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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders

edited by

Shabnam Nohesara

submission deadline 31 Dec 2025 | 1 articles | Viewed by 505 | Submission Open

Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites

(This special issue belongs to the Section Cells of the Nervous System)

Epigenetic Mechanisms and Aging

edited by

Nicholas Tolwinski

submission deadline 31 Dec 2025 | Viewed by 374 | Submission Open

Keywords: drosophila melanogaster; model organism; cell biology; developmental biology; genetics; molecular biology; cell signaling; cellular differentiation; cell proliferation; cell cycle; cellular morphogenesis; cell-cell communication; stem cells; cell migration; apoptosis; cytoskeleton; cell adhesion; cellular metabolism; functional genomics; CRISPR/Cas9 in drosophila; omics technologies; disease models; drug discovery; regeneration; genetic screens; cellular stress responses

(This special issue belongs to the Section Cellular Aging)

Cellular and Molecular Mechanisms of Heart Diseases

edited by

Sumita Mishra

submission deadline 31 Dec 2025 | Viewed by 233 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies

(This special issue belongs to the Section Cellular Pathology)

Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer

edited by

Jessica Petiti

and Marika Fava

submission deadline 31 Dec 2025 | Viewed by 212 | Submission Open

Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 31 Dec 2025 | Viewed by 202 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Rho Family Small GTPases in Health and Diseases

edited by

Katalin Szászi

submission deadline 31 Dec 2025 | Viewed by 153 | Submission Open

Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors

(This special issue belongs to the Section Cell Signaling)

How Does Gene Regulation Affect Cancer Development?

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Dec 2025 | Viewed by 147 | Submission Open

Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs

(This special issue belongs to the Section Cell Microenvironment)

Integrated Approaches Between Metabolomics and Cellular Aging

edited by Maria Nikolaou and

Nikolaos Theodorakis

submission deadline 31 Dec 2025 | Viewed by 143 | Submission Open

Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism

(This special issue belongs to the Section Cellular Aging)

Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies

edited by Ana Rita Carlos

submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open

Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies

Genetic Mechanisms in Cellular Genomics and Therapeutics

edited by Elaine T. Lim and Yingleong Chan

submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open

Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases

Mechanisms of Immune Responses and Therapy

edited by

Zhuang Wang

and

Bernhard Ryffel

submission deadline 31 Dec 2025 | Viewed by 97 | Submission Open

Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

The Role of T Cells and Cellular Signalling in Immune Diseases

edited by Daniela Gallo

submission deadline 31 Dec 2025 | Viewed by 84 | Submission Open

Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies

(This special issue belongs to the Section Cellular Immunology)

Immunology and Immune Therapies for Cancer

edited by

Mei Yu

submission deadline 31 Dec 2025 | Viewed by 77 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; CAR-T cells; immune checkpoint inhibitors; immune surveillance; cancer vaccines; immuno-oncology

(This special issue belongs to the Section Cell Microenvironment)

Kinin System in Health and Disease: Cellular and Molecular Perspectives

edited by Marcos Gregnani and Leonardo Martins

submission deadline 31 Dec 2025 | Viewed by 68 | Submission Open

Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways

(This special issue belongs to the Section Cellular Pathology)

Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures

edited by

Ivo Bozovic

and

Bogdan Bjelica

submission deadline 31 Dec 2025 | Viewed by 67 | Submission Open

Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures

(This special issue belongs to the Section Tissues and Organs)

Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities

edited by

Vesna Ceriman Krstic

and Dragana Jovanovic

submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open

Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Traumatic Injury and Resolution

edited by

Upendra K. Kar

and Hamed Moheimani

submission deadline 31 Dec 2025 | Viewed by 50 | Submission Open

Keywords: traumatic injury-associated immunometabolism; trauma-induced coagulopathy; endothelial dysfunction; cell death pathways; extracellular vesicles; single-cell and spatial omics; multi-omics; damage-associated molecular patterns; biomarker discovery; precision therapeutics

(This special issue belongs to the Section Cellular Pathology)

Inflammation and Aging in Acute and Chronic Kidney Injury

edited by

Massimiliano Migliori

Vincenzo Cantaluppi

and

Marita Marengo

submission deadline 31 Dec 2025 | Viewed by 48 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; inflammation; aging

(This special issue belongs to the Section Cellular Aging)

The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis

edited by

Sanjit Mukherjee

submission deadline 31 Dec 2025 | Viewed by 35 | Submission Open

Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis

(This special issue belongs to the Section Cellular Pathology)

Colorectal Cancer: Molecular Mechanisms and Treatment Progress

edited by

Maurizio Capuozzo

submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open

Keywords: colorectal cancer (CRC); tumor microenvironment; genetic and epigenetic alterations; immune evasion; targeted therapy and personalized medicine

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles in Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk, and Translational Opportunities

edited by

Mangesh Hade

submission deadline 31 Dec 2025 | Viewed by 25 | Submission Open

Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Genomics and Cellular Mechanisms in Ovarian Cancer

edited by Hao Huang

submission deadline 31 Dec 2025 | Viewed by 22 | Submission Open

Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Tissues and Organs)

Hematopoietic Cell Lines as Models for Leukemia and Lymphoma

edited by Stefan Nagel

submission deadline 31 Dec 2025 | Viewed by 21 | Submission Open

Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes

Molecular and Genetic Pathogenesis of Hematological Disorders

edited by

Hong Chang

submission deadline 10 Jan 2026 | 1 articles | Viewed by 1706 | Submission Open

Keywords: hematological disorders; molecular and genetic mechanisms; signal transduction pathways; microenvironment; gene editing technologies; targeted therapies; novel biomarkers; mechanisms of treatment resistance; innovative therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

