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Modulation of the Immune System and Oxidative Stress in Liver Illnesses

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1555

Special Issue Editors


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Guest Editor Assistant
Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: genetic polymorphisms; inflammation; oxidative stress; sepsis; internal medicine; acute pancreatitis; diabetes mellitus; liver diseases; rheumatic disease
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Guest Editor
Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Interests: inflammatory bowel diseases; digestive cancers; endoscopic imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The regulation of the immune system and oxidative stress plays a direct role in liver disorders. However, they are not solely engaged in processes linked to harm. Oxidative stress is linked to the redox state and plays a significant role in various physiological processes, including cellular signaling adaptations and the hypothalamic regulation of hunger. Inflammatory mediators play a crucial role in the mechanisms involved in liver diseases. Nevertheless, when these two events are no longer subject to regulations, their impact becomes detrimental.

Within this Special Issue, we hope to cover all the immunoregulatory mechanisms involved in liver disease and the best approaches and timing to prevent inflammation and oxidative stress.

Dr. Vlad Pădureanu
Prof. Dr. Dan Ionut Gheonea
Guest Editors

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Keywords

  • oxidative stress
  • liver illnesses
  • immune system
  • inflammatory

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Published Papers (1 paper)

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Research

16 pages, 4159 KiB  
Article
Therapeutic Efficacy of Silymarin, Vitamin E, and Essential Phospholipid Combination Therapy on Hepatic Steatosis, Fibrosis, and Metabolic Parameters in MASLD Patients: A Prospective Clinical Study
by Dan-Ionuț Gheonea, Cristina Tocia, Victor-Mihai Sacerdoțianu, Alexandra-Georgiana Bocioagă, Irina-Paula Doica, Nicolae Cătălin Manea, Adina Turcu-Știolică, Carmen-Nicoleta Oancea and Eugen Dumitru
Int. J. Mol. Sci. 2025, 26(12), 5427; https://doi.org/10.3390/ijms26125427 - 6 Jun 2025
Viewed by 1260
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, and current estimates indicate an increase in incidence and prevalence in the general population. The design of the prospective study was to evaluate the response of patients with MASLD [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, and current estimates indicate an increase in incidence and prevalence in the general population. The design of the prospective study was to evaluate the response of patients with MASLD to an original formula consisting of silymarin, vitamin E, and essential phospholipids. In total, 200 patients were initially enrolled in the study and a total of 190 who participated in all four visits were included in our analysis. During the visits, liver function tests, lipid profiles, blood glucose level, fibrosis, and steatosis values and grades were assessed. From baseline, visit 0, to month 6th, visit III, a statistically significant difference (p-value < 0.0001) was observed in the reduction in ALT, AST, GGT, ALP, TG, total cholesterol, and blood glucose levels. There was a significant decrease in the fibrosis value from the first visit to the last visit (p = 0.002). Even though administered separately, silymarin, essential phospholipids, and vitamin E have established their efficacy in MASLD, this study demonstrates that their combination produces an indubitable effect on liver steatosis, even in a short cure of 6 months, and it can be proposed due to it having no adverse effects on patients with MASLD. Full article
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