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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insight into Oral Diseases
edited by Lorenzo Azzi
submission deadline 27 Sep 2024 | Viewed by 253 | Submission Open
Keywords: dental caries; periodontal disease; oral cancer; oral potentially malignant disorders; salivary gland disease; oral lichen planus; benign mucous membrane pemphigoid; bullous dermatoses; odontogenic cysts; odontogenic tumors; orofacial pain; human papillomavirus; oral diagnosis; oral pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research of Therapeutic Target Enzymes
edited by Jinkuk Yang and Wonchull Kang
submission deadline 27 Sep 2024 | Viewed by 149 | Submission Open
Keywords: enzyme kinetics; molecular biology; therapeutics; catalysis; drug design; precision medicine; therapeutic applications; biochemical regulation; enzyme evolution
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Human Parturition
edited by
submission deadline 28 Sep 2024 | 2 articles | Viewed by 2015 | Submission Open
Keywords: pregnancy; parturition; birth; uterine contractions; cervix; pharmacological interventions in birthing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Novelties in Chiral Enantioseparation and Discrimination submission deadline 28 Sep 2024 | 2 articles | Viewed by 1683 | Submission Open
Keywords: chiral chromatography; enantiomers; racemates; enantioseparation; chiral stationary phases (CSPs); high-performance liquid chromatography (HPLC); ultra-performance liquid chromatography (UPLC); supercritical fluid chromatography (SFC)
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Insights into Neurodegeneration—Pathways, Diagnosis and Treatment Strategies
edited by
submission deadline 28 Sep 2024 | 1 articles | Viewed by 897 | Submission Open
Keywords: neurodegeneration; protein aggregation; amyloids; proteostasis; diagnosis; treatment; biomarkers; drugs  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Advances in Reproduction Biology
edited by Clara Malo
submission deadline 28 Sep 2024 | 1 articles | Viewed by 741 | Submission Open
Keywords: gamete formation; fertilization; embryo formation; embryo implantation; fertility; infertility; molecular markers; reproductive biology
(This special issue belongs to the Section Molecular Biology)
Bone Marrow Concentrate: New Molecular Research
edited by
submission deadline 28 Sep 2024 | Viewed by 184 | Submission Open
Keywords: bone marrow aspirate concentrate; mesechymal stem cell; tissue repair; tissue regeneration; wound healing; anti-inflammatory; immunomodulation; angiogenesis; degenerative disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Healthy Aging
edited by
submission deadline 28 Sep 2024 | Viewed by 159 | Submission Open
Keywords: immunology; inflammation; ageing diseases; healthy ageing; metabolic diseases; molecular mechanisms of ageing; bio-actives; physical activity; regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeting Tumor Angiogenesis: Challenges and Opportunities
edited by
submission deadline 28 Sep 2024 | Viewed by 145 | Submission Open
Keywords: tumor angiogenesis; lymphangiogenesis; transcription factors; growth factors; targeted therapy; gene therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Apoptosis and Autophagy as Strategies in Cancer Treatment
edited by Dorota Ciołczyk-Wierzbicka
submission deadline 29 Sep 2024 | 2 articles | Viewed by 2551 | Submission Open
Keywords: apoptosis; autophagy; cancer therapy/treatment; drug resistance; signaling pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Organic Compounds: Structure, Function and Drug Design
edited by Roberta Ettari
submission deadline 29 Sep 2024 | 1 articles | Viewed by 1756 | Submission Open
Keywords: chemical entities; nutraceuticals; parasite; virus; bacteria; cancer; autoimmune diseases; inflammatory diseases
(This special issue belongs to the Section Macromolecules)
Emerging Treatment of Glioblastoma Multiforme
edited by
submission deadline 29 Sep 2024 | 1 articles | Viewed by 1648 | Submission Open
Keywords: glioblastoma; emerging therapies; drug delivery; immunotherapy; nanomedicine; radiotherapy; viral therapy
(This special issue belongs to the Section Molecular Oncology)
Lymphatic Disorders: From Molecular Mechanisms to Therapies
edited by
submission deadline 29 Sep 2024 | 1 articles | Viewed by 1218 | Submission Open
Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Lipid Signaling Molecules
edited by Roberta Ottria
submission deadline 29 Sep 2024 | 1 articles | Viewed by 1079 | Submission Open