New Insights into Therapeutic Targets for Cardiovascular Diseases

edited by

Tamer Elbayoumi

and

Molly (Mingyi) Yao

submission deadline 15 Jan 2026 | 3 articles | Viewed by 6887 | Submission Open

Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy

(This special issue belongs to the Section Cells of the Cardiovascular System)

Recent Progress on Fibrosis and Cardiac Dysfunction

edited by

Tabito Kino

and

Tomoaki Ishigami

submission deadline 15 Jan 2026 | Viewed by 337 | Submission Open

Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Targeting Breast Cancer: Mechanisms of Resistance and Innovative Therapeutic Strategies

edited by Stefania Belli,

Daniela Esposito

and

Roberto Bianco

submission deadline 15 Jan 2026 | Viewed by 68 | Submission Open

Keywords: breast cancer; targeted therapies; novel therapeutic targets; mechanisms of drug resistance; innovative therapeutic strategies; targeting tumor microenvironment; immunotherapy in breast cancer

(This special issue belongs to the Section Cell Microenvironment)

Organ Regeneration: Cells, Organoids and Organs

edited by Jia Huang

submission deadline 15 Jan 2026 | Viewed by 39 | Submission Open

Keywords: organ regeneration; stem cells; organoids; tissue engineering; 3D bioprinting; regenerative medicine; interspecies chimera; blastocyst complementation; vascularization; immune compatibility

(This special issue belongs to the Section Tissues and Organs)

New Insights into Gene Research and Therapy for Diabetes Mellitus

edited by

Ann Simpson

and

Najah Therese Nassif

submission deadline 15 Jan 2026 | Viewed by 26 | Submission Open

Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors

Oral Stem Cells in Regenerative Biology

edited by

Oriana Trubiani

submission deadline 15 Jan 2026 | Viewed by 16 | Submission Open

Keywords: stem cells; differentiation; regenerative medicine; angiogenesis; inflammation; secretome; oral tissue induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Mechanisms of Lung Growth and Regeneration

edited by

Saverio Bellusci

and

Yuanlin Song

submission deadline 15 Jan 2026 | Viewed by 9 | Submission Open

Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq

(This special issue belongs to the Section Cell Microenvironment)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1038 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Role of Cell Organelles in Normal Aging, Senescence, and Cancer

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 20 Jan 2026 | Viewed by 416 | Submission Open

Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8

(This special issue belongs to the Section Cellular Aging)

Study on Human Mesenchymal Stem Cells—2nd Edition

edited by

Michela Noseda

submission deadline 20 Jan 2026 | Viewed by 253 | Submission Open

Keywords: mesenchymal stem cells; disease; cardiac; therapy

(This special issue belongs to the Section Stem Cells)

Dental Pulp Stem Cells in Tissue Repair and Regeneration

edited by

Sarah Peters

Kyle Vining

, Cristiane Franc and Jacques Nör

submission deadline 20 Jan 2026 | Viewed by 47 | Submission Open

Keywords: dental pulp stem cells; regenerative endodontics; regenerative medicine; dental pulp; reparative dentinogenesis

(This special issue belongs to the Section Tissues and Organs)

The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead

edited by

Rai Ajit K. Srivastava

submission deadline 20 Jan 2026 | Viewed by 28 | Submission Open

Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO

Cellular Origin of Glioma: From Triggers to Treatments

edited by Katherine Karakoula

submission deadline 20 Jan 2026 | Viewed by 23 | Submission Open

Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells

Intestinal Stem Cells

edited by

Natalia Soshnikova

and

Arunkumar Jagadeesan

submission deadline 20 Jan 2026 | Viewed by 20 | Submission Open

Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt

(This special issue belongs to the Section Stem Cells)

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 20 Jan 2026 | Viewed by 19 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting

edited by

Mehdi Sanati

submission deadline 20 Jan 2026 | Submission Open

Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | 2 articles | Viewed by 3930 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies

edited by

Qiwei Wang

submission deadline 25 Jan 2026 | Viewed by 37 | Submission Open

Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies

(This special issue belongs to the Section Cellular Immunology)

Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms

edited by Masmoudi-Kouki Olfa and

Gérard Lizard

submission deadline 25 Jan 2026 | Viewed by 37 | Submission Open

Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling

(This special issue belongs to the Section Stem Cells)

Plant Stress and Acclimation Responses During Global Warming

edited by

Stanisław Karpiński

submission deadline 25 Jan 2026 | Viewed by 26 | Submission Open

Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread

edited by Erica Pranzini

submission deadline 25 Jan 2026 | Viewed by 21 | Submission Open

Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism

The Developments and Applications of Vibrational Spectroscopy in Cellular Research

edited by

Maria Lasalvia

submission deadline 25 Jan 2026 | Viewed by 17 | Submission Open

Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging

(This special issue belongs to the Section Cell Methods)

Targeting Immune Dysfunction in Aging and Age-Related Diseases

edited by

Anna Aiello

and

Anna Calabrò

submission deadline 25 Jan 2026 | Viewed by 13 | Submission Open

Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions

Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches

edited by

Luigi Racioppi

submission deadline 25 Jan 2026 | Viewed by 1 | Submission Open

Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics

(This special issue belongs to the Section Stem Cells)

Mechanisms Underlying Cardiovascular Aging

edited by Soheil Saeedi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 1590 | Submission Open

Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Tumor Immune Responsiveness in the Era of T Cell Immunotherapy

edited by

Xin Li

and

Wenjian Wang

submission deadline 30 Jan 2026 | Viewed by 34 | Submission Open

Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation

Displaying special issue 401-450 on page 9 of 11.

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