Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Examining the Cellular Biology of Adenovirus
edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard
submission deadline 31 Jan 2026 | Viewed by 49 | Submission Open
Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome
Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation submission deadline 31 Jan 2026 | Viewed by 46 | Submission Open
Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics
(This special issue belongs to the Section Stem Cells)
Aquaporins at the Crossroads of Human Health and Disease
edited by
submission deadline 31 Jan 2026 | Viewed by 46 | Submission Open
Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics
New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response
edited by
submission deadline 31 Jan 2026 | Viewed by 43 | Submission Open
Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors
Role of Oxidative Stress in Cardiovascular Diseases submission deadline 31 Jan 2026 | Viewed by 23 | Submission Open
Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances in the Role of Lipid Signaling in Diseases
edited by and
submission deadline 5 Feb 2026 | Viewed by 60 | Submission Open
Keywords: lipid signaling; membrane lipid dynamics; autophagy; disease pathology; mitochondria; transcription; protein degradation
Role of Alpha-Synuclein in Neurodegenerative Diseases
edited by
submission deadline 10 Feb 2026 | Viewed by 115 | Submission Open
Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases
(This special issue belongs to the Section Cellular Aging)
Decoding Cellular Organization Through Spatial Omics
edited by Elizabeth Neumann
submission deadline 10 Feb 2026 | Viewed by 47 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Exclusive Review Papers in Autophagy—Second Edition
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 13396 | Submission Open
Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades
(This special issue belongs to the Section Autophagy)
Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 11245 | Submission Open
Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 5921 | Submission Open
Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Molecular Therapeutic Advances for Neurodegenerative Diseases
edited by
submission deadline 15 Feb 2026 | 3 articles | Viewed by 3850 | Submission Open
Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders
(This special issue belongs to the Section Cellular Aging)
Spotlight on Natural Killer Cells in Immuno-Oncology submission deadline 15 Feb 2026 | 1 articles | Viewed by 2668 | Submission Open
Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells
(This special issue belongs to the Section Cellular Immunology)
Cancers and Metabolic Diseases—the Molecular Players in the Game
edited by
submission deadline 15 Feb 2026 | Viewed by 47 | Submission Open
Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics
Cellular Mechanisms and Therapies of Hematologic Malignancies
edited by Sayantani Sinha and Stanley Chun-Wei Lee
submission deadline 15 Feb 2026 | Viewed by 46 | Submission Open
Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance
(This special issue belongs to the Section Cellular Pathology)
GPCR Signaling in PDA: Calcium, cAMP, and Ras Activation in Pancreatic Ductal Adenocarcinoma
edited by
submission deadline 15 Feb 2026 | Viewed by 34 | Submission Open
Keywords: G protein-coupled receptor (GPCR); receptor tyrosine kinases (RTK); oncogenic Kras; pancreatic ductal adenocarcinoma (PDA); epigenetic regulation; Wnt and Hedgehog (HH); second messengers (cAMP and intracellular calcium); acinar to ductal metaplasia (ADM); tumor microenvironment; therapeutic drugs list of solicited contributors
Placenta in Tissue Engineering and Regeneration
edited by
submission deadline 15 Feb 2026 | Viewed by 7 | Submission Open
Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration
Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease
edited by , , Michy P. Kelly and Leila Gobejishvili
submission deadline 20 Feb 2026 | 15 articles | Viewed by 31686 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications
edited by and Elisabetta Zucchi
submission deadline 20 Feb 2026 | 3 articles | Viewed by 6572 | Submission Open
Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth
edited by Khondoker M. Akram
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4013 | Submission Open
Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth
(This special issue belongs to the Section Cellular Pathology)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2844 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
T Cells in Inflammation and Cancer
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1659 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
The Cell Biology of Heart Disease
edited by Rajeshwary Ghosh and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1272 | Submission Open
Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Role of Gene Regulation in Neurological Disorders
edited by and Yulin Jin
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1123 | Submission Open
Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)
(This special issue belongs to the Section Cell and Gene Therapy)
Molecular Mechanisms of Leukemias
edited by and Frode Selheim
submission deadline 20 Feb 2026 | Viewed by 135 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)
(This special issue belongs to the Section Cellular Pathology)
Advances in Molecular Research on Cancer Drug Targets and Drug Resistance submission deadline 20 Feb 2026 | Viewed by 65 | Submission Open
Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers
Elucidating Roles of Cell Adhesion Molecules in Health and Disease
edited by Vladimir Sytnyk
submission deadline 20 Feb 2026 | Viewed by 47 | Submission Open
Keywords: cell adhesion molecules (CAMs); immunoglobulin superfamily CAMs(IgSF-CAMs); integrins; cadherins; selectins; proteoglycans
Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications submission deadline 20 Feb 2026 | Viewed by 44 | Submission Open
Keywords: autophagy; pathology; physiology; therapy; methods
(This special issue belongs to the Section Autophagy)
Advances in T Cell Targeting for Cancer Immunotherapy
edited by Ryma Toumi
submission deadline 20 Feb 2026 | Viewed by 32 | Submission Open
Keywords: immunotherapy; immune checkpoint blockade; immunosuppressive microenvironment; exhaustion; armored T cells; adoptive cell therapy
Astrocytes: Roles and Functions in the Brain submission deadline 21 Feb 2026 | Viewed by 30 | Submission Open
Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting
Natural Products and Their Derivatives Against Human Disease
edited by
submission deadline 25 Feb 2026 | 5 articles | Viewed by 8234 | Submission Open
Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Small Molecule Inhibitors: A New Era in Cancer Treatment
edited by , and Suman Asalla
submission deadline 25 Feb 2026 | Viewed by 105 | Submission Open
Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance
Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs submission deadline 25 Feb 2026 | Viewed by 61 | Submission Open
Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds
Molecular and Cellular Mechanisms of Ischemic Stroke
edited by Milani Deb-Chatterji
submission deadline 25 Feb 2026 | Viewed by 58 | Submission Open
Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy
Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment
edited by
submission deadline 25 Feb 2026 | Viewed by 50 | Submission Open
Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease
Remyelination: From Molecular Mechanism to Therapy submission deadline 25 Feb 2026 | Viewed by 39 | Submission Open
Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration
Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives
edited by Peter Van Endert
submission deadline 25 Feb 2026 | Viewed by 38 | Submission Open
Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy
Research on Extracellular Vesicles in Health and Disease submission deadline 25 Feb 2026 | Viewed by 35 | Submission Open
Keywords: extracellular vesicles; molecular mechanism; biomarker discovery; therapeutics; translational medicine; proteins; DNA and RNA
Molecular Mechanisms of Treatment Resistance in Prostate Cancer
edited by
submission deadline 25 Feb 2026 | Viewed by 33 | Submission Open
Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance
New Trends and Advances in Induced Neural Cells and iPSC Technologies
edited by
submission deadline 25 Feb 2026 | Viewed by 10 | Submission Open
Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling
(This special issue belongs to the Section Cells of the Nervous System)
The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease submission deadline 26 Feb 2026 | Viewed by 1 | Submission Open
Keywords: extracellular matrix; matrisome; cell– ECM interactions; cell signaling
(This special issue belongs to the Section Tissues and Organs)
Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders
edited by Mohamed Eldeeb
submission deadline 27 Feb 2026 | 1 articles | Viewed by 1048 | Submission Open
Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration
(This special issue belongs to the Section Mitochondria)
Novel Insights into Mechanism and Treatment of Degenerative Disc Disease
edited by Yejia Zhang
submission deadline 27 Feb 2026 | 1 articles | Viewed by 745 | Submission Open
Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury
(This special issue belongs to the Section Cellular Pathology)
Targeting of Cancer Cells with Small Molecule Drugs
edited by
submission deadline 27 Feb 2026 | Viewed by 42 | Submission Open
Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology
(This special issue belongs to the Section Cellular Pathology)
Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies
edited by Kyle Lauren Poulsen
submission deadline 27 Feb 2026 | Viewed by 20 | Submission Open
Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics
Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets
edited by Saverio Gentile
submission deadline 27 Feb 2026 | Viewed by 19 | Submission Open
Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment
Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation
edited by Hari Krishna Reddy Rachamala and
submission deadline 27 Feb 2026 | Viewed by 12 | Submission Open
Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology
(This special issue belongs to the Section Cell Methods)
Signaling in Cancer Stem Cells
edited by Upasana Ray
submission deadline 28 Feb 2026 | 3 articles | Viewed by 9155 | Submission Open
Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs
(This special issue belongs to the Section Stem Cells)
Role of Extracellular Matrix in Cancer and Disease submission deadline 28 Feb 2026 | 5 articles | Viewed by 5206 | Submission Open
Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling
(This special issue belongs to the Section Cell Microenvironment)
Cellular Pathology: Emerging Discoveries and Perspectives in the USA submission deadline 28 Feb 2026 | 2 articles | Viewed by 4675 | Submission Open
Keywords: cellular pathology; diseases; mechanisms
(This special issue belongs to the Section Cellular Pathology)
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