Allergen-Specific Immune Cell Responses

Dear Colleagues,

Globally, allergic diseases represent one of the most important hypersensitivity disorders, affecting more than 30% of the world's population. Their prevalence has increased substantially over recent decades, imposing a significant medical and social burden. Clinical manifestations of allergic diseases are critically linked to the production of allergen-specific IgE antibodies and subsequent IgE-mediated activation of mast cells and basophils.

A large number of studies have investigated the humoral immune response in allergy, particularly the mechanisms underlying allergen-specific IgE production. However, despite this progress, important questions remain unclear regarding the regulation of primary IgE sensitization, the maintenance of long-term memory, and the interplay between B cells and T-cell subsets that shape the magnitude and persistence of allergic reactions.

This Special Issue focuses on recent advances in understanding the cellular mechanisms that drive allergic sensitization and immune memory. Particular emphasis is placed on the interactions between T-cell subsets and B cells that regulate allergen-specific IgE production and effector cell activation.

Prof. Dr. Rudolf Valenta
Dr. Maria G. Byazrova
Guest Editors

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