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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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miRNAs in Cancers: From Molecular Biology to Treatment
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 2180 | Submission Open
Keywords: cancer; miRNA; epigenetic
(This special issue belongs to the Section Molecular Biology)
The Roles of AI in Disease Diagnosis and Treatment submission deadline 20 Jun 2026 | 2 articles | Viewed by 2178 | Submission Open
Keywords: artificial intelligence; radiomics; machine learning; deep learning; diagnosis; treatment; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Insights for the Development of Emerging Photovoltaics Through Molecular Research submission deadline 20 Jun 2026 | 2 articles | Viewed by 2175 | Submission Open
Keywords: molecular photovoltaics; perovskite solar cells; quantum dot solar cells; organic solar cells; dye-sensitized solar cells; molecular design and engineering; molecular semiconductors
(This special issue belongs to the Section Materials Science)
Endometriosis: Current Trends and Research Developments submission deadline 20 Jun 2026 | 1 articles | Viewed by 2144 | Submission Open
Keywords: endometriosis; molecular mechanisms; pathophysiology; hormonal regulation; immune response; epigenetics; inflammation; biomarkers; transcriptomics; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recombinant Proteins and Antibody Engineering for Diagnostic and Treatment of Emerging Infectious Diseases
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 2135 | Submission Open
Keywords: recombinant proteins; antibody engineering; monoclonal antibodies; hemorrhagic fevers; tuberculosis; emerging infectious diseases; neglected viruses; diagnostics; therapeutic antibodies
(This special issue belongs to the Section Molecular Immunology)
Gene Regulation in Endocrine Disease, 2nd Edition
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 2097 | Submission Open
Keywords: gene regulation; endocrine disease; endocrinology; diabetes mellitus; thyroid disorders
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research in Nanotechnology for Natural Products submission deadline 20 Jun 2026 | 1 articles | Viewed by 2082 | Submission Open
Keywords: molecular nanotechnology; natural products; bioactive compounds; nanocarriers; targeted delivery; encapsulation; bioavailability; pharmacological applications; food applications; biomedical nanotechnology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Composites of Carbon Nanomaterials and Transition Metals: Preparation, Properties, Bioapplications
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 2054 | Submission Open
Keywords: composite materials; carbon nanomaterials; nanoparticles of transition metals and their compounds; preparation and functionalization of composite materials; biosensors; bioapplications
(This special issue belongs to the Section Molecular Nanoscience)
Antibacterial Nanomaterials for Medicinal Applications
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 2029 | Submission Open
Keywords: nanotechnology; antibacterial; nanomaterials; toxicity; biocompatibility; medicinal applications
(This special issue belongs to the Section Molecular Nanoscience)
Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 2002 | Submission Open
Keywords: mesenchymal stem/stromal cells (MSCs); MSC homing; MSC properties; immune cells; macrophages; injury; inflammation; cell therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights into Virus-Host Immune Interactions
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1994 | Submission Open
Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2
(This special issue belongs to the Section Molecular Immunology)
Histological and Molecular Perspectives on Immune Mechanisms of the Nasal and Bronchial Mucosa Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1954 | Submission Open
Keywords: nasal and bronchial mucosa; nasal polyposis; bronchial inflammation; immunotherapy; mucosal immunity; inflammatory biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Genome-Edited Animal Models
edited by Takayuki Sakurai and
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1944 | Submission Open
Keywords: genome editing; prime editing; base editing; CRISPRa/CRISPRi; knock-in/out; conditional genome editing; multiplex genome editing; manipulation of early embryos and germ cells; in vivo gene delivery; genome-edited animals; disease animal model
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research on Orchid Plants: 2nd Edition
edited by Wen‑Chieh Tsai
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1941 | Submission Open
Keywords: orchid; genomics; genome; genes; tumor; inflammation; drug; transcriptomics
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Tau Protein Research submission deadline 20 Jun 2026 | 2 articles | Viewed by 1922 | Submission Open
Keywords: tau biology; disease model systems; protein aggregation; tauopathies; neurodegeneration; Alzheimer’ s disase; seeded aggregation; amyloid filaments; tau propagation; antibodies; targeted protein degradation; tau therapeutics
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Plant Reproductive Development
edited by Zsolt Pónya and
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1905 | Submission Open
Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls
(This special issue belongs to the Section Molecular Plant Sciences)
Synthesis, Characterization and Applications of Advanced Polymer Materials
edited by Namil Kim
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1900 | Submission Open
