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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Potential of Induced Pluripotent Stem Cells

edited by Yun Chang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3666 | Submission Open

Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials

(This special issue belongs to the Section Stem Cells)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2480 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2294 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Membrane Dynamics and the Role of Aquaporins in Plant Cells

edited by

Farzana Sabir

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1787 | Submission Open

Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1609 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Unconventional T Cells in Health and Disease

edited by Lauren Howson

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1488 | Submission Open

Keywords: MR1-restricted T cells; γ δ T cells; CD1-restricted T cells; unconventional T cells

(This special issue belongs to the Section Cellular Immunology)

Signal Transduction and Targeted Therapy for Tumors

edited by

Rodolfo Daniel Cervantes-Villagrana

submission deadline 28 Feb 2026 | Viewed by 635 | Submission Open

Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy

(This special issue belongs to the Section Cell Signaling)

Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis

edited by

Mona Batish

submission deadline 28 Feb 2026 | Viewed by 353 | Submission Open

Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 28 Feb 2026 | Viewed by 275 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

Novel Insights into Neuroinflammation and Related Diseases

edited by Tahmineh Mokhtari

submission deadline 28 Feb 2026 | Viewed by 226 | Submission Open

Keywords: neuroinflammation; neuropsychological disorders; neurodegeneration; neuro-immune interactions; glial-neuronal crosstalk; autophagy and apoptosis; cellular and molecular mechanisms; neuroinflammatory biomarkers; imaging techniques; novel therapeutic strategies

(This special issue belongs to the Section Cells of the Nervous System)

Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies

edited by

Asad Jan

and Sara Elfarrash

submission deadline 28 Feb 2026 | Viewed by 179 | Submission Open

Keywords: Parkinson’ s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics

(This special issue belongs to the Section Cellular Aging)

Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology

edited by

Jinu Kim

submission deadline 28 Feb 2026 | Viewed by 163 | Submission Open

Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms

(This special issue belongs to the Section Tissues and Organs)

Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms

edited by Tirthadipa Pradhan-Sundd

submission deadline 28 Feb 2026 | Viewed by 161 | Submission Open

Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells

Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition

edited by

Qiwei Yang

submission deadline 28 Feb 2026 | Viewed by 146 | Submission Open

Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome

(This special issue belongs to the Section Cellular Pathology)

Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses

edited by

Edit Tóth-Molnár

submission deadline 28 Feb 2026 | Viewed by 95 | Submission Open

Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies

Lung Development: Challenges and Opportunities

edited by David Warburton

submission deadline 28 Feb 2026 | Viewed by 93 | Submission Open

Keywords: alveolar gas diffusion surface; alveolar development; injury; repair; and replacement; alveolar stresses and strains; lung microenvironment; tissue engineering in pulmonary regeneration

(This special issue belongs to the Section Tissues and Organs)

Recent Advances in Microfluidics and Organoids for Biomedical Applications

edited by Lionel Fernel Gamarra

submission deadline 28 Feb 2026 | Viewed by 79 | Submission Open

Keywords: microfluidics; organoids; biomimetic models; organ-on-a-chip; tissue engineering; pharmacology; biosensors; computational modeling; artificial intelligence; nanomedicine; personalized medicine; bioprinting; in silico; induced pluripotent stem cells (iPSCs); mesenchymal and pluripotent stem cells

(This special issue belongs to the Section Tissues and Organs)

The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition

edited by

Paola Palumbo

and Silvano J. Santini

submission deadline 28 Feb 2026 | Viewed by 66 | Submission Open

Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment

Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies

edited by

Bogdan Pavel

and

Mingui Fu

submission deadline 28 Feb 2026 | Viewed by 59 | Submission Open

Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics

(This special issue belongs to the Section Cellular Pathology)

The Lipid Metabolism and Signaling in Dry Eye Disease

edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak

submission deadline 28 Feb 2026 | Viewed by 57 | Submission Open

Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms

The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes

edited by Mayur Doke, Juan Domínguez-Bendala and Oscar Alcazar

submission deadline 28 Feb 2026 | Viewed by 55 | Submission Open

Keywords: pancreatic beta-cells; GLP-1; obesity; type 2 diabetes; islet biology; beta-cell regeneration; insulin resistance; incretin therapies; single-cell transcriptomics; metabolic stress

Molecular Insights into Inherited Metabolic Disorders

edited by Paul Gissen

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: metabolic disorders; enzyme defects; protein misfolding; metabolic pathways; cellular metabolism; molecular pathology; disease mechanisms; therapeutic targets; organelle dysfunction; metabolic networks

(This special issue belongs to the Section Cellular Metabolism)