Keywords: endocannabinoid hydrolytic enzyme inhibitors; endocannabinoids; oxylipins; eicosanoids; lipid signaling (fatty acid derivatives); protectins; maresins; and resolvins
(This special issue belongs to the Section Molecular Biology)
Bioactive Polymer-Based Materials Dedicated to Wound Healing submission deadline 29 Sep 2024 | 1 articles | Viewed by 926 | Submission Open
Keywords: wound healing; polymer; bioactive materials; tissue engineering; biomaterials; thin films; scaffolds; hydrogels
(This special issue belongs to the Section Materials Science)
Neurodegenerative Diseases: New Insights into Mechanisms, Prevention, Markers, and Therapeutic Targets submission deadline 29 Sep 2024 | 2 articles | Viewed by 916 | Submission Open
Keywords: Alzheimer’ s disease; Parkinson’ s disease; molecular targets; biomarkers; disease modeling; therapeutic strategies; prevention; drug design
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into Plant–Microbe Interactions
edited by
submission deadline 29 Sep 2024 | Viewed by 269 | Submission Open
Keywords: plant– microbe interaction; plant immunity; metabolism; omics; single-cell sequencing; climate change; synthetic biology; engineered plants and microbes
(This special issue belongs to the Section Molecular Plant Sciences)
New Strategies and Materials for Tooth Whitening and Antibacterials
edited by Shujuan Liu
submission deadline 29 Sep 2024 | Viewed by 147 | Submission Open
Keywords: tooth whitening; antibacterials; biofilm eradication; oral care; caries; periodontitis
(This special issue belongs to the Section Materials Science)
Uterine Fibroids: Molecular Pathogenesis and Therapeutic Strategies submission deadline 29 Sep 2024 | Viewed by 142 | Submission Open
Keywords: uterine fibroids; leiomyoma; pathogenic signaling; molecular diagnosis; histological variants; comorbidity; therapeutic target  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Quantum Chemistry, Vibrational Spectroscopy and Biophysics on Biomolecules submission deadline 29 Sep 2024 | Viewed by 135 | Submission Open
Keywords: molecular simulations; computer calculations; structure predictions; molecular structure; DNA structure; nucleobases pairs; inter-molecular interactions; spectroscopic predictions; scaling; Raman simulations; macromolecular crystallography; molecular modeling; electronic properties
(This special issue belongs to the Section Molecular Biophysics)
Developmental Biology: Computational and Experimental Approaches submission deadline 30 Sep 2024 | 12 articles | Viewed by 19310 | Submission Open
Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations; fertilization; zygote; cell cycle; stem cell; meristem; cell layer; tissue; embryo; multicellular organism; ontogenesis; morphogenesis; life cycle; molecular mechanism; signal transduction; gene regulation; gene-networks; cellular process; differentiation; migration; segmentation; high-resolution 3D-map; real-time in silico simulator; developmental hourglass; transcriptome ontogenetic switch; developmental abnormality; premature aging; neurodegeneration; tumorigenesis; atherogenesis; autoimmunity; induced pluripotent cell; wound healing; regeneration; assisted reproductive technologies; epigenetic reprogramming; predictive preventive personalized participatory (4P) medicine
(This special issue belongs to the Section Molecular Biology)
Role of Silicon and Biochar in Plant Stress Tolerance
edited by and Haijun Gong
submission deadline 30 Sep 2024 | 4 articles | Viewed by 18125 | Submission Open
Keywords: silicon; biochar; silica nanoparticles; disease resistance; salinity; drought; heavy metal stress; plant growth
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research Progress of Skin and Skin Diseases
edited by
submission deadline 30 Sep 2024 | 8 articles | Viewed by 17480 | Submission Open
Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Molecular Basis of Extracellular Vesicles in Health and Diseases
edited by Taral R. Lunavat
submission deadline 30 Sep 2024 | 11 articles | Viewed by 16759 | Submission Open
Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Basis and Advances of Targeted Therapy for Breast Cancer
edited by and Monica Iorfida
submission deadline 30 Sep 2024 | 10 articles | Viewed by 15718 | Submission Open
(This special issue belongs to the Section Molecular Oncology)
Advances in Aging and Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics
edited by
submission deadline 30 Sep 2024 | 8 articles | Viewed by 14702 | Submission Open
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insight into Cell Signalling Proteins submission deadline 30 Sep 2024 | 6 articles | Viewed by 13963 | Submission Open
