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MicroRNAs and Other Non-Coding RNAs as Regulators, Biomarkers, and Therapeutic Targets, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 2243

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Guest Editor
1. Department of Biochemistry, Dongguk University School of Medicine, Gyeongju 38066, Republic of Korea
2. Channelopathy Research Center (CRC), Dongguk University School of Medicine, Ilsan 10326, Republic of Korea
Interests: mechanotransduction; cytoskeleton remodeling; proliferation; differentiation; myogenesis; sarcopenia; insulin resistance; diabetes; metabolism; glucose metabolism; lipid metabolism; metabolic diseases; energy metabolism
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Special Issue Information

Dear Colleagues,

RNA biology has seen significant advances over the preceding decades. Non-coding RNAs, which are divided into small non-coding RNAs and long non-coding RNAs (lncRNAs) on the basis of length, are becoming a hot topic in molecular and cellular biology and have received extensive attention. Non-coding RNAs orchestrate cell-to-cell communication and regulate biological processes epigenetically as "key regulators" of physiological and pathological processes. A rapidly increasing body of research demonstrates that microRNAs and lncRNAs play crucial roles in cellular homeostasis and human health. Furthermore, non-coding RNAs have also been linked to a wide range of human diseases, such as cancer, cardiovascular diseases, and metabolic disorders, and they can be used as biomarkers to diagnose or predict the severity of a disease.

This Special Issue will explore the novel functions and mechanisms of non-coding RNAs, including microRNAs, lncRNAs, and circRNAs, in diverse cells and tissues. The Issue will also discuss advances in the discovery of non-coding RNAs as novel biomarkers and therapeutic targets for human disorders. We encourage the submission of original research articles, as well as review articles covering all aspects of non-coding RNAs as regulators, biomarkers, or therapeutic targets.

More published papers can be found in the closed Special Issue: MicroRNAs and Other Non-coding RNAs as Regulators, Biomarkers, and Therapeutic Targets.

Prof. Dr. Wan Lee
Guest Editor

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Keywords

  • non-coding RNAs
  • microRNA
  • lncRNA
  • circRNA
  • piRNA
  • biomarker
  • therapeutic target

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Published Papers (1 paper)

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Research

16 pages, 3076 KiB  
Article
MicroRNA-181a Targets GNAI2 and Affects the Proliferation and Induction Ability of Dermal Papilla Cells: The Potential Involvement of the Wnt/β-Catenin Signaling Pathway
by Mingliang He, Xiaoyang Lv, Joram M. Mwacharo, Yutao Li, Shanhe Wang and Wei Sun
Int. J. Mol. Sci. 2024, 25(14), 7950; https://doi.org/10.3390/ijms25147950 - 20 Jul 2024
Viewed by 1556
Abstract
Wool is generated by hair follicles (HFs), which are crucial in defining the length, diameter, and morphology of wool fibers. However, the regulatory mechanism of HF growth and development remains largely unknown. Dermal papilla cells (DPCs) are a specialized cell type within HFs [...] Read more.
Wool is generated by hair follicles (HFs), which are crucial in defining the length, diameter, and morphology of wool fibers. However, the regulatory mechanism of HF growth and development remains largely unknown. Dermal papilla cells (DPCs) are a specialized cell type within HFs that play a crucial role in governing the growth and development of HFs. This study aims to investigate the proliferation and induction ability of ovine DPCs to enhance our understanding of the potential regulatory mechanisms underlying ovine HF growth and development. Previous research has demonstrated that microRNA-181a (miR-181a) was differentially expressed in skin tissues with different wool phenotypes, which indicated that miR-181a might play a crucial role in wool morphogenesis. In this study, we revealed that miR-181a inhibited the proliferation and induction ability of ovine DPCs by quantitative Real-time PCR (qRT-PCR), cell counting Kit-8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU), flow cytometry, and alkaline phosphatase staining. Then, we also confirmed G protein subunit alpha i2 (GNAI2) is a target gene of miR-181a by dual luciferase reporter assay, qRT-PCR, and Western blot, and that it could promote the proliferation and induction ability of ovine DPCs. In addition, GNAI2 could also activate the Wnt/β-Catenin signaling pathway in ovine DPCs. This study showed that miR-181a can inhibit the proliferation and induction ability of ovine DPCs by targeting GNAI2 through the Wnt/β-Catenin signaling pathway. Full article
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