Advance in Glycation End-Products in Aging and Metabolic Diseases
A Special Issue of Cells (ISSN 2073-4409) belonging to the section "Cellular Aging".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 201
Editor
Interests: Stab2 receptor, advanced glycation end-products; protein-ligand interactions; structural biology; psychrophilic enzymes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Advanced glycation end-products (AGEs) constitute a chemically diverse group of complex biomolecules absorbed exogenously from diet or formed endogenously on the course of various pathways in the human body. AGEs are formed non-enzymatically through condensation of the carbonyl group of reducing saccharides and the free amine group of amino acids, nucleic acids, or lipids, yielding unstable intermediates undergoing further rearrangements to irreversible, stable end-products. The most investigated AGE representatives include Nε-(1-carboxyethyl)lysine (CEL), Nε-(carboxymethyl)lysine (CML), pentosidine, crossline, and others. Levels of certain glycated proteins, such as circulatory glycated haemoglobin (HbA1c), serve as well-established biomarkers of states like hyperglycaemia, insulin resistance, and diabetes mellitus (DM).
AGEs are recognized by several cellular receptors, including the primary Receptor for AGEs (RAGE); however, the structural aspects of AGE recognition remain limited. Elevated AGE levels trigger a series of signaling pathways related to oxidative stress, inflammation, aging and several pathological processes. They have been implicated in lifestyle-related metabolic diseases, including DM, cancer, renal, and cardiovascular and neurodegenerative diseases. Although many pharmacologic anti-AGE therapies have been reported, their efficacy often still needs to be evaluated in clinical trials.
The aim of this Special Issue is to gather original papers and reviews that advance the field of glycation end-products in the context of aging and metabolic diseases. We look forward to receiving your contributions.
Dr. Aleksandra Twarda-Clapa
Guest Editor
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Keywords
- advanced glycation end-products
- AGEs
- AGE receptors
- scavenger receptors
- signalling pathways
- AGE-related diseases
- inflammation
- aging
- metabolic diseases
- anti-AGE therapies
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