Advanced Research on CAR-T Cell Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (20 August 2025) | Viewed by 4537
Special Issue Editor
Interests: antibody screening; T cell therapy;cancer vaccine; chimeric antigen receptor; T cell receptor; immunological synaps
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although CAR T cell therapy is effective in liquid cancer therapy, its application in solid cancer is difficult. On the other hand, TCR T cell therapy appears to be effective in some cases, for example, NY-ESO-1 and MAGE-A4. Compared with the TCR-T cell therapy, infused CAT T cells cannot be maintained for long or their function decreases rapidly. As a majority of infused cells differentiate into effector memory or terminal memory cells, central memory and stem cell memory formation is not enough. In this Special Issue, several studies will be reported. The co-expression of IL-7 and CCL19 can recruit APC cells and activate bystander host cells and induce antigen spread. The co-expression of membrane-bound IL-12 induces memory differentiation after antigen stimulation and increased tumor suppression. Lymph-node-targeting amphiphile vaccine can boost CAR-T cells and induce antigen spread. Using these approaches and few new ones, several cases of solid tumors will be cured with CAR T cell therapy.
Dr. Yasushi Akahori
Guest Editor
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Keywords
- CAR T cell therapy
- T cell activation
- memory lymphocyte differentiation
- cancer vaccine
- antigen spread
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