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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of Transposons in Regulating the Neural Genome and the Mechanisms of Neuropsychiatric Diseases

edited by Fabio M. Macciardi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1200 | Submission Open

Keywords: transposable elements; genome evolution; central nervous system development; neural genome; neural gene regulation; neuropsychiatric disorders

(This special issue belongs to the Section Cellular Neuroscience)

Cancer-Associated Fibroblasts: Challenges and Directions—Second Edition

edited by

Paul J. Higgins

and

Ramesh Mukkamala

submission deadline 20 Sep 2026 | 1 articles | Viewed by 434 | Submission Open

Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms of miRNA Metabolism and Extracellular Transport

edited by

Suvendra N Bhattacharyya

submission deadline 20 Sep 2026 | Viewed by 355 | Submission Open

Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers

New Insights in Translational Pain Research

edited by

Huan Cui

submission deadline 20 Sep 2026 | Viewed by 175 | Submission Open

Keywords: translational pain research; chronic pain; neuroinflammation; pain mechanisms; therapeutic targets

The Role of Glial Cells in Neurodegenerative Disorders

edited by Osama Al Dalahmah and Sebastian Quintremil

submission deadline 20 Sep 2026 | Viewed by 145 | Submission Open

Keywords: astrocytes; oligodendrocytes; microglia; neuropathology

(This special issue belongs to the Section Cellular Neuroscience)

Advances in DNA Damage Responses in Viral Infection

edited by Roger J. Grand

submission deadline 20 Sep 2026 | Viewed by 134 | Submission Open

Keywords: DNA damage response; DNA viruses; RNA viruses; viral replication; DNA repair pathways

(This special issue belongs to the Section Cellular Pathology)

The Silent Regulators: Non-Coding RNAs in Cell Function and Disease

edited by

Christiane Branlant

and

Mirolyuba Simeonova Ilieva

submission deadline 25 Sep 2026 | 5 articles | Viewed by 7231 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics

(This special issue belongs to the Section Cell and Gene Therapy)

Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance

edited by

Tijana Subotički

Olivera Mitrović Ajtić

and

Vladan P. Čokić

submission deadline 25 Sep 2026 | 1 articles | Viewed by 944 | Submission Open

Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration

edited by

Zhaoyu Li

submission deadline 25 Sep 2026 | 1 articles | Viewed by 713 | Submission Open

Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control

Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities

edited by

Giovannino Silvestri

, Aditi Chatterjee and Maria Baer

submission deadline 25 Sep 2026 | Viewed by 634 | Submission Open

Keywords: AML; leukemic stem cells; hypoxia; metabolism; fatty-acid oxidation; one-carbon metabolism; proteostasis; bone-marrow niche; multi-omics; metabolic inhibitors

Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches

edited by

Neeraj Soni

submission deadline 25 Sep 2026 | Viewed by 319 | Submission Open

Keywords: chronic pain; synaptic plasticity; circuit dysfunction

(This special issue belongs to the Section Cellular Pathology)

New Molecular Perspectives in Pelvic Floor and Genitourinary Disorders

edited by Mahadevan Rajasekaran

submission deadline 25 Sep 2026 | Viewed by 171 | Submission Open

Keywords: pelvic floor disorders; genitourinary diseases; molecular mechanisms; biomarkers; biomaterials; regenerative medicine; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Natural Products and Their Derivatives Against Human Disease—2nd Edition

edited by

Mamunur Rashid

submission deadline 25 Sep 2026 | Viewed by 117 | Submission Open

Keywords: microbiome-mediated modulation; biomarker; therapeutic strategies; drug delivery

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Targeting Metabolic Vulnerabilities to Selectively Eliminate Cancer Cells

edited by Nina Semenova and

Juan Sebastián Yakisich

submission deadline 29 Sep 2026 | Viewed by 327 | Submission Open

Keywords: cancer cell metabolism; cancer cell signaling pathways; cancer epigenetic regulation; nutrient deprivation; tumor microenvironment; chemotherapy; chemoresistance; radiotherapy; cell death

