission Open
Keywords: Developmental Origins of Health and Disease (DOHaD); fetal development; maternal nutrition; molecular programming; epigenetic modifications; environmental exposures; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Review Papers in Molecular and Cellular Biology 2024
edited by
submission deadline 30 Jun 2024 | 6 articles | Viewed by 6130 | Submission Open
Keywords: molecular biology; cell biology; signal transduction; macromolecules and complexes; gene expression; DNA structure; damage and repair; bioinformatics; imaging techniques
(This special issue belongs to the Section Molecular Biology)
Together and Apart: Acute Kidney Injury and Chronic Kidney Disease
edited by
submission deadline 30 Jun 2024 | 5 articles | Viewed by 6035 | Submission Open
Keywords: kidney disease; acute kidney injury; nephrotoxicity; chronic kidney disease; fibrosis; inflammation in vivo model; in vitro model
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Structure Research 2024
edited by and
submission deadline 30 Jun 2024 | 4 articles | Viewed by 5920 | Submission Open
Keywords: fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins
(This special issue belongs to the Section Molecular Biophysics)
Latest Research on Plant Genomics and Genome Editing
edited by
submission deadline 30 Jun 2024 | 7 articles | Viewed by 5905 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Current and Future Roles of Tumor Markers in Prostate Adenocarcinoma
edited by
submission deadline 30 Jun 2024 | 3 articles | Viewed by 5896 | Submission Open
Keywords: prostate cancer; miRNAs; cancer epigenetics; heterogeneity; risk stratification; circulating tumour cells; PCA3; TMPRSS2:ERG; metabolomics; androgen receptor; personalised medicine; clinical decision-making  
(This special issue belongs to the Section Molecular Oncology)
Latest Review Papers in Molecular Neurobiology 2024
edited by
submission deadline 30 Jun 2024 | 6 articles | Viewed by 5827 | Submission Open
Keywords: neurobiology; neurochemistry; neurology; neuropathology; neurophysiology; neuropharmacology; neurogenetics; neuro-oncology; aging neuroscience; neurotrauma; neurogenesis; neurotransmitter; neuroinflammation; neuroendocrine tumor; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Mechanisms of Antipsychotic Action: From the Researcher Bench to the Patient Bedside 2.0
edited by
submission deadline 30 Jun 2024 | 4 articles | Viewed by 5814 | Submission Open
Keywords: schizophrenia; glutamate; dopamine; gene expression; synapse; post-synaptic density; second-messenger; psychosis; synaptic plasticity
(This special issue belongs to the Section Molecular Neurobiology)
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