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Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1336

Special Issue Editor


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Guest Editor
Department of Internal Medicine I and Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany
Interests: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; bone marrow; hematopoiesis; emergency myelopoiesis; endothelial cells; megakaryocytes

Special Issue Information

Dear Colleagues,

Peter Libby once told me how he got side-eyed by his peers for calling atherosclerosis an inflammatory disease as an aspiring junior researcher. At that time, the interdisciplinary approach to decipher the intricate interplay between cardiovascular tissue, inflammation and immunity - known as Cardioimmunology today - was seen as a niche area investigating a “byproduct” of blood vessel occlusion, genetic predisposition, and lifestyle factors.

A few decades later, the interaction between the immune system and cardiovascular organs has unequivocally been recognized as a driving force behind the development and progression of cardiovascular disease. By revealing the contribution of inflammation and immune cells to disease initiation and progression, Cardioimmunology has reshaped our current understanding of myocardial infarction, myocarditis, atherosclerosis, heart failure, arterial hypertension, and - most recently - cardiac arrhythmia. Further insights into the molecular and cellular mechanisms of both innate and adaptive immune cell involvement offer promising avenues for novel diagnostics and targeted therapies aimed at refined prevention and improved treatment for patients suffering from cardiovascular disease.

This Special Issue seeks to capture cutting-edge research and provide expert reviews on cardioimmune interactions. We invite submissions of original research articles and comprehensive reviews that focus on a deeper understanding of how inflammation and immunity contribute to the pathogenesis, diagnosis, and treatment of cardiovascular disease.

Dr. David Rohde
Guest Editor

Manuscript Submission Information

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Keywords

  • myocardial infarction
  • heart failure
  • atherosclerosis
  • arterial hypertension
  • myocarditis
  • arrhythmia
  • inflammation
  • hematopoiesis
  • myelopoiesis
  • tissue macrophages
  • neutrophil biology
  • lymphocytes
  • endothelial cells
  • megakaryocytes
  • platelet biology
  • biomarkers

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Published Papers (1 paper)

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Research

13 pages, 1204 KiB  
Article
Acute Immune Cell Dynamics During Myocardial Infarction and Their Association with Mortality
by Harris Avgousti, Reina Nagasaka, Adovich S. Rivera, Anna Pawlowski, Edward B. Thorp and Matthew J. Feinstein
Int. J. Mol. Sci. 2025, 26(13), 6543; https://doi.org/10.3390/ijms26136543 - 7 Jul 2025
Viewed by 564
Abstract
Acute neutrophil responses following myocardial infarction (MI) play a central role in remodeling, contributing to both repair and potential maladaptive responses. Although prior studies have investigated circulating immune cell indices at a single time point during hospitalization for MI, limited data exist on [...] Read more.
Acute neutrophil responses following myocardial infarction (MI) play a central role in remodeling, contributing to both repair and potential maladaptive responses. Although prior studies have investigated circulating immune cell indices at a single time point during hospitalization for MI, limited data exist on acute intra-individual changes in circulating immune profiles during evolving MI. We analyzed clinical measurements, such as the count and proportion of immune cell components in a serial complete blood count, with differential tests conducted for patients hospitalized with ST-elevation MI (STEMI) in various hospitals in the Northwestern Medicine system from 1 January 2002 to 1 August 2024. Patients with STEMI diagnosis, troponin peaks ≥ 5 ng/mL, and cell count and proportion data prior to the troponin peak and within 24 h after the troponin peak were included. Primary analyses investigated the associations between the troponin peak and peri-STEMI changes in immune cell subsets. Multivariable-adjusted Cox models were used to investigate associations between these peri-STEMI immune cell changes and mortality at 1 year and 3 years. Among the 694 STEMI patients meeting the inclusion criteria, a higher troponin peak was associated with a modest peri-MI increase in neutrophil proportion. Higher adjusted peri-STEMI increases in neutrophil count and proportion were strongly associated with mortality at one and three years [hazard ratio (HR) = 1.31 (95% confidence interval (CI) 1.15–1.49) and HR = 1.27 (95% CI 1.14–1.45) per 1000 cells/μL absolute neutrophil increase, respectively]. Individuals with higher STEMI-related neutrophil increases had higher mortality at one year and three years, independent of the extent of troponin elevation. Full article
(This article belongs to the Special Issue Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease)
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