Molecular and Cellular Research on the Glioma and Tumor Microenvironment

Dear Colleagues,

Gliomas are the most prevalent primary brain cancer among adults, accounting for 75% of all cases. Known as a grade IV glioma, GBM is the most aggressive form of this disease. As a standard treatment, tumors are surgically resected, followed by postoperative radiation therapy, followed by concurrent and adjuvant Temozolomide treatment. As a result of the development of resistance to TMZ in GBM, and the high-level heterogeneity between and within tumors, the prognosis remains poor. In this scenario, the tumour microenvironment (TME) plays a central role. It is believed that glioblastoma cells subvert the microglia and macrophages for tumor growth to form the bulk of a tumor microenvironment dominated by inflammatory infiltrates. There are also different cell populations within the TME, including fibroblasts, precursor cells, endothelial cells, signaling molecules, and extracellular matrix components. As a consequence, developing models and techniques that allow the monitoring of the TME during growth or treatment is essential for an improved understanding of tumors and for more precise diagnosis and treatment.

This Special Issue of the International Journal of Molecular Sciences welcomes both original research articles and review papers that deal with the molecular mechanisms underlying the role of microenvironment signaling in gliomas.

Dr. Maria Beatrice Morelli
Guest Editor

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• tumour microenvironment

• immune cells
• cell siganling
• tumor niche
• tumor heterogeneity
• TMZ resistance
• new therapeutic strategies
• endothelial cells
• fibroblasts
• extracellular matrix