Roles of Lipid Rafts in Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 1185
Special Issue Editor
Special Issue Information
Dear Colleagues,
Lipid rafts are dynamic assemblies of glycosphingolipids, sphingomyelin, cholesterol, and glycosylphosphatidylinositol (GPI)-anchored proteins and a variety of signaling molecules, such as Src family kinases and the α-subunit of the heterotrimeric G proteins, which are stabilized into platforms involved in the regulation of several cellular processes and diseases. Low-density, detergent-insoluble membrane raft fractions can be isolated from all mammals, such as Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Dictyostelium, and protozoan parasites. Gene mutation of synthase or degrading enzymes of glycosphingolipids, sphingomyelin, sterol, and GPI-anchored proteins impairs the integrity of lipid rafts and results in various phenotypes. Furthermore, several microorganisms have been found to use lipid rafts in their infection processes. The presence of lipid rafts in vivo is supported by several lines of evidence, including the results of a single-molecule imaging study, a fluorescence resonance energy transfer study, a photonic force microscopic study, and a chemical crosslinking study.
Dr. Kohji Kasahara
Guest Editor
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Keywords
- lipid rafts
- glycosphingolipid
- ganglioside
- sphingomyelin
- cholesterol
- GPI-anchored proteins
- caveolae
- detergent-resistant membrane
- signal transduction
- disease
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