Immune Cell Signaling Networks: Receptors, Second Messengers and Gene Programs
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 51
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue in Cells focuses on immune cell signaling networks that connect surface receptors to second messengers and gene programs controlling host defense and regulation. We welcome mechanistic studies on pattern-recognition, cytokine/chemokine, GPCR, and antigen receptor systems; intracellular cascades including JAK–STAT, NF-κB, MAPK, IRF, PI3K–AKT–mTOR, cGAS–STING, Ca2+/cAMP, and transcriptional/epigenetic outputs. Priority topics include signal integration and plasticity, immune synapse dynamics, tolerance and exhaustion, spatiotemporal control of signaling, and cell–cell communication across innate and adaptive compartments. We encourage single-cell and spatial approaches, phospho-proteomics, live-cell imaging/biosensors, CRISPR perturbations, and computational network modeling in contexts such as infection, aging, autoimmunity, vaccination, and tumor immunity. Submissions should demonstrate mechanistic insight and, where possible, point to biomarkers or therapeutic entry points.
Themes
- Receptor system logic: PRRs, cytokine/chemokine receptors, GPCRs, TCR/BCR, co-stimulation/checkpoints
- Second messengers: Ca2+, cAMP/cGMP, DAG/IP3, ROS/RNS
- Core pathways: JAK–STAT, NF-κB, MAPK/ERK, IRF, PI3K–AKT–mTOR, cGAS–STING
- Spatiotemporal signaling and immune synapse organization
- Tolerance/exhaustion, plasticity, and memory encoding
- Cytokine and chemokine network integration; vesicle-mediated signaling
Dr. Nima Gharahdaghi
Guest Editor
Manuscript Submission Information
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Keywords
- immune signaling
- receptor signaling
- cytokine receptors
- immune cells
- infectious disease
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