Oral Squamous Cell Carcinoma: Insights into Molecular Pathways and Emerging Therapeutic Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 2462
Special Issue Editor
Special Issue Information
Dear Colleagues,
Oral squamous cell carcinoma (OSCC) represents a prevalent and aggressive form of malignancy arising from the epithelial cells of the oral cavity. It accounts for the majority of oral cancer cases, with a higher incidence in adults, particularly those with significant risk factors such as tobacco and alcohol use and human papillomavirus.
Despite advances in treatment modalities, managing aggressive forms of OSCC remains a considerable challenge, particularly in achieving the long-term control of localized tumors. The prognosis for patients with advanced or metastatic OSCC continues to be poor. However, recent technological innovations are facilitating a deeper understanding of the molecular drivers behind OSCC development and progression. Disruptions in key regulatory mechanisms, such as transcriptional, post-transcriptional, and post-translational processes, have been identified as being crucial to OSCC behavior. These molecular dysregulations reveal potential therapeutic vulnerabilities and offer new opportunities for biomarker discovery and targeted treatments.
For this Special Issue, we invite submissions of high-quality original research and review articles focused on fundamental and translational research that sheds light on the regulatory networks driving OSCC pathogenesis and progression. We particularly welcome studies that explore novel mechanisms related to radiotherapy and drug resistance, with the goal of advancing therapeutic strategies and improving patient outcomes.
This Special Issue invites submissions of high-quality original research articles and reviews that explore the molecular and translational aspects of OSCC. We encourage studies that uncover novel regulatory mechanisms contributing to OSCC pathogenesis and progression, with a focus on improving therapeutic outcomes and the development of innovative treatment strategies.
Dr. Silvia Pomella
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oral squamous cell carcinoma
- epigenetics
- molecular genetics
- gene expression targeted therapy
- molecular biomarkers
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