Cellular Mechanisms in Oral Cavity Homeostasis and Disease

edited by

Mohamed Mekhemar

submission deadline 28 Feb 2026 | Viewed by 52 | Submission Open

Keywords: oral cavity; cell signaling; periodontal disease; stem cells; regeneration; inflammation; oral epithelium; tissue homeostasis; immunomodulation; cellular microenvironment

Exploring New Treatments: Innovative Strategies Based on the Mechanism and Pathogenesis of Neurodevelopmental Disorders

edited by

Muhammad Nauman Arshad

and

Bruce Carter

submission deadline 28 Feb 2026 | Viewed by 39 | Submission Open

Keywords: rett syndrome; fragile X; GABA; seizures; cognition; Cdkl5 deficiency disorder; motor deficits; developmental delay

The Role of Cell Signaling Pathway Starvation Therapy for Cancer

edited by

Niramol Savaraj

and Min You

submission deadline 28 Feb 2026 | Viewed by 19 | Submission Open

Keywords: signaling pathways; nutrient deprivation; starvation therapy; metabolic reprogramming; metabolic pathways

(This special issue belongs to the Section Cell Signaling)

Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer

edited by

Madalina Anca Moldovan

and

Ciprian Tomuleasa

submission deadline 1 Mar 2026 | Viewed by 152 | Submission Open

Keywords: tumor microenvironment; epithelial– mesenchymal transition (EMT); tumor– stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology

Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms

edited by Isabel Martinez-Pena y Valenzuela

submission deadline 9 Mar 2026 | Viewed by 34 | Submission Open

Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells

Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects

edited by

Markus Mandl

submission deadline 10 Mar 2026 | 1 articles | Viewed by 715 | Submission Open

Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics

Omics Technologies for Understanding Cell Pathophysiology

edited by

Ciro Isidoro

Annalisa Chiocchetti

and

Alessandra Ferraresi

submission deadline 10 Mar 2026 | Viewed by 324 | Submission Open

Keywords: epigenomics; cytomics; immunomics; exosomics; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Targeting Tumor Suppressor Genes for Cancer Therapy

edited by Jogendra Pawar, Smita Kumari and Naseem Akhter

submission deadline 10 Mar 2026 | Viewed by 246 | Submission Open

Keywords: tumor suppressor genes; cancer therapy; gene editing; CRISPR-Cas9; DNA damage repair; oncogenic signaling; immunotherapy; tumor microenvironment; artificial intelligence; personalized medicine

Endothelial Dysfunction in Vascular Diseases

edited by Antonio Nesci

submission deadline 10 Mar 2026 | Viewed by 32 | Submission Open

Keywords: endothelial dysfunction; vascular diseases; atherosclerosis; oxidative stress; nitric oxide; hypertension; vascular inflammation; endothelial repair

α-Synuclein in Parkinson’s Disease

edited by

Maria Ilenia De Bartolo

and

Matteo Costanzo

submission deadline 10 Mar 2026 | Viewed by 28 | Submission Open

Keywords: α -synuclein; protein aggregation; neurodegeneration; Parkinson’ s disease; clinical subtypes; biomarkers; detection techniques; disease heterogeneity; prognostic stratification; translational neuroscience

Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis III

edited by

Ralf Weiskirchen

submission deadline 15 Mar 2026 | 7 articles | Viewed by 22057 | Submission Open

(This special issue belongs to the Section Tissues and Organs)

Oral Tissue Stem Cells in Regenerative Dentistry

edited by

Jelena Milasin

and

Miloš M. Lazarević

submission deadline 15 Mar 2026 | 6 articles | Viewed by 15667 | Submission Open

Keywords: oral tissue stem cells; oral tissue regeneration; dental materials; stem cell-derived exosomes; stem cell engineering

(This special issue belongs to the Section Stem Cells)

Nanofluidics, Nanopores, and Nanomaterials for Understanding Biology

edited by

Malgorzata A. Witek

submission deadline 15 Mar 2026 | 2 articles | Viewed by 3290 | Submission Open

Keywords: nanofluidics; nanopores; nanomaterials; biology; biochemistry; bioengineering; biotechnology; drug delivery; sequencing; reaction kinetics; single-molecule detection

(This special issue belongs to the Section Cell Methods)

Glioblastoma Cells: From Cellular and Molecular Mechanisms to Innovative Therapy—2nd Edition

edited by

Antonella Arcella

submission deadline 15 Mar 2026 | Viewed by 319 | Submission Open

Keywords: glioma; glioblastoma; glioma stem cells (GSCs); MGMT methylation; EGFR signaling; apoptosis; autophagy; molecular-targeted therapy; personalized medicine; radiotherapy; glioma cell biology; prognostic biomarkers; in vitro glioma models; in vivo glioblastoma studies

