Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring New Treatments: Innovative Strategies Based on the Mechanism and Pathogenesis of Neurodevelopmental Disorders submission deadline 30 Sep 2026 | Viewed by 281 | Submission Open
Keywords: rett syndrome; fragile X; GABA; seizures; cognition; Cdkl5 deficiency disorder; motor deficits; developmental delay
Sickle Cell Disease: Pathogenesis and Therapies
edited by and Geoffrey Cheminet
submission deadline 30 Sep 2026 | Viewed by 279 | Submission Open
Keywords: sickle cell disease; erythrocyte sickling; chronic inflammation; endothelial dysfunction; hematopoietic stem cell transplantation
(This special issue belongs to the Section Cellular Pathology)
Paradigm-Challenging Research and Out-of-the-Box (OB) Hypotheses submission deadline 30 Sep 2026 | Viewed by 262 | Submission Open
Noncoding RNAs: Immunity, Mechanisms, and Biomarker Potential
edited by
submission deadline 30 Sep 2026 | Viewed by 250 | Submission Open
Keywords: noncoding RNAs (ncRNAs); MicroRNAs (miRNAs); long noncoding RNAs (lncRNAs); circular RNAs (circRNAs); immune regulation; tumor microenvironment; immune checkpoints; cancer immunotherapy; liquid biopsy biomarkers; immune evasion
Oral Disease: Cellular Mechanisms and Emerging Therapeutic Strategies
edited by and Marziyeh Aghazadeh
submission deadline 30 Sep 2026 | Viewed by 248 | Submission Open
Keywords: oral diseases; amelogenesis; dentinogenesis; periodontitis; dental fluorosis; oral manifestations of systemic diseases; oral squamous cell carcinoma; leukoplakia; erythroplakia
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms and Biomarker Development in Prostate Cancer
edited by Vikas Mehta and Behtash Ghazi Nezami
submission deadline 30 Sep 2026 | Viewed by 245 | Submission Open
Keywords: androgen receptor; prostate molecular alterations; biomarkers
State of the Art in Tumor Immunotherapy: From Cell Biology to Therapeutic Perspectives submission deadline 30 Sep 2026 | Viewed by 239 | Submission Open
Keywords: T-cell exhaustion; immune checkpoint blockade (PD-1/PD-L1); CAR-T cell engineering; tumor microenvironment (TME); antigen presentation machinery; TCR signaling; myeloid-derived suppressor cells (MDSCs); cancer immunoediting; immunogenic cell death; adoptive cell transfer
(This special issue belongs to the Section Cellular Immunology)
mRNA Regulation in Endoplasmic Reticulum Stress and Protein Homeostasis submission deadline 30 Sep 2026 | Viewed by 225 | Submission Open
Keywords: mRNA; secondary structures of mRNA; upstream open reading frames (uORFs); biomarkers; endoplasmic reticulum stress; unfolded protein response; protein homeostasis
(This special issue belongs to the Section Cell and Gene Therapy)
Immune Cell Signaling Networks: Receptors, Second Messengers and Gene Programs
edited by
submission deadline 30 Sep 2026 | Viewed by 220 | Submission Open
Keywords: immune signaling; receptor signaling; cytokine receptors; immune cells; infectious disease
(This special issue belongs to the Section Cell Signaling)
Advances in Cardiometabolic Pathophysiology and Treatment
edited by and
submission deadline 30 Sep 2026 | Viewed by 217 | Submission Open
Keywords: insulin resistance; immunometabolism; low-grade chronic inflammation; cardiovascular diseases; obesity; type 2 diabetes mellitus; adipose/adipocyte dysfunction; dyslipidemia; atherosclerosis; metabolic-associated steatotic liver disease
(This special issue belongs to the Section Cellular Metabolism)
Aging, Oxidative Stress, and Inflammation in Ocular Diseases
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 179 | Submission Open
Keywords: aging; oxidative stress; inflammation; ocular diseases
Organelle-Driven Oncogenic Programs: Regulation, Cross-Talk and Targetable Vulnerabilities
edited by Tejinder Pal Khaket
submission deadline 30 Sep 2026 | Viewed by 178 | Submission Open
Keywords: organelle cross-talk; mitochondrial signaling; ER stress and unfolded protein response (UPR); lysosomal function and autophagy; metabolic reprogramming; redox homeostasis and oxidative stress; organelle stress responses; multi-omics and spatial biology; therapeutic vulnerabilities in cancer; organelle-targeted therapies
