Oral Squamous Cell Carcinoma: Insights into Molecular Pathways and Emerging Therapeutic Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (20 January 2026) | Viewed by 7332
Special Issue Editor
Interests: oral squamous cell carcinoma; epigenetics; transcriptional regulation; molecular biomarkers; targeted therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oral squamous cell carcinoma (OSCC) represents a prevalent and aggressive form of malignancy arising from the epithelial cells of the oral cavity. It accounts for the majority of oral cancer cases, with a higher incidence in adults, particularly those with significant risk factors such as tobacco and alcohol use and human papillomavirus.
Despite advances in treatment modalities, managing aggressive forms of OSCC remains a considerable challenge, particularly in achieving the long-term control of localized tumors. The prognosis for patients with advanced or metastatic OSCC continues to be poor. However, recent technological innovations are facilitating a deeper understanding of the molecular drivers behind OSCC development and progression. Disruptions in key regulatory mechanisms, such as transcriptional, post-transcriptional, and post-translational processes, have been identified as being crucial to OSCC behavior. These molecular dysregulations reveal potential therapeutic vulnerabilities and offer new opportunities for biomarker discovery and targeted treatments.
For this Special Issue, we invite submissions of high-quality original research and review articles focused on fundamental and translational research that sheds light on the regulatory networks driving OSCC pathogenesis and progression. We particularly welcome studies that explore novel mechanisms related to radiotherapy and drug resistance, with the goal of advancing therapeutic strategies and improving patient outcomes.
This Special Issue invites submissions of high-quality original research articles and reviews that explore the molecular and translational aspects of OSCC. We encourage studies that uncover novel regulatory mechanisms contributing to OSCC pathogenesis and progression, with a focus on improving therapeutic outcomes and the development of innovative treatment strategies.
Dr. Silvia Pomella
Guest Editor
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Keywords
- oral squamous cell carcinoma
- epigenetics
- molecular genetics
- gene expression targeted therapy
- molecular biomarkers
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