ijms-logo

Journal Browser

Journal Browser

Molecular Pathology and Novel Therapies for Lymphoma

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1156

Special Issue Editor


E-Mail Website
Guest Editor
Institut Jules Bordet, Brussels, Belgium
Interests: lymphoproliferative disorders; lymphoma; cellular therapy

Special Issue Information

Dear Colleagues,

Lymphoproliferative disorders comprise a wide variety of histopathological and clinical entities , mostly treated with chemotherapy for many years. The emergence of small-molecule targeted therapies, antibody–drug conjugates, chimeric antigen receptor T cells (CAR-T), and bispecific T-cell engagers (BITEs) is profoundly modifying the therapeutic approach in this field. However, there is still a gap in understanding the physiopathology of these disorders, determining a lack of effective therapeutic agents.

With this Special Issue, we aim to explore the current knowledge of the molecular pathways and mechanisms of Hodgkin and non-Hodgkin tumorigenesis, covering advances in basic and preclinical research, and proposing relevant and novel therapeutic strategies.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Pathology, cell metabolism, and biomarkers in lymphoma.
  • New therapeutic approaches and drug delivery in lymphoma.
  • Genetic susceptibility and genomic instability in lymphoma.
  • Interaction between tumor cells and the microenvironment in lymphoma.

Dr. Fulvio Massaro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hodgkin lymphoma
  • non-Hodgkin lymphoma
  • hematopathology
  • biomarker
  • new therapeutic approaches

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 1761 KiB  
Article
microRNA Profile of High-Grade B-Cell Lymphoma with 11q Aberration
by Michalina Zajdel, Łukasz Michał Szafron, Agnieszka Paziewska, Grzegorz Rymkiewicz, Michalina Dąbrowska, Zbigniew Bystydzieński, Mariusz Kulińczak, Beata Grygalewicz, Maria Sromek, Katarzyna Błachnio, Maria Kulecka, Filip Hajdyła, Krzysztof Goryca, Magdalena Chechlińska and Jan Konrad Siwicki
Int. J. Mol. Sci. 2025, 26(1), 285; https://doi.org/10.3390/ijms26010285 - 31 Dec 2024
Viewed by 815
Abstract
High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare germi-nal centre lymphoma characterised by a typical gain/loss pattern on chromo-some 11q but without MYC translocation. It shares some features with Burkitt lymphoma (BL), HGBCLs and germinal centre-derived diffuse large B-cell lym-phoma, not [...] Read more.
High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare germi-nal centre lymphoma characterised by a typical gain/loss pattern on chromo-some 11q but without MYC translocation. It shares some features with Burkitt lymphoma (BL), HGBCLs and germinal centre-derived diffuse large B-cell lym-phoma, not otherwise specified (GCB-DLBCL-NOS). Since microRNA expression in HGBCL-11q remains unknown, we aimed to identify and compare the mi-croRNA expression profiles in HGBCL-11q, BL and in GCB-DLBCL-NOS. Next-generation sequencing (NGS)-based microRNA profiling of HGBCL-11q (n = 6), BL (n = 8), and GCB-DLBCL-NOS without (n = 3) and with MYC rearrange-ment (MYC-R) (n = 7) was performed. We identified sets of 39, 64, and 49 mi-croRNAs differentiating HGBCL-11q from BL, and from GCB-DLBCL-NOS without MYC-R, respectively. The expression levels of miR-223-3p, miR-193b-3p, miR-29b-3p, and miR-146a-5p consistently differentiated HGBCL-11q from both BL, GCB-DLBCL-NOS without MYC-R. In addition, HGBCL-11q presented greater heterogeneity in microRNA expression than BL. The expression profile of MYC-regulated microRNAs differed in HGBCL-11q and in BL, while also clearly distinguishing HGBCL-11q and BL from GCB-DLBCL-NOS. The microRNA pro-file of HGBCL-11q differs from those of BL and GCB-DLBCL-NOS, exhibiting greater heterogeneity compared to BL. The microRNA profile further supports that HGBCL-11q is a distinct subtype of B-cell lymphoma. Full article
(This article belongs to the Special Issue Molecular Pathology and Novel Therapies for Lymphoma)
Show Figures

Figure 1

Back to TopTop