(This special issue belongs to the Section Cellular Pathology)
Applications of Organ-on-a-Chip Model in Vascular Disease
edited by Abidemi Junaid and Netanel Korin
submission deadline 30 Sep 2026 | Viewed by 162 | Submission Open
Keywords: organ‑on‑a‑chip; microfluidics; vascular disease; endothelial dysfunction; hemodynamics and shear stress; thrombosis and inflammation; drug screening; precision medicine
(This special issue belongs to the Section Cells of the Cardiovascular System)
Pathogenesis and Therapies of Chronic Obstructive Lung Diseases
edited by
submission deadline 30 Sep 2026 | Viewed by 149 | Submission Open
Keywords: chronic obstructive pulmonary disease; COPD; asthma; airway inflammation; lung remodeling; oxidative stress; animal models; epithelial dysfunction; therapeutic targeting
(This special issue belongs to the Section Cellular Pathology)
Molecular and Cellular Advances in Understanding Early Embryo Development—3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 138 | Submission Open
Keywords: metabolism; biomembrane transport; genetics; epigenetic modifications; transgenerational inheritance; signaling; ART; in vitro culture; trophectoderm; inner cell mass
(This special issue belongs to the Section Reproductive Cells and Development)
AMPK Signaling Networks in Cellular Energy Metabolism
edited by William Smiles
submission deadline 30 Sep 2026 | Viewed by 130 | Submission Open
Keywords: metabolism; phosphorylation; cancer; type 2 diabetes; signaling; exercise; skeletal muscle; mTOR
(This special issue belongs to the Section Cell Signaling)
Cellular and Molecular Mechanisms of Obstructive Sleep Apnea
edited by Jivan Lamichhane, Abhishek Thakur and
submission deadline 30 Sep 2026 | Viewed by 123 | Submission Open
Keywords: sleep; sleep apnea; obstructive sleep apnea (OSA); intermittent hypoxia (IH); cellular mechanisms; molecular mechanisms; STOP-Bang; actigraphy; polysomnography; CPAP; BiPAP; obesity; snoring; hypopnea; apnea– hypopnea index
(This special issue belongs to the Section Cellular Pathology)
How the DNA Damage Response Modifies Transcription Regulators
edited by Norbert Lehming
submission deadline 30 Sep 2026 | Viewed by 122 | Submission Open
Keywords: DNA damage; chromatin; gene expression; conditional mRNA degradation; DNA repair; cancer; apoptosis
Neuron–Glia Synergy and Dysfunction in Parkinson’s Disease
edited by
submission deadline 30 Sep 2026 | Viewed by 118 | Submission Open
Keywords: Parkinson’ s disease; neuron– glia interactions; neuroinflammation; glial cells dysfunction
(This special issue belongs to the Section Cellular Neuroscience)
DNA Damage in Neurodegeneration
edited by and Sofia Francia
submission deadline 30 Sep 2026 | Viewed by 115 | Submission Open
Keywords: DNA damage; neurodegeneration; DNA repair; oxidative stress; genomic instability; neuronal cell death; aging; animal models; cellular senescence
(This special issue belongs to the Section Cellular Neuroscience)
Immunological Study of Islet Transplantation
edited by Wanxing Cui
submission deadline 30 Sep 2026 | Viewed by 115 | Submission Open
Keywords: islet transplantation; transplant immunology; immune rejection; immune tolerance; regulatory T cells; autoimmunity; islet encapsulation; islet preservation; cGMP cell processing; type 1 diabetes
(This special issue belongs to the Section Cellular Immunology)
Advances in Aging-Related Hyperphosphatemia submission deadline 30 Sep 2026 | Viewed by 111 | Submission Open
Keywords: hyperphosphatemia; age-related diseases; cellular senescence; biomarkers; sarcopenia; endothelial dysfunction
(This special issue belongs to the Section Cellular Aging)
Allergen-Specific Immune Cell Responses
edited by and Maria G. Byazrova
submission deadline 30 Sep 2026 | Viewed by 108 | Submission Open
Keywords: allergen; allergic sensitization; allergen-specific IgE; B cells; T cells
(This special issue belongs to the Section Cellular Immunology)
Advance in Glycation End-Products in Aging and Metabolic Diseases