Keywords: molecular signalling pathways; cell signalling; cellular communication; receptor molecules; cell-surface receptors; transmembrane receptors; internal receptors; ion channel linked receptors; G-protein coupled receptors; enzyme linked receptors; ERK signalling; AKT signalling; STAT signalling; downstream signalling; tyrosine kinase receptors; cytokines; chemokines; growth factors; signal transduction; second messenger; chemical signals/ligands; signal transduction; developmental biology; pathobiology; human disease; molecular tumour pathology; tumour microenvironment; angiogenesis; cancer; neuronal diseases; metabolic diseases; developmental diseases; physiological diseases
(This special issue belongs to the Section Molecular Biology)
Organoid Culture and Characterization Systems for Tissue Engineering Applications submission deadline 30 Sep 2024 | 6 articles | Viewed by 13641 | Submission Open
Keywords: organoid manufacture; organoids isolation; 3D culture; precision medicine; disease modeling; stem cells; hiPSC; decellularized extracellular matrix
(This special issue belongs to the Section Molecular Biology)
Targeting CAR T-cell Therapy: Molecular Research and Its Future Implication
edited by
submission deadline 30 Sep 2024 | 5 articles | Viewed by 13419 | Submission Open
Keywords: CAR T-cell therapy; malignant diseases; molecular pathways; CAR T-related toxicities; resistance mechanisms
(This special issue belongs to the Section Molecular Immunology)
Genetics and Multi-Omics for Crop Breeding submission deadline 30 Sep 2024 | 8 articles | Viewed by 13109 | Submission Open
(This special issue belongs to the Section Molecular Plant Sciences)
Nanoparticles: From Synthesis to Applications 2.0
edited by
submission deadline 30 Sep 2024 | 6 articles | Viewed by 12926 | Submission Open
Keywords: nanotechnology; nanocrystals; colloidal nanoparticles; synthesis of nanoparticles; nanostructures; spectroscopy; surface functionalization; diagnosis; sensors; theranostics; biomedical applications; drug delivery; control release; biocompatibility
(This special issue belongs to the Section Materials Science)
Systemic and Mucosal Inflammation in Colorectal Cancer: Underlying Factors, Significance, and Related Biomarkers
edited by
submission deadline 30 Sep 2024 | 8 articles | Viewed by 12718 | Submission Open
Keywords: molecular changes; colorectal cancer; normal mucosa; apoptotic proteins; inflammatory mechanism; adenoma– carcinoma sequence; cancer biomarkers
(This special issue belongs to the Section Molecular Oncology)
Raman Spectroscopy and Machine Learning in Human Disease
edited by
submission deadline 30 Sep 2024 | 7 articles | Viewed by 11963 | Submission Open
Keywords: Raman spectroscopy; machine learning; disease; molecular diagnostics; optical biopsy; liquid biopsy
(This special issue belongs to the Section Molecular Biophysics)
Research Progress of Biodegradable Materials
edited by , and Odile Francesca Restaino
submission deadline 30 Sep 2024 | 5 articles | Viewed by 11536 | Submission Open
Keywords: biodegradability; controlled biodegradability; bioplastics; renewable resources; environmental pollution; environmentally friendly materials
(This special issue belongs to the Section Materials Science)
The Zebrafish Model in Animal and Human Health Research submission deadline 30 Sep 2024 | 8 articles | Viewed by 11250 | Submission Open
Keywords: zebrafish; environmental toxicology; predictive toxicology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammation in Skin and Joints submission deadline 30 Sep 2024 | 5 articles | Viewed by 10240 | Submission Open
Keywords: inflammatory skin conditions; inflammation in joints; psoriasis; psoriatic arthritis; rheumatoid arthritis; collagen-induced arthritis; dermatitis; barrier function; angiogenesis; keratinocytes; inflammatory cells; immune cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic Variants in Neurological and Psychiatric Diseases submission deadline 30 Sep 2024 | 7 articles | Viewed by 9497 | Submission Open
Keywords: genetic variants; polymorphisms; genetic profile; neurological diseases; psychiatric disorders; therapeutic drug monitoring (TDM)
(This special issue belongs to the Section Molecular Genetics and Genomics)
Hormone Signaling in Cancers and Cancer-Promoting Pathologies
edited by
submission deadline 30 Sep 2024 | 4 articles | Viewed by 9456 | Submission Open
Keywords: estrogen; androgen; thyroxine; thyroid hormones; adrenalin; adrenocorticoids; progesterone; medroxyprogesterone; mifepristone; corticosteroids; glucocorticoids; mineralocorticoids; testosterone; cortisol; prednisolone; hormones; hormone receptors; endocrine-related cancers; hormone therapy; hormone therapy resistance; drug resistance; epigenetics; microRNA
