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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Glial Cells in Aging Neuroscience

edited by

Renato Socodato

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2626 | Submission Open

Keywords: glial cells; aging; neuroinflammation; neurodegeneration; glial– neuronal interactions; glial– glial crosstalk; astrocytes; oligodendrocytes; microglia; ependymal cells

(This special issue belongs to the Section Cellular Aging)

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 25 Nov 2025 | Viewed by 401 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

CAR T Cells in Human Cancers

edited by

Tabish H. Khan

and

Naoshad Muhammad

submission deadline 25 Nov 2025 | Viewed by 41 | Submission Open

Keywords: CAR T cells; engineered immune cell therapies; CAR T cell engineering

Cellular Senescence and Senotherapies in the Aging Retina

edited by

Bhavana Chhunchha

submission deadline 28 Nov 2025 | Viewed by 248 | Submission Open

Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Cellular Aging)

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 28 Nov 2025 | Viewed by 65 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities

edited by

Mohammed S. Razzaque

submission deadline 30 Nov 2025 | 5 articles | Viewed by 12525 | Submission Open

Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities

(This special issue belongs to the Section Tissues and Organs)

Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3556 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

Molecular and Cellular Research on Spinal Cord Injury

edited by

Vinnitsa Buzoianu-Anguiano

and

Jörg Mey

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1676 | Submission Open

Keywords: spinal cord injury; growth inhibitory factors; axonal regeneration; neuroprotection; combined therapies; cell trasnplants; regenerative medicine; inhibition scar formation; extracellular matrix molecules

(This special issue belongs to the Section Cellular Pathology)

Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions

edited by

Nongthombam Boby

and Susanta Pahari

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1005 | Submission Open

Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use

(This special issue belongs to the Section Cellular Immunology)

Updates of Stem Cell Applications in Bone Tissue Engineering

edited by Fahad Karim Kidwai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 555 | Submission Open

Keywords: stem cells; bone tissue engineering; bone diseases; bone repair; bone defect; bone healing; bone regeneration; osteogenic progenitor cells

(This special issue belongs to the Section Stem Cells)

Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression

edited by

Anand Singh

and Sudheer Kumar Gara

submission deadline 30 Nov 2025 | Viewed by 527 | Submission Open

Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling

(This special issue belongs to the Section Cellular Pathology)

Hypoxia Pathway Proteins in the Immune System: Regulation, Disease, and Therapeutics

edited by Ben Wielockx

submission deadline 30 Nov 2025 | Viewed by 294 | Submission Open

Keywords: hypoxia; oxygen sensors; immune system; HIF; disease mechanisms; therapeutics; inflammation; autoimmunity; cancer immunology

(This special issue belongs to the Section Cellular Immunology)

Molecular and Cellular Mechanisms of Brain Development and Neurodevelopmental Disorders

edited by

Mojgan Rastegar

submission deadline 30 Nov 2025 | Viewed by 268 | Submission Open

Keywords: brain development; neural stem cells; neurodevelopmental disorders; brain diseases; cellular and molecular mechanisms; embryonic and adult brain

(This special issue belongs to the Section Cellular Pathology)

CRISPR-Based Genome Editing Approaches in Cancer Therapy

edited by Martin Pal

submission deadline 30 Nov 2025 | Viewed by 193 | Submission Open

Keywords: CRISPR; genome editing; cancer therapy; precision medicine

(This special issue belongs to the Section Cell and Gene Therapy)

Aging and Neurodegeneration: Molecular Insights and Emerging Strategies

edited by

Piotr Paweł Chmielewski

submission deadline 30 Nov 2025 | Viewed by 166 | Submission Open

Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research

(This special issue belongs to the Section Cellular Aging)

Non-Coding RNAs as Regulators of Cellular Function and Disease

edited by

Lucia Natarelli

submission deadline 30 Nov 2025 | Viewed by 74 | Submission Open

Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms

Brain Organoids for Disease Modeling

edited by

Jonghun Kim

submission deadline 30 Nov 2025 | Viewed by 62 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening

(This special issue belongs to the Section Stem Cells)

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Nov 2025 | Viewed by 52 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 30 Nov 2025 | Viewed by 52 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Redox Regulation by Nrf2 in Health and Disease

edited by Pandu Gangula

submission deadline 30 Nov 2025 | Viewed by 46 | Submission Open

Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response

ROS in Atherosclerosis and Cardiometabolic Disorders

edited by

Weibin Shi

submission deadline 30 Nov 2025 | Viewed by 46 | Submission Open

Keywords: reactive oxygen/nitrogen species; oxidative stress; atherosclerosis; cardiovascular; inflammation; endothelial dysfunction; obesity; dyslipidemia

(This special issue belongs to the Section Tissues and Organs)

Molecular Mechanisms of Drug Delivery in Ophthalmology

edited by Alekha K. Dash and Surabhi Shukla

submission deadline 30 Nov 2025 | Viewed by 41 | Submission Open

Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery

(This special issue belongs to the Section Tissues and Organs)

Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke

edited by

William James Antonisamy

Zahoor Shah

and Moorthi Ponnusamy

submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open

Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death

Microautophagy: The Least Known of the Autophagy Strategies

edited by

Patrice X. Petit

submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open

Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs

(This special issue belongs to the Section Autophagy)

Protein and RNA Regulation in Cells

edited by

Delai Huang

and

Denis Mottet

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay

Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine

edited by Renata Kelly Da Palma

submission deadline 30 Nov 2025 | Viewed by 28 | Submission Open

Keywords: cell therapy; lung diseases; tissue regeneration

(This special issue belongs to the Section Tissues and Organs)

The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention

edited by Vivek Kumar Kashyap and Himanshu Narayan Singh

submission deadline 30 Nov 2025 | Viewed by 21 | Submission Open

Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors

Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments

edited by Konrad Talbot

submission deadline 30 Nov 2025 | Viewed by 14 | Submission Open

Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease

(This special issue belongs to the Section Cellular Aging)

Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics

edited by Mangesh Dattu Hade

submission deadline 30 Nov 2025 | Viewed by 5 | Submission Open

Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine

(This special issue belongs to the Section Cellular Aging)

Advances in Pulmonary Fibrosis

edited by Sergio Piñeiro Hermida

submission deadline 1 Dec 2025 | Viewed by 125 | Submission Open

Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics

(This special issue belongs to the Section Cellular Pathology)

New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis

edited by

Francesc Mitjans

submission deadline 10 Dec 2025 | 2 articles | Viewed by 2877 | Submission Open

Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody

(This special issue belongs to the Section Cell Microenvironment)

Therapeutic Mechanism of Nervous System Inflammation—Second Edition

edited by

Maria Anttonietta Panaro

and

Antonia Cianciulli

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1050 | Submission Open

Keywords: neuroinflammation; neurodegeneration; therapy; drug target; cell signaling; cells of nervous system

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Dec 2025 | Viewed by 338 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Stem Cells)

Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma

edited by

Swapan K. Ray

submission deadline 15 Dec 2025 | 21 articles | Viewed by 58302 | Submission Open

Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities

(This special issue belongs to the Section Cells of the Nervous System)

Focus on Machinery of Cell Death

edited by

Subhadip Mukhopadhyay

, Prashanta Kumar Panda and

Suprabhat Mukherjee

submission deadline 15 Dec 2025 | 6 articles | Viewed by 12758 | Submission Open

Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy

(This special issue belongs to the Section Cellular Pathology)

Mitochondria and Metabolism in Cancer Stem Cells (CSCs)

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2106 | Submission Open

Keywords: cancer stem cells; circulating tumor cells; drug resistance; metabolism; mitochondria; OXPHSOS; mitochondrial DNA (mtDNA); glycolysis; cell cycle; DNA damage; other metabolic processes; oxidative stress; senescence; therapeutic approaches

(This special issue belongs to the Section Stem Cells)

Cell Therapies in Cancer Treatment

edited by

Giovanni Amabile

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1305 | Submission Open

Keywords: cellular therapies; cancer; immune

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 15 Dec 2025 | Viewed by 196 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 Dec 2025 | Viewed by 94 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Dec 2025 | Viewed by 58 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Dec 2025 | Viewed by 46 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

Physics of Cancer: Mechanobiology Drives Cancer Progression

edited by Claudia Tanja Mierke

submission deadline 15 Dec 2025 | Viewed by 44 | Submission Open

Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer

The Symphony of Nature—the Precision of Life’s Regulation

edited by Weiguang Wang and Baocheng Liu

submission deadline 15 Dec 2025 | Viewed by 39 | Submission Open

Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding

(This special issue belongs to the Section Cell Methods)

Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms—Second Edition

edited by

Zhuo Wang

submission deadline 15 Dec 2025 | Viewed by 24 | Submission Open

Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition

(This special issue belongs to the Section Tissues and Organs)

The Role of the Extracellular Vesicles in Kidney Disease

edited by

Amankeldi Salybekov

and Ciro Tetta

submission deadline 15 Dec 2025 | Viewed by 19 | Submission Open

Keywords: extracellular vesicles (EVs); microRNAs (miRs); chronic kidney disease (CKD); acute kidney injury (AKI); regenerative medicine; biomarkers; artificial intelligence (AI); nephrology; urology; precision medicine

(This special issue belongs to the Section Cell Microenvironment)

Molecular Mechanisms of Cognitive Function and Dysfunction

edited by

Parasuraman Padmanabhan

Balázs Gulyás

and

Domokos Máthé

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1989 | Submission Open

Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy

(This special issue belongs to the Section Cells of the Nervous System)

State-of-the-Art Insights into the Cell Microenvironment

edited by

Said M. Afify

submission deadline 20 Dec 2025 | Viewed by 63 | Submission Open

Keywords: cell microenvironment; stem cells; organoid and 3D culture models

Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids

edited by

Joanna Romanek

and Sylwia Orczewska-Dudek

submission deadline 20 Dec 2025 | Viewed by 32 | Submission Open

Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress

Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease

edited by

Alexander E. Berezin

submission deadline 25 Dec 2025 | 1 articles | Viewed by 1279 | Submission Open

Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management

(This special issue belongs to the Section Tissues and Organs)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Dec 2025 | Viewed by 464 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

Displaying special issue 401-450 on page 9 of 11.

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