Biological Role of Oxidative Stress in Inflammatory Diseases: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 1110
Special Issue Editor
Interests: nutrition; cellular biology; oxidative stress; cardiovascular disease; endogenous antioxidant enzymes; bioactive vegetable; molecules
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The imbalance between reactive oxidant species and endogenous antioxidant defense mechanisms promotes the development of a condition of oxidative stress, which has considerable biological consequences. Increasing evidence is proving that oxidative stress plays a pivotal role in the development and progression of inflammation, and thus contributes to the pathophysiology of a number of diseases, such as cancer, cardiovascular diseases, diabetes, and neurodegenerative processes.
Oxidant species influence all phases of the inflammatory response, including the release by damaged tissues of molecules acting as endogenous danger signals. Their sensing by innate immune receptors from the Toll-like (TLRs) and the NOD-like (NLRs) families leads to activation of signaling pathways promoting the adaptive cellular response to such signals.
While we tend to describe oxidative stress simply as harmful for the human body, it is also true that it is exploited as a therapeutic approach to treat clinical conditions such as cancer, with a certain degree of clinical success.
We can conclude that oxidative stress, although being one of the major injuries to individuals’ wellness and health, can also be exploited as a treatment tool.
Therefore, correlations between oxidative stress, inflammation, and disease should be carefully investigated in order to better understand the etiopathogenesis of diseases and to develop ad hoc future treatments.
Dr. Sara Franceschelli
Guest Editor
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Keywords
- oxidative stress
- inflammation
- endogenous antioxidant enzymes
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