Molecular Mechanisms and Regulation in Blood-Brain Barrier
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 772
Special Issue Editor
Special Issue Information
Dear Colleagues,
The blood brain barrier (BBB) is a highly selective, multi-cellular permeability barrier that protects the brain from blood related substances as well as tightly regulate CNS homeostasis. Tightly organized microvascular endothelial cells are the principal constituent of BBB, supported by astrocytic end feet, pericytes neurons and extra cellular matrix, together referred to as neurovascular unit (NVU). Compromised BBB is prominent in stroke, encephalopathy, AD, and other neurodegenerative diseases. The current special issue of IJMS focuses on “Molecular Mechanisms and Regulation in Blood-Brain Barrier”, exploring the latest advances in understanding the cellular and molecular dynamics of the BBB. We invite articles and reviews investigating the role of tight junctions, NVU cell types and the molecular mechanisms pertaining to BBB, especially in the context of neurodegenerative and neuro-inflammatory diseases. Also, articles relating to emphasis on novel therapeutic strategies aimed at modulating BBB transport for enhanced drug delivery are encouraged. The special issue focuses on comprehensive insights on novel technologies developing BBB models that offer potential areas for clinical application and treating CNS diseases.
Dr. Rajkumar Vutukuri
Guest Editor
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Keywords
- blood brain barrier (BBB)
- tight junctions
- NVU cell types
- neurodegenerative diseases
- neuro-inflammation
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