Mitochondrial Dynamics and Quality Control in Neuromuscular Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 61
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria are central to cellular energy homeostasis, calcium signaling, and reactive oxygen species management, making their proper function critical in highly metabolic tissues such as skeletal muscle and nervous tissues. The dynamic processes of mitochondrial biogenesis, fusion, fission, transport, and targeted degradation (mitophagy) constitute a vital quality control network essential for maintaining mitochondrial function and neuromuscular health. Emerging evidence indicates that dysregulation of these mechanisms is increasingly implicated in the pathogenesis of a spectrum of neuromuscular disorders, including amyotrophic lateral sclerosis, Charcot–Marie–Tooth disease, muscular dystrophies, and mitochondrial myopathies.
This Special Issue aims to advance our understanding of the roles of mitochondrial dynamics and quality control within the neuromuscular axis and pave the way for innovative interventions in neuromuscular diseases. We welcome original research and review articles that elucidate how disruptions in mitochondrial dynamics and quality control contribute to neurodegeneration and muscle pathology in neuromuscular diseases and explore emerging therapeutic strategies targeting these mitochondrial pathways. Submissions addressing fundamental mitochondrial biology, innovative in vivo and in vitro models, mechanistic molecular and cellular mechanisms, and translational studies are particularly encouraged.
Dr. Kai Zou
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondrial dynamics
- mitophagy
- neuromuscular disorders
- axonal transport
- metabolic dysfunction
- neurodegeneration
- skeletal muscle homeostasis
- mitochondrial biogenesis
- organelle crosstalk.
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