Paradigm-Challenging Research and Out-of-the-Box (OB) Hypotheses
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 September 2026 | Viewed by 71
Special Issue Editors
2. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
Interests: gene expression (mammalian); regulation of protein synthesis under normal and stress conditions; ER-stress response; cell cycle; neurodegeneration (VWM disease)
Special Issues, Collections and Topics in MDPI journals
Interests: Rho GTPases; keratinocytes; mouse disease models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Molecular and Cellular Biology experiences a rapid revolution, inspired by biochemical tools, cell visualization expertise, advanced detection systems, and sophisticated OMICs technologies, which generate massive amounts of experimental information. Sporadically, the obtained data contradict the driving hypothesis; therefore, it is neglected. Occasionally, the DOGMA-challenging data generate an updated, out-of-the-box (OB) hypothesis, which is difficult to fully pursue in the original lab. Moreover, the preference of high-impact journals for complete, evidence-based narratives generates a significant hurdle for paradigm-challenging research. Therefore, high-quality paradoxical information often remains unpublished, resulting in valuable dogma-challenging observations never reaching the scientific community.
This Special Issue aims to address this gap by providing a legitimate publication platform for paradoxical phenomena supported by rigorous experimental DOGMA-challenging observations, accompanied by complementary OB hypotheses.
By creating a resource for "orphan" yet high-quality contradictory findings, we aim to foster scientific synergy and empower OB-innovative discoveries.
Manuscripts related to any aspect of Molecular and Cellular Biology are invited. The abstracts must include (i) a short introduction including the original hypothesis; (ii) experimental methodologies used to pursue it; (iii) how the obtained data contradict the original hypothesis; and (iv) the new OB hypothesis.
Prof. Dr. Orna Elroy-Stein
Prof. Dr. Cord Brakebusch
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
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