Pathogenesis and Therapies of Chronic Obstructive Lung Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 138
Special Issue Editor
Interests: chronic obstructive pulmonary disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic obstructive lung diseases, encompassing conditions such as chronic obstructive pulmonary disease (COPD) and asthma, represent a growing global health burden driven by complex interactions between environmental exposures and genetic susceptibility. Hence, there is a requirement to characterize the fundamental cellular and molecular mechanisms underlying airway inflammation, tissue remodeling, and progressive loss of lung function to deliver better insight into disease pathogenesis. This necessitates the use of relevant cellular and animal models that recapitulate the key pathological features of chronic airway obstruction and parenchymal destruction in vivo. The potential of novel therapeutic strategies targeting these core mechanisms to modify disease progression in preclinical models remains to be determined.
This Special Issue will examine the identification of key inflammatory and structural cell populations driving disease pathology; methods to isolate and maintain primary airway and alveolar cells ex vivo; the effects of cigarette smoke, pollutants, and allergens on epithelial and immune cell function; co-culture and organoid models recapitulating airway remodeling and epithelial barrier dysfunction; in vitro systems for studying mucociliary clearance and innate immune responses; bioengineered lung tissue models for drug testing; and in vivo models to investigate the efficacy of targeted interventions in halting or reversing disease progression.
Dr. Neeraj Vij
Guest Editor
Manuscript Submission Information
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Keywords
- chronic obstructive pulmonary disease
- COPD
- asthma
- airway inflammation
- lung remodeling
- oxidative stress
- animal models
- epithelial dysfunction
- therapeutic targeting
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