Latest Advances in Molecular and Cellular Mechanisms of Alzheimer's Disease in Canada
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".
Deadline for manuscript submissions: 10 October 2026 | Viewed by 199
Special Issue Editor
2. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Québec, QC G1E 6W2, Canada
Interests: duchenne muscular dystrophy; friedreich ataxia; alzheimer’s disease; CRISPR; base editing; myoblast transplantation
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Special Issue Information
Dear Colleagues,
Alzheimer's disease (AD) remains one of the most pressing public health challenges of our time, affecting nearly one million Canadians and accounting for over 60% of dementia cases among individuals aged 85 and older. While the clinical manifestations of AD—progressive memory loss, cognitive decline, and behavioral changes—are well recognized, the fundamental molecular and cellular mechanisms driving disease onset and progression continue to be the focus of intensive investigation. Canadian researchers are at the forefront of unraveling these complex mechanisms, making seminal contributions that span protein aggregation dynamics, vascular contributions to neurodegeneration, neuroimmune interactions, and innovative therapeutic targeting.
The Canadian research landscape in AD is characterized by its remarkable breadth and depth, encompassing fundamental discoveries in protein misfolding and clearance, the intricate relationship between cerebrovascular health and cognitive function, the role of microglial cells in disease modulation, and the emerging understanding of how peripheral systems—such as the gut microbiome—influence brain health. These efforts are supported by national research networks, including the Canadian Consortium on Neurodegeneration in Aging (CCNA) and the Canadian Institutes of Health Research (CIHR), which foster collaboration across institutions and disciplines.
Prof. Dr. Jacques P. Tremblay
Guest Editor
Manuscript Submission Information
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Keywords
- Alzheimer's disease
- neurodegeneration
- amyloid-beta
- protein aggregation
- chaperone proteins
- neuroinflammation
- cerebrovascular system
- CD2AP
- blood–brain barrier
- cholinergic neurons, neuronal regeneration
- gut–brain axis
- GSK3
- BACE1
- CD33 isoforms
- translational neuroscience
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