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Systems Metabolic Engineering Strategies
edited by
submission deadline 30 Sep 2024 | 3 articles | Viewed by 9352 | Submission Open
Keywords: systems metabolic engineering; synthetic biology; genome-scale metabolic modeling; microbial cell factory; enzyme engineering; metabolic pathway design
(This special issue belongs to the Section Biochemistry)
Protein Structure Research 2024
edited by and
submission deadline 30 Sep 2024 | 7 articles | Viewed by 9218 | Submission Open
Keywords: fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins
(This special issue belongs to the Section Molecular Biophysics)
Current Research on Cancer Biology and Therapeutics: 2nd Edition submission deadline 30 Sep 2024 | 7 articles | Viewed by 9146 | Submission Open
Keywords: antiangiogenic; anticancer therapy; antimetastatic; apoptosis; antiproliferative; cancer; peptides; signaling molecules; transcription factors; tumor
(This special issue belongs to the Section Molecular Oncology)
Biomolecular Structure, Function and Interactions
edited by
submission deadline 30 Sep 2024 | 8 articles | Viewed by 9100 | Submission Open
Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability
(This special issue belongs to the Section Biochemistry)
Phytochemicals and Nutrients in Cancer Prevention and Treatment: Recent Trends and Advances, 2nd Edition submission deadline 30 Sep 2024 | 4 articles | Viewed by 8983 | Submission Open
Keywords: phytochemicals; polyphenols; cancer; antioxidant; pro-oxidant; DNA damage; dietary supplements; signaling pathways; epigenetic; metabolism; immune system; chemoprevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in New Combination Therapies for Cancer
edited by Valeria Lucarini and
submission deadline 30 Sep 2024 | 5 articles | Viewed by 8751 | Submission Open
Keywords: immunotherapy; target therapy; chemotherapy; tumor microenvironment; combination therapies; preclinical models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
A Commemorative Special Issue in Honor of Prof. Giovanni De Toni: A Pediatrician and Innovator at the Gaslini Children’s Hospital, Genoa, Italy
edited by , Angelo Ravelli and
submission deadline 30 Sep 2024 | 9 articles | Viewed by 8345 | Submission Open
Keywords: bone; soft tissue sarcomas; neuroblastoma
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Molecular Diagnostics of Agriculture Pathogens and Pests
edited by
submission deadline 30 Sep 2024 | 6 articles | Viewed by 8285 | Submission Open
Keywords: plant pathogens; pests; high-throughput molecular detection; molecular diagnostics; plant pathogenic bacteria
(This special issue belongs to the Section Molecular Plant Sciences)
Technology Advance and Application of Cryo-Electron Microscopy in Molecular Biology and Biomedicine
edited by and Jesús Gerardo Galaz-Montoya
submission deadline 30 Sep 2024 | 3 articles | Viewed by 7940 | Submission Open
Keywords: cryo-electron microscopy (cryo-EM)  ; cryo-electron tomography (cryo-ET)  ; cryo-EM sample preparation  ; single-particle analysis  ; sub-tomogram averaging  ; structural determination  ; molecular machines  ; structural dynamics  ; structure-based drug discovery  ; machine learning  ; conformational states  ; conformational landscape  ; conformational continuum  ; time-resolved cryo-EM  ; atomic modeling
(This special issue belongs to the Section Molecular Biophysics)
Glycobiology: The New Discoveries, Approaches, and Technical Developments
edited by Sanja Dabelić
submission deadline 30 Sep 2024 | 8 articles | Viewed by 7907 | Submission Open
Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics
(This special issue belongs to the Section Macromolecules)
Synthesis and Functions of Peptides and Peptidomimetics
edited by
submission deadline 30 Sep 2024 | 4 articles | Viewed by 7783 | Submission Open
Keywords: peptides; peptidomimetics; peptide-based drugs; structure optimization; synthesis
(This special issue belongs to the Section Macromolecules)
Purinergic Signalling in Physiology and Pathophysiology 2.0
edited by
submission deadline 30 Sep 2024 | 5 articles | Viewed by 7341 | Submission Open
Keywords: purinergic signalling; purinome; ATP; ADP; UTP; UDP; UDP-glucose; adenosine; P2X receptors; P2Y receptors; P1 receptors; adenosine receptors; ectoenzymes; nucleotidases; nucleotide release; nucleoside release; nucleotide transport; nucleoside transport
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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