Keywords: synthesis methodologies; molecular architecture; functional polymers; characterization techniques; cutting-edge applications
(This special issue belongs to the Section Macromolecules)
RNA in Biology and Medicine (2nd Edition)
edited by and William A. Haseltine
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1843 | Submission Open
Keywords: noncoding RNAs; coding RNAs; RNA-based therapy; RNA vaccine; RNA structure; RNA function
(This special issue belongs to the Section Molecular Biology)
Molecular Modeling in Pharmaceutical Sciences
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 1836 | Submission Open
Keywords: molecular modeling; computer-aided drug design; molecular docking; drug discovery; quantum chemistry; molecular dynamics simulations; virtual screening; computational pharmacology; pharmacy; in silico methods
(This special issue belongs to the Section Molecular Pharmacology)
Oxidative Stress and Disease: Basic and Biochemical Approaches submission deadline 20 Jun 2026 | 1 articles | Viewed by 1819 | Submission Open
Keywords: aging; antioxidant mechanisms; cancer; cytokines; enzymatic pathways; inflammatory processes; oxidative stress; reactive oxygen species (ROS)
(This special issue belongs to the Section Molecular Biology)
Molecular Aspects of Tumor Radiotherapy
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1798 | Submission Open
Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies
(This special issue belongs to the Section Molecular Oncology)
Molecular Signaling and Cellular Mechanisms in Asthma
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1795 | Submission Open
Keywords: asthma; endotypes; pausi-immune asthma; nonatopic asthma; steroid insensitivity; neutrophilic asthma; innate lymphoid cells; Th2 cells
(This special issue belongs to the Section Molecular Immunology)
Chronic Kidney Disease: Novel Advances in Pathophysiology and Therapeutics
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1791 | Submission Open
Keywords: anti-fibrosis; anti-inflammation; biomarker; chronic kidney disease; complement; glucagon-like peptide-1 receptor agonist; immuno modulaton; sodium– glucose cotransporter-2 inhibitor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular Memory in Response to Environmental Conditions
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1779 | Submission Open
Keywords: cellular memory; cellular environment; embryonic development; epigenetics; transgenerational inheritance; mammals; DOHaD
(This special issue belongs to the Section Molecular Biology)
The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage
edited by Antonio Arnaiz-Villena
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1769 | Submission Open
Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G; E; F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolution; MHC phylogenetics; Vertebrate MHC; Amimal  MHC; Veterinary
(This special issue belongs to the Section Molecular Immunology)
Regulation of Brown Adipose Function submission deadline 20 Jun 2026 | 1 articles | Viewed by 1769 | Submission Open
Keywords: brown adipose tissue; metabolic disorders; thermogenesis; endocrine function; cellular signaling
(This special issue belongs to the Section Biochemistry)
Molecular Research on Stroke
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1765 | Submission Open
Keywords: stroke; microglia; neuroinflammation; molecular mechanisms; ischemic injury
(This special issue belongs to the Section Molecular Neurobiology)
The Molecular Life of Sperm: New Horizons in Male Infertility submission deadline 20 Jun 2026 | 2 articles | Viewed by 1740 | Submission Open
Keywords: human sperm; fertilization; infertility; biomarkers; genetics
(This special issue belongs to the Section Molecular Biology)
Protein–Protein Interactions in Human Cancer
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1736 | Submission Open
Keywords: protein– protein interactions; protein– protein complexes; human cancer; signal transduction pathways; protein structure and function
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Precision Cancer Medicine: Molecular Insights, Biological Events and Clinical Perspectives submission deadline 20 Jun 2026 | 1 articles | Viewed by 1728 | Submission Open
Keywords: multi-omics at bulk level; single-cell multi-omics; precision oncology; precision immune-oncology; tumor molecular profiling
(This special issue belongs to the Section Molecular Oncology)
Molecular and Genetic Insights into Neuropsychiatric Disorders: From Mechanisms to Management submission deadline 20 Jun 2026 | 2 articles | Viewed by 1725 | Submission Open
Keywords: psychiatry; neurology; psychotic disorders; depressive disorders; neurocognitive disorders; neuropsychiatry; genetics; psychopharmacology; neuromodulation; genome-wide association studies (GWAS); transcriptomics; epigenetics; gene-environment interactions
(This special issue belongs to the Section Molecular Neurobiology)
New Molecular Mechanisms of Genotoxicity
edited by Francesca Marcon and
submission deadline 20 Jun 2026 | Viewed by 1703 | Submission Open
Keywords: DNA damage; DNA repair; genotoxicity; carcinogenesis; chronic degenerative diseases; human health; molecular mechanisms
(This special issue belongs to the Section Molecular Toxicology)
Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses and Therapies
edited by Magdalena Wawrzyńska
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1694 | Submission Open
Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition) submission deadline 20 Jun 2026 | 1 articles | Viewed by 1692 | Submission Open
Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design
(This special issue belongs to the Section Molecular Biophysics)
Innovative Advances and Applications in Medical and Molecular Virology
edited by and
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1673 | Submission Open
Keywords: medical virology; molecular virology; molecular diagnostics; genomics; metagenomics; interactomics; integrative omics
(This special issue belongs to the Section Molecular Microbiology)
Molecular Informatics and AI in Cancer Research
edited by and
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1642 | Submission Open
Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data
(This special issue belongs to the Section Molecular Informatics)
Bioactive Compounds in Cancers: Second Edition submission deadline 20 Jun 2026 | 1 articles | Viewed by 1636 | Submission Open
Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Leukemia: Molecular Immune Mechanisms submission deadline 20 Jun 2026 | 1 articles | Viewed by 1627 | Submission Open
Keywords: leukemia; immune system; Genetic Mutations and Alterations; Immune Evasion Mechanisms; Immune Cell Dysfunction; Cytokine Networks; Bone Marrow Microenvironment; immunotherapy strategies
(This special issue belongs to the Section Molecular Immunology)
Molecular and Cellular Research on Adipose Tissue Development and Functions, 2nd Edition
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1621 | Submission Open
Keywords: adipose tissue; development; expansion; white adipose tissue; brown adipose tissue; beige adipose tissue; adipocytes; adipogenesis; lipogenesis; peroxisome proliferator-activated receptor gamma (PPAR-γ ); CCAAT enhancer binding proteins (CEBP-α ; CEBP-β ; and CEBP-δ ); carbohydrate response element binding protein (ChREBP)
(This special issue belongs to the Section Molecular Biology)
New Insights into Intercellular Communication and Signal Transduction
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1616 | Submission Open
Keywords: intercellular communication; signal transduction; extracellular vesicles (EVs); exosomes; tunneling nanotubes (TNTs); cytokines; hormonal signaling; neurotransmitters; mechanotransduction; immune signaling
(This special issue belongs to the Section Molecular Biology)
Advances in Angiogenesis: From Molecular Insights to Therapeutic Strategies
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1583 | Submission Open
Keywords: angiogenesis; molecular signaling; endothelial cells; tumor microenvironment; pro-angiogenic factors; anti-angiogenic therapy; vascular remodeling; hypoxia; VEGF pathway; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Organoid Models in Host–Pathogen Interactions and Disease Pathogenesis
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1580 | Submission Open
Keywords: organoids; host– pathogen interaction; infectious disease models; mucosal immunity; tissue engineering; microbial pathogenesis; immune organoids; 3D culture systems
(This special issue belongs to the Section Molecular Biology)
Antiviral Mechanisms of Natural/Synthetic Compounds
edited by Cybele Carina García
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1578 | Submission Open
Keywords: antiviral mechanisms; natural compound; synthetic compound; druggable viral/host target; emerging virus; host– virus interaction; innate antiviral response; cell-intrinsic restriction factor
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Canonical and Noncanonical Inflammasomes in Inflammation and Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1575 | Submission Open
Keywords: canonical; noncanonical; inflammasome; inflammation; human diseases; anti-inflammatory therapeutics
(This special issue belongs to the Section Molecular Immunology)
Molecular Research and Application of Platelet-Rich Plasma
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1569 | Submission Open
Keywords: platelet-rich plasma; fibrin scaffold; regenerative medicine; molecular biology; translational medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Actinomycetes-Derived Natural Products
edited by Fong Tian Wong
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1565 | Submission Open
Keywords: actinomycetes; natural products; actinobacterial; genome mining; omics; secondary metabolites; genetic engineering; discovery; structural diversity
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Effects of Chemicals on Brain Health and Development
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1563 | Submission Open
Keywords: brain development; environmental chemicals; prescribed medicines; addictive drugs; neuronal plasticity; behavior; learning and memory; neurogenesis; cell death (apoptosis and necrosis)
(This special issue belongs to the Section Molecular Neurobiology)
Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity
edited by Bourlaye Fofana and
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1559 | Submission Open
Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity
(This special issue belongs to the Section Molecular Plant Sciences)
Latest Molecular Research on Polymer Coatings
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1555 | Submission Open
Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.
(This special issue belongs to the Section Materials Science)
Lectins: Structural Diversity, Molecular Recognition and Emerging Applications submission deadline 20 Jun 2026 | 2 articles | Viewed by 1547 | Submission Open
Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications
(This special issue belongs to the Section Biochemistry)
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