edited by Aleksandra Twarda-Clapa
submission deadline 30 Sep 2026 | Viewed by 103 | Submission Open
Keywords: advanced glycation end-products; AGEs; AGE receptors; scavenger receptors; signalling pathways; AGE-related diseases; inflammation; aging; metabolic diseases; anti-AGE therapies
(This special issue belongs to the Section Cellular Aging)
Heart Development: Mechanisms, Disorders, and Translational Perspectives
edited by , Wenhui Wei and
submission deadline 30 Sep 2026 | Viewed by 99 | Submission Open
Keywords: heart development; cardiac morphogenesis; gene regulatory networks
(This special issue belongs to the Section Reproductive Cells and Development)
Mitochondrial Dynamics and Quality Control in Neuromuscular Health and Disease
edited by Kai Zou
submission deadline 30 Sep 2026 | Viewed by 97 | Submission Open
Keywords: mitochondrial dynamics; mitophagy; neuromuscular disorders; axonal transport; metabolic dysfunction; neurodegeneration; skeletal muscle homeostasis; mitochondrial biogenesis; organelle crosstalk.
(This special issue belongs to the Section Mitochondria)
Cellular and Molecular Mechanisms of Aquaporins in Plants
edited by
submission deadline 30 Sep 2026 | Viewed by 95 | Submission Open
Keywords: aquaporins; plant cells; transport regulation
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Repeat Expansion Diseases: From Molecular Mechanisms to Emerging Therapies submission deadline 30 Sep 2026 | Viewed by 94 | Submission Open
Keywords: repeat expansion disease; short tandem repeats; pathogenic mechanisms; long-read sequencing; therapeutic strategies
(This special issue belongs to the Section Cellular Pathology)
Role of Reverse Transcriptase in Aging and Age-Related Disease
edited by
submission deadline 30 Sep 2026 | Viewed by 92 | Submission Open
Keywords: aging; age-related disease; reverse transcriptase; NRTI; anti-aging; DNA damage
(This special issue belongs to the Section Cellular Aging)
The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition
edited by and Silvano J. Santini
submission deadline 1 Oct 2026 | 2 articles | Viewed by 2877 | Submission Open
Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment
The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine
edited by
submission deadline 1 Oct 2026 | 2 articles | Viewed by 2418 | Submission Open
Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering
Emerging Strategies in Osteosarcoma: Cell Biology, Biomarkers, and Immunotherapy
edited by
submission deadline 1 Oct 2026 | 1 articles | Viewed by 459 | Submission Open
Keywords: osteosarcoma; biomarkers; immunotherapy; metastasis; resistance
(This special issue belongs to the Section Cellular Pathology)
Advances in Matrix Metalloproteinase Research for Cancer Detection and Therapy
edited by Neha Atale, Vibha Rani and
submission deadline 1 Oct 2026 | Viewed by 238 | Submission Open
Keywords: cancer; chemotherapy; EMT (epithelial to mesenchymal transition); matrix metalloproteinase; metastasis; metalloproteinase inhibitors; natural MMP inhibitors; tumor microenvironment
Human Brain Development: Insights from Experimental and Stem Cell-Based Models
edited by Nicole Amberg
submission deadline 1 Oct 2026 | Viewed by 114 | Submission Open
Keywords: progenitor cells; neurons; glia; regional identity; neurodevelopmental disorders; cerebral organoids; iPSCs
(This special issue belongs to the Section Cellular Neuroscience)
Mitochondria: Multifaceted Regulators of Cell Death
edited by Rasa Banienė and Sonata Trumbeckaite
submission deadline 10 Oct 2026 | Viewed by 362 | Submission Open
Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer
New Advances in Proteomics for Understanding Health and Disease
edited by
submission deadline 10 Oct 2026 | Viewed by 227 | Submission Open
Keywords: mass spectrometry; single-cell proteomics; plasma proteomics; systems biology; cancer biology; health and disease; precision medicine; protein networks; clinical proteomics; multi-omics integration
(This special issue belongs to the Section Cell Methods)