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Mar 2026 | Viewed by 249 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Retinal Pigment Epithelium Dysfunction in Retinal Disorders: Pathophysiology and Therapeutic Strategies

edited by

Deepthi Rajendran Nair

and Sushma Kalmodia

submission deadline 15 Mar 2026 | Viewed by 77 | Submission Open

Keywords: retinal pigment epithelium (RPE); inherited retinal disease; RPE dysfunction

(This special issue belongs to the Section Tissues and Organs)

Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies

edited by Thomas Kapapa,

Hayrettin Tumani

and Andreas Pfnür

submission deadline 15 Mar 2026 | Viewed by 59 | Submission Open

Keywords: traumatic brain injury; stroke; blood– brain barrier; neuroinflammation; neuroimmunology

(This special issue belongs to the Section Tissues and Organs)

Host–Pathogen Interactions and Immune Responses

edited by Harish Chandra

submission deadline 15 Mar 2026 | Viewed by 42 | Submission Open

Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling

(This special issue belongs to the Section Cellular Immunology)

Targeting Metabolic Vulnerabilities to Selectively Eliminate Cancer Cells

edited by Nina Semenova and

Juan Sebastián Yakisich

submission deadline 15 Mar 2026 | Viewed by 27 | Submission Open

Keywords: cancer cell metabolism; cancer cell signaling pathways; cancer epigenetic regulation; nutrient deprivation; tumor microenvironment; chemotherapy; chemoresistance; radiotherapy; cell death

Primary and Continued Cell Cultures

edited by

Xuefeng Liu

submission deadline 20 Mar 2026 | 5 articles | Viewed by 39985 | Submission Open

Keywords: primary normal cells; primary tumor cells; patient-derived cells; CRC (conditionally reprogrammed cells); organoids; circulating tumor cells; human diseases; toxicity; cancer models; drug discovery

(This special issue belongs to the Section Cell Methods)

Organoids as an Experimental Tool

edited by

Ralf Weiskirchen

Leo A. Van Grunsven

and Anjali A. J. Roeth

submission deadline 20 Mar 2026 | 10 articles | Viewed by 24051 | Submission Open

Keywords: organoid culture models; primary cell and cancer spheroid models; organotypic models; organoid research for animal replacement (3R); chip-based methods; general 3D cell culture protocols; in silico approaches; microinjection apical-out organoids; organoid manipulation techniques; organoid intelligence; organoids in diagnostics; imaging in organoids

(This special issue belongs to the Section Tissues and Organs)

New Advances and Perspectives in Nanotechnology for the Treatment of Cancer Cells

edited by

Karuppusamy Shanmugapriya

submission deadline 20 Mar 2026 | 8 articles | Viewed by 19177 | Submission Open

Keywords: nanotechnology; immunotherapeutics; cancer biotherapeutics; proliferation; regulating factors; cell culture; biomedical application; nutraceuticals; cancer treatment

(This special issue belongs to the Section Cell Methods)

Highlights in Red Blood Cell Research

edited by

Anna Bogdanova

and

Lars Kaestner

submission deadline 20 Mar 2026 | 3 articles | Viewed by 18363 | Submission Open

Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling

Insight into Cardiomyopathy

edited by Sobuj Mia

submission deadline 20 Mar 2026 | 1 articles | Viewed by 16269 | Submission Open

Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics

edited by

Uta Flucke

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5785 | Submission Open

Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics

(This special issue belongs to the Section Cell Microenvironment)

Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases

edited by Xinrui Gui and Jinjun Wu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1224 | Submission Open

Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases

(This special issue belongs to the Section Cellular Biophysics)

Targeting Cellular Microenvironment in Aging and Disease

edited by

Alexander Dityatev

and Egor Dzyubenko

submission deadline 20 Mar 2026 | 1 articles | Viewed by 951 | Submission Open

Keywords: proteoglycans; glycans; glycoproteins; matricellular proteins; integrins; matrix metalloproteinases; extracellular vesicles; EV release; exosomes; extracellular scaffold; ECM remodeling; fibrosis; ECM gene therapy; ECM pharmacology; synthetic ECM

(This special issue belongs to the Section Cellular Aging)

Cell and Molecular Mechanisms of Cytogenesis

edited by

Luisa Alexandra Meireles Pinto

and

Teresa Correia Soares Canedo Calado

submission deadline 20 Mar 2026 | Viewed by 41 | Submission Open

Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders

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