State of the Art in Tumor Immunotherapy: From Cell Biology to Therapeutic Perspectives
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 272
Editor
2. Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA
Interests: cancer immunology; molecular therapeutics; translational medicine; functional genomics; small molecule inhibitors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, tumor immunotherapy has transitioned from bench to bedside, yielding unprecedented remissions in multiple cancers. Breakthroughs in immune checkpoint blockade, CAR-T engineering and bispecific antibodies have reshaped the therapeutic landscape, yet durable responses remain limited by T-cell exhaustion, antigen escape and immunosuppressive microenvironments. Decoding these roadblocks now demands deeper insight into the cell–cell crosstalk, signal transduction cascades and epigenetic circuits that govern antitumor immunity.
This Special Issue aims to bridge fundamental research and clinical application by highlighting cutting-edge studies that decipher the cellular signaling pathways, immune cell behaviors, and molecular networks shaping antitumor immunity. We seek to highlight the molecular pathways and cellular interactions that are being targeted to develop the next generation of immunotherapies.
We invite investigators worldwide to submit high-quality manuscripts that illuminate these mechanisms. Both comprehensive review articles and original research articles are welcome.
Dr. Cristabelle De Souza
Guest Editor
Manuscript Submission Information
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Keywords
- T-cell exhaustion
- immune checkpoint blockade (PD-1/PD-L1)
- CAR-T cell engineering
- tumor microenvironment (TME)
- antigen presentation machinery
- TCR signaling
- myeloid-derived suppressor cells (MDSCs)
- cancer immunoediting
- immunogenic cell death
- adoptive cell transfer
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