Latest Advances in Molecular and Cellular Mechanisms of Alzheimer's Disease in Canada submission deadline 10 Oct 2026 | Viewed by 183 | Submission Open
Keywords: Alzheimer's disease; neurodegeneration; amyloid-beta; protein aggregation; chaperone proteins; neuroinflammation; cerebrovascular system; CD2AP; blood– brain barrier; cholinergic neurons; neuronal regeneration; gut– brain axis; GSK3; BACE1; CD33 isoforms; translational neuroscience
(This special issue belongs to the Section Cellular Neuroscience)
Integrating Advanced Cellular Models in Radiation Biology: From Electromagnetic Fields to Photons and Emerging Particle Modalities
edited by and
submission deadline 10 Oct 2026 | Viewed by 175 | Submission Open
Keywords: ionizing radiation; particle radiation; electromagnetic; radiation biology; cell cultures; preclinical models
(This special issue belongs to the Section Cellular Biophysics)
The Effects of Stress on Cells and Organisms submission deadline 10 Oct 2026 | Viewed by 128 | Submission Open
Keywords: stress; biological stress; stress response; TEs activity following stress; heat-shock proteins; epigenetic control of the stress; stress granules; alteration of metabolism following stress; stress adaptation; stress-related diseases
Advances in Zebrafish Disease Models submission deadline 15 Oct 2026 | 4 articles | Viewed by 10680 | Submission Open
Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders
Molecular and Cellular Insights into Platelet Function, 2nd Edition submission deadline 15 Oct 2026 | 5 articles | Viewed by 5720 | Submission Open
Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity
T Cells in Inflammation and Cancer
edited by
submission deadline 15 Oct 2026 | 2 articles | Viewed by 5590 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Cellular Mechanisms in Pregnancy and Foetal Development submission deadline 15 Oct 2026 | 3 articles | Viewed by 4806 | Submission Open
Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth
Gut Dysbiosis in Inflammatory Diseases
edited by Weiwei Liu
submission deadline 15 Oct 2026 | 2 articles | Viewed by 3708 | Submission Open
Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation
(This special issue belongs to the Section Cellular Pathology)
The Artificial Intelligence to the Rescue of Cancer Research submission deadline 15 Oct 2026 | 1 articles | Viewed by 2575 | Submission Open
Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine
(This special issue belongs to the Section Cell Methods)
Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies submission deadline 15 Oct 2026 | 1 articles | Viewed by 2364 | Submission Open
Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing
Cellular and Molecular Studies of the Adrenal Gland
edited by Wen-Jun Shen, and Salman Azhar
submission deadline 15 Oct 2026 | Viewed by 301 | Submission Open
Keywords: adrenal zonation; steroid hormones; steroidogenesis; congenital adrenal hyperplasia; hyperaldosteronism; Cushing’ s syndrome
Molecular and Cellular Mechanisms of Inherited Retinal Dystrophies
edited by Rosellina Guarascio, and
submission deadline 15 Oct 2026 | Viewed by 101 | Submission Open
Keywords: retinal degeneration; photoreceptors; RPE; phototransduction; connecting cilium; retinoid cycle; protein folding; inflammation; oxidative stress; light damage
(This special issue belongs to the Section Cellular Pathology)
Regenerative Medicine for Bone and Dental Tissues: Biology and Applications submission deadline 15 Oct 2026 | Viewed by 68 | Submission Open
Keywords: bone regeneration; dental tissue regeneration; stem and progenitor cells; biomaterials and bioactive scaffolds; translational regenerative strategies
(This special issue belongs to the Section Tissues and Organs)
Age-Related Macular Degeneration (AMD): From Cellular and Molecular Mechanisms to Therapies
edited by
submission deadline 15 Oct 2026 | Viewed by 59 | Submission Open
Keywords: age‑related macular degeneration; cellular mechanism; molecular mechanism; gene therapies; neuroprotective strategies
(This special issue belongs to the Section Cellular Aging)
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