Role of Extracellular Matrix in Cancer and Disease

edited by

Maurizio Onisto

Marco Franchi

and

Valentina Masola

submission deadline 30 Sep 2026 | 7 articles | Viewed by 23213 | Submission Open

Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms of Immune Responses and Therapy

edited by

Zhuang Wang

and

Bernhard Ryffel

submission deadline 30 Sep 2026 | 3 articles | Viewed by 11776 | Submission Open

Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Antioxidants in Redox Homeostasis of Plant Development

edited by

Dragana Z. Jakovljević

and

Milan Stankovic

submission deadline 30 Sep 2026 | 3 articles | Viewed by 9792 | Submission Open

Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

The Potential of Induced Pluripotent Stem Cells

edited by Yun Chang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 9011 | Submission Open

Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials

(This special issue belongs to the Section Stem Cells)

Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy

edited by

Xin Lu

submission deadline 30 Sep 2026 | 2 articles | Viewed by 8848 | Submission Open

Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies

(This special issue belongs to the Section Cell Microenvironment)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5858 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

The Cell Biology of Heart Disease

edited by Rajeshwary Ghosh and

Samreen Sadaf

submission deadline 30 Sep 2026 | 6 articles | Viewed by 5359 | Submission Open

Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Novel Insights into Cancer Immune Responsiveness

edited by

Luigi Racioppi

and

Tanmoy Mondal

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5282 | Submission Open

Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines

Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition

edited by

Qiwei Yang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5170 | Submission Open

Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome

(This special issue belongs to the Section Cellular Pathology)

Cell Therapeutics for Corneal Diseases

edited by

Dimitrios Karamichos

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4827 | Submission Open

Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair

(This special issue belongs to the Section Tissues and Organs)

Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis

edited by

Mona Batish

submission deadline 30 Sep 2026 | 5 articles | Viewed by 4697 | Submission Open

Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration

edited by

Guoping Fan

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4552 | Submission Open

Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling

(This special issue belongs to the Section Cellular Neuroscience)

The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention

edited by Vivek Kumar Kashyap and Himanshu Narayan Singh

submission deadline 30 Sep 2026 | 1 articles | Viewed by 4377 | Submission Open

Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors

(This special issue belongs to the Section Cellular Pathology)

The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies

edited by

Chiara Di Berardino

and

Yves St.-Pierre

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4269 | Submission Open

Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline

(This special issue belongs to the Section Reproductive Cells and Development)

Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies

edited by

Asad Jan

and Sara Elfarrash

submission deadline 30 Sep 2026 | 1 articles | Viewed by 4083 | Submission Open

Keywords: Parkinson’ s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics

(This special issue belongs to the Section Cellular Aging)

Pediatric Liver Tumors: Molecular Mechanisms and Therapeutic Strategies

edited by

Edward V. Prochownik

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2568 | Submission Open

Keywords: hepatoblastoma; hepatocellular carcinoma; pediatric liver tumors; fibrolamellar carcinoma; Beck-with-Wiedmann syndrome; hereditary tyrosinemia; molecular mechanisms; therapeutic strategies

Stress Signaling and Cell Fate Determination: The Role of Mitochondria

edited by

Daniel Maddison

and

Bilal Malik

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2374 | Submission Open

Keywords: mitochondria; cell death; integrated stress response; retrograde signaling; apoptosis; necroptosis; ferroptosis; mitophagy; mitochondrial dynamics; ROS; calcium signaling; inter-organelle communication

Cellular and Molecular Insights into Gynecologic Tumors

edited by

Mladen Anđić

and

Jianjun Wei

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2191 | Submission Open

Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies

Brain Organoids for Disease Modeling

edited by

Jonghun Kim

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2012 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening

(This special issue belongs to the Section Stem Cells)

Molecular and Cellular Drivers of Parkinson's Disease

edited by

Fatema Currim

and

Jason Cannon

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1958 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death

(This special issue belongs to the Section Cellular Neuroscience)

Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration

edited by Mukund Srinivasan

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1804 | Submission Open

Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress

The Role of Light in Ocular Health and Disease

edited by Krisztina Valter,

María Ana Contín

and

Monica Acosta

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1722 | Submission Open

Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics

Role of Endothelial Progenitor Cells in Vascular Dysfunction

edited by

Catherine Yzydorczyk

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1101 | Submission Open

Keywords: cardiovascular diseases; endothelial progenitor cells; vasculogenesis; angiogenesis; inflammation; oxidative stress; cellular senescence; developmental programming; cellular therapy

Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders

edited by

Walid Shaalan

, Benedikt Schaefgen and

Nourhan Hassan

submission deadline 30 Sep 2026 | Viewed by 578 | Submission Open

Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling

(This special issue belongs to the Section Stem Cells)

Cell Signaling of Cancer Therapy

edited by

Anna Boguszewska-Czubara

and Anna Wawruszak

submission deadline 30 Sep 2026 | 1 articles | Viewed by 571 | Submission Open

Keywords: cell signaling; cancer therapy; signal transduction; targeted therapy; gene therapy; RNA-based therapeutics; drug resistance; tumor microenvironment; precision oncology

(This special issue belongs to the Section Cell Signaling)

Novel Insights into Endothelial Cells in Vascular Disease

edited by

LI Zhang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 544 | Submission Open

Keywords: endothelial cells; vascular diseases; vascular signaling

Neural Governance of Gastrointestinal Motility

edited by Jiande Chen

submission deadline 30 Sep 2026 | Viewed by 451 | Submission Open

Keywords: enteric nervous system; gastrointestinal motility; neural circuitry; neurotransmitter signaling; smooth muscle regulation; neuron– epithelial; organoid models; gut-brain axis; neuro-immune interaction; neuromodulation

New Tools to Address Old Challenges in Tolerogenic Cellular Therapies

edited by Konstantinos Mengrelis and

Nina Pilat

submission deadline 30 Sep 2026 | Viewed by 436 | Submission Open

Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation

Interleukin-1 Signaling in Cancer: Novel Mechanisms and Therapeutic Opportunities

edited by Afshan Fathima Nawas and

Jaehong Kim

submission deadline 30 Sep 2026 | Viewed by 387 | Submission Open

Keywords: interleukin-1 signaling; tumor microenvironment; inflammatory pathways; cytokine networks; cancer cell proliferation; epigenetic regulation in cancer; non-coding RNAs; immune modulation; cancer metabolism

Multi-Omics Technologies in Immunity Within Tumors

edited by

Muhammad A. Alsherbiny

and

Anas M. Abdel Rahman

submission deadline 30 Sep 2026 | Viewed by 341 | Submission Open

Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity

Aging, Oxidative Stress, and Inflammation in Ocular Diseases

edited by

Bhavana Chhunchha

submission deadline 30 Sep 2026 | 1 articles | Viewed by 339 | Submission Open

Keywords: aging; oxidative stress; inflammation; ocular diseases

Astrocytes: Roles and Functions in the Brain

edited by

Victor Huang

and

Rita Raisman-Vozari

submission deadline 30 Sep 2026 | Viewed by 305 | Submission Open

Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting

Heat Shock Proteins and Human Cancers—2nd Edition

edited by

Alexander Kabakov

submission deadline 30 Sep 2026 | Viewed by 302 | Submission Open

Keywords: heat shock protein; glucose-regulated protein; cancer; tumorigenesis; theranostics; anticancer vaccine

Ubiquitin Ligases in Health and Diseases

edited by Haitao Luan

submission deadline 30 Sep 2026 | Viewed by 291 | Submission Open

Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting

(This special issue belongs to the Section Cell Signaling)

Exploring New Treatments: Innovative Strategies Based on the Mechanism and Pathogenesis of Neurodevelopmental Disorders

edited by