Microsatellite Instability (MSI) and Mismatch Repair Deficient (dMMR)-Related Diseases: From Detection Methods to Practice

Dear Colleagues,

Microsatellite instability (MSI-H) and mismatch repair deficiency (dMMR) have been observed in several types of cancer, most commonly in colorectal, endometrial, and gastric cancers. Patients with MSI-positive tumors can benefit from immunotherapy; however, many studies have shown that there is wide heterogeneity in terms of detection assays, prognosis, and immunotherapy sensitivity. This Special Issue will encompass a diverse range of topics related to MSI in cancer, including the prevalence and potentially expanded role for clinical MSI testing across multiple tumor types that could benefit from immunotherapy; the inherited germline MMR pathway mutations, such as in Lynch syndrome; and the proper methods of identification, such as IHC, NGS, and PCR. This Special Issue focuses, but is not limited to, on recent developments regarding the MSI in colorectal, endometrial, and gastric cancer and the MSI role as an emerging biomarker in other tumors, such as gliomas, triple-negative breast cancers, renal carcinomas, pediatric tumors, bladder carcinomas, and lung cancers.

We are organizing a Special Issue on “Microsatellite instability (MSI) and Mismatch Repair Deficient (dMMR)-Related Diseases: From Detection Methods to Practice” that may be of interest to you. The clinical significance of MSI has been well described in colorectal, endometrial, and gastric cancers; however, MSI was observed to be frequent in other tumor types with potential clinical relevance. In this view, this Special issue will focus on methods of identification and the prevalence of MSI in various cancers. 

We are pleased to invite you to submit research papers, reviews, communications, etc., for this Special Issue.

Dr. Federica Zito Marino
Guest Editor

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• microsatellite instability (MSI)
• mismatch repair deficient (dMMR)
• immunotherapy
• next-generation sequencing (NGS)
• immunohistochemistry (IHC)
• polymerase chain reaction (PCR)
• MSI